Myokines in Response to a Tournament Season among Young Tennis Players.

The study investigated changes in myokines, heat shock proteins, and growth factors in highly ranked, young, male tennis players in response to physical workload during the competitive season and their potential correlations with match scores. Blood collections were carried out at the beginning, the midpoint, and the end of the tournament season. Data analysis revealed a significant increase in interleukin 6 and its inverse correlation with the number of lost games (r = -0.45; 90% CI -0.06 to 0.77). Neither the irisin nor BDNF level changed notably, yet delta changes of irisin across the season significantly correlated with the number of games won. The concentration of HSP27 recorded a small increase (31.2%; 90% CI 10.7 to 55.5, most likely). A negative correlation was noted between IGF-1 and HSP27 concentration at baseline (-0.70 very high; 90% CI -0.89 to -0.31, very likely). At the end of the season IGF-1 correlated positively with the number of games won (r = 0.37 moderate, 90% CI -0.16 to 0.73, likely) but negatively with the number of games lost (r = -0.39, 90% CI -0.14 to -0.74, likely). In conclusion our data indicated that Il-6, irisin, and growth factor IGF-1 may modify overall performance during a long lasting season, expressed in the amount of games won or lost.

Failure to unlearn the precedence effect.

Studies of the precedence effect using two binaural clicks have shown that listeners' ability to discriminate changes in the interaural time difference (ITD) of the lagging click is much poorer than that for the leading click [e.g., Zurek, J. Acoust. Soc. Am. 67, 952-964 (1980)]. This difference is thought to reflect an auditory process that suppresses directional information from the lagging sound and attributes greater perceptual weight to directional information contained in the leading one. A report by Saberi and Perrott [J. Acoust. Soc. Am. 87, 1732-1737 (1990)] suggested that listeners can "unlearn" this suppression of the lag's directional information after training with an adaptive psychophysical procedure involving 100 reversals and extremely small step sizes. Here, an attempt was made to find a similar effect using psychophysical procedures that are more common to precedence studies. Eight subjects were rigorously trained on the precedence task using either a blocked procedure or an adaptive procedure to vary ITD. Listeners showed no sign of unlearning. After 9-31 h of participating in the task, all subjects maintained high lag just-noticeable differences (jnd's) and low single source jnd's. This failure to train away the precedence effect (as manifested in discrimination suppression) suggests that directional information contained in the lagging source is not easily accessed. Several possible explanations for the discrepancies between the present study and Saberi and Perrott's finding are discussed.

Evaluation of feedback-reduction algorithms for hearing aids.

Three adaptive feedback-reduction algorithms were implemented in a laboratory-based digital hearing aid system and evaluated with dynamic feedback paths and hearing-impaired subjects. The evaluation included measurements of maximum stable gain and subjective quality ratings. The continuously adapting CNN algorithm (Closed-loop processing with No probe Noise) provided the best performance: 8.5 dB of added stable gain (ASG) relative to a reference algorithm averaged over all subjects, ears, and vent conditions. Two intermittently adapting algorithms, ONO (Open-loop with Noise when Oscillation detected) and ONQ (Open-loop with Noise when Quiet detected), provided an average of 5 dB of ASG. Subjects with more severe hearing losses received greater benefits: 13 dB average ASG for the CNN algorithm and 7-8 dB average ASG for the ONO and ONQ algorithms. These values are conservative estimates of ASG because the fitting procedure produced a frequency-gain characteristic that already included precautions against feedback. Speech quality ratings showed no substantial algorithm effect on pleasantness or intelligibility, although subjects informally expressed strong objections to the probe noise used by the ONO and ONQ algorithms. This objection was not reflected in the speech quality ratings because of limitations of the experimental procedure. The results clearly indicate that the CNN algorithm is the most promising choice for adaptive feedback reduction in hearing aids.

Intraoperative and laboratory evaluation of skeletonized versus pedicled internal thoracic artery.

BACKGROUND: The skeletonization of internal thoracic artery is postulated to improve graft length, early blood flow, sternal blood supply, and postoperative respiratory function. Concern exists that skeletonization may injure internal thoracic artery, precluding good results of surgery. Reports on endothelial function of skeletonized internal thoracic artery are lacking. METHODS: A prospective assessment of early clinical outcomes of 357 consecutive patients undergoing coronary artery bypass grafting was performed: 287 patients with nonskeletonized and 70 with skeletonized left internal thoracic artery (LITA). The lengths of LITA and of its discarded distal segment, as well as free LITA blood flow, were measured. The dose-effect relationship for relaxation to acetylcholine was studied in the organ bath. RESULTS: Apart from a higher incidence of breaching the pleura with nonskeletonized LITA the clinical outcomes were comparable. The length of skeletonized LITA was 17.8+/-1.14 cm versus 20.3+/-0.52 cm skeletonized (p = 0.11). The length of discarded LITA was shorter in nonskeletonized artery (0.8+/-0.28 cm versus 2.6+/-0.49 cm; p = 0.022). The free LITA blood flow was 66.3+/-7.42 mL/min in nonskeletonized vessel versus 100.3+/-14.84 mL/min in skeletonized (p = 0.048). The acetylcholine-induced relaxation was similar in both groups (maximal relaxation, 80.7%+/-5.95% in nonskeletonized versus 72.9%+/-9.11% in skeletonized; not significant; negative logarithm of half-maximal effect, 7.43+/-0.18 versus 7.1+/-0.10, respectively; p = 0.063). CONCLUSIONS: Skeletonization does not damage the endothelial function of the LITA. Higher free blood flow and available LITA length should encourage the use of skeletonized LITA in clinical practice.

Onset dominance in lateralization.

Saberi and Perrott [Acustica 81, 272-275 (1995)] found that the in-head lateralization of a relatively long-duration pulse train could be controlled by the interaural delay of the single pulse pair that occurs at onset. The present study examined this further, using an acoustic pointer measure of lateralization, with stimulus manipulations designed to determine conditions under which lateralization was consistent with the interaural onset delay. The present stimuli were wideband pulse trains, noise-burst trains, and inharmonic complexes, 250 ms in duration, chosen for the ease with which interaural delays and correlations of select temporal segments of the stimulus could be manipulated. The stimulus factors studied were the periodicity of the ongoing part of the signal as well as the multiplicity and ambiguity of interaural delays. The results, in general, showed that the interaural onset delay controlled lateralization when the steady state binaural cues were relatively weak, either because the spectral components were only sparsely distributed across frequency or because the interaural time delays were ambiguous. Onset dominance can be disrupted by sudden stimulus changes within the train, and several examples of such changes are described. Individual subjects showed strong left-right asymmetries in onset effectiveness. The results have implications for understanding how onset and ongoing interaural delay cues contribute to the location estimates formed by the binaural auditory system.

Villchur revisited: another look at automatic gain control simulation of recruiting hearing loss.

An algorithm to simulate the effects of sensorineural hearing impairment on speech reception was investigated. Like that described by Villchur [J. Acoust. Soc. Am. 62, 665-674 (1977)], this simulation employs automatic gain control in independent frequency bands to reproduce the elevated audibility thresholds and loudness recruitment that are characteristic of this type of loss. In the present implementation, band gains are controlled in an effort to simulate loudness recruitment directly, using recruitment functions that depend only on the magnitude of hearing loss in the band. In a preliminary evaluation, two normal-hearing subjects listened to the simulation matched to hearing losses studied previously [Zurek and Delhorne, J. Acoust. Soc. Am. 82, 1548-1559 (1987)] with noise-masking simulations. This evaluation indicated that the present automatic gain control simulation yielded scores roughly similar to those of both the hearing-impaired listeners and the masked-normal listeners. In the more-detailed evaluation, the performance of three listeners with severe sensorineural hearing loss on several speech intelligibility tests was compared to that of normal-hearing subjects listening to the output of the simulation. These tests included consonant-vowel syllable identification and sentence keyword identification for several combinations of speech-to-noise ratio, frequency-gain characteristic, and overall level. Generally, the simulation algorithm reproduced speech intelligibility well, though there was a clear trend for the simulation to result in better intelligibility than observed for impaired listeners when high-frequency emphasis placed more of the speech spectrum above threshold at higher frequencies. Also, the hearing-impaired listener with the greatest loss showed the largest discrepancies with the simulation. Overall, however, the simulation provides a very good approximation to speech reception by hearing-impaired listeners. The results of this study, together with previous studies of noise-making simulation, suggest that threshold elevation and recruitment, which are necessary features of a simulation of cochlear hearing loss, can also be largely sufficient for simulating the speech-reception performance of listeners with moderate to severe hearing impairments.

Cross-frequency interactions in the precedence effect.

This paper concerns the extent to which the precedence effect is observed when leading and lagging sounds occupy different spectral regions. Subjects, listening under headphones, were asked to match the intracranial lateral position of an acoustic pointer to that of a test stimulus composed of two binaural noise bursts with asynchronous onsets, parametrically varied frequency content, and different interaural delays. The precedence effect was measured by the degree to which the interaural delay of the matching pointer was independent of the interaural delay of the lagging noise burst in the test stimulus. The results, like those of Blauert and Divenyi [Acustica 66, 267-274 (1988)], show an asymmetric frequency effect in which the lateralization influence of a lagging high-frequency burst is almost completely suppressed by a leading low-frequency burst, whereas a lagging low-frequency burst is weighted equally with a leading high-frequency burst. This asymmetry is shown to be the result of an inherent low-frequency dominance that is seen even with simultaneous bursts. When this dominance is removed (by attenuating the low-frequency burst) the precedence effect operates with roughly equal strength both upward and downward in frequency. Within the scope of the current study (with lateralization achieved through the use of interaural time differences alone, stimuli from only two frequency bands, and only three subjects performing in all experiments), these results suggest that the precedence effect arises from a fairly central processing stage in which information is combined across frequency.

Adjustment and discrimination measurements of the precedence effect.

A simple model to summarize the precedence effect is proposed that uses a single metric to quantify the relative dominance of the initial interaural delay over the trailing interaural delay in lateralization. This model is described and then used to relate new measurements of the precedence effect made with adjustment and discrimination paradigms. In the adjustment task, subjects matched the lateral position of an acoustic pointer to the position of a composite test stimulus made up of initial and trailing binaural noise bursts. In the discrimination procedure, subjects discriminated interaural time differences in a target noise burst in the presence of another burst either trailing or preceding the target. Experimental parameters were the delay between initial and trailing stimuli and the overall level of the stimulus. The model parameters (the metric c and the variability of lateral position judgments) were estimated from the results of the matching experiment and used to predict results of the discrimination task with good success. Finally, the observed values of the metric were compared to values derived from previous studies.

A note on onset effects in binaural hearing.

Various definitions of interaural "onset" delays in binaural stimuli have led to discrepant conclusions about the relative strength of onset versus ongoing cues. A distinction is offered here between gating (envelope-onset) delays, and early fine-structure (carrier) delays. This distinction, in conjunction with independent experimental results on the relative effectiveness of interaural envelope and carrier delays, leads to a reconciling interpretation.

Detectability of transient and sinusoidal otoacoustic emissions.

An analysis is presented of the detectability of the two types of otoacoustic emissions being considered for use in clinical tests of hearing. It is estimated that, for equal emission levels and equal probability of error, measurement of distortion-product emissions can be made at least 30 times faster than transient-evoked emissions using current techniques.

Evaluation of an adaptive beamforming method for hearing aids.

In this paper evaluations of a two-microphone adaptive beamforming system for hearing aids are presented. The system, based on the constrained adaptive beamformer described by Griffiths and Jim [IEEE Trans. Antennas Propag. AP-30, 27-34 (1982)], adapts to preserve target signals from straight ahead and to minimize jammer signals arriving from other directions. Modifications of the basic Griffiths-Jim algorithm are proposed to alleviate problems of target cancellation and misadjustment that arise in the presence of strong target signals. The evaluations employ both computer simulations and a real-time hardware implementation and are restricted to the case of a single jammer. Performance is measured by the spectrally weighted gain in the target-to-jammer ratio in the steady state. Results show that in environments with relatively little reverberation: (1) the modifications allow good performance even with misaligned arrays and high input target-to-jammer ratios; and (2) performance is better with a broadside array with 7-cm spacing between microphones than with a 26-cm broadside or a 7-cm endfire configuration. Performance degrades in reverberant environments; at the critical distance of a room, improvement with a practical system is limited to a few dB.

Potential benefits of adaptive frequency-gain characteristics for speech reception in noise.

Some current single-microphone hearing aids employ techniques for adaptively varying the frequency-gain characteristics in an attempt to improve speech reception in noise. The potential benefit of this strategy depends on the spectral spread of masking and the degree to which it can be reduced by changing the frequency-gain characteristic. In this study these benefits were examined for subjects with normal hearing under static listening conditions. In the unprocessed condition, subjects were presented with nonsense syllables in an octave-band noise centered on 0.5, 1, or 2 kHz. The frequency-gain characteristic was then modified with the goal of reducing the intensity of the frequency region containing the octave-band noise. This processing resulted in increases as large as 60 percentage points in consonant-correct scores with the low- and mid-frequency octave noise bands, and a small increase with the high-frequency noise. Masking patterns produced by the octave noises were also measured and were related to the intelligibility results via an analysis based on Articulation Theory. The Articulation Index was also used to compare the effectiveness of three adaptive rules. A simple multiband volume control is expected to provide much of the benefit of more sophisticated systems without the need for separate estimation of input speech and noise spectra.

Probability distributions of interaural phase and level differences in binaural detection stimuli.

Probability distributions of interaural phase and level differences are derived for the stimuli used in many studies of binaural detection and interaural-correlation discrimination. Example distributions are shown and summary plots give the standard deviations of these distributions as functions of signal-to-noise ratio.

Robustness of an adaptive beamforming method for hearing aids.

We describe the results of computer simulations of a multimicrophone adaptive-beamforming system as a noise reduction device for hearing aids. Of particular concern was the system's sensitivity to violations of the underlying assumption that the target signal is identical at the microphones. Two- and four-microphone versions of the system were tested in simulated anechoic and modestly-reverberant environments with one and two jammers, and with deviations from the assumed straight-ahead target direction. Also examined were the effects of input target-to-jammer ratio and adaptive-filter length. Generally, although the noise-reduction performance of the system is degraded by target misalignment and modest reverberation, the system still provides positive advantage at input target-to-jammer ratios up to about 0 dB. This is in contrast to the degrading target-cancellation effect that the system can have when the equal-target assumption is violated and the input target-to-jammer ratio is greater than zero.

Lateralization of coherent and incoherent targets added to a diotic background.

Lateralization responses to noise targets were obtained in a diotic noise background. On each trial, a noise target was added to the background noise in one earphone. Subjects were required to identify the earphone containing the target. Noise targets were either coherent or incoherent with the background. The long-term power spectrum of the incoherent target was identical to that of the background noise, and its amplitude was adjusted so that the addition of either the coherent or incoherent target to the background produced the same average increment in power. When 50-ms noise targets were presented in the middle of a 750-ms diotic background, lateralization thresholds were lower for the incoherent targets. The advantage with incoherent targets was shown to depend on the temporal relationships between target and masker. Superior performance with incoherent targets is inconsistent with predictions based on an analysis of interaural phase and amplitude differences. Models based on interaural subtraction, on the other hand, are able to account for the lateralization advantage shown by incoherent targets but are unable to account for the variations in threshold produced by altering the temporal relationships between target and masker.

Ear canal acoustic distortion at 2f1-f2 from human ears: relation to other emissions and perceived combination tones.

Two aspects of the intermodulation distortion product at 2f1-f2 generated by normal human ears and measured acoustically in the ear canal were studied: (1) its relation to tone-evoked and spontaneous otoacoustic emissions, and (2) its relation to the perceived combination tone at the same frequency. With regard to (1), substantial differences among ears in the detectability of emissions were observed; ears tended to exhibit all or none of the emission types that were sought. Within ears possessing emissions, the magnitudes of tone-evoked emissions and acoustic distortion showed a similar dependence on frequency. With regard to (2), a three-primary-tone stimulus was employed to ask whether the ear canal acoustic distortion tone is canceled under the same stimulus conditions that produce perceptual cancellation. Simultaneous cancellation of perceptual and acoustic distortion was produced rarely. Results are interpreted qualitatively with a model in which primary tones produce distortion at their interaction region within the cochlea; this distortion propagates to the distortion-frequency place where it mediates perception. This same distortion wave produces emission components at additional locations, including the primary-tone interaction region, which sum vectorially to mediate the emitted acoustic distortion product.

Resonance-frequency discrimination.

Measurements of the just-noticeable change in resonance frequency delta Fr of a second-order filter are reported. The source signal was either periodic, with or without a smooth change in fundamental frequency, or it was random white noise. These differences in the nature of the source had little effect on delta Fr. Over the investigated ranges of reference resonance frequency (Fr = 300 to 2000 Hz) and filter selectivity (Q = 1 to 36), the results are well summarized by delta Fr = 0.079 Fr/square root Q. The data were used to evaluate filter-bank models employing different filter shapes and performance-prediction schemes. A good fit to the resonance-discrimination data was obtained with filters derived in a masking study by Patterson [J. Acoust. Soc. Am. 55, 802-809 (1974)] and with performance based on use of the maximum level difference over all bands. The latter finding indicates that listeners may not make optimal use of small level differences distributed over multiple bands.

Consonant reception in noise by listeners with mild and moderate sensorineural hearing impairment.

The goal of this study was to determine the extent to which the difficulty experienced by impaired listeners in understanding noisy speech can be explained on the basis of elevated tone-detection thresholds. Twenty-one impaired ears of 15 subjects, spanning a variety of audiometric configurations with average hearing losses to 75 dB, were tested for reception of consonants in a speech-spectrum noise. Speech level, noise level, and frequency-gain characteristic were varied to generate a range of listening conditions. Results for impaired listeners were compared to those of normal-hearing listeners tested under the same conditions with extra noise added to approximate the impaired listeners' detection thresholds. Results for impaired and normal listeners were also compared on the basis of articulation indices. Consonant recognition by this sample of impaired listeners was generally comparable to that of normal-hearing listeners with similar threshold shifts listening under the same conditions. When listening conditions were equated for articulation index, there was no clear dependence of consonant recognition on average hearing loss. Assuming that the primary consequence of the threshold simulation in normals is loss of audibility (as opposed to suprathreshold discrimination or resolution deficits), it is concluded that the primary source of difficulty in listening in noise for listeners with moderate or milder hearing impairments, aside from the noise itself, is the loss of audibility.

Spectral-shape discrimination. I. Results from normal-hearing listeners for stationary broadband noises.

This research is concerned with the ability of normal-hearing listeners to discriminate broadband signals on the basis of spectral shape. The signals were six broadband noises whose spectral shapes were modeled after the spectra of unvoiced fricative and plosive consonants. The difficulty of the discriminations was controlled by the addition of noise filtered to match the long-term speech spectrum. Two-interval discrimination measurements were made in which loudness cues were eliminated by randomizing (roving) the overall stimulus level between presentation intervals. Experimental results, examined as a function of intensity rove width, stimulus duration, and stimulus pair, were related to the predictions of a simple filter-bank model whose fitting parameter provides an estimate of internal noise. Most results, with the notable exception of duration effects, were predicted by the model. Estimates of internal noise in each frequency channel averaged roughly 7 dB for long-duration stimuli and 13 dB for short-duration stimuli. Results and predictions are compared to results of other studies concerned with the discrimination of spectral shape.