1.
Bioorg Med Chem Lett
; 8(10): 1201-6, 1998 May 19.
Artículo
en Inglés
| MEDLINE
| ID: mdl-9871735
RESUMEN
The syntheses of several heparin-like glycoconjugates (i.e., 16a-f) containing identical AT III binding domains (ABD) and spacers but different thrombin binding domains (TBDs) are described. Biological activities of conjugates 16a-f indicate that the thrombin inhibitory activity is mainly determined by the charge density of the TBD moiety.