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Nucleosides Nucleotides Nucleic Acids
; 23(8-9): 1367-70, 2004 Oct.
Artículo
en Inglés
| MEDLINE
| ID: mdl-15571260
RESUMEN
Thymidine phosphorylase (TP) catalyzes the phosphorolytic cleavage of thymidine to thymine and deoxyribose-1-phosphate. TP, which is overexpressed in a wide variety of solid tumors, is involved in the activation and inactivation of fluoropyrimidines. TP is known to be regulated by several cytokines and interferons. In our HT29 cell line the TP mRNA and activity expression increased 2-3 fold after treatment with interferon alpha.