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Acta Neurobiol Exp (Wars) ; 82(2): 217-225, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35833821

RESUMEN

The lateral hypothalamus (LH) sends neural pathways to structures involved on predator­related defensive behaviours, escape and antinociception. The aim of this study was to investigate the role played by µ-opioid receptors located on LH neurons in defensive behaviour and unconditioned fear­induced antinociception elicited by electric stimulation of LH. To achieve the goals, the µ1-opioid receptor selective antagonist naloxonazine was administered at different concentrations in the LH, and the defensive behaviour and fear­induced antinociception elicited by electrical stimulation of LH were evaluated. The electrical stimulation of LH caused escape behaviour followed by defensive antinociception. Microinjections of naloxonazine in a concentration of 5.0 µg/0.2 µL in the LH decreased the aversive stimulus­induced escape behaviour thresholds, but diminished defensive antinociception. These findings suggest that µ-opioid receptors of LH can be critical to panic attack­related symptoms and facilitate the unconditioned fear­induced antinociception produced by LH neurons activation.


Asunto(s)
Conducta Animal , Área Hipotalámica Lateral , Trastorno de Pánico , Receptores Opioides mu , Animales , Conducta Animal/efectos de los fármacos , Conducta Animal/fisiología , Bicuculina/farmacología , Miedo/fisiología , Área Hipotalámica Lateral/efectos de los fármacos , Área Hipotalámica Lateral/metabolismo , Naloxona/análogos & derivados , Naloxona/farmacología , Antagonistas de Narcóticos/farmacología , Nocicepción , Pánico/fisiología , Trastorno de Pánico/metabolismo , Trastorno de Pánico/psicología , Ratas , Ratas Wistar , Receptores Opioides mu/antagonistas & inhibidores , Receptores Opioides mu/metabolismo
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