Prevalence and Severity of Diabetic Retinopathy in Patients with Macular Telangiectasia Type 2.

PURPOSE: To study the prevalence and severity of diabetic retinopathy (DR) in patients with macular telangiectasia type 2 (MacTel 2). DESIGN: Retrospective case series. PARTICIPANTS: Patients with a diagnosis of MacTel 2 treated at the Rotterdam Eye Hospital or Erasmus Medical Center between 2014 and 2018 were included. METHODS: The following information was retrieved from patient files: demographics, history of diabetes mellitus and hypertension, presence of DR, and severity of DR, that is, mild, moderate, severe, or proliferative. Presence of diabetic macular edema (DME) was assessed using OCT. MAIN OUTCOME MEASURES: Presence and severity of DR. RESULTS: Two hundred six eyes of 103 patients were included. At the onset of MacTel 2, the mean age was 61 years (standard deviation [SD], 9.8 years) and 64 (62%) were women. Mean follow-up was 71 months (SD, 60 months). Diabetes mellitus type 2 was present in 50 patients (49%) and hypertension was present in 47 patients (46%). Mild DR was present in 22 eyes (11%), of which 14 eyes (7%) showed signs at baseline and 8 eyes (4%) showed signs at a later time during follow-up. Ten eyes (5%) demonstrated remission of mild DR during follow-up. Both eyes (1%) in 1 patient progressed to moderate DR. Severe DR, proliferative DR, and DME did not occur. CONCLUSIONS: Although diabetes mellitus was highly prevalent among MacTel 2 patients, no patients showed severe or proliferative DR or DME. These findings suggest that MacTel 2 could have a protective effect on the progression of DR. We hypothesize that our results may be explained by the role of Müller cells in the development of MacTel 2 and DR, and therefore a link between both diseases warrants additional studies.

Accuracy of Total Corneal Astigmatism Measurements With a Scheimpflug Imager and a Color Light-Emitting Diode Corneal Topographer.

PURPOSE: To determine the accuracy of total corneal astigmatism measurements with a Scheimpflug imager and a color light-emitting diode corneal topographer, and to compare the accuracy of total corneal astigmatism measurements with the accuracy of measurements that are based only on the anterior corneal surface. DESIGN: Prospective validity assessment. METHODS: This study was conducted at the Rotterdam Ophthalmic Institute, Rotterdam, Netherlands. The study population consisted of 91 eyes of 91 patients with monofocal, non-toric intraocular lenses (IOLs). Refractive astigmatism was measured with the ARK-530A autorefractor (Nidek, Gamagori, Japan). Anterior and total corneal astigmatism were measured with the Pentacam HR (Oculus, Wetzlar, Germany) and the Cassini (i-Optics, The Hague, Netherlands). Under the assumption that refractive astigmatism must equal total corneal astigmatism in these patients, accuracy of the corneal astigmatism measurements was defined as the vectorial difference with the refractive astigmatism, with lower vector differences denoting higher accuracy. RESULTS: The median refractive astigmatic magnitude was 0.84 diopter (D). The mean difference vector lengths were 0.61 D, 0.58 D, 0.49 D, and 0.45 D for Pentacam anterior, Cassini anterior, Pentacam total, and Cassini total corneal astigmatism, respectively. The mean difference vector length decreased by 0.12 and 0.13 D for Pentacam and Cassini, respectively, if the total instead of anterior corneal astigmatism was measured. These decreases were statistically significant (P < .001). CONCLUSIONS: With Pentacam as well as with Cassini, the accuracy of total corneal astigmatism measurements was higher than that of anterior corneal astigmatism measurements. Measuring total instead of anterior corneal astigmatism may therefore decrease the residual astigmatism in toric IOL implantation.

Value of posterior keratometry in the assessment of surgically induced astigmatic change in cataract surgery.

PURPOSE: To investigate the value of posterior keratometry in the assessment of surgically induced astigmatic change (AC) in cataract surgery, with particular emphasis on the influence of test-retest variability. METHODS: Seventy-seven eyes of 77 cataract patients scheduled for routine cataract surgery were enrolled. All patients received a 2.2-mm self-sealing scleral incision (n = 24), single-plane clear corneal incision (SPCCI; n = 29) or biplanar clear corneal incision (BPCCI; n = 24). Measurements of anterior and posterior corneal astigmatism were performed with a rotating Scheimpflug camera (Pentacam HR) preoperatively and postoperatively. Two repeated readings were taken preoperatively to assess the role of the test-retest effect. Astigmatic change (AC) was analysed according to the polar value method. RESULTS: On the anterior corneal surface, SPCCIs and BPCCIs caused a statistically significant mean flattening of the incisional meridian of 0.37 and 0.27 dioptres (D), respectively. Scleral incisions on average did not cause AC, although steepening, flattening or torque beyond the test-retest effect was observed in individual cases. On the posterior surface, mean power changes in the incisional meridian were below 0.1 D for all incisions, and these changes were of the same order of magnitude as the test-retest effect. CONCLUSION: Surgically induced AC of the posterior corneal surface after cataract surgery is of negligible clinical relevance. Moreover, it is of the same order of magnitude as the test-retest variability of the measurement device and therefore cannot (yet) be reliably assessed.