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2.
Zhonghua Kou Qiang Yi Xue Za Zhi ; 55(11): 864-870, 2020 Nov 09.
Artículo en Chino | MEDLINE | ID: mdl-33171560

RESUMEN

Objective: To evaluate long-term clinical outcome of implant-supported fixed prosthesis with the guidance of computer-aided design/computer-aided manufacturing (CAD/CAM) surgical template in old patients. Methods: Fifteen 50-67(58.6±5.3) year-old patients (11 males and 4 females) who received the digital implant surgery with the guidance of CAD/CAM surgical template and implant-supported fixed prosthesis in Department of Oral Implantology, Yantai Stomatological Hospital Affiliated to Binzhou Medical College from August, 2013 to Janurary, 2016 were included. There are 15 edentulous maxillas, 8 edentulous mandibles on which 145 implants were placed in total. After the placement of implant, the accuracy of CAD/CAM surgical template was assessed by comparing the post-operative 3-dimensional location of implant with the pre-operative design. The 5-year survival rate of implant and prosthesis was recorded, and marginal bone loss around implants and the development of complication were evaluated by radiological and clinical examination respectively. Results: The result on accuracy of CAD/CAM surgical template showed that deviations in neck and apex of implants were (0.78±0.59) and (1.38±0.63) mm respectively, depth deviation was (0.65±0.35) mm and angle deviation was 4.12°±2.77°. The 5-year cumulative survival rate of implants was 98.6%(143/145). In all 145 implants, the prevalence of implant-related biological complication was 4.1%(6/145). The prosthesis-related mechanical complication rate was 57%(13/23). After 5-year function, mean peri-implant bone loss was (0.69±0.35) mm. Conclusions: This 5-year follow-up retrospective study showed that implant-supported fixed prosthesis with the guidance of CAD/CAM surgical template in middle aged and elderly patients could achieve good long-term clinical outcome and patient satisfaction.


Asunto(s)
Implantes Dentales , Arcada Edéntula , Cirugía Asistida por Computador , Anciano , Diseño Asistido por Computadora , Implantación Dental Endoósea , Prótesis Dental de Soporte Implantado , Femenino , Humanos , Arcada Edéntula/cirugía , Masculino , Persona de Mediana Edad , Estudios Retrospectivos
3.
Phys Rev Lett ; 124(9): 095101, 2020 Mar 06.
Artículo en Inglés | MEDLINE | ID: mdl-32202894

RESUMEN

Electrostatic solitary wave (ESW)-a Debye-scale structure in space plasmas-was believed to accelerate electrons. However, such a belief is still unverified in spacecraft observations, because the ESW usually moves fast in spacecraft frame and its interior has never been directly explored. Here, we report the first measurements of an ESW's interior, by the Magnetospheric Multiscale mission located in a magnetotail reconnection jet. We find that this ESW has a parallel scale of 5λ_{De} (Debye length), a superslow speed (99 km/s) in spacecraft frame, a longtime duration (250 ms), and a potential drop eφ_{0}/kT_{e}∼5%. Inside the ESW, surprisingly, there is no electron acceleration, no clear change of electron distribution functions, but there exist strong electrostatic electron cyclotron waves. Our observations challenge the conventional belief that ESWs are efficient at particle acceleration.

4.
Opt Express ; 27(16): A1146-A1155, 2019 Aug 05.
Artículo en Inglés | MEDLINE | ID: mdl-31510496

RESUMEN

Near-ultraviolet micro-LEDs with different diameters were fabricated on GaN substrates. The electroluminescence and the light output power-current density and current density-voltage relationships were measured. A saturated current density of 358 kA/cm2 was achieved with a 20 µm LED. The ideality factor curves showed steps and peaks when the injection current density was increased from 20 to 150 kA/cm2 and an abnormal efficiency increase. The transport and recombination processes of micro-LEDs at high injection current densities were simulated, and the many-body effect and phase space filling in the integrated quantum drift-diffusion model were considered. Serious current crowding was observed above 100 kA/cm2, even for the 20 µm LED.

6.
J Econ Entomol ; 112(3): 1162-1166, 2019 05 22.
Artículo en Inglés | MEDLINE | ID: mdl-30892599

RESUMEN

The lower developmental threshold (LDT) and the number of developmental degree days (DDs) are fundamental parameters used to build phenology models that can be used to predict the timing of biological events during insect development. The Chinese citrus fly, Bactrocera minax (Enderlein) (Diptera: Tephritidae) is one of the most destructive citrus pest in China and Bhutan. This species overwinters as diapausing pupae in the soil before emerging as adults in the spring. In this study, B. minax collected from three representative geographical populations in China (Guizhou, Hubei, and Shaanxi) was used to conduct LDT experiments under laboratory conditions. Emergence data collected from pupae exposed to 10 constant temperatures was used to estimate the LDT and DDs required to complete pupal development for the three populations. The results show that LDT and DDs values for the Hubei and Shaanxi population are 11.9°C, 447.3 DDs and 11.5°C, 511.3 DDs, respectively. However, the geographic variation in pupal developmental rates was not statistically significant between the two populations. In addition, the Guizhou population was identified as a mixture of B. minax and B. tsuneonis (Miyake). The LDT and DDs values for the Hubei and Shaanxi populations obtained in this study can be used to predict adult emergence of naturally occurring field populations of B. minax within the majority of the citrus-growing production areas of China. These data can also be used in models to predict the risk of establishment of this species in the United States or other citrus-growing regions.


Asunto(s)
Citrus , Tephritidae , Animales , China , Pupa
7.
Zhonghua Yi Xue Za Zhi ; 99(5): 354-358, 2019 Jan 29.
Artículo en Chino | MEDLINE | ID: mdl-30772976

RESUMEN

Objective: To analyze the clinical presentation, imaging features, and the mutation of the pathogenic genes in a Chinese Han atypical neuroaxonal dystrophy pedigree. Methods: A family of atypical neuroaxonal dystrophy pedigree who came to Henan Provincal People's Hospital in July 2016 was included. Clinical presentation, imaging features of the pedigree were analyzed, and all exon gene detection of the proband was performed to capture the target variations, then verified by sanger sequence. Another 4 family members' and 100 normal healthy controls' gene sequence of the mutations were also verified. Results: The proband(Ⅱ(3)) of the family presented with walking unsteadily, intellectual disability, glossolalia, dystonia, epilepsy, and autonomic nervous dysfunction. The magnetic resonance imaging (MRI) of the proband showed cerebellar atrophy and iron deposit in basal ganglia. The gene detection showed the PLA2G6 gene compound complicated mutation of 80 codon p.A80T in the exon 3 and 331 codon p.D331Y in the exon 7. The two sisters of the proband (Ⅱ(1),Ⅱ(2)) had the same mutation, the father of the proband carried the p.A80T, however, the mother carried the D331Y mutation. One of the proband's sister (Ⅱ(1)), whose onset age was 10 years old, had the similar symptoms with the proband. The proband's another sister(Ⅱ(1)) had abnormal gait at 24 years old. However, the MRI of the two sisters all showed cerebellar atrophy. Conclusion: We report a PLA2G6 compound complicated mutation in an atypical neuroaxonal dystrophy Chinese family, that is the p. A80T and p.D331Y mutation, which may be a pathogenic mutation to cause the family's disease.


Asunto(s)
Fosfolipasas A2 Grupo VI/genética , Trastornos del Metabolismo del Hierro , Distrofias Neuroaxonales , Niño , Humanos , Trastornos del Metabolismo del Hierro/genética , Mutación , Distrofias Neuroaxonales/genética , Linaje , Adulto Joven
8.
Bull Entomol Res ; 109(2): 212-220, 2019 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-29925448

RESUMEN

The oriental fruit moth, Grapholita molesta, is an important pest in many commercial orchards including apple, pear and peach orchards, and responsible for substantial economic losses every year. To help in attaining a comprehensive and thorough understanding of the ecological tolerances of G. molesta, we collected life history data of individuals reared on apples under different constant temperature regimes and compared the data with moths reared under a variable outdoor temperature environment. Because G. molesta individuals reared at a constant 25°C had the heaviest pupal weight, the highest survival rate from egg to adult, highest finite rate of increase, and greatest fecundity, 25°C was considered as the optimum developmental temperature. The G. molesta population reared at a constant 31°C had the shortest development time, lowest survival rate and fecundity, resulting in population parameters of r < 0, λ < 1, lead to negative population growth. The population parameters r and λ reared under fluctuating temperature were higher than that reared under constant temperatures, the mean generation time (T) was shorter than it was in all of the constant temperatures treatments. This would imply that the outdoor G. molesta population would have a higher population growth potential and faster growth rate than indoor populations raised at constant temperatures. G. molesta moths reared under fluctuating temperature also had a higher fertility than moths reared under constant temperatures (except at 25°C). Our findings indicated that the population raised under outdoor fluctuating temperature conditions had strong environment adaptiveness.


Asunto(s)
Mariposas Nocturnas/crecimiento & desarrollo , Temperatura , Animales , Larva/crecimiento & desarrollo , Malus
9.
Zhonghua Xue Ye Xue Za Zhi ; 39(9): 766-772, 2018 Sep 14.
Artículo en Chino | MEDLINE | ID: mdl-30369190

RESUMEN

Objective: To investigate the relationship between miRNA-196b-5p and miRNA-99a-5p expression and autophagy and apoptosis in multiple myeloma cells. Methods: Human myeloma cell line U266 and normal CD138+ plasma cells were selected as the research objects. The subjects were divided into 45 cases of multiple myeloma patients and 40 healthy controls. The expression of miRNA-196b-5p and miRNA-99a-5p was measured by real-time quantitative PCR, and Western blot was used to determine the expression of autophagy related protein LC3-Ⅱ, LC3-Ⅰ, P62, Beclin-1 expression, apoptosis related protein CL caspase3, CL caspase7, Bcl-2, Bax, and TGF-ß/Smad pathway associated proteins TGF-ß1, Smad2/3, p-Smad3 and Smad7. The cell apoptosis rate was determined by flow cytometry. The correlation between miRNA expression level and clinical characteristics of multiple myeloma patients was analyzed. Results: Compared with normal plasma cells, the expression of miRNA-196b-5p in myeloma cells increased significantly (0.43±0.15 vs 2.44±0.63 or 2.02±0.85, all P<0.001), the expression of miRNA-99a-5p was significantly decreased (1.87±0.61 vs 0.62±0.15 or 0.80±0.33, P<0.001), LC3-Ⅱ/LC3-Ⅰ increased significantly (P<0.05), Beclin-1 expression increased significantly (P<0.05), P62 expression decreased significantly (P<0.05). The expression of Bax, CL caspase3 and CL caspase7 decreased significantly (P<0.05), and the expression of Bcl-2 increased significantly (P<0.05) and apoptosis rate significantly decreased (P<0.05). After transfected with miRNA-196b-5p mimic or miRNA-99a-5p inhibitor, the LC3-Ⅱ/LC3-Ⅰ of CD138+ plasma cells increased significantly (P<0.05), the expression of Beclin-1 increased significantly (P<0.05), P62 expression decreased significantly (P<0.05), and the apoptosis rate significantly decreased (P<0.05). However, after autophagy inhibitor of 3-MA was administered, the apoptotic rate of the above reaction system did not change significantly (P>0.05). The expression of miRNA-196b-5p and miRNA-99a-5p was significantly correlated with DS and ISS stage in multiple myeloma patients (P<0.05). Conclusion: miRNA-196b-5p and miRNA-99a-5p are closely related to the clinical characteristics of patients with multiple myeloma. The overexpression of miRNA-196b-5p and down regulation of miRNA-99a-5p could inhibit the apoptosis of myeloma cells by up regulation of autophagy, and the mechanism is related to the activation of the TGF-ß/Smad signaling pathway.


Asunto(s)
Autofagia , Mieloma Múltiple , Apoptosis , Beclina-1 , Línea Celular Tumoral , Humanos , MicroARNs
10.
Zhonghua Xin Xue Guan Bing Za Zhi ; 46(9): 706-712, 2018 Sep 24.
Artículo en Chino | MEDLINE | ID: mdl-30293377

RESUMEN

Objective: To characterize the gut microbial community structure of two-kidney-one-clip (2K1C) hypertensive rats, provide new evidences for prevention and treatment of hypertension. Methods: Adult male SD rats were divided into 2K1C hypertensive model group and sham operation group (n=8 each). Blood pressure was recorded by tail-cuff technique weekly for 4 weeks. Then, the total fecal DNA of rats in 2K1C model group and sham operation group were extracted. The structure and principal components of intestinal flora in 2K1C model rats and sham operated rats were analyzed using Hiseq3000 sequencing platform. Additionally, real time fluorescent quantitative polymerase chain reaction technology was used to detect the content of predominant bacteria, including Escherichia, Bifidobacterium, Lactobacillus and Bacteroides. Results: Compared with sham operation group, significant reduction in the relative abundance of Firmicutes (31.72 (30.06, 32.18) vs. 40.99 (38.78, 44.41), U=0.00, P<0.05) and increase in Bacteroidetes (48.13(41.16,50.25) vs. 27.81(25.84,31.38),U=0.00, P<0.05) were observed in the fecal samples from model group. The relative abundance of Escherichia coli (0.08(0.07,0.11) vs. 0.07(0.06,0.08),U=12.50, P<0.05) was increased and the short chain fatty acid producing strains such as Coprococcus, Roseburia, Blautia, Clostridium and Bacteroides was reduced in 2K1C model group than in sham operation group (all P<0.05). Moreover, the relative abundance of Prevotella (Bacteroidetes) was also significantly higher in 2K1C model group than in sham operation group (18.14(17.78,18.75) vs.1.83(1.50,5.19), U=0.00, P<0.05). Moreover, the relative abundance of Ruminococcus (Firmicutes) was significant higher in 2K1C model group than in sham operation group (7.73(6.04,9.34) vs. 3.68(2.46,4.67),U=0.00, P<0.05). Principal coordinate analysis showed that there was significant difference in the gut microbial community structure between 2K1C model group and sham operation group. Conclusion: There are significant changes in the gut microbial community structure in 2K1C model group as compared to sham operation group, indicating renovascular hypertension might affect gut microbial community structure in this rat model.


Asunto(s)
Microbioma Gastrointestinal , Hipertensión Renovascular , Riñón , Animales , Presión Sanguínea , Masculino , Ratas , Ratas Sprague-Dawley , Instrumentos Quirúrgicos
11.
Zhonghua Zhong Liu Za Zhi ; 39(4): 274-279, 2017 Apr 23.
Artículo en Chino | MEDLINE | ID: mdl-28550667

RESUMEN

Objective: To investigate the clinicopathological characteristic and risk factors for recurrence in different subtypes of mucinous breast cancer(MBC). Methods: Clinical data of 97 MBC patients at Zhejiang Cancer Hospital from August 2005 to November 2012 were retrospectively analyzed. All of patients were divided into 3 subtypes according to the mucinous components in the tumors, named as partial mixed MBC with less than 50% of mucinous components, main mixed MBC where the mucinous component accounted for 50% to 90%, and pure MBC with more than 90% of mucinous components. In this study, 43, 16 and 38 patients were included in partial mixed MBC, main mixed MBC, and pure MBC, respectively. Follow-up was collected by out-patient, in-patient system and phone call. The relationship between different subtypes and clinicopathological significance were analyzed by χ(2) test. Kaplan-Meier curve combined with Log-rank test was used to evaluate the risk factors of relapse free survival(RFS) at 3- and 5-year. Cox proportional hazard regression model was used for multivariate analysis. Results: The median follow-up time was 65 months (range 24-125). Of the 97 patients, 14 patients were relapse or metastasis at the end point. The 3- and 5-year RFS were 90.7% and 85.7%, respectively. Tumor size, number of involved lymph nodes (LN), axillary LN metastasis, TNM stages and p53 mutant status were all related with subtypes of MBC(all of P<0.05). There was no correlation between subtypes of MBC and the other parameters, including age at surgery, estrogen receptor (ER) status, progesterone receptor (PR) status, human epidermal growth factor receptor-2 (HER-2) overexpression, menstruation status, and the relapse of disease(all of P>0.05). Univariate analysis showed menstruation status and TNM stages were associated with the relapse of breast cancer(P<0.05). The patients with menopause and stage Ⅲ-Ⅳ showed significantly shorter RFS time(both of P<0.05). Multivariate Cox proportional hazard regression analysis revealed that tumor size, PR status and postoperative radiotherapy were the independent prognostic factors for the relapse of MBC. Conclusions: Tumor size, status of axillary LN metastasis, TNM stages, and p53 mutation status are differ among different subtypes of MBC. The tumor size (>30 mm), PR status and postoperative radiotherapy are the independent risk factors for recurrence, whereas the proportion of the mucinous component is not associated with relapse in MBC patients.


Asunto(s)
Adenocarcinoma Mucinoso , Neoplasias de la Mama , Recurrencia Local de Neoplasia , Adenocarcinoma Mucinoso/química , Adenocarcinoma Mucinoso/clasificación , Adenocarcinoma Mucinoso/patología , Axila , Neoplasias de la Mama/química , Neoplasias de la Mama/clasificación , Neoplasias de la Mama/genética , Neoplasias de la Mama/patología , Supervivencia sin Enfermedad , Femenino , Estudios de Seguimiento , Humanos , Estimación de Kaplan-Meier , Ganglios Linfáticos/patología , Menstruación , Persona de Mediana Edad , Modelos de Riesgos Proporcionales , Receptor ErbB-2 , Receptores Estrogénicos/análisis , Estudios Retrospectivos , Factores de Riesgo , Tasa de Supervivencia , Factores de Tiempo , Carga Tumoral
12.
Zhonghua Yi Xue Za Zhi ; 97(1): 7-11, 2017 Jan 03.
Artículo en Chino | MEDLINE | ID: mdl-28056282

RESUMEN

Objective: To analysis the value of susceptibility vessel sign (SVS) in susceptibility weighted imaging (SWI) in detecting thrombogenesis in middle cerebral artery (MCA) and its association with clinical prognosis. Methods: From December 2014 to December 2015 in People's Hospital of Zhengzhou University, we retrospectively examined clinical, imaging and experimental datafrom 104 consecutive patients with acute ischemic strokeand compared the consistency of detecting thrombus between SWI and magnetic resonance angiography (MRA) using Kappa analysis. Clot Burden Score (CBS) was used to analysis extent and scope of thrombus. The association between CBS and clinical prognosiswere analyzed by Spearman rank correlation. Results: Mean age was 60 years old of the 104 patients with acute cerebral infarction and female accounted for 32%. There were 39 patients (37.5%) with SVS positive in SWI and 32 patients (30.8%) with both SVS positive and MRA occlusion or severe stenosis. The consistency in predicting arterial thrombosis of occlusion or severe stenosis between MRA and SVS in SWI was statistically significant (Kappa=0.502, P<0.001). There were 6 cases with SVS positive and none stenosis in MRA, and all the clots in this 6 case were located in distal artery. CBS was significantly associated with 3-month outcome (Spearman ρ =-0.472; P<0.001). Conclusion: SWI is superior to MRA for the detection of intracranial distal thrombus in patients with acute ischemic stroke of the MCA territory. Higher clot burden(lower CBS) could be an important clinical tool to estimate poor outcome in patients with acutecerebral infarction.


Asunto(s)
Isquemia Encefálica , Accidente Cerebrovascular , Constricción Patológica , Femenino , Humanos , Trombosis Intracraneal , Angiografía por Resonancia Magnética , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Arteria Cerebral Media , Pronóstico , Estudios Retrospectivos , Trombosis
14.
Opt Express ; 23(13): 16565-74, 2015 Jun 29.
Artículo en Inglés | MEDLINE | ID: mdl-26191668

RESUMEN

Different size InGaN/GaN based micro-LEDs (µLEDs) are fabricated. An extremely high injection level above 16 kA/cm2 is achieved for 10 µm-diameter LED. The lateral current density and carrier distributions of the µLEDs are simulated by APSYS software. Streak camera time resolved photoluminescence (TRPL) results show clear evidence that the band-gap renormalization (BGR) effect is weakened by strain relaxation in smaller size µLEDs. BGR affects the relaxation of free carriers on the conduction band bottom in multiple quantum wells (MQWs), and then indirectly affects the recombination rate of carriers. An energy band model based on BGR effect is made to explain the high-injection-level phenomenon for µLEDs.

15.
Genet Mol Res ; 14(3): 7630-3, 2015 Jul 13.
Artículo en Inglés | MEDLINE | ID: mdl-26214442

RESUMEN

The purpleback flying squid (Sthenoteuthis oualaniensis) is a pelagic squid with tremendous potential for commercial exploitation. We isolated and characterized 21 polymorphic microsatellite loci for S. oualaniensis using a (GT)13-enriched genomic library. The number of alleles per locus varied from 6 to 32. The observed and expected heterozygosities ranged from 0.188 to 0.890, and 0.537 to 0.968, respectively. No significant linkage disequilibrium was detected at these loci. Five loci significantly deviated from the Hardy-Weinberg equilibrium, and four loci may have exhibited null alleles. These microsatellite markers will facilitate further studies in population genetics and the sustainable utilization of S. oualaniensis.


Asunto(s)
ADN/genética , ADN/aislamiento & purificación , Decapodiformes/genética , Sitios Genéticos , Repeticiones de Microsatélite/genética , Animales , Polimorfismo Genético
16.
Genet Mol Res ; 13(3): 5254-7, 2014 Jul 24.
Artículo en Inglés | MEDLINE | ID: mdl-25078580

RESUMEN

Twenty-two polymorphic microsatellite loci were isolated and characterized from a (GT)13-enriched Nemipterus bathybius genomic library. The number of alleles per locus ranged from 4 to 13, with an average of 7.86. The observed and expected heterozygosity was 0.167-0.889 and 0.278-0.904, respectively, with averages of 0.590 and 0.690. Three loci deviated from Hardy-Weinberg proportions, and 2 loci showed evidence of null alleles. No significant linkage disequilibrium was detected in the pairwise comparisons among the 22 loci. These markers are expected to be useful for the population genetic analysis of N. bathybius.


Asunto(s)
Sitios Genéticos , Repeticiones de Microsatélite , Perciformes/genética , Polimorfismo Genético , Alelos , Animales , Cruzamiento , Explotaciones Pesqueras , Frecuencia de los Genes , Ligamiento Genético , Biblioteca Genómica , Heterocigoto
17.
JBR-BTR ; 95(4): 251-6, 2012.
Artículo en Inglés | MEDLINE | ID: mdl-23019994

RESUMEN

PURPOSE: To explore the technical feasibility of double contrast percutaneous transhepatic cholangiographic CT (DC-PCT-CT) in patients with bile duct obstruction. METHODS: Seven patients with bile duct obstructive diseases were studied, including 5 males and 3 females, ranging in age from 24 yrs to 74 yrs (average: 47.7 yrs). There were 5 cases of hilar cholangiocarcinoma, 1 case of sclerosing cholangitis, and 1 case of malignant transformation of adenoma at the distal end of the common bile duct. PTC was carried out initially, involving injection of 30 ml 4.5-6.0 mgl iohexol. After the bile duct system was filled, CT scan was performed, and further followed by enhanced CT with intravenous injection of 300 mgl/ml contrast agent. Arterial phase, venous phase, and parenchymal phase acquisitions were obtained. Raw CT images were viewed and multiplanar reconstruction (MPR), maximum intensity projection (MIP), and volume rendering (VR) image post-processing were performed. RESULTS: DC-PCT-CT was performed successfully and bile duct drainage was carried out. Mild lesion enhancement was demonstrated in three cases in arterial phase, while all seven cases demonstrated enhancement of various degrees in venous phase.The lesions lead to track-like, asymmetrical or irregular bile duct obstructive narrowing, and in one case intra-luminal filling defect. Reliable diagnosis was suggested in all cases. MPR, MIP and VR images were useful in demonstrating precise lesion location and for surgical planning. CONCLUSION: In patients with bile duct obstruction, DC-PTC-CT is a feasible technique offering both important diagnostic value and drainage application.


Asunto(s)
Enfermedades de los Conductos Biliares/diagnóstico por imagen , Colangiografía/métodos , Medios de Contraste , Ictericia Obstructiva/diagnóstico por imagen , Intensificación de Imagen Radiográfica/métodos , Tomografía Computarizada por Rayos X/métodos , Adenoma/complicaciones , Adenoma/diagnóstico por imagen , Adulto , Anciano , Enfermedades de los Conductos Biliares/complicaciones , Neoplasias de los Conductos Biliares/complicaciones , Neoplasias de los Conductos Biliares/diagnóstico por imagen , Colangiocarcinoma/complicaciones , Colangiocarcinoma/diagnóstico por imagen , Colangitis Esclerosante/complicaciones , Colangitis Esclerosante/diagnóstico por imagen , Conducto Colédoco/diagnóstico por imagen , Diagnóstico Diferencial , Estudios de Factibilidad , Femenino , Humanos , Procesamiento de Imagen Asistido por Computador/métodos , Yohexol , Ictericia Obstructiva/etiología , Masculino , Persona de Mediana Edad , Reproducibilidad de los Resultados , Adulto Joven
18.
Transplant Proc ; 43(5): 1456-61, 2011 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-21693217

RESUMEN

AIM: The aim of this study was to determine whether Astragaloside IV (AST-IV) inhibited the transcriptional activity of nuclear factor-κB (NF-κB), attenuating liver transplant ischemia-reperfusion injury (IRI). METHODS: Sprague Dawley (SD) rats were randomly divided into 2 groups: donors given AST-IV (1.5 mL; 100 µg/mL, intravenous [IV]) 1 hour before surgery (n = 32), versus controls treated with 1.5 mL physiological saline (n = 32). Orthotropic liver transplantation was performed according to the Kamada technique. Eight animals in each group were followed for seven days after surgery to assess survival. The remaining hosts in each group were divided into 3 subgroups (n = 8) to be examined at 3, 6, and 24 hours after portal vein reperfusion. We analyzed levels of alanine aminotransferase (ALT), tumor necrosis factor (TNF)-α, and NF-κB transcriptional activity and performed a morphological study of liver tissues, NF-κB, and glucocorticoid receptor (GR) expression in Kupffer cells (KCs). RESULTS: Pretreatment with AST-IV significantly improved survival rates and liver function, attenuating liver parenchymal cell damage by down-regulating TNF-α levels and NF-κB expressions, inhibiting NF-κB transcriptional activity, up-regulating GR expression. CONCLUSION: AST-IV attenuated hepatic IRI by inhibiting NF-κB transcriptional activity. The mechanism may relate to up-regulation of GR expression.


Asunto(s)
Trasplante de Hígado , Daño por Reperfusión/prevención & control , Saponinas/uso terapéutico , Triterpenos/uso terapéutico , Animales , Secuencia de Bases , Western Blotting , Cartilla de ADN , Inmunohistoquímica , Trasplante de Hígado/efectos adversos , Masculino , Ratones , Microscopía Confocal , FN-kappa B/metabolismo , Ratas , Ratas Sprague-Dawley , Receptores de Glucocorticoides/metabolismo , Tasa de Supervivencia , Factor de Necrosis Tumoral alfa/metabolismo
19.
Dentomaxillofac Radiol ; 39(3): 149-56, 2010 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-20203276

RESUMEN

OBJECTIVES: The aim of this study was to investigate the correlation between disc displacement types and locations of disc perforation in the temporomandibular joint (TMJ). METHODS: 157 patients (162 joints) with disc perforation observed through arthroscopy were included in this study. The types of disc displacement were analysed by TMJ MRI before operation. The locations of disc perforation under arthroscopy were recorded. The correlation between types of disc displacement and locations of disc perforation was analysed by Fisher's exact test. RESULTS: Medial disc perforation was observed in 55.6% of patients with anterolateral displacement without reduction, but was observed in only 3.7% of patients with pure anterior displacement, and was not observed in patients with anteromedial displacement without reduction. There was a statistically significant difference between these groups in the incidence of medial disc perforation. CONCLUSIONS: There is a correlation between different disc displacements and locations of disc perforation. The incidence of medial disc perforation in patients with anterolateral displacement was significantly higher. The types of disc displacement may have direct influence over the locations of disc perforation.


Asunto(s)
Imagen por Resonancia Magnética/métodos , Disco de la Articulación Temporomandibular/patología , Trastornos de la Articulación Temporomandibular/diagnóstico , Adulto , Artroscopía , Femenino , Humanos , Masculino , Rotura , Disco de la Articulación Temporomandibular/cirugía , Trastornos de la Articulación Temporomandibular/patología , Trastornos de la Articulación Temporomandibular/cirugía
20.
J Phys Condens Matter ; 21(49): 495502, 2009 Dec 02.
Artículo en Inglés | MEDLINE | ID: mdl-21836198

RESUMEN

We studied the effect of Al doping in Zn(0.94)Co(0.05)Al(0.01)O nano-powders from the electronic structure point of view by applying x-ray absorption spectroscopy and resonant inelastic x-ray scattering at the oxygen K- and Co L-edges. The intensity of the pre-edge structure of the O-K XAS spectra is enhanced following the introduction of the Al defect. Multiple scattering calculations demonstrate it can be accounted for by the gain of the hybridization strength between O 2p and Al 3p (and/or Co 3d) states. The consensus on the hybridization strength is reached by combining Co-L XAS and RIXS investigations and multiplet calculations. It reveals different spatial substitutions of Al doping can alter the number of shared oxygen atoms between the Co and Al tetrahedrons. These shared ligands are responsible for the Al 3p and Co 3d state hybridization strength as well as the ferromagnetism of the ground state. The magnetic difference is better understood to be governed by various shared oxygen atoms rather than the distance between the Al defect and Co impurities.

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