Asunto(s)
Aneurisma de la Aorta Abdominal/diagnóstico por imagen , Aneurisma de la Aorta Torácica/diagnóstico por imagen , Hallazgos Incidentales , Imagen de Perfusión , Trombosis/diagnóstico por imagen , Aortografía , Dolor en el Pecho/etiología , Diagnóstico Diferencial , Disnea/etiología , Humanos , Masculino , Persona de Mediana Edad , Embolia Pulmonar/diagnóstico , Trombosis/complicaciones , Tomografía Computarizada por Rayos XAsunto(s)
Defectos de los Tabiques Cardíacos/diagnóstico por imagen , Hipertensión Pulmonar/diagnóstico por imagen , Pulmón/diagnóstico por imagen , Embolia Pulmonar , Adulto , Encéfalo/diagnóstico por imagen , Diagnóstico Diferencial , Femenino , Fibrosis , Defectos de los Tabiques Cardíacos/complicaciones , Enfermedad de Hodgkin/complicaciones , Enfermedad de Hodgkin/radioterapia , Humanos , Hipertensión Pulmonar/etiología , Hallazgos Incidentales , Riñón/diagnóstico por imagen , Mediastino/lesiones , Mediastino/patología , Mediastino/efectos de la radiación , Ventilación Pulmonar , Traumatismos por Radiación/etiología , Traumatismos por Radiación/patología , Cintigrafía , Radiofármacos/farmacocinética , Agregado de Albúmina Marcado con Tecnecio Tc 99m/farmacocinética , Distribución Tisular , Tomografía Computarizada por Rayos XRESUMEN
OBJECTIVE: To analyse the behaviour of serum thyroglobulin (Tg), antithyroglobulin antibodies (TgAb), thyrotropin (TSH), free thyroxine (FT4) and total triiodothyronine (TT3) levels at each time during the rhTSH stimulation protocol in patients with differentiated thyroid carcinoma (DTC). MATERIALS AND METHODS: We carried out 117 rhTSH stimulations in DTC patients. We determined the serum levels of Tg, TgAb, TSH, FT4 and TT3 at baseline and 24, 48 and 96 hours after beginning stimulation, using RIA or IRMA. The software program SPSS 15.0 was used for statistical analysis of data. RESULTS: We found statistically significant differences between the mean Tg values at different times (2.08 ng/ml baseline; 2.64 ng/ml at 24 hours; 4.98 ng/ml at 48 hours; 6.59 ng/ml at 96 hours), reaching maximum values at 96 hours. During this time, we observed the highest percentage of pathological values. After administration of rhTSH, there was a significant increase in the mean TSH value (98.88 mIU/l at 24 hours; 111.10 mIU/l at 48 hours). The mean TSH value at 96 hours decreased approximately 5 times with respect to the mean 48 hour value. We did not observe changes in the TgAb, FT4 or TT3 levels. CONCLUSIONS: The assessment of Tg after rhTSH stimulation should be performed 96 hours after beginning stimulation. Administration of rhTSH causes a significant elevation in serum TSH levels, without modifying serum TgAb, FT4 or TT3 levels.
Asunto(s)
Autoanticuerpos/sangre , Carcinoma/sangre , Proteínas Recombinantes , Tiroglobulina/sangre , Tiroglobulina/inmunología , Neoplasias de la Tiroides/sangre , Tirotropina/sangre , Tiroxina/sangre , Triyodotironina/sangre , Humanos , Factores de TiempoRESUMEN
INTRODUCTION: The need for quality assurance of all technical aspects of nuclear medicine studies is widely recognised. However, little attention has been paid to the quality assurance of the applications software. Our work reported here aims at verifying the analysis software for processing of renal nuclear medicine studies (renograms). MATERIAL AND METHODS: The software tools were used to build a synthetic dynamic model of renal system. The model consists of two phases: perfusion and function. The organs of interest (kidneys, bladder and aortic artery) were simple geometric forms. The uptake of the renal structures was described by mathematic functions. Curves corresponding to normal or pathological conditions were simulated for kidneys, bladder and aortic artery by appropriate selection of parameters. RESULTS: There was no difference between the parameters of the mathematic curves and the quantitative data produced by the renal analysis program. CONCLUSION: Our test procedure is simple to apply, reliable, reproducible and rapid to verify the renal applications software.