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1.
Cells ; 8(12)2019 12 06.
Artículo en Inglés | MEDLINE | ID: mdl-31817583

RESUMEN

Recent studies have investigated the control of adipose tissue expansion and inflammatory process by microRNAs (miRNAs). These two processes are of great interest because both are associated with obesity and metabolic syndrome. However, despite the great relevance of the role of miRNAs in obesity and adipose tissue, no qualitative and quantitative analysis on the subject has been performed. Thus, we aimed to examine global research activity and current trends with respect to the interaction between obesity, adipose tissue and miRNAs through a bibliometric analysis. This research was performed on the Scopus database for publications containing miRNA, obesity, and adipose tissue keyword combinations. In total, 898 articles were analyzed and the most frequently occurring keywords were selected and clustered into three well-defined groups. As a result, first group of keywords pointed to the research area on miRNAs expressed in obesity-associated diseases. The second group demonstrated the regulation of the adipogenesis process by miRNAs, while the third group highlighted brown adipose tissue and thermogenesis as one of the latest global research trends related to the theme. The studies selected in this paper describe the expression and performance of different miRNAs in obesity and comorbidities. Most studies have focused on identifying miRNAs and signaling pathways associated with obesity, type 2 diabetes mellitus, and cardiovascular disease. Thus, the miRNA profile for these diseases may be used as biomarkers and therapeutic targets in the prevention and treatment of obesity-associated diseases.


Asunto(s)
Tejido Adiposo/metabolismo , Bibliometría , Susceptibilidad a Enfermedades , MicroARNs/genética , Obesidad/etiología , Obesidad/metabolismo , Biomarcadores , Biología Computacional/métodos , Perfilación de la Expresión Génica , Regulación de la Expresión Génica , Humanos
2.
J Sports Med Phys Fitness ; 57(5): 556-564, 2017 May.
Artículo en Inglés | MEDLINE | ID: mdl-26868642

RESUMEN

BACKGROUND: A hyperbolic function as well as a linear relationship between power output and time to exhaustion (Tlim) has been consistently observed during dynamic non-resistive exercises. However, little is known about its concept to resistance exercises (RE), which could be defined as critical load (CL). This study aimed to verify the existence of CL during dynamic RE and to verify the number of workbouts necessary to determine the optimal modeling to achieve it. METHODS: Fifteen healthy men (23±2.5 yrs) completed 1 repetition maximum test (1RM) on a leg press and 3 (60%, 75% and 90% of 1RM) or 4 (+ 30% of 1RM) workbouts protocols to obtain the CL by hyperbolic and linear regression models between Tlim and load performed. Blood lactate and leg fatigue were also measured. RESULTS: CL was obtained during RE and 3 workbouts protocol estimate it at 53% while 4 tests at 38% of 1 RM. However, based on coefficients of determination, 3 protocols provided a better fit than the 4-parameter model, respectively (R2>0.95 vs. >0.77). Moreover, all intensities increased blood lactate and leg fatigue, however, when corrected by Tlim, were significantly lower at CL. CONCLUSIONS: It was possible to determinate CL during dynamic lower limbs RE and that 3 exhaustive workbouts can be used to better estimate the CL, constituting a new concept of determining this threshold during dynamic RE and reducing the physically demanding nature of the protocol. These findings may have important applications for functional performance evaluation and prescription of RE programs.


Asunto(s)
Umbral Anaerobio/fisiología , Tolerancia al Ejercicio/fisiología , Fatiga Muscular/fisiología , Fuerza Muscular/fisiología , Músculo Esquelético/metabolismo , Entrenamiento de Fuerza/métodos , Adaptación Fisiológica , Voluntarios Sanos , Humanos , Masculino , Músculo Esquelético/fisiología , Adulto Joven
3.
Clinics (Sao Paulo) ; 71(9): 528-36, 2016 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-27652835

RESUMEN

OBJECTIVE: The purpose of this study was to investigate the effects of resistance training on angiogenesis markers of visceral adipose tissue in ovariectomized rats. METHOD: Adult Sprague-Dawley female rats were divided into four groups (n=6 per group): sham-sedentary, ovariectomized sedentary, sham-resistance training and ovariectomized resistance training. The rats were allowed to climb a 1.1-m vertical ladder with weights attached to their tails and the weights were progressively increased. Sessions were performed three times per week for 10 weeks. Visceral adipose tissue angiogenesis and morphology were analyzed by histology. VEGF-A mRNA and protein levels were analyzed by real-time PCR and ELISA, respectively. RESULTS: Ovariectomy resulted in higher body mass (p=0.0003), adipocyte hypertrophy (p=0.0003), decreased VEGF-A mRNA (p=0.0004) and protein levels (p=0.0009), and decreased micro-vascular density (p=0.0181) in the visceral adipose tissue of the rats. Resistance training for 10 weeks was not able to attenuate the reduced angiogenesis in the visceral adipose tissue of the ovariectomized rats. CONCLUSION: Our findings indicate that the resistance training program used in this study could not ameliorate low angiogenesis in the visceral adipose tissue of ovariectomized rats.


Asunto(s)
Estrógenos/deficiencia , Grasa Intraabdominal/irrigación sanguínea , Neovascularización Fisiológica/fisiología , Ovariectomía/métodos , Condicionamiento Físico Animal/fisiología , Entrenamiento de Fuerza/métodos , Adipocitos/fisiología , Animales , Biomarcadores/análisis , Ensayo de Inmunoadsorción Enzimática , Femenino , Inmunohistoquímica , Grasa Intraabdominal/metabolismo , Distribución Aleatoria , Ratas Sprague-Dawley , Reacción en Cadena en Tiempo Real de la Polimerasa , Reproducibilidad de los Resultados , Proteínas Ribosómicas/análisis , Factores de Tiempo , Factor A de Crecimiento Endotelial Vascular/análisis , Receptor 2 de Factores de Crecimiento Endotelial Vascular/análisis
4.
Clinics ; 71(9): 528-536, Sept. 2016. tab, graf
Artículo en Inglés | LILACS | ID: lil-794640

RESUMEN

OBJECTIVE: The purpose of this study was to investigate the effects of resistance training on angiogenesis markers of visceral adipose tissue in ovariectomized rats. METHOD: Adult Sprague-Dawley female rats were divided into four groups (n=6 per group): sham-sedentary, ovariectomized sedentary, sham-resistance training and ovariectomized resistance training. The rats were allowed to climb a 1.1-m vertical ladder with weights attached to their tails and the weights were progressively increased. Sessions were performed three times per week for 10 weeks. Visceral adipose tissue angiogenesis and morphology were analyzed by histology. VEGF-A mRNA and protein levels were analyzed by real-time PCR and ELISA, respectively. RESULTS: Ovariectomy resulted in higher body mass (p=0.0003), adipocyte hypertrophy (p=0.0003), decreased VEGF-A mRNA (p=0.0004) and protein levels (p=0.0009), and decreased micro-vascular density (p=0.0181) in the visceral adipose tissue of the rats. Resistance training for 10 weeks was not able to attenuate the reduced angiogenesis in the visceral adipose tissue of the ovariectomized rats. CONCLUSION: Our findings indicate that the resistance training program used in this study could not ameliorate low angiogenesis in the visceral adipose tissue of ovariectomized rats.


Asunto(s)
Animales , Femenino , Condicionamiento Físico Animal/fisiología , Ovariectomía/métodos , Neovascularización Fisiológica/fisiología , Grasa Intraabdominal/irrigación sanguínea , Estrógenos/deficiencia , Entrenamiento de Fuerza/métodos , Proteínas Ribosómicas/análisis , Factores de Tiempo , Ensayo de Inmunoadsorción Enzimática , Inmunohistoquímica , Biomarcadores/análisis , Distribución Aleatoria , Reproducibilidad de los Resultados , Ratas Sprague-Dawley , Adipocitos/fisiología , Receptor 2 de Factores de Crecimiento Endotelial Vascular/análisis , Factor A de Crecimiento Endotelial Vascular/análisis , Grasa Intraabdominal/metabolismo , Reacción en Cadena en Tiempo Real de la Polimerasa
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