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Arch Physiol Biochem ; 128(6): 1548-1558, 2022 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-32574082

RESUMEN

CONTEXT: Transforming growth factor-ß1 (TGF-ß1), endothelin-1 and angiotensin II are responsible for extracellular matrix accumulation within the kidney in diabetic nephropathy. OBJECTIVE: This study evaluated the effect of adding Gum Arabic (GA) and insulin on serum glucose, renal function, TGF-ß1, endothelin-1, and angiotensin II in rats with diabetic nephropathy. METHODS: Sixty male Sprague-Dawley rats were divided into; normal, normal plus GA, diabetic rats (DM), DM plus insulin, DM plus GA, and DM plus insulin plus GA groups. Levels of glucose and creatinine in serum, TGF-ß1, angiotensin II, and endothelin-1 in renal homogenate and HbA1c were measured. RESULTS: Serum creatinine, TGF-ß1, angiotensin II, and endothelin-1 were increased in diabetic rats. GA decreased serum glucose, TGF-ß1, angiotensin II, endothelin-1, and HbA1c in diabetic rats. GA and insulin decreased serum glucose, creatinine, TGF-ß1, angiotensin II, endothelin-1, and HbA1c in diabetic rats. CONCLUSION: Co-administration of GA with insulin to rats with diabetic nephropathy improved the glycemic state, renal function, TGF-ß1, endothelin-1, and angiotensin II.


Asunto(s)
Acacia , Diabetes Mellitus Experimental , Nefropatías Diabéticas , Insulinas , Masculino , Ratas , Animales , Factor de Crecimiento Transformador beta1 , Creatinina , Angiotensina II/farmacología , Diabetes Mellitus Experimental/complicaciones , Endotelina-1 , Goma Arábiga/farmacología , Hemoglobina Glucada , Senegal , Ratas Sprague-Dawley , Riñón , Glucosa/farmacología , Insulinas/farmacología
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