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Food Chem Toxicol ; 135: 110946, 2020 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-31712106

RESUMEN

This study investigated the inhibitory activity of serine protease, as well as antibacterial and antibiotic modifying activities of the crude extract and fractions of A. cearensis seeds. Microdilution assay was used to evaluate the antibacterial activity and the antibiotic resistance-modulating effects of samples against multiresistant bacteria Staphylococcus aureus (SA10) and Escherichia coli (EC06). In the inhibition test for serine protease, all the samples showed inhibition of enzymatic activity. Crude extract and fractions of A. cearensis seeds showed a Minimum Inhibitory Concentration ≥1024 µg/mL for all microorganisms tested. However, the samples acted as resistance modifying agent, presenting synergism when associated with gentamicin, norfloxacin and penicillin. The present study provides data indicating a possible use of the seeds extract of A. cearensis in association with antibiotics in the fight against bacterial infections.


Asunto(s)
Antibacterianos/farmacología , Fabaceae/química , Extractos Vegetales/farmacología , Inhibidores de Serina Proteinasa/farmacología , Antibacterianos/aislamiento & purificación , Escherichia coli/efectos de los fármacos , Pruebas de Sensibilidad Microbiana , Extractos Vegetales/aislamiento & purificación , Semillas/química , Inhibidores de Serina Proteinasa/aislamiento & purificación , Staphylococcus aureus/efectos de los fármacos
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