Relevance of breast cancer subtypes for magnetic resonance imaging response monitoring during neoadjuvant chemotherapy

Changes in magnetic resonance imaging (MRI) during neoadjuvant chemotherapy (NAC) have been reported as predictive of pathology outcome in triple-negative and HER2-positive breast cancer. The purpose of our study was to evaluate the relevance of breast cancer subtype for MRI response in 24 women before and during NAC in our centre. Our results show that a reduction greater than 23% is associated with a pathological complete response (pCR) in Her-2-positive and ER-negative/Her2-negative breast cancer, and suggest a trend correlation between higher ADC values and pCR in these subtypes in comparison with ER-positive/Her2-negative breast cancers. Higher proliferating tumours respond better to chemotherapy and our study suggests that changes in MRI during NAC are predictive of pCR in these breast cancer subtypes (AU)

[Evolution of the darbepoetin alpha resistance index in patients on dialysis who change from weekly to fortnightly treatments in clinical practice]. / Evolución del índice de resistencia a darbepoetina alfa en pacientes dializados que cambian de administración semanal a quincenal en la práctica clínica.

BACKGROUND: Darbepoetin alpha (DA) administered every-other-week (Q2W) is efficacious and safe for the treatment of anaemia in patients undergoing dialysis. There are no data available regarding the evolution of erythropoietic resistance index (ERI) after conversion from weekly (QW) to Q2W administration of DA in clinical practice. MATERIAL AND METHODS: Multicenter, observational, retrospective, 16-weeks study, which included stable patients undergoing dialysis who were converted from DA QW to DA Q2W in clinical practice. Conversion was done according to product specifications (duplicating QW dose). The ERI to DA was calculated by dividing the weekly DA dose per kilogram of weight (microg/wk.kg)*200 by the Hb level (g/dL). ERI evolution with time was evaluated by multivariate repeated measures ANOVA, adjusting for significant covariates. RESULTS: A total of 202 patients were included (137 patients undergoing haemodialysis [HD], intravenous (IV) DA, and 65 patients receiving peritoneal dialysis [PD], subcutaneous DA). Mean (SD) age was 66 (17) years; 61% of patients were men. Large intercentre variability was observed for the ERI at conversion time (coefficient of variation of 88%, p < 0.001 for differences between centres). In the univariate analysis, predictor factors for high baseline ERI were low albumin level (r = -0.29; p =0.001), HD (mean ERI of 9.3 [8.4] vs 6.8 [4.6] for PD; p = 0.005), or previous cardiovascular disease (9.9 [8.7] vs 7.4 [6.3] for patients without history; p =0.025). During the follow up, the ERI was slightly increased in HD patients (9.3 [8.4] at conversion vs 11.1 [7.3] at 16 weeks; p < 0.05), and remained stable in PD patients (6.8 [4.6] vs 6.7 [4.0], respectively; NS). In the multivariate analysis, there were no significant differences in ERI during the 16 weeks post-conversion after adjusting for albumin levels and centre (adjusted baseline mean [95% CI] of 10.0 [8.7-11.4] vs 10.5 [9.3-11.8] at 16 weeks, adjusted change of +0.5 [-0.67; 1.67]; NS). After 16 weeks, only 7 patients (3.5%) had discontinued Q2W administration. CONCLUSIONS: Extension from weekly to once every other-week darbepoetin alpha allows to simplify anaemia treatment without increasing the resistance index, regardless of dialysis type. The multivariate analysis shows that, after adjusting by center and inflammation/nutritional status, there were no changes in the response to darbepoetin alpha during the first 16 weeks after conversion in clinical practice.

[Nursing and the prevention of biological risks: from education to professional activity]. / Enfermeria y prevención de riesgos biológicos. Desde la formación hasta el ejercicio de su profesión.

OBJECTIVE: To discover the training nursing students receive regarding prevention and control of infection inside hospital settings and the means of self-protection as well as making people aware of the need to improve this training if deemed necessary. METHODS: This is a transversal descriptive study which took place in the nursing schools in Spain. Data was gathered by means of a questionnaire each respondent filled in by themselves. The lack of a response was also studied. A followup meeting was held with those who participated in this study to seek consensus in the search for solutions to those necessary changes detected. RESULTS: 86% responded to the questionnaire. During the course of career preparation, these were the average number of hours dedicated to various areas of study: 34.5 to Biological Statistics, 40 to Epidemiology, 28 to Infectious Diseases, 29 to Microbiology, 9 to Infection Control, 11 to Concepts of Aspesis and Antisepsis, and 36 to Methods of Research and Investigation. More than 50% of the professors teaching these classes are licensed nurses. Student followup during their clinical practice was carried out basically by nurses in university hospitals. 39% of nursing schools teach the concept and content for universal precautions prior to clinical practice. In the majority of public nursing schools, the followup of a student after a biological accident is carried out by the preventive medicine service, whereas this is done by the school insurance company in private nursing schools. Therefore, significant differences exist. COMMENTS: The theoretical knowledge taught is adequate; the number of hours dedicated to each subject varies among the schools; it is necessary to come to an agreement on the minimum levels of training required before engaging in clinical practice in a safe manner. Universal precautions should be taught in all schools before clinical practice occurs.