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1.
Arq Bras Cardiol ; 115(3): 587-589, 2020 09.
Artículo en Inglés, Portugués | MEDLINE | ID: mdl-33027386

RESUMEN

Familial hypercholesterolemia (FH) is a genetic disease caused by a primary defect in the LDL-receptor gene. Distinct variants in the same gene characterize a compound heterozygote, but little is known about the phenotypes of the carriers. Therefore, herein, we describe the cascade screening of a Brazilian family with this characteristic. The index case, a 36-year-old male, had a total cholesterol level of 360 mg/dL (9.3 mmol/L) and LDL-c value of 259 mg/dL (6.7 mmol/L), in addition to Achilles tendon xanthomas, obesity and prehypertension. Genotyping identified the variants 661G>A, 670G>A, 682G>A in exon 4 and 919G>A in exon 6. The same variant in exon 4 was found in the index case's son (7-y), who also had hypercholesterolemia and xanthomas, while the index case's daughter (9-y) had the variant in exon 6 and hyperlipidemia, without xanthomas. In summary, this report allows for a better insight into the molecular basis of FH in Brazil, a multi-racial country where a heterogeneous population is expected.

2.
Arq. bras. cardiol ; 115(3): 587-589, out. 2020.
Artículo en Portugués | LILACS-Express | LILACS, Sec. Est. Saúde SP | ID: biblio-1131306

RESUMEN

Resumo A hipercolesterolemia familiar (HF) é uma doença genética causada por um defeito primário no gene que codifica o receptor da LDL. Mutações diferentes no mesmo gene caracterizam um heterozigoto composto, mas pouco se sabe sobre o fenótipo dos portadores. Portanto, neste estudo, descrevemos o rastreamento em cascata de uma família brasileira com essa característica. O caso-índice é um homem de 36 anos, com colesterol total (CT) de 360 mg/dL (9,3 mmol/L) e concentração de LDL-c de 259 mg/dL (6,7 mmol/L), além de xantomas de tendão de Aquiles, obesidade e pré-hipertensão. A genotipagem identificou as mutações 661G>A, 670G>A e 682G>A, no exon 4, e 919G>A, no exon 6. A mesma mutação no exon 4 foi observada no filho do caso-índice (7 anos), que também tem hipercolesterolemia e xantomas tendinosos, ao passo que a filha do caso-índice (9 anos) apresenta mutação no exon 6 e hiperlipidemia, sem xantomas. Em suma, este relato permite uma melhor compreensão acerca da base molecular da HF no Brasil, um país multirracial, onde é esperada uma população heterogênea.


Abstract Familial hypercholesterolemia (FH) is a genetic disease caused by a primary defect in the LDL-receptor gene. Distinct variants in the same gene characterize a compound heterozygote, but little is known about the phenotypes of the carriers. Therefore, herein, we describe the cascade screening of a Brazilian family with this characteristic. The index case, a 36-year-old male, had a total cholesterol level of 360 mg/dL (9.3 mmol/L) and LDL-c value of 259 mg/dL (6.7 mmol/L), in addition to Achilles tendon xanthomas, obesity and prehypertension. Genotyping identified the variants 661G>A, 670G>A, 682G>A in exon 4 and 919G>A in exon 6. The same variant in exon 4 was found in the index case's son (7-y), who also had hypercholesterolemia and xanthomas, while the index case's daughter (9-y) had the variant in exon 6 and hyperlipidemia, without xanthomas. In summary, this report allows for a better insight into the molecular basis of FH in Brazil, a multi-racial country where a heterogeneous population is expected.

3.
Rev Bras Epidemiol ; 23: e200070, 2020.
Artículo en Inglés, Portugués | MEDLINE | ID: mdl-32638850

RESUMEN

OBJECTIVE: To analyze the associations between changes in the level of leisure-time physical activity in adults and the prevalence of metabolic syndrome. METHODS: This is a population-based study conducted with 818 adults aged 20 years or older from Florianópolis, Santa Catarina, Southern Brazil, between 2009 and 2014. We tested the association of maintenance and/or changes in the level of physical activity with the prevalence of metabolic syndrome, adjusted for sociodemographic variables (gender, age, schooling, income, marital status, and ethnicity) and smoking habits. We used logistic regression and estimated the odds ratios (OR) and their respective confidence intervals (95%CI). RESULTS: The overall prevalence of metabolic syndrome was 30.9% (95%CI 27.2-34.7). Regardless of adjustment variables, adults who ceased to be active and/or remained physically inactive during leisure time in the study period presented, respectively, 108 and 124% higher odds of developing metabolic syndrome (OR=2.08; 95%CI 1.30-3.33 and OR=2.24; 95%CI 1.38-3.65). Women and individuals younger than 45 years showed lower odds of having metabolic syndrome. CONCLUSIONS: This sample presented a significant association between remaining or becoming inactive and a greater chance of developing metabolic syndrome.


Asunto(s)
Ejercicio Físico , Actividades Recreativas , Síndrome Metabólico/epidemiología , Adulto , Brasil/epidemiología , Femenino , Humanos , Masculino , Prevalencia , Factores de Riesgo , Conducta Sedentaria
4.
Rev. bras. epidemiol ; 23: e200070, 2020. tab
Artículo en Portugués | LILACS-Express | LILACS | ID: biblio-1126028

RESUMEN

RESUMO: Objetivo: Analisar as associações entre mudanças do nível de atividade física de lazer em adultos com a prevalência de síndrome metabólica. Métodos: Estudo de base populacional realizado com 818 adultos de 20 anos ou mais em Florianópolis, Santa Catarina, entre 2009 e 2014. Testou-se a associação da manutenção e/ou mudança do nível de atividade física com a prevalência de síndrome metabólica, ajustada por variáveis sociodemográficas (sexo, idade, escolaridade, renda, estado civil e cor da pele) e tabagismo. Empregou-se regressão logística, estimando-se as razões de chance (OR) e os respectivos intervalos de confiança (IC95%). Resultados: A prevalência geral de síndrome metabólica foi de 30,9% (IC95% 27,2 - 34,7). Independentemente das variáveis de ajuste, os adultos que deixaram de ser ativos e/ou se mantiveram fisicamente inativos no lazer no período apresentaram, respectivamente, 108 e 124% maiores chances para a síndrome metabólica (OR = 2,08; IC95% 1,30 - 3,33) e (OR = 2,24; IC95% 1,38 - 3,65). As mulheres e os indivíduos com idade inferior a 45 anos apresentaram menores chances para a síndrome metabólica. Conclusões: Nesta amostra, manter-se inativo ou passar a sê-lo associou-se, significativamente, com maiores chances para a síndrome metabólica.


ABSTRACT: Objective: To analyze the associations between changes in the level of leisure-time physical activity in adults and the prevalence of metabolic syndrome. Methods: This is a population-based study conducted with 818 adults aged 20 years or older from Florianópolis, Santa Catarina, Southern Brazil, between 2009 and 2014. We tested the association of maintenance and/or changes in the level of physical activity with the prevalence of metabolic syndrome, adjusted for sociodemographic variables (gender, age, schooling, income, marital status, and ethnicity) and smoking habits. We used logistic regression and estimated the odds ratios (OR) and their respective confidence intervals (95%CI). Results: The overall prevalence of metabolic syndrome was 30.9% (95%CI 27.2-34.7). Regardless of adjustment variables, adults who ceased to be active and/or remained physically inactive during leisure time in the study period presented, respectively, 108 and 124% higher odds of developing metabolic syndrome (OR=2.08; 95%CI 1.30-3.33 and OR=2.24; 95%CI 1.38-3.65). Women and individuals younger than 45 years showed lower odds of having metabolic syndrome. Conclusions: This sample presented a significant association between remaining or becoming inactive and a greater chance of developing metabolic syndrome.

5.
Cad. saúde colet., (Rio J.) ; 27(2): 210-224, abr.-jun. 2019. tab
Artículo en Portugués | LILACS-Express | LILACS | ID: biblio-1011753

RESUMEN

Resumo Introdução Exames complementares podem contribuir para a compreensão da etiologia de agravos à saúde de idosos. Objetivo Descrever os aspectos operacionais e protocolos referentes à coleta, análise e armazenamento de material biológico, exames de imagem e capacidade físico-funcional. Método Estudo longitudinal, de base populacional, com 604 idosos (≥ 60 anos) do estudo EpiFloripa Idoso, em 2014. Foram coletados dados de material biológico, composição corporal, densitometria óssea, ultrassonografia da espessura íntima média das artérias carótidas, força de preensão manual e a atividade física. Resultados A taxa de resposta foi de 50,4%. Houve perda de seguimento em relação à faixa etária, estado cognitivo e atividades de vida diária. Os indivíduos que realizaram os exames eram mais novos, trabalhavam no momento da entrevista, ingeriam álcool, eram fisicamente ativos. Além de apresentarem menor grau de dependência, ausência de déficit cognitivo, ausência de sintomas depressivos e ausência de dificuldade na mobilidade. Conclusão Espera-se que a descrição das rotinas aplicadas possa auxiliar no desenvolvimento de novas pesquisas semelhantes em grupos de idosos. Assim, poderá ser acompanhado o processo de envelhecimento da população, seus fatores de risco e proteção.


Abstract Background Complementary exams may contribute to the understanding of the etiology of health problems in older adults. Objective To describe the operational aspects and protocols used to collect, analyze and storage biological materials, image exams and physical-functional capacity tests. Method This is a longitudinal and population-based study with 604 older adults (≥ 60 years) from EpiFloripa Ageing Study, in 2014. Data of biological material, body composition, bone densitometry, ultrasonography of the carotid artery intima average thickness, hand grip strength and physical activity were collected. Results The response rate was 50.4%. There was loss of follow-up in relation to age, cognitive status, and activities of daily living. The individuals who performed the tests were younger, worked by the time of the interview, ingested alcohol and were physically active. Also, they were less dependent, absence of cognitive impairment, absence of depressive symptoms and absence of difficulty in mobility. Conclusion It is expected that the description of the applied routines may help in the development of new similar research in the older adult population. Thus, the aging process of the population, its risk and protection factors can be followed.

6.
J Sports Sci ; 37(1): 50-58, 2019 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-29882716

RESUMEN

This study aimed to investigate if moderate to vigorous physical activity (MVPA) and aerobic fitness are associated with cardiovascular risk factors in HIV+ children and adolescents. Sixty-five children and adolescents (8 to 15 years) provided minutes of MVPA measured by accelerometers and peak oxygen uptake (peak VO2) by breath-by-breath respiratory exchange. Cardiovascular risk factors were characterized by body fat, blood pressure, total cholesterol, HDL-c, LDL-c, triglycerides, glucose, insulin, C-reactive protein (CRP), interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α) and carotid intima-media thickness. Results indicated that higher MVPA was associated with lower values of total (ß =  -3.566) and trunk body fat (ß = -3.495), total cholesterol (ß = -0.112) and LDL-c (ß = -0.830). Likewise, higher peak VO2 was associated with lower total (ß = -0.629) and trunk body fat values (ß = -0.592) and levels of CRP (ß = -0.059). The physically active participants had lower total cholesterol (-24.4 mg.dL-1) and LDL-c (-20.1 mg.dL-1) compared to participants judged to be insufficiently active. Moreover, participants with satisfactory peak VO2 showed lower total (-4.1%) and trunk (-4.3%) body fat, CRP (-2.3 mg.L-1), IL-6 (-2.4 pg.mL-1) and TNF-α (-1.0 pg.mL-1) compared to low peak VO2 peers. High levels of MVPA and aerobic fitness may prevent developing of cardiovascular risk factors in children and adolescents HIV+.


Asunto(s)
Adiposidad , Capacidad Cardiovascular , Dislipidemias/fisiopatología , Ejercicio Físico/fisiología , Infecciones por VIH/fisiopatología , Mediadores de Inflamación/sangre , Acelerometría , Adolescente , Glucemia/metabolismo , Presión Sanguínea , Enfermedades Cardiovasculares/fisiopatología , Grosor Intima-Media Carotídeo , Niño , Estudios Transversales , Femenino , Infecciones por VIH/sangre , Humanos , Lípidos/sangre , Masculino , Consumo de Oxígeno , Intercambio Gaseoso Pulmonar , Factores de Riesgo
7.
Cien Saude Colet ; 23(4): 1019-1031, 2018 Apr.
Artículo en Inglés, Portugués | MEDLINE | ID: mdl-29694574

RESUMEN

The scope of this study was to identify the characteristics of sexual abuse against children including the profiles of the victims and the perpetrators, and associated factors notified in a health service of reference with the database of the Brazilian Case Registry Database, in a city in the south of Brazil. Categorical variables are presented in prevalence with 95% confidence intervals. There were 489 notifications from 2008 to 2014 of confirmed or suspected child sexual abuse. The majority was related to female victims, but the repeated abuse was reported mainly with male victims. In most cases, the abuse took place at the victims' or perpetrators' homes and the main perpetrators of abuse were male and acquainted with the victims. Twelve victims have contracted sexually transmitted infections; pregnancies were six, five of them legally terminated. This study highlights that the child sexual abuse profiles were similar in almost all of Brazilian regions, showing that it is possible to have a coordinated national action to prevent this offence.


Asunto(s)
Abuso Sexual Infantil/estadística & datos numéricos , Víctimas de Crimen/estadística & datos numéricos , Criminales/estadística & datos numéricos , Aborto Inducido/estadística & datos numéricos , Adolescente , Distribución por Edad , Brasil , Niño , Preescolar , Estudios Transversales , Femenino , Humanos , Lactante , Masculino , Embarazo , Prevalencia , Distribución por Sexo , Enfermedades de Transmisión Sexual/epidemiología
8.
Ciênc. Saúde Colet ; 23(4): 1019-1031, abr. 2018. tab, graf
Artículo en Portugués | LILACS | ID: biblio-952624

RESUMEN

Resumo O objetivo deste estudo foi identificar características do abuso sexual contra crianças, como perfil da vítima, do autor da agressão e fatores associados, notificadas em um serviço de referência, utilizando o Sistema de Informação de Agravos de Notificação, em todos os casos suspeitos ou confirmados de abuso sexual infantil, de 2008 a 2014, em Florianópolis/SC. As variáveis foram: características da vítima, do agressor, da ocorrência, tipologia da violência, consequências, encaminhamentos e procedimentos realizados. Variáveis categóricas são apresentadas em prevalências e intervalos de confiança de 95%. Houve 489 notificações, predominando vítimas do sexo feminino, maior recorrência no masculino e ocorrendo em residências. Estupro foi duas vezes mais frequente no sexo feminino e em mais da metade dos casos o autor era homem conhecido da vítima. Doze vítimas contraíram infecções sexualmente transmissíveis, houve seis gestações, cinco delas interrompidas legalmente. Mesmo sendo inédito para a região estudada, se observou características semelhantes às encontradas em outros estudos brasileiros, mostrando ser possível ações coordenadas nacionalmente para prevenir esse agravo.


Abstract The scope of this study was to identify the characteristics of sexual abuse against children including the profiles of the victims and the perpetrators, and associated factors notified in a health service of reference with the database of the Brazilian Case Registry Database, in a city in the south of Brazil. Categorical variables are presented in prevalence with 95% confidence intervals. There were 489 notifications from 2008 to 2014 of confirmed or suspected child sexual abuse. The majority was related to female victims, but the repeated abuse was reported mainly with male victims. In most cases, the abuse took place at the victims' or perpetrators' homes and the main perpetrators of abuse were male and acquainted with the victims. Twelve victims have contracted sexually transmitted infections; pregnancies were six, five of them legally terminated. This study highlights that the child sexual abuse profiles were similar in almost all of Brazilian regions, showing that it is possible to have a coordinated national action to prevent this offence.


Asunto(s)
Humanos , Masculino , Femenino , Embarazo , Lactante , Preescolar , Niño , Adolescente , Abuso Sexual Infantil/estadística & datos numéricos , Víctimas de Crimen/estadística & datos numéricos , Criminales/estadística & datos numéricos , Brasil , Enfermedades de Transmisión Sexual/epidemiología , Prevalencia , Estudios Transversales , Aborto Inducido/estadística & datos numéricos , Distribución por Sexo , Distribución por Edad
9.
PLoS One ; 13(1): e0190785, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-29320547

RESUMEN

HIV-infected children and adolescents may be at risk for cardiovascular disease due to chronic inflammation and exacerbation of risk factors. The aim of this study was as follows: 1) compare cardiovascular risk factors, chronic inflammation, and carotid intima-media thickness (IMTc) between the HIV and control groups; 2) determine the association of HIV and antiretroviral (ART) regimens with cardiovascular risk factors, chronic inflammation, and IMTc; and 3) identify variables associated with elevated IMTc. Cross-sectional analysis of 130 children and adolescents, 8-15 years of age, divided into HIV-infected (n = 65) and healthy control (n = 65) participants. Body fat, blood pressure, glycemia, insulin, and glycated hemoglobin, total cholesterol and fractions (LDL-C and HDL-C), triglycerides, C-reactive protein (CRP), interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α), and the IMTc were measured. The results showed HIV-infected children and adolescents had higher levels of glycemia (87.9 vs. 75.9 mg.dL-1, p< 0.001), LDL-c (94.7 vs. 79.5 mg.dL-1, p = 0.010), triglycerides (101.2 vs. 61.6 mg.dL-1, p< 0.001), CRP (1.6 vs. 1.0 mg.L-1, p = 0.007), IL-6 (1.42 vs. 0.01 pg.mL-1, p< 0.001), TNF-α (0.49 vs. 0.01 pg.mL-1, p< 0.001), mean IMTc (0.526 vs. 0.499 mm, p = 0.009), and lower HDL-c (53.7 vs. 69.4 mg.dL-1, p< 0.001) compared to controls. Systolic blood pressure (ß = 0.006, p = 0.004) and TNF-α (ß = -0.033, p = 0.029) accounted for 16% of IMTc variability in HIV-infected children and adolescents. In patients using protease inhibitors-based ART, male gender (ß = -0.186, p = 0.008), trunk body fat (ß = -0.011, p = 0.006), glucose (ß = 0.005, p = 0.046), and IL-6 (ß = 0.017, p = 0.039) accounted for 28% of IMTc variability. HIV-infected children and adolescents may be at risk for premature atherosclerosis due to chronic inflammation and dyslipidemia. Interventions with the potential to improve lipid profile, mitigate inflammation, and reduce cardiovascular risk are needed.


Asunto(s)
Aterosclerosis/complicaciones , Dislipidemias/complicaciones , Infecciones por VIH/complicaciones , Inflamación/complicaciones , Adiposidad , Adolescente , Antirretrovirales/uso terapéutico , Aterosclerosis/diagnóstico por imagen , Aterosclerosis/epidemiología , Aterosclerosis/fisiopatología , Biomarcadores/sangre , Glucemia , Grosor Intima-Media Carotídeo , Niño , Estudios Transversales , Dislipidemias/diagnóstico por imagen , Dislipidemias/epidemiología , Dislipidemias/fisiopatología , Femenino , Infecciones por VIH/diagnóstico por imagen , Infecciones por VIH/tratamiento farmacológico , Infecciones por VIH/fisiopatología , Humanos , Inflamación/diagnóstico por imagen , Inflamación/epidemiología , Inflamación/fisiopatología , Interleucina-6/sangre , Lípidos/sangre , Masculino , Inhibidores de Proteasas/uso terapéutico , Factores de Riesgo , Factores Sexuales
10.
J Clin Densitom ; 19(4): 457-464, 2016 10.
Artículo en Inglés | MEDLINE | ID: mdl-26206526

RESUMEN

Children and adolescents living with HIV have low bone mass for age. There are reliable and accurate methods for evaluation of bone mass, however, alternative methods are necessary, especially, for application in limited-resource scenarios. Anthropometry is a noninvasive and low cost method that can predict bone mass in healthy youths. The aim of the study was to develop predictive equations for bone mineral content and bone mineral density in children and adolescents living with HIV based on anthropometric variables. Forty-eight children and adolescents of both sexes (24 females) from 7 to 17 years, living in greater Florianopolis area, Santa Catarina, Brazil, who were under clinical follow-up at "Hospital Infantil Joana de Gusmão", participated in the study. Dual-energy X-ray absorptiometry was used to evaluate whole-body bone mineral content (BMC) and areal bone mineral density (aBMD). Height, body weight, bone diameters, arm circumference, and triceps skinfold were measured and the body mass index and arm muscle area were calculated. Multiple regression models were fitted to predict BMC and aBMD, using backward selection (p ≥ 0.05). Two predictive models with high R2 values (84%-94%) were developed. Model 1 to estimate aBMD [Y = -0.1450124 + (height × 0.0033807) + (age × 0.0146381) + (body mass index × 0.0158838) + (skin color × 0.0421068)], and model 2 to estimate BMC [Y = 1095.1 + (body weight × 45.66973) + (age × 31.36516) + (arm circumference × -53.27204) + (femoral diameter × -9.594018)].The predictive models using anthropometry provided reliable estimates and can be useful to monitor aBMD and BMC in children and adolescents living with human immunodeficiency virus where limited resources are available.


Asunto(s)
Antropometría , Densidad Ósea/fisiología , Infecciones por VIH/fisiopatología , Absorciometría de Fotón/métodos , Adolescente , Brasil , Niño , Estudios Transversales , Femenino , Humanos , Masculino
11.
ACM arq. catarin. med ; 44(4): 63-71, out. - dez. 2015. Tab
Artículo en Portugués | LILACS-Express | LILACS | ID: biblio-1948

RESUMEN

As redes sociais estão mudando o mundo. Com o formato comunicativo abreviado e o padrão viral de disseminar a informação, associados aos fenômenos de desinibição e contaminação emocional, elas modificam a interação humana. Na medicina, o principal impacto é sobre os relacionamentos entre médicos, pacientes e a sociedade, fazendo aflorar preocupações quanto aos deveres profissionais de respeito e de zelo, sem, entretanto se deixar de reconhecer os potenciais benefícios da nova ferramenta. Por meio de coleta de 800 manifestações provenientes de médicos e de acadêmicos de medicina na rede social Facebook, o presente estudo analisa comportamentos a respeito da profissão médica. Após a coleta realizada pela pesquisadora, o material foi enviado para avaliação a cinco pessoas, que deveriam opinar sobre a adequação ou não do comportamento representado pelas manifestações virtuais. Os avaliadores eram três cirurgiões em atividade, um cirurgião residente e uma psicóloga, isenta de influência na corporação médica. Na análise geral das 4000 opiniões, 1739 (43,5%) foram consideradas inaceitáveis. Tanto o residente como a psicóloga considerou inaceitáveis aproximadamente 85% das manifestações. Para o cirurgião mais conivente com os comportamentos analisados esse número foi de 4% e aproximadamente 20% para os outros dois cirurgiões. Diante da grande divergência entre os avaliadores, expurgam-se os extremos, e as opiniões medianas revelam aproximadamente 20% de manifestações inaceitáveis, o que gera preocupação e chama atenção para a maneira como a população médica vem se comunicando na rede social.


The social networks are changing the world. The abbreviated format, the capacity of disseminate information in a viral way, put together with phenomena of disinhibition and emotional contamination, they change the human relationships. On medical area, the concerns arise around the interaction between doctors, patients and society. Although the benefits of the new tool are recognized, professional duties of care and respect seem to be under threat. This study was carried out to analyze the behavior of medical students and doctors in the social network Facebook. 800 manifestations from medical students and doctors were collected and posteriorly analyzed as acceptable or non-acceptable behavior, according to personal values of five evaluators, being three surgeons in activity, one surgeon resident, and a psychologist, without medical familiarity. In the general analysis of the 4000 opinions, 1739 (43%) were unacceptable. Both the psychologist as the resident considered unacceptable nearly 85% of the manifestations. One of the surgeons considered unacceptable 4% of the manifestations and the other two surgeons nearly 20%. Despite the big diversity of opinions of the evaluators, it is worrying to note that nearly 20% of the manifestations were considered unacceptable, if the extremes are excludes. These results make community aware of the necessity to construct an base of orientation to medical population communicate in the social networks without harm patients or the profession.

12.
Rev. bras. queimaduras ; 14(4): 273-278, Out-Dez.2015. tab, 3 tabelas, ilusuras, 1, ilusura
Artículo en Portugués | LILACS | ID: lil-793078

RESUMEN

Determinar o perfil e evolução de menores de até 14 anos, vítimas de injúrias de causas externas que necessitaram internação hospitalar, em Florianópolis, SC, entre abril de 2013 e março de 2014. Método: Estudo longitudinal e observacional. Utilizado formulário estruturado para coleta dos dados e acompanhamento clínico dos casos. Foram determinadas frequências dos dados categóricos, mediana e intervalo de referência - entre os 5o e 95o percentis (IRP5-95); as associações foram determinadas pelo teste qui-quadrado e regressão logística anterógrada, não condicional. Resultados: Analisaram-se 211 atendimentos. 67,8% do sexo masculino, idade mediana de 6 anos (IRP5-95:1-14) e predomínio da cor branca. O principal cuidador foi a mãe, com companheiro estável, idade mediana de 30,5 anos (IRP5-95:19,5-47) e de escolaridade de 8 anos (IRP5-95:3,4-15,6). Os casos ocorreram mais no domicílio e as queimaduras resultaram na categoria mais frequente. Os pacientes eram procedentes principalmente da Grande Florianópolis e a maioria não apresentou gravidade. Tempo médio de internação foi de 5 dias (IRP5-95:1-23). O modelo que melhor explicou o desfecho internação prolongada (mais de 8 dias) incluiu “queimaduras” (RC: 2,55; IC95: 1,34-4,84; p=0,004) e ter menos de 6 anos (RC: 1,69; IC95: 0,83 - 3,46, p=0,15). O teste de Hosmer e Lemeshow foi de 0,878, explicando 67,8% dos casos (29% dos positivos e 88,7% dos negativos). Conclusão: O perfil da amostra estudada é semelhante a outros grupos descritos previamente, com forte caráter social. Isto deve ser levado em conta na criação de estratégias de controle dessa importante causa de sequelas na população infantil...


To determine the victims, up to 14 years of age, of externally caused injuries, taking into account the sociodemographic and clinical variables and intra-hospital outcome characteristics. Patients and Methods: This is a longitudinal and observational study. Between April 2013 and March 2014, hospitalized patients were studied in Florianopolis, SC, victims of externally injuries, using a structured questionnaire and follow-up. Frequency and median with reference range, i.e. between 5% and 95% percentiles (RRP5-95) were determined. Results: The sample consisted of 211 patients, 67.8% were male with median age of 6 years (RRP5-95:1-14). The main caregiver was the mother, with a stable partner; the median age of the caregiver was 30.5 years (RRP5-95: 19.5-47) and the median schooling was 8 years (RRP5-95: 3.4-15.6). The cases mainly occurred at victim’s home. The common test lesion was burns. Patients came mainly from Florianópolis. The majority of cases weren’t severe. The median hospitalization was 5 days (RRP5-95: 1-23). Were significantly associated with prolonged hospitalization (over 8 days), burn-type injuries (p<0.001), and to have less than 6 years-old (p=0.007). The model that best explained the results included “burns” (OR: 2.55; CI95%: 1.34-4.84; p=0.004) and to have less than 6 years-old (OR: 1.69; CI95%: 0.83 – 3.46, p=0.15). The Hosmer and Lemeshow test was 0.878, explaining 67.8% of cases (29% of positive and negative 88.7%). Conclusion: The profile of the sample is similar to other groups studied in the country and the world, with strong social profile. Such features should be taken into account to implement strategies, in order to control this major cause of morbidity and sequela in children...


Determinar el perfil y evolución de menores hasta 14 años, víctimas de injurias de causas externas que necesitaron internación hospitalaria, en Florianópolis, SC, entre abril de 2013 y marzo de 2014. Método: Estudio longitudinal y observacional. Los datos fueron colectados utilizando formulario estructurado y seguimiento clínico de los casos. Fueron determinadas frecuencias de los datos categóricos, mediana e intervalo de referencia – entre el 5º y 95º percentiles (IRP5-95); las asociaciones fueron determinadas por el test de chi-cuadrado y regresión logística anterógrada, no-condicional. Resultados: Fueron analizados 211 atendimientos. 67,8% de sexo masculino, mediana de edad de 6 años (IRP5-95:1-14), y predominancia de color blanco. El principal cuidador fue la madre, con compañero estable, edad mediana= 30,5 años (IRPP5-95:19,5-47) y 8 años de escolaridad (IRP5-95:3,4-15,6). Los casos ocurrieron más en el domicilio y las quemaduras fueron las más frecuente. Los pacientes eran procedentes principalmente de la Grande Florianópolis y la mayoría no presentó gravedad. Mediana de tiempo de internación = 5 días (IRP5-95:1-23). El modelo que mejor explicó el resultado internación prolongada (>8 días) incluyó “quemaduras” (RC: 2,55; IC95%: 1,34-4,84; p=0,004) y tener menos de 6 años (RC: 1,69; IC95%: 0,83 - 3,46, p=0,151). El test de Hosmer and Lemeshow fue de 0,878, explicando 67,8% de los casos (29% de los positivos y 88,7% de los negativos). Conclusión: El perfil de la muestra estudiada es semejante a otros grupos descritos previamente, con fuerte carácter social. Esto debe ser visto en la creación de estrategias de control de esa importante causa de secuelas en la populación infantil...


Asunto(s)
Humanos , Masculino , Femenino , Niño , Adolescente , Accidentes , Quemaduras , Epidemiología , Causas Externas , Violencia
13.
ACM arq. catarin. med ; 22(3): 119-26, jul.-set. 1993. tab
Artículo en Portugués | LILACS | ID: lil-144432

RESUMEN

No presente trabalho, foram analisados os prontuarios de 53 criancas, com o diagnostico de febre reumatica, internadas no Hospital Infantil Joana de Gusmao e no Hospital Universitario, em Florianopolis, nos anos de 1988 e 1991. Do total de casos, 62,2 por cento estavam no seu primeiro surto e 58,5 por cento eram do sexo masculino. A faixa etaria mais atingida foi de 10 a 15 anos incompletos. Os criterios maiores de Jones revisados ocorreram na seguinte frequencia: cardite com 94,3 por cento , artrite com 60,3 por cento , coreia com 7,5 por cento e eritema marginado e nodulos subcutaneos com 1,9 por cento cada. A alteracao eletrocardiografica mais frequente foi a taquicardia sinusal. O folheto cardiaco mais atingido foi o endocardio, seguido pela associacao de endo e miocardio, sendo que, pericardio e miocardio nao foram acometidos isoladamente. A valvula cardiaca tricuspide foi comprometida em apenas um paciente. Nao ocorreram obitos durante o periodo de internacao e nao foram necessarias cirurgias durante esse periodo.


Asunto(s)
Humanos , Masculino , Femenino , Preescolar , Niño , Adolescente , Fiebre Reumática/diagnóstico , Fiebre Reumática/complicaciones , Fiebre Reumática/etiología
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