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2.
Clinics (Sao Paulo) ; 61(3): 223-30, 2006 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-16832555

RESUMEN

OBJECTIVE: The aim of this study is to compare the effects of traditional nonsteroidal anti-inflammatory drugs with nonsteroidal anti-inflammatory drugs that are selective cyclooxygenase-2 (COX-2) inhibitors in the process of bone regeneration in a rat model. MATERIALS AND METHODS: Forty-four Wistar strain rats were subjected to osteotomy of the right femur and randomly divided into 3 groups according to the drug to be given (diclofenac, rofecoxib, or placebo). Each group was divided into 2 subgroups according to the time to euthanasia after the surgery. The animals of Subgroup 1 were submitted to euthanasia 2 weeks after surgery, and those of Subgroup 2, underwent euthanasia 4 weeks after surgery. Radiographic examinations and bone callus histomorphometry were analyzed. RESULTS: No intergroup statistical difference was found in the bone callus area or in bone formation area 2 and 4 weeks after surgery. Intra-group analysis concerning the bone neoformation area inside the callus showed a significant difference within the diclofenac group, which presented less tissue. CONCLUSIONS: Fracture consolidation in Wistar rats occurs within less than 2 weeks, and the use of nonsteroidal anti-inflammatory drugs does not significantly influence this process.


Asunto(s)
Antiinflamatorios no Esteroideos/farmacología , Regeneración Ósea/efectos de los fármacos , Callo Óseo/cirugía , Inhibidores de la Ciclooxigenasa 2/farmacología , Diclofenaco/farmacología , Lactonas/farmacología , Sulfonas/farmacología , Animales , Callo Óseo/diagnóstico por imagen , Callo Óseo/patología , Osteotomía , Radiografía , Ratas , Ratas Wistar , Factores de Tiempo
3.
Rev. bras. ortop ; 30(4): 191-6, abr. 1995. ilus
Artículo en Portugués | LILACS | ID: lil-160932

RESUMEN

Os autores analisam casuística de 11 pacientes vítimas de amputaçöes ao nível do polegar provocadas por mecanismo de avulsäo. Relatam as técnicas das reconstruçöes realizadas e referem os resultados obtidos, imediatamente e tardios. A maioria das amputaçöes ocorreu ao nível da articulaçäo metacarpofalangiana. O índice de sucesso em termos de sobrevida e resultado funcional satisfatório foi de 64 por cento. Concluem que, mesmo nestas situaçöes de alta complexidade, os reimplantes do polegar sempre devem ser realizados


Asunto(s)
Humanos , Masculino , Femenino , Preescolar , Niño , Adolescente , Adulto , Amputación Traumática , Reimplantación , Pulgar/cirugía , Articulación Metacarpofalángica/lesiones , Microcirugia , Pulgar/fisiología , Resultado del Tratamiento , Arteria Cubital/trasplante
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