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Transpl Infect Dis ; 23(4): e13630, 2021 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-33915010

RESUMEN

Surveillance programs have been reporting decreasing rates of carbapenem-sensitivity in Serratia marcescens, leading to a concern regarding the few remaining therapeutic options to treat these multidrug-resistant (MDR) organisms. Here, we describe a case series of 11 stem cell hematopoietic transplantation patients infected (N = 6) or colonized (N = 5) by carbapenem-resistant S marcescens (CrSm) from 2010 to 2013. The comorbidities found were acute renal insufficiency (3/11), neutropenia (7/11), and mucositis (8/11), and the mortality rate was 64%. KPC was the most prevalent carbapenemase detected (8/11) and tigecycline and gentamicin were the antimicrobials used as treatment.


Asunto(s)
Bacteriemia , Trasplante de Células Madre Hematopoyéticas , Antibacterianos/uso terapéutico , Bacteriemia/tratamiento farmacológico , Bacteriemia/epidemiología , Carbapenémicos/farmacología , Carbapenémicos/uso terapéutico , Trasplante de Células Madre Hematopoyéticas/efectos adversos , Humanos , Serratia marcescens , beta-Lactamasas
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