1.
Bioorg Med Chem Lett
; 23(21): 5829-32, 2013 Nov 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-24075732
RESUMEN
A sub-class of distinct small molecule ROMK inhibitors were developed from the original lead 1. Medicinal chemistry endeavors led to novel ROMK inhibitors with good ROMK functional potency and improved hERG selectivity. Two of the described ROMK inhibitors were characterized for the first in vivo proof-of-concept biology studies, and results from an acute rat diuresis model confirmed the hypothesis that ROMK inhibitors represent new mechanism diuretic and natriuretic agents.