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1.
J Prosthet Dent ; 2021 Jan 07.
Artículo en Inglés | MEDLINE | ID: mdl-33423821

RESUMEN

STATEMENT OF PROBLEM: The clinical success of monolithic lithium disilicate glass-ceramic (LDGC) crowns manufactured with computer-aided design and computer-aided manufacturing (CAD-CAM) technology provided by predoctoral students has not been fully investigated. PURPOSE: The purpose of this retrospective clinical study was to evaluate the performance of laboratory-fabricated monolithic posterior LDGC CAD-CAM crowns provided by predoctoral students at the University of Toronto. Specific patient- and provider-related factors were also investigated. MATERIAL AND METHODS: A sample of posterior LDGC CAD-CAM crowns (IPS e.max) provided by predoctoral students was evaluated. Crown preparations were made according to specific criteria, and crowns were milled in an in-house laboratory by using the CEREC Bluecam system. The crowns were cemented with Rely-X Unicem (3M ESPE) and Calibra Universal (Dentsply Sirona) resin cements. Clinical assessments of the crowns and supporting periodontal structures were performed following the modified California Dental Association (CDA) criteria. Intraoral photographs and periapical and bitewing radiographs were obtained for further assessment by 2 evaluators. Descriptive statistics, McNemar, t test, log rank (Mantel-Cox) tests, Pearson chi-squared tests, simple logistic regression, odds ratios, and Kaplan Meier survival analyses were performed (α=.05). RESULTS: A total of 189 patients receiving 210 crowns (108 premolar and 102 molar) were examined with a follow-up period of up to 6 years. Altogether, 28 complications were observed (12 technical, 11 biological, and 5 esthetic). No significant association was found between patient age, sex, periodontal condition, tooth type, tooth vitality, cement type, and crown longevity. However, significantly lower survival and success rates were found for mandibular crowns than for maxillary crowns (P=.029). The provider's experience had no significant effect on the clinical performance of LDGC CAD-CAM crowns. The 6-year cumulative survival rate was 93.0%, and the success rate was 86.4%. CONCLUSIONS: The ease of use of the CAD-CAM system and clinical performance of LDGC suggest that this technology should be used in the dental school setting by predoctoral students.

2.
Eur Heart J ; 42(3): 228-239, 2021 Jan 20.
Artículo en Inglés | MEDLINE | ID: mdl-33477168

RESUMEN

AIMS : Many patients with angina, especially women, do not have obstructive coronary artery disease (CAD) yet have impaired prognosis. We investigated whether routine assessment of coronary microvascular dysfunction (CMD) is feasible and predicts adverse outcome in women with angina and no obstructive CAD. METHODS AND RESULTS : After screening 7253, we included 1853 women with angina and no obstructive CAD on angiogram who were free of previous CAD, heart failure, or valvular heart disease in the prospective iPOWER (Improving Diagnosis and Treatment of Women with Angina Pectoris and Microvascular Disease) study. CMD was assessed by Doppler echocardiography in the left anterior descending artery as coronary flow velocity reserve (CFVR). Patients were followed for a composite outcome of cardiovascular death, myocardial infarction (MI), heart failure, stroke, and coronary revascularization. CFVR was obtained in 1681 patients (91%) and the median CFVR was 2.33 (quartiles 1-3: 2.00-2.74). During a median follow-up of 4.5 years, 96 events occurred. In univariate Cox regression, CFVR was associated with the composite outcome {hazard ratio (HR) 1.07 [95% confidence interval (CI) 1.03-1.11] per 0.1 unit decrease in CFVR; P < 0.001}, primarily driven by an increased risk of MI and heart failure. Results remained significant in multivariate analysis [HR 1.05 (95% CI 1.01-1.09) per 0.1 unit decrease in CFVR; P = 0.01]. In exploratory analyses, CFVR was also associated with the risk of repeated hospital admission for angina and all-cause mortality. CONCLUSION : Assessment of CFVR by echocardiography is feasible and predictive of adverse outcome in women with angina and no obstructive CAD. Results support a more aggressive preventive management of these patients and underline the need for trials targeting CMD.

3.
Open Heart ; 8(1)2021 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-33462108

RESUMEN

OBJECTIVES: Coronary microvascular dysfunction (CMD) is considered to cause angina pectoris in a large proportion of women with no obstructive coronary artery disease (CAD). However, data supporting a relation between angina pectoris and CMD are limited. We compared CMD in women with angina with asymptomatic women and evaluated the relation between presence of CMD, angina characteristics, cardiovascular risk factors and results of stress testing. METHODS: In a cross-sectional study, we included 1684 women with angina and <50% coronary artery stenosis on invasive angiography. Asymptomatic women from the community-based Copenhagen City Heart Study served as reference group (n=102). Coronary microvascular function was determined by coronary flow velocity reserve (CFVR) assessed by transthoracic Doppler stress echocardiography. CFVR < 2 was defined as CMD. Symptoms were obtained from standardised angina questionnaires and results of stress testing from health records. RESULTS: Median CFVR was 2.33 (IQR 2.00-2.75) in symptomatic women versus 2.60 (2.19-2.95) in asymptomatic (p=0.007). CFVR <2 was found in 25% of symptomatic and in 19% of asymptomatic women. Symptomatic women had a greater risk factor burden. After adjusting for age, hypertension, diabetes, smoking and heart rate the difference in CFVR between groups disappeared (p=0.213). We found no associations between CFVR and angina characteristics, symptom burden or results from stress testing. CONCLUSIONS: Impaired CFVR is more prevalent in symptomatic than in asymptomatic women and related to the cardiovascular risk factors hypertension, diabetes, smoking and increased heart rate. Neither a positive bicycle test, single photon emission CT stress test nor chest pain characteristics identify women with impaired CFVR among women with angina and no obstructive CAD. Results may question the concept of microvascular angina as currently defined.

4.
Endosc Int Open ; 8(12): E1826-E1831, 2020 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-33269316

RESUMEN

Background and study aims Hands-on training for per-oral endoscopic myotomy (POEM) in the United States is limited and without a structured curriculum or assessment tool. Training to competency in POEM is critical and POEM trainees must acquire multiple cognitive and technical skills to achieve proficiency. The aim of this study was to develop a POEM training and skills evaluation tool. Patients and methods The training protocol included initial explant porcine models followed by live human cases, proctored by a single endoscopist experienced in POEM who prospectively graded trainees for each step ("skill") of the procedure on a 5-point scale. Procedural skills were divided into cognitive and technical skills. Acceptable passing level was considered a score ≥ 4 for each skill. Results Three trainees completed a total of 18 cases (8 cases on animal explant models and 10 human cases). Overall, cognitive skills were acquired early in training with scores of ≥ 4 achieved by ≤ 3 cases. Technical skills required more cases and direction with scores ≥ 4 in technical skills achieved by three porcine and eight human cases. Entry of the endoscope into the submucosal space and submucosal tunneling were the most challenging steps followed by myotomy. Conclusion This pilot study introduces a POEM training and skills evaluation tool for training to competency. Submucosal entry, tunneling, and myotomy were the most challenging to learn while cognitive skills were learned early in training. Evaluation of more trainees at multiple sites will be necessary to further validate the utility of this tool.

5.
Sensors (Basel) ; 20(20)2020 Oct 10.
Artículo en Inglés | MEDLINE | ID: mdl-33050504

RESUMEN

This paper proposes a low-complexity and energy-efficient light emitting diode (LED)-to-LED communication system for Internet of Things (IoT) devices with data rates up to 200 kbps over an error-free transmission distance up to 7 cm. The system is based on off-the-shelf red-green-blue (RGB) LEDs, of which the red sub-LED is employed as photodetector in photovoltaic mode while the green sub-LED is the transmitter. The LED photodetector is characterized in the terms of its noise characteristics and its response to the light intensity. The system performance is then analysed in terms of bandwidth, bit error rate (BER) and the signal to noise ratio (SNR). A matched filter is proposed, which optimises the performance and increases the error-free distance.

6.
Breast ; 53: 119-124, 2020 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-32745951

RESUMEN

INTRODUCTION: Breast cancer is the most prevalent cancer in the United Arab Emirates (UAE). This is the first study to provide data on predisposition of breast cancer susceptibility genes with associated clinical and pathological aspects in the UAE. MATERIAL & METHODS: A retrospective chart review for breast cancer patients undergoing genetic testing from 2016 to 2018. According to National Comprehensive Cancer Network (NCCN) guidelines genetic testing was offered. The analyzed data included; age, ethnicity, family cancer history, pathogenic variant, histopathology, stage, molecular subtype and proliferation. RESULTS: 309 patients underwent genetic testing with a positive result in 130 patients (11.9%) over a period of 36 months. In 34.6% pathogenic and likely pathogenic variants were identified. BRCA2 was the most common gene identified. The mean age was 42.9 years (±9.01). Positive family history was identified in 66 patients (50.7%). Majority had stage 1 or 2 disease (66.2%), invasive ductal carcinoma (81.5%) and hormone receptor positive cancer (45.3%). CONCLUSIONS: This is the first study in the UAE to describe the clinical and pathological characteristics of hereditary breast cancer in a mixed ethnic group with dominant Arabic population. Further genetic studies will be required in the UAE population, as the prevalence of breast cancer continues to rise.

7.
Dent Med Probl ; 57(2): 197-206, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32673449

RESUMEN

The use of ceramic materials and the computer-aided design/computer-aided manufacturing (CAD/CAM) technology for the fabrication of complete-coverage restorations has significantly increased in the last decade. The aim of this study was to evaluate the survival rate of anterior and posterior monolithic and bilayered lithium disilicate glass-ceramic (LDGC) CAD/CAM crowns, and to identify the types of complications associated with the main clinical outcomes reported in clinical trials. MEDLINE/PubMed, Embase, Scopus, Web of Science, Cochrane Library, and ClinicalTrials.gov were searched by 2 independent reviewers for clinical studies published between 2006 and 2019, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The electronic search was supplemented by a hand search. Quality assessment for the included studies was performed. Qualitative and quantitative data was extracted from each study. Out of 219 studies, 6 studies that evaluated LDGC CAD/CAM crowns were identified and used for data extraction. The included studies had 154 participants, who received 204 crowns. The shortto medium-term survival and success rates were high. Biological complications occurred more frequently than technical complications. No esthetic complications were reported. This review indicated that the medium-term survival rate of LDGC CAD/CAM crowns was high. Further multicenter studies with longer follow-ups and larger sample sizes are needed in order to augment the data already in existence.


Asunto(s)
Diseño de Prótesis Dental , Estética Dental , Cerámica , Diseño Asistido por Computadora , Coronas , Porcelana Dental , Humanos
8.
Circulation ; 141(25): 2052-2063, 2020 Jun 23.
Artículo en Inglés | MEDLINE | ID: mdl-32434381

RESUMEN

BACKGROUND: In patients with increased bleeding risk, the biolimus A9-coated BioFreedom stent, a stainless steel drug-coated stent free from polymer, has shown superiority compared with a bare-metal stent. The aim of this study was to investigate whether the BioFreedom stent is noninferior to a modern ultrathin strut biodegradable polymer cobalt-chromium sirolimus-eluting Orsiro stent in an all-comers patient population treated with percutaneous coronary intervention. METHODS: The SORT OUT IX trial (Scandinavian Organization for Randomized Trials With Clinical Outcome IX), was a large-scale, registry-based, randomized, multicenter, single-blind, 2-arm, noninferiority trial. The primary end point, major adverse cardiovascular events, was defined as the composite of cardiac death, myocardial infarction not related to any segment other than the target lesion, or target lesion revascularization within 1 year, analyzed by intention-to-treat. The trial was powered to assess noninferiority for major adverse cardiovascular events of the BioFreedom stent compared with the Orsiro stent with a predetermined noninferiority margin of 0.021. RESULTS: Between December 14, 2015 and April 21, 2017, 3151 patients were assigned to treatment with the BioFreedom stent (1572 patients, 1966 lesions) or to the Orsiro stent (1579 patients, 1985 lesions). Five patients were lost to follow-up because of emigration (99.9% follow-up rate). Mean age was 66.3±10.9, diabetes mellitus was seen in 19.3% of patients, and 53% of the patients had acute coronary syndromes. At 1 year, intention-to-treat analysis showed that 79 (5.0%) patients, who were assigned the BioFreedom stent, and 59 (3.7%), who were assigned the Orsiro stent, met the primary end point (absolute risk difference 1.29% [upper limit of one-sided 95% CI 2.50%]; Pnoninferiority=0.14). Significantly more patients in the BioFreedom stent group had target lesion revascularization than those in the Orsiro stent group (55 [3.5%] vs 20 [1.3%], rate ratio 2.77 [95% CI, 1.66-4.62]; P<0.0001). CONCLUSIONS: The biolimus A9-coated BioFreedom polymer-free stent did not meet criteria for noninferiority for major adverse cardiovascular events at 12 months when compared with the ultrathin strut biodegradable polymer sirolimus-eluting Orsiro stent in an all-comers population Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02623140.

9.
Int Microbiol ; 23(4): 533-547, 2020 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-32306109

RESUMEN

The increasing mandate for fresh-like food products and the possible hazards of chemically preserved foods necessitate the search for alternatives. Bacteriocins represent a promising food biopreservative. In the present study, one hundred enterococci isolates recovered from Egyptian raw cow milk and homemade dairy products were screened for bacteriocin production. The overall detection rate was 10%. Three isolates, namely, Enterococcus faecalis (OE-7 and OE-12) and Enterococcus hirae (OE-9), showed the highest antibacterial activity with narrow spectrum against multidrug-resistant (MDR) Gram-positive foodborne bacteria: Enterococcus faecalis and Staphylococcus aureus. The antimicrobial activity was completely abolished by trypsin and proteinase K but not affected by lipase and/or amylase indicating the protein nature of the antimicrobial activity. Optimum conditions for bacteriocin production were cultivation in MRS broth at 37 °C, pH 6-6.5 for 16-24 h. The tested bacteriocins exhibited bactericidal activity on S. aureus subsp. aureus ATCC 25923; such activity was further investigated by transmission electron microscopy that revealed leakage and lysis of treated cells. Characterization of tested bacteriocins revealed high activity in a wide range of pH and temperature, storage stability, and heat resistance. PCR analysis revealed that the tested isolates produced multiple enterocins showing homology with the enterocins L50A, AS-48, and 31. Finally, this study reported potent antibacterial activity of bacteriocins derived from dairy products Enterococci against MDR foodborne and spoilage pathogens. The potency, specificity, and stability of these bacteriocins presented promising perspectives for application as biopreservatives in the food industry. The biopreservation of foods by bacteriocins produced by lactic acid bacteria recovered directly from foods remains an innovative approach.

10.
J Dent Educ ; 84(3): 329-335, 2020 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-32176349

RESUMEN

The aims of this study were to determine the convergence angles of posterior teeth prepared by dental students at the University of Toronto for lithium disilicate glass-ceramic (LDGC) CAD/CAM crowns and to investigate their effect on loss of retention rate. A total of 280 preparations for posterior monolithic LDGC CAD/CAM crowns were performed on 270 patients (169 women and 101 men). Crowns were cemented with RelyX Unicem and Calibra Universal resin cements. Mesial, distal, and angle of convergence were measured on the bitewing radiographs. Cemented crowns were followed for up to six years. Data were analyzed for tooth type and location and for operator experience. The results showed the majority of convergence angles were greater than the recommended guidelines but fell within a clinically acceptable range (20 to 24 degrees). However, angles of convergence for mandibular molar preparations were highest (28.06±5.50 degrees), while maxillary premolars exhibited the lowest values (24.72±6.59 degrees). No significant difference was found between the results of dental students and foreign-trained dentists. Over a six-year observation period, only two crowns lost retention. The findings of this study indicated that ideal taper angles were impractical and difficult to achieve in clinical education settings.


Asunto(s)
Coronas , Estudiantes de Odontología , Cerámica , Diseño Asistido por Computadora , Porcelana Dental , Diseño de Prótesis Dental , Femenino , Humanos , Masculino , Ensayo de Materiales
11.
Arthrosc Tech ; 9(1): e39-e44, 2020 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-32021772

RESUMEN

There is strong association between meniscal lesions and anterior cruciate ligament injuries. Recently, light was shown on a new entity: ramp lesions. The incidence of these lesions and their management is still unclear. Although some believe that some lesions, when stable, can be managed conservatively, most surgeons repair ramp tears. Accessibility of these tears is challenging; they are best accessed through posterior portals, which is time-consuming and poses potential risk to vital structures. Our technique allows access to and management of ramp lesions through safe standard anterior portals. Ramp lesions are searched for as a routine step during anterior cruciate ligament reconstruction by advancing the scope through the intercondylar notch just beside the medial femoral condyle. If a lesion is found, it is repaired; only very stable small tears are treated with needling to refresh the edges and induce a healing response. A simple suture, horizontal mattress suture, or a circumferential stitch is used.

12.
Appl Opt ; 58(30): 8272-8281, 2019 Oct 20.
Artículo en Inglés | MEDLINE | ID: mdl-31674499

RESUMEN

In this paper, the impact of water channels under different communication link parameters is studied for underwater visible light communication (UVLC). The objective is to highlight the best results for non-line of sight (NLoS) communication links. In addition, NLoS links are studied under different parameters: LED colors, viewing angle, receiving angle, and data rates. The results are obtained and plotted using MATLAB simulation. The performance of the received power is first measured at different wavelengths and data rates. Then, the best results are further investigated at different viewing angles and receiving angles. The obtained results show that using cyan color provides more depth for the NLoS case, as well as a low bit error rate compared to the other colors. Most of the literature is concerned with unpractical configurations in underwater scenarios, such as an empty sea or assuming no human-object or blockage environment. We use the practical setup in Zemax Optics Studio to allow a precise description of ray tracing and high order of reflections inside a sea water environment. The channel impulse response (CIR) is obtained for static channel modeling, including a blockage environment to evaluate the best transmitters in sea water. Also, we are able to compare the average delay and the average delay spread of the source colors. The reflection characteristics of the sea water are considered as wavelength dependent. The CIR obtained by Zemax Solver and MATLAB indicates that cyan is the best source in sea water for different LED chips. Moreover, other previous studies assume perfect alignment scenarios between divers, which is not practical and not suitable for real channel gain results. Accordingly, we present a comprehensive dynamic channel modeling and characterization study for UVLC. Our study is based on Zemax programming language (ZPL) combined with Zemax Optics Studio. Using ZPL enables us to apply a mobility algorithm for divers and measure the channel gain variations due to random motion. We introduce a dynamic motion in a single-input single-output scenario and a single-input multiple-output scenario in the presence of blockage divers. Statistical analyses are studied for the appropriate distributions that can fit the data with various transmitter and receiver specifications. All dynamic scenarios are performed using cyan color in sea water, as it is proven to have satisfactory performance. The statistical results are beneficial for further analysis. As case studies, we consider various underwater scenarios, and the resulting parameters of statistical distributions can be used for future analysis in UVLC dynamic environments.

13.
Arch Med Res ; 50(6): 325-332, 2019 08.
Artículo en Inglés | MEDLINE | ID: mdl-31677537

RESUMEN

BACKGROUND: The timing of initiation of Norepinephrine (NEP) in septic shock is controversial. AIM OF THE STUDY: We evaluated the impact of early NEP simultaneously with fluids in those patients. METHODS: We randomized 101 patients admitted to the emergency department with septic shock to early NEP simultaneously with IV fluids (early group) or after failed fluids trial (late group). The primary outcome was the in-hospital survival while the secondary outcomes were the time to target mean arterial pressure (MAP) of 65 mmHg, lactate clearance and resuscitation volumes. RESULTS: There was no significant difference between the two groups regarding the baseline characteristics. NEP infusion started after 25 (20-30) and 120 (120-180) min in the early and late groups (p = 0.000). MAP of 65 mmHg was achieved faster in the early group (2 [1-3.5] h vs. 3 [2-4.75] h, p = 0.003). Serum lactate was decreased by 37.8 (24-49%) and 22.2 (3.3-38%) in both groups respectively (p = 0.005). Patients with early NEP were resuscitated by significantly lower volume of fluids (25 [18.8-28.7] mL/kg vs. 32.5 [24.4-34.6] mL/kg) in the early and late groups (p = 0.000). The early group had survival rate of 71.9% compared to 45.5% in the late group (p = 0.007). NEP started after 30 (20-120 min) in survivors vs. 120 (30-165 min) in non-survivors (p = 0.013). CONCLUSIONS: We concluded that early Norepinephrine in septic shock might cause earlier restoration of blood pressure, better lactate clearance and improve in-hospital survival.


Asunto(s)
Agonistas alfa-Adrenérgicos/uso terapéutico , Norepinefrina/uso terapéutico , Resucitación/métodos , Choque Séptico/tratamiento farmacológico , Anciano , Presión Sanguínea/fisiología , Femenino , Humanos , Infusiones Intravenosas/métodos , Lactatos/sangre , Masculino , Persona de Mediana Edad , Estudios Prospectivos
14.
J Esthet Restor Dent ; 31(6): 613-619, 2019 11.
Artículo en Inglés | MEDLINE | ID: mdl-31565848

RESUMEN

OBJECTIVES: To evaluate the clinical performance and the effect of various patient and provider-related factors on the longevity of chairside monolithic posterior lithium disilicate glass-ceramic (LDGC) computer-aided design (CAD)-computer-aided manufacturing (CAM) crowns provided by predoctoral students. MATERIALS AND METHODS: A sample of posterior LDGC CAD-CAM crowns was evaluated. Crown preparations were milled chairside using the CEREC Omnicam system and cemented with Rely-X Unicem or Calibra Universal resin cements. Clinical assessment of the crowns and supporting periodontal structures was performed using the modified California Dental Association (CDA) criteria. Intraoral photographs as well as radiographs were taken for further assessment by two evaluators. Kaplan-Meier survival analysis was performed. RESULTS: A total of 40 crowns were inserted in 32 patients and evaluated for 4 years. Three complications were observed (two-technical and one-biological). No chipping or fracture of crowns was observed. No significant association was found between age, sex, periodontal condition, tooth type, tooth vitality, cement type, and longevity. The 4-year cumulative survival and success rates were 95.0 and 92.3%, respectively. CONCLUSION: Chairside LDGC CAD-CAM crowns exhibited a high survival rate after 4 years in function and were shown to be a viable and reliable treatment option for posterior teeth. CLINICAL SIGNIFICANCE: The high survival rate of chairside CAD-CAM crowns observed in this study suggests the likelihood of predictable performance in the predoctoral setup.


Asunto(s)
Porcelana Dental , Diseño de Prótesis Dental , Cerámica , Diseño Asistido por Computadora , Coronas , Humanos , Ensayo de Materiales
15.
J Clin Transl Endocrinol ; 17: 100197, 2019 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-31193780

RESUMEN

Aim: To study the relationship between obesity, insulin resistance, vitamin D deficiency and sclerostin as a bone biomarker. Materials and methods: Cross-section study of 75 subjects grouped into 3 groups; obese (n = 31), overweight (n = 23) and normal (n = 21) subjects. Sclerostin, fasting insulin, fasting plasma glucose and 25(OH)D were measured and anthropometric measures were taken. Results: 25(OH)D was lower in obese subjects than overweight and control groups (mean ±â€¯SD 5.27 ±â€¯5.14 vs. 12.55 ±â€¯6.99 vs.17.65 ±â€¯4.07 ng/L, p < 0.001). Sclerostin was significantly lower in obese subjects versus the control (mean ±â€¯SD 1.02 ±â€¯0.45 vs 1.58 ±â€¯0.83 ng/mL, p = 0.014). Conclusion: These results lead us to hypothesize that the relationship between sclerostin and Vitamin D levels has an important role in the link between obesity and bone metabolism. DObesity could be an active focus of research in the coming years.

16.
Open Access Maced J Med Sci ; 7(9): 1466-1470, 2019 May 15.
Artículo en Inglés | MEDLINE | ID: mdl-31198456

RESUMEN

BACKGROUND: Many randomised control studies showed that percutaneous coronary interventions using biodegradable-polymer drug-eluting stents (DES) offer a safe and effective alternative to durable-polymer DES. However, not many studies have discussed its use in the setting of acute coronary syndromes. AIM: We aim to compare the biodegradable-polymer DES with durable-polymer DES when it comes to reducing the incidence of non-ST elevation acute coronary syndrome (NSTEACS) associated with adverse events. METHODS: We enrolled 205 patients presenting with NSTEACS and a TIMI risk score ≥ 3 in this study and divided them into two groups, group A and group B. Biodegradable-polymer DESs were exclusively used in group A, while durable-polymer DESs were used in group B. Major adverse events were reported in both groups during the hospital stay and patients were followed-up for 1 year. RESULTS: In our patients, we intervened on 390 diseased segments in a total of 360 vessels. After intervention, TIMI 0 was achieved in 0.97%, TIMI 1 in 1.46%, TIMI 2 in 2.45%, and TIMI 3 in 95.12% of the treated segments (P-value= 0.677). We implanted 121 biodegradable-polymer DESs and 146 durable-polymer DESs. Clinical success was achieved in 95.12% of our cases. We had 55 patients who needed repeated coronary angiography within 1 year (15 patients treated with biodegradable-polymer DES and 24 patients treated with durable-polymer DES). Eighteen patients experienced angina pains (8 patients treated with biodegradable-polymer DES and 10 patients treated with durable-polymer DES). Only 5 patients needed TLR (2 patients treated with biodegradable-polymer DES and 3 patients treated with durable -polymer DES) (P-value = 0.591), three of them had a myocardial infarction with documented angiographic evidence of significant in-stent restenosis (1 patient treated with biodegradable-polymer DES and 2 patients treated with durable-polymer DESs). CONCLUSION: Biodegradable-polymer DES represents a comparable alternative to durable-polymer DES in the setting of acute coronary syndromes.

17.
Mol Biol Rep ; 46(3): 3437-3443, 2019 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-30972606

RESUMEN

The increasing percentage of Pseudomonas aeruginosa strains that are resistant to multiple antibiotics is a global problem. The exposure of P. aeruginosa isolates to repeated sub lethal concentrations of biocides in hospitals and communities may be one of the causes leading to increased antibiotic resistance. Benzalkonium chloride (BAC) is widely used as disinfectant and preservative. This study investigated the effect of exposure of P. aeruginosa clinical isolates to sub lethal concentrations of BAC on their antibiotic resistance, growth process and biofilm formation. The collected 43 P. aeruginosa clinical isolates were daily subjected to increasing sub lethal concentrations of BAC. The effect of adaptation on antibiotic resistance, growth process, cell surface hydrophobicity and biofilm formation of P. aeruginosa isolates were examined. Interestingly, Most P. aeruginosa isolates adapted to BAC showed an increase in antibiotic resistance and 66% of the isolates showed retardation of growth, 63% showed increased cell surface hydrophobicity and 23.5% exhibited enhanced biofilm formation by crystal violet assay. To define whether the effect of BAC adaptation on biofilm production was manifested at the transcriptional level, quantitative RT-PCR was used. We found that 60% of the tested isolates showed overexpression of ndvB biofilm gene. More efforts are required to diminish the increasing use of BAC to avoid bacterial adaptation to this biocide with subsequent retardation of growth and enhanced biofilm formation which could lead to antibiotic resistance and treatment failure of infections caused by this opportunistic pathogen.


Asunto(s)
Compuestos de Benzalconio/farmacología , Pseudomonas aeruginosa/efectos de los fármacos , Pseudomonas aeruginosa/metabolismo , Aclimatación/efectos de los fármacos , Adaptación Biológica/fisiología , Adaptación Fisiológica/efectos de los fármacos , Antibacterianos/farmacología , Compuestos de Benzalconio/metabolismo , Biopelículas/efectos de los fármacos , Desinfectantes/farmacología , Farmacorresistencia Bacteriana Múltiple/genética , Humanos , Pruebas de Sensibilidad Microbiana , Pseudomonas aeruginosa/crecimiento & desarrollo
18.
Open Access Maced J Med Sci ; 7(1): 127-133, 2019 Jan 15.
Artículo en Inglés | MEDLINE | ID: mdl-30740176

RESUMEN

BACKGROUND: Piezocision-assisted orthodontics (PAO) is considered one of the modern techniques aiming at reducing the treatment time and overcoming some limitations of orthodontic treatment. The use of piezocision as an adjunct in the treatment of posterior crossbite is limited, so additional research in this area is required. AIM: To three-dimensionally compare the skeletal and dental effects produced by piezocision-assisted rapid maxillary expansion (PARME) and conventional rapid maxillary expansion (RME) using cone beam computed tomography (CBCT). MATERIALS AND METHODS: This prospective controlled study comprised 14 consecutive non-syndromic patients with posterior crossbite. In 7 patients (mean age = 16.1 ± 0.3 years), PARME was used to correct the crossbite; whereas in the remaining 7 (mean age = 15.9 ± 0.5 years), RME was done. Cone beam computed tomography (CBCT) scans were performed before expansion (T1) and 3 months later after expansion (T2) to compare the skeletal and dental effects produced by the two expansion techniques. Transverse skeletal, dentolinear, and dentoangular variables at the level of maxillary first and second premolars and maxillary first molars were measured and compared within and between groups using the appropriate statistical test. RESULTS: For the transverse skeletal variables, PARME showed a non-significant increase; whereas, RME showed a significant increase. Regarding the dentolinear measurements, a significant increase in coronal widths and an insignificant increase in apical widths was seen in PARME, whereas, the RME showed a non-significant increase for both coronal and apical widths. Non-significant decreases (protrusion of teeth) in the dentoangular measurements were seen in both groups. Between-group comparisons showed a non-significant difference except for the dentolinear coronal widths. CONCLUSION: PARME is effective in treating posterior crossbite. Because of the more dental expansion produced by PARME as compared to the conventional RME, PARME should be limited only to mild or moderate not severe forms of palatal constriction. The available evidence regarding the effectiveness of corticotomy- and/or piezocision-assisted maxillary expansion for correction of posterior crossbite is limited and inadequate.

19.
F1000Res ; 8: 2078, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-32431802

RESUMEN

Background: Safinamide, a recently developed drug with several mechanisms of action has been investigated as an add-on therapy for Parkinson's disease patients suffering from motor complications due to the usage of anti-Parkinson's medications such as levodopa and dopaminergic drugs. The aim of the study is to investigate the efficacy and safety of Safinamide as add-on therapy for Parkinson's disease patients.   Methods: A computerized literature search was conducted of PubMed, EMBASE, ClinicalTrial.gov and Cochrane Library until August 2019. We selected relevant randomized controlled trials comparing safinamide groups to placebo groups. Relevant outcomes were pooled as mean difference (MD) and risk ratio (RR) using Review Manager 5.3. Results: We found that the overall MD of changes in "off-time" and "on time without troublesome dyskinesia" favored the safinamide group over the placebo group (MD -0.72 h, 95% CI -0.89 to -0.56 and MD 0.71 h, 95% CI 0.52 to 0.90, respectively). Additionally, the overall MD of change in Unified Parkinson's Disease Rating Scale part three (UPDRS III) favored the safinamide group (MD -1.83, 95% CI -2.43 to -1.23). In case of adverse events, the pooled meta-analysis did not favor the safinamide group over the placebo group. Conclusions: In this study, we provide class I evidence about the potential role of safinamide as an add-on therapy for Parkinson's disease patients suffering from motor fluctuations. However, a few included studies did not mention the data of important outcomes. Also, we report high risk of bias in individual studies. Future randomized controlled trials with different doses are recommended to provide more evidence for the efficacy and safety of safinamide as a treatment for motor complications of anti-Parkinson's medications.


Asunto(s)
Alanina/análogos & derivados , Antiparkinsonianos/uso terapéutico , Bencilaminas/uso terapéutico , Enfermedad de Parkinson/tratamiento farmacológico , Alanina/uso terapéutico , Humanos , Levodopa , Calidad de Vida , Ensayos Clínicos Controlados Aleatorios como Asunto
20.
Int J Biol Macromol ; 126: 478-487, 2019 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-30572045

RESUMEN

Actually, the most common cancer in women is the breast cancer which is the second most widespread cancer overall. In 2018, there were over two million new cases of women breast cancer. Particularly, we tried to extract chitosan from crayfish Procambarus clarkii, Crustacea: Cambaridae, by N-deacetylation of chitin. The chemical structure of chitosan was characterized by Fourier transform infrared (FT-IR) spectroscopy. Also DDA was calculated from FT-IR and ultraviolet spectrophotometry data. Chitosan nanoparticles were prepared using a ball-milling technique. The as-prepared chitosan nanoparticles were characterized by transmission electron microscopy, dynamic light scattering as well as zeta potential. The cytotoxicity of chitosan and its nanoparticles (50 and 100 µg/mL) against human breast cancer (SK BR3 and MDA-MB-231 cell lines) was evaluated. MTT assay asserts the significant inhibitory action of both chitosan and its nanoparticles on the proliferation of human breast cancer cells in vitro. Chitosan nanoparticles had more anti-proliferative effects on MDA-MB-231 and SK-BR-3 cell lines than its corresponding chitosan. Although, chitosan nanoparticles, that has higher DDA, had a higher cytotoxic activity against human breast cancer MDA-MB-231 and SK-BR-3 cell lines in vitro. Eventually, chitosan and its nanoparticles can be considered as a promising natural compounds in human breast cancer treatment.


Asunto(s)
Astacoidea/química , Neoplasias de la Mama/patología , Quitosano/farmacología , Nanopartículas/química , Acetilación , Animales , Línea Celular Tumoral , Proliferación Celular/efectos de los fármacos , Supervivencia Celular/efectos de los fármacos , Quitosano/aislamiento & purificación , Femenino , Humanos , Nanopartículas/ultraestructura , Tamaño de la Partícula , Espectroscopía Infrarroja por Transformada de Fourier , Electricidad Estática
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