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1.
Sci Rep ; 10(1): 4981, 2020 Mar 18.
Artículo en Inglés | MEDLINE | ID: mdl-32188877

RESUMEN

Atomically thin materials, like semiconducting transition metal dichalcogenides (S-TMDs), are highly sensitive to the environment. This opens up an opportunity to externally control their properties by changing their surroundings. Photoluminescence and reflectance contrast techniques are employed to investigate the effect of metallic substrates on optical properties of MoSe2 monolayer (ML). The optical spectra of MoSe2 MLs deposited on Pt, Au, Mo and Zr have distinctive metal-related lineshapes. In particular, a substantial variation in the intensity ratio and the energy separation between a negative trion and a neutral exciton is observed. It is shown that using metals as substrates affects the doping of S-TMD MLs. The explanation of the effect involves the Schottky barrier formation at the interface between the MoSe2 ML and the metallic substrates. The alignment of energy levels at the metal/semiconductor junction allows for the transfer of charge carriers between them. We argue that a proper selection of metallic substrates can be a way to inject appropriate types of carriers into the respective bands of S-TMDs.

2.
J Phys Condens Matter ; 31(45): 455301, 2019 Nov 13.
Artículo en Inglés | MEDLINE | ID: mdl-31323648

RESUMEN

Owing to exchange interaction between the exciton and magnetic ion, a quantum dot embedding a single magnetic ion is a great platform for optical control of individual spin. In particular, a quantum dot provides strong and sharp optical transitions, which give experimental access to spin states of an individual magnetic ion. We show, however, that physics of quantum dot excitons also complicate spin readout and optical spin manipulation in such a system. This is due to electron-hole exchange interaction in anisotropic quantum dots, which affects the polarisation of the emission lines. One of the consequences is that the intensity of spectral lines in a single spectrum are not simply proportional to the population of various spin states of magnetic ion. In order to provide a solution of the above problem, we present a method of extracting both the spin polarisation degree of a neutral exciton and magnetic dopant inside a semiconductor quantum dot in an external magnetic field. Our approach is experimentally verified on a system of CdSe/ZnSe quantum dot containing a single Fe2+ ion. Both the resonant and non-resonant excitation regimes are explored resulting in a record high optical orientation efficiency of dopant spin in the former case. The proposed solutions can be easily expanded to any other system of quantum dots containing magnetic dopants.

3.
J Phys Condens Matter ; 28(26): 265302, 2016 07 06.
Artículo en Inglés | MEDLINE | ID: mdl-27173643

RESUMEN

We present a comparative study of two self-assembled quantum dot (QD) systems based on II-VI compounds: CdTe/ZnTe and CdSe/ZnSe. Using magneto-optical techniques we investigated a large population of individual QDs. The systematic photoluminescence studies of emission lines related to the recombination of neutral exciton X, biexciton XX, and singly charged excitons (X(+), X(-)) allowed us to determine average parameters describing CdTe QDs (CdSe QDs): X-XX transition energy difference 12 meV (24 meV); fine-structure splitting δ1=0.14 meV (δ1=0.47 meV); g-factor g = 2.12 (g = 1.71); diamagnetic shift γ=2.5 µeV T(-2) (γ =1.3 µeV T(-2)). We find also statistically significant correlations between various parameters describing internal structure of excitonic complexes.

4.
Lupus ; 24(14): 1492-7, 2015 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-26124236

RESUMEN

OBJECTIVE: Neuropsychiatric (NP) lupus, a common manifestation of systemic lupus erythematosus (SLE), is still insufficiently understood, in part, because of the lack of specific biomarkers. Neuron specific enolase (NSE), an important neuronal glycolytic enzyme, shows increased serum levels following acute brain injury, and decreased serum levels in several chronic disorders of the nervous system, including multi infarct dementia, multiple sclerosis and depression. The aim of the study was to evaluate serum NSE levels in SLE patients with and without nervous system involvement, and in healthy controls, and to assess the correlation of NSE serum levels of patients with neuropsychiatric systemic lupus erythematosus (NPSLE) with clinical parameters. METHODS: The study comprised 47 SLE patients and 28 controls. SLE activity was assessed using the Systemic Lupus Activity Measure (SLAM). A neurologist and a psychiatrist examined all patients. NP involvement was diagnosed according to strict NPSLE criteria proposed by Ainiala and coworkers, as modification to American College of Rheumatology (ACR) nomenclature and case definitions. NSE serum levels were determined by use of an immunoassay. RESULTS: Mean NSE serum concentrations in patients with NPSLE were significantly lower than in non-NPSLE patients (6.3 ± 2.6 µg/L vs. 9.7 ± 3.3 µg/L, p < 0.01) and in controls (8.8 ± 3.3 µg/L, p < 0.05). There were significant negative correlations between NSE serum levels and SLE activity (r = -0.42, p < 0.05) and the number of NPSLE manifestations diagnosed (-0.37; p = 0.001). CONCLUSION: Decreased serum concentrations of NSE may reflect chronic neuronal damage with declined metabolism of the nervous tissue in patients with NPSLE.


Asunto(s)
Lupus Eritematoso Sistémico/sangre , Lupus Eritematoso Sistémico/psicología , Fosfopiruvato Hidratasa/sangre , Adulto , Anciano , Biomarcadores/sangre , Daño Encefálico Crónico/sangre , Estudios de Casos y Controles , Femenino , Humanos , Vasculitis por Lupus del Sistema Nervioso Central/sangre , Vasculitis por Lupus del Sistema Nervioso Central/psicología , Masculino , Trastornos Mentales/sangre , Trastornos Mentales/líquido cefalorraquídeo , Trastornos Mentales/etiología , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Índice de Severidad de la Enfermedad , Adulto Joven
5.
Nat Commun ; 5: 3191, 2014.
Artículo en Inglés | MEDLINE | ID: mdl-24463946

RESUMEN

Solotronics, optoelectronics based on solitary dopants, is an emerging field of research and technology reaching the ultimate limit of miniaturization. It aims at exploiting quantum properties of individual ions or defects embedded in a semiconductor matrix. It has already been shown that optical control of a magnetic ion spin is feasible using the carriers confined in a quantum dot. However, a serious obstacle was the quenching of the exciton luminescence by magnetic impurities. Here we show, by photoluminescence studies on thus-far-unexplored individual CdTe dots with a single cobalt ion and CdSe dots with a single manganese ion, that even if energetically allowed, nonradiative exciton recombination through single-magnetic-ion intra-ionic transitions is negligible in such zero-dimensional structures. This opens solotronics for a wide range of as yet unconsidered systems. On the basis of results of our single-spin relaxation experiments and on the material trends, we identify optimal magnetic-ion quantum dot systems for implementation of a single-ion-based spin memory.

6.
Neurol Neurochir Pol ; 47(5): 476-83, 2013.
Artículo en Polaco | MEDLINE | ID: mdl-24166569

RESUMEN

Apomorphine is the most potent dopamine receptor agonist and its symptomatic effectiveness is comparable to levodopa. Subcutaneous apomorphine is rapidly and completely absorbed. Plasma peak concentrations are achieved after 5-15 minutes and onset of clinical effect is within 20 minutes. Apomorphine intermittent subcutaneous injections are effective as rescue therapy for unpredictable off periods in advanced Parkinson disease (PD). More often apomorphine is administered as a subcutaneous infusion which secures the continuous dopaminergic stimulation. The benefit on 'off' periods is consistent across all studies, but dyskinesia improvement is not so obvious. Two infusion therapies (apomorphine and intraduodenal levodopa) and deep brain stimulation (DBS) are effective in advanced PD patients with untreatable motor complications. Apomorphine infusions should be considered in patients unable to undergo DBS because of cognitive impairment and neurosurgical contraindications.


Asunto(s)
Antiparkinsonianos/administración & dosificación , Apomorfina/administración & dosificación , Enfermedad de Parkinson/tratamiento farmacológico , Índice de Severidad de la Enfermedad , Contraindicaciones , Estimulación Encefálica Profunda , Humanos , Infusiones Subcutáneas , Enfermedad de Parkinson/fisiopatología , Resultado del Tratamiento
7.
Acta Neurol Scand ; 122(5): 360-6, 2010 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-20078445

RESUMEN

AIM: Holmes tremor (HT) is a combination of rest, postural and action tremor. A parallel dysfunction of cerebello-thalamic and nigrostriatal pathways seems necessary to produce this kind of tremor. We present the clinical and neuroimaging study verifying that hypothesis. MATERIAL AND METHODS: A total of 10 patients: five male, five female, fulfilling consensus criteria were included. Demographic, clinical and neuroimaging data (MRI = 9; CT = 1, SPECT with the use of 123-I-FP CIT: DaTSCAN in six patients to assess the presynaptic dopaminergic nigrostriatal system involvement, indices of asymmetry for ligand uptake for each striatum were calculated) were analyzed. RESULTS: Hemorrhage was the most frequent etiology and thalamus - the most commonly involved structure. Contrary to the previous reports, the visual assessment did not reveal remarkable interhemispheric differences of DaTSCAN uptake. Quantitative measurements showed only minimal differences. CONCLUSIONS: It is open to debate whether nigrostriatal pathway damage is crucial for the phenomenology of HT. Alternative hypothesis is presented that HT represents the heterogeneous spectrum of tremors with similar phenomenology, but different pathophysiology.


Asunto(s)
Encéfalo , Diagnóstico por Imagen/métodos , Temblor/diagnóstico , Adulto , Anciano , Anciano de 80 o más Años , Encéfalo/diagnóstico por imagen , Encéfalo/patología , Femenino , Humanos , Imagen por Resonancia Magnética/métodos , Masculino , Persona de Mediana Edad , Tomografía Computarizada de Emisión de Fotón Único/métodos , Tomografía Computarizada por Rayos X/métodos , Tropanos
8.
Cell Mol Life Sci ; 63(17): 2067-77, 2006 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-16909199

RESUMEN

The development of functional blood and lymphatic vessels requires spatio-temporal coordination of the production and release of growth factors such as vascular endothelial growth factors (VEGFs). VEGF family proteins are produced in multiple isoforms with distinct biological properties and bind to three types of VEGF receptors. A VEGF-A splice variant, VEGF-A(165)b, has recently been isolated from kidney epithelial cells. This variant is identical to VEGF-A(165) except for the last six amino acids encoded by an alternative exon. VEGF-A(165)b and VEGF-A(165) bind VEGF receptors 1 and 2 with similar affinity. VEGF-A(165)b elicits drastically reduced activity in angiogenesis assays and even counteracts signaling by VEGF-A(165). VEGF-A(165)b weakly binds to heparan sulfate and does not interact with neuropilin-1, a coreceptor for VEGF receptor 2. To determine the molecular basis for altered signaling by VEGF-A(165)b we measured VEGF receptor 2 and ERK kinase activity in endothelial cells in culture. VEGF-A(165) induced strong and sustained activation of VEGF receptor 2 and ERK-1 and -2, while activation by VEGF-A(165)b was only weak and transient. Taken together these data show that VEGF-A(165)b has attenuated signaling potential through VEGF receptor 2 defining this new member of the VEGF family as a partial receptor agonist.


Asunto(s)
Membrana Corioalantoides/irrigación sanguínea , Heparitina Sulfato/metabolismo , Neuropilina-1/metabolismo , Factor A de Crecimiento Endotelial Vascular/genética , Receptor 2 de Factores de Crecimiento Endotelial Vascular/metabolismo , Empalme Alternativo , Animales , Línea Celular , Embrión de Pollo , Membrana Corioalantoides/metabolismo , Humanos , Técnicas In Vitro , Ratones , Neovascularización Fisiológica , Unión Proteica , Isoformas de Proteínas/farmacología , Transducción de Señal , Factor A de Crecimiento Endotelial Vascular/farmacocinética , Factor A de Crecimiento Endotelial Vascular/farmacología , Receptor 1 de Factores de Crecimiento Endotelial Vascular/metabolismo
9.
Neurol Sci ; 26(1): 32-9, 2005 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-15877185

RESUMEN

Current antispastic medications are unsatisfactory for spasticity treatment, but botulinum toxin type A (BTX-A) shows promise as a new therapeutic option. This open-label, prospective study aimed to assess the effectiveness of BTX-A in improving functional mobility in the early post-stroke population using an individualised, flexible range of doses and targeted muscle groups. Twenty-one stroke patients (13 male, 8 female) were enrolled and injected with BTX-A (Botox, Allergan, mean dose: 255 U; range: 185-300) according to individual spasticity patterns. Assessments were made at baseline and weeks 2, 4, 6, 10 and 16 post-treatment. Outcome measures comprised: Modified Ashworth Scale (MAS), finger flexion scale (Bhakta), MRC scale, Physician's Rating Scale (PRS), Nine Hole Peg Test (9HPT), Motor Assessment Scale, Clinical Global Impression (CGI), Global Assessment of Spasticity (GASS) and Visual Analogue Scale (VAS) for pain assessment. Statistically significant improvements in muscle tone as determined by the MAS were found in all areas (except arm) till week 16 (p<0.05). Finger positioning improved for the study duration, whilst muscle power increased only slightly in specific muscles. PRS revealed significant improvements to week 10 and slight improvement in 9HPT performance in selected patients was observed. Motor Assessment Scale results were statistically significant for arm, hand and advanced hand functions, although the overall functional benefit was mild. GASS and CGI results also showed improvement. Pain was present only in 11 patients and did not significantly improve following treatment. Individualised BTX-A injection regimens may be an effective, reversible and safe new treatment option for patients with spasticity. Nevertheless, functional improvement may be reached only in selected patients.


Asunto(s)
Brazo/fisiopatología , Toxinas Botulínicas Tipo A/administración & dosificación , Espasticidad Muscular/tratamiento farmacológico , Paresia/tratamiento farmacológico , Accidente Cerebrovascular/complicaciones , Adulto , Anciano , Toxinas Botulínicas Tipo A/efectos adversos , Evaluación de la Discapacidad , Relación Dosis-Respuesta a Droga , Femenino , Dedos/fisiopatología , Humanos , Inyecciones Intramusculares/métodos , Masculino , Persona de Mediana Edad , Espasticidad Muscular/etiología , Espasticidad Muscular/fisiopatología , Tono Muscular/efectos de los fármacos , Tono Muscular/fisiología , Músculo Esquelético/efectos de los fármacos , Músculo Esquelético/inervación , Músculo Esquelético/fisiopatología , Examen Neurológico , Fármacos Neuromusculares/administración & dosificación , Fármacos Neuromusculares/efectos adversos , Paresia/etiología , Paresia/fisiopatología , Estudios Prospectivos , Recuperación de la Función/efectos de los fármacos , Recuperación de la Función/fisiología , Resultado del Tratamiento
10.
Ortop Traumatol Rehabil ; 3(4): 562-6, 2001.
Artículo en Inglés | MEDLINE | ID: mdl-17984917

RESUMEN

This article discusses the technical and medical difficulties involved in the proper fitting of prostheses on the lower extremity. The factors determining the success of a prosthesis include the quality of the stump, the skill of prosthesis socket fabrication, and the proper ordering of components, as well as rehabilitation supervised by experts and professional care for the amputee.

11.
Ortop Traumatol Rehabil ; 3(3): 418-21, 2001.
Artículo en Inglés | MEDLINE | ID: mdl-17984921

RESUMEN

This article presents the medical indications and contemporary technological capabilities in the orthotic treatment of the upper limb. The devices that today constitute an integral part of therapeutic procedures are presented, as well as the potential created by the application of low-temperature thermoplastic materials. Therapeutic success is conditioned by professional cooperation between the physician, the kinesitherapist, the orthotic technician, and the patient.

12.
Ortop Traumatol Rehabil ; 3(1): 120-5, 2001.
Artículo en Inglés | MEDLINE | ID: mdl-17986974

RESUMEN

This article discusses the indications and typical technical difficulties encountered in the use of foot orthoses, especially shoe inserts and prescription shoes.

13.
Ortop Traumatol Rehabil ; 3(2): 283-6, 2001 Apr 30.
Artículo en Inglés | MEDLINE | ID: mdl-17987000

RESUMEN

This article discusses the technical and medical difficulties involved in managing prostheses of the upper limb. The level of amputation governs the type of prosthesis construction chosen, but does not affect emotional acceptance. The factors determining therapeutic success include the quality of the stump, the skill involved in prosthetic socket fabrication, and the proper selection of modular components, as well as good rehabilitation and professional care for the patient with amputated upper limb.

14.
Plant J ; 28(6): 671-7, 2001 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-11851913

RESUMEN

Precise modification by gene targeting (GT) provides an important tool for studies of gene function in vivo. Although routine with many organisms, only isolated examples of GT events have been reported for flowering plants. These were at low frequencies precluding reliable estimation of targeting efficiency and evaluation of GT mechanisms. Here we present an unambiguous and straightforward system for detection of GT events in Arabidopsis using an endogenous nuclear gene encoding protoporphyrinogen oxidase (PPO), involved in chlorophyll and heme syntheses. Inhibition of PPO by the herbicide Butafenacil results in rapid plant death. However, the combination of two particular mutations renders PPO highly resistant to Butafenacil. We exploited this feature for selection of GT events by introducing the mutations into the PPO gene by homologous recombination. We have estimated the basal GT frequency to be 2.4 x 10(-3). Approximately one-third of events were true GT (TGT) leading to the anticipated modification of the chromosomal PPO copy. The remaining events could be classified as ectopic GT (EGT) arising by modification of vector DNA by the chromosomal template and its random integration into the Arabidopsis genome. Thus the TGT frequency in our experimental setup is 0.72 x 10(-3). In view of the high efficiency of Arabidopsis transformation, GT experiments of a reasonable size followed by a PCR screen for GT events should also allow for modification of non-selectable targets. Moreover, the system presented here should contribute significantly to future improvement of GT technology in plants.


Asunto(s)
Arabidopsis/genética , Marcación de Gen , Southern Blotting , Vectores Genéticos
15.
Plant J ; 24(2): 183-9, 2000 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-11069693

RESUMEN

The Arabidopsis MIM gene encodes a protein belonging to the SMC family (structure maintenance of chromosomes) which is required for intrachromosomal homologous recombination (ICR). Both ICR and MIM gene expression are enhanced by DNA-damaging treatments, suggesting that MIM is a factor limiting DNA repair by homologous recombination (HR) under genotoxic stress. We tested this hypothesis by measuring the levels of recombination in the mim mutant under genotoxic stress, using methyl methanesulfonate. Although the mutant clearly showed diminished basal and induced levels of ICR, enhancement of ICR by DNA-damaging treatments was similar to that observed in the wild type. This suggests that the MIM gene product is required for DNA repair by HR, but is not critical for HR induction. To determine whether enhanced availability of MIM would increase basal HR levels in Arabidopsis, we examined ICR frequencies in transgenic Arabidopsis strains overexpressing the MIM gene after ectopic insertion of additional MIM copies. Two independent lines showed a twofold increase in ICR frequency relative to the wild type. Thus MIM is required for efficient ICR in plants, and its manipulation can be used to change homologous recombination frequencies. Since MIM is one of the components responsible for chromatin dynamics, our results suggest that the chromatin environment determines the frequency of homologous recombination.


Asunto(s)
Proteínas de Arabidopsis , Arabidopsis/genética , Proteínas de Plantas/biosíntesis , Recombinación Genética , Relación Dosis-Respuesta a Droga , Genes de Plantas , Metilmetanosulfonato/toxicidad , Proteínas de Plantas/genética , Proteínas Recombinantes/biosíntesis
16.
J Shoulder Elbow Surg ; 9(3): 211-6, 2000.
Artículo en Inglés | MEDLINE | ID: mdl-10888165

RESUMEN

Thirty rabbits were anesthetized, and the supraspinatus tendon was detached from the greater tuberosity and the infraspinatus and subscapularis tendons. After 6 weeks (group A), 3 months (group B), and 6 months (group C), in vivo evaluation of twitch tension and fatigue index was done. Next, scapulas with muscles were examined with computed tomography. The most prominent decrease of twitch tension and fatigue index was noted during the first 6 weeks. The twitch tension and fatigue index after 2 and 4 minutes of the muscle operated on expressed as a percentage of the values developed by healthy contralateral nonoperated muscle were 58.2%, 34.5%, and 32.7% at the beginning of stimulation, 45.4%, 35.3%, and 26.7% after 2 minutes, and 42.5%, 32.6%, and 18.5% after 4 minutes of stimulation, respectively, in groups A, B, and C. Computed tomography examination showed fatty degeneration of the supraspinatus averaging 1.85 (group A), 2.28 (group B), and 2.43 (group C). Moderate infraspinatus fatty degeneration was noted in all groups. There was no significant fatty degeneration of subscapularis muscle.


Asunto(s)
Músculo Esquelético/patología , Manguito de los Rotadores/cirugía , Tejido Adiposo , Animales , Atrofia , Estudios de Seguimiento , Masculino , Fatiga Muscular , Músculo Esquelético/fisiología , Conejos , Tomografía Computarizada por Rayos X
17.
Ortop Traumatol Rehabil ; 2(4): 126-9, 2000 Dec 30.
Artículo en Inglés | MEDLINE | ID: mdl-17984892

RESUMEN

This article presents excerpts from statues and regulations governing the legal aspects of providing orthopedic devices. The author suggests that the rules of the Committee on Prosthetics and Orthotics of the American Academy of Orthopaedic Surgeons be applied for the classification and terminology of orthopedic devices.

18.
Chir Narzadow Ruchu Ortop Pol ; 64(3): 237-41, 1999.
Artículo en Polaco | MEDLINE | ID: mdl-10495545

RESUMEN

The aim of this study was the quantitative analysis of the phenomena of pain radiation in the case of rotator cuff tear. The clinical material concerns 97 patients, age range from 45 to 86 years. Radiating pain was noted in 33 cases; radiation into distal part of arm--12.4%, elbow--9.3%, forearm--6.2%, hand--1%, hand and thumb 2.1%, 5th finger--1.0%, neck--1.0% and into axilla--1.0%. The radiation of pain was provoked by one finger pressure over tender point (84.8%) or by impingement sign (15.2%). Next the impingement test was performed and additionally supplemented by intraarticular lidocaine injection in 5 cases. Radiation of pain disappeared completely in 26 cases, partly in 6 and persisted in one.


Asunto(s)
Dolor/diagnóstico , Lesiones del Manguito de los Rotadores , Anciano , Anciano de 80 o más Años , Vértebras Cervicales/lesiones , Femenino , Humanos , Masculino , Persona de Mediana Edad , Dimensión del Dolor , Estudios Retrospectivos
19.
Eur J Neurol ; 6(4): 461-7, 1999 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-10362900

RESUMEN

Serial single fiber electromyography (SFEMG) examinations of orbicularis oculi muscle in patients with blepharospasm or hemifacial spasm treated with botulinum toxin injections were performed. The aim of the study was to evaluate the impairment of neuromuscular transmission, to follow reinnervation after botulinum toxin administration and to find out whether there was a relationship between SFEMG parameters and clinical symptoms. Examinations were performed before injection, during early and late remission of symptoms, and after recurrence of the involuntary movement. Severe impairment of neuromuscular transmission, as revealed by increased jitter and increased presence of abnormal potential pairs and pairs with blocking, was found in early remission, but fiber density remained unchanged when compared with pretreatment values. In late remission, increased fiber density was registered for the first time. The recurrence of involuntary movements was related to the further increase of fiber density and tendency to normalization of jitter parameters. The study therefore suggests that formation of new neuromuscular junctions and their functional maturation is responsible for muscle recovery after botulinum toxin administration.


Asunto(s)
Blefaroespasmo/tratamiento farmacológico , Toxinas Botulínicas/uso terapéutico , Espasmo Hemifacial/tratamiento farmacológico , Síndrome de Meige/tratamiento farmacológico , Músculos Oculomotores/fisiopatología , Potenciales de Acción/efectos de los fármacos , Adulto , Anciano , Anciano de 80 o más Años , Blefaroespasmo/fisiopatología , Electromiografía , Femenino , Espasmo Hemifacial/fisiopatología , Humanos , Masculino , Síndrome de Meige/fisiopatología , Persona de Mediana Edad , Músculos Oculomotores/efectos de los fármacos , Músculos Oculomotores/inervación , Recurrencia
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