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1.
J Prosthet Dent ; 2021 Feb 03.
Artículo en Inglés | MEDLINE | ID: mdl-33549342

RESUMEN

STATEMENT OF PROBLEM: Zirconia restorations create significant artifacts on 3D cone beam computed tomography (CBCT) imaging. Static computer-assisted implant surgery (s-CAIS) relies on the accuracy of superimposition between an intraoral surface scan and CBCT imaging. However, how the artifacts from zirconia on the tomographic image might affect the predictability of s-CAIS is unclear. PURPOSE: The purpose of this in vitro study was to evaluate the effect of zirconia crown restorations on the superimposition process for s-CAIS. MATERIAL AND METHODS: Four stone casts generated 4 groups: a control group (CG) with no crowns and 3 experimental groups with 4 (TG4), 7 (TG7), and 13 (TG13) zirconia crowns. A total of 40 CBCT scans were made for the 4 groups (n=10). All CBCTs were imported into a computer planning software program, and the casts from all 4 groups were scanned by using a high-resolution laboratory scanner. The standard tessellation language (STL) files were imported, segmented, and the 3 files superimposed for all groups. The accuracy of the superimposition was assessed, in millimeters, in 3 planes corresponding to anterior-posterior, horizontal, and vertical, as well as the overall measurement, and the results were analyzed statistically (α=.05). RESULTS: The overall analysis demonstrated statistically significant differences between all groups (P<.001), except between CG and TG4. The anterior-posterior dimension demonstrated significant differences between CG and TG7 (P<.001), CG and TG13 (P<.001), TG4 and TG7 (P=.004), and TG4 and TG13 (P=.001). For the vertical dimension analysis, significant differences were found between CG and TG7 (P=.001), CG and TG13 (P<.001), and TG4 and TG13 (P<.001). For the horizontal variable, statistically significant differences were found between CG and TG7 (P=.049), CG and TG13 (P<.001), TG4 and TG13 (P<.001), and TG7 and TG13 (P=.003). CONCLUSIONS: The accuracy of the superimposition of the images was influenced by the number of zirconia crowns, with an increased number reducing the superimposition accuracy.

2.
Sci Total Environ ; 773: 145066, 2021 Feb 04.
Artículo en Inglés | MEDLINE | ID: mdl-33582326

RESUMEN

Biological nitrogen fixation is a key process for the maintenance of natural ecosystems productivity. In tropical forests, the contribution of asymbiotic nitrogen fixation (ANF) to the nitrogen (N) input has been underestimated, even though few studies have shown that ANF may be as important as symbiotic nitrogen fixation in such environments. The inputs and abiotic modulators of ANF in the Amazon forest are not completely understood. Here, we determined ANF rates and estimated the N inputs from ANF in the phyllosphere, litter and rhizospheric soil of nine tree species in the Amazon forest over time, including an extreme drought period induced by the El Niño-Southern Oscillation. Our data showed that ANF rates in the phyllosphere were 2.8- and 17.6-fold higher than in the litter and rhizospheric soil, respectively, and was highly dependent on tree taxon. Sampling time was the major factor modulating ANF in all forest compartments. At the driest period, ANF rates were approximately 1.8-fold and 13.1-fold higher than at periods with higher rainfall, before and after the extreme drought period, respectively. Tree species was a key modulator of ANF in the phyllosphere, as well as N and Vanadium concentrations. Carbon, molybdenum and vanadium concentrations were significant modulators of ANF in the litter. Based on ANF rates at the three sampling times, we estimated that the N input in the Amazon forest through ANF in the phyllosphere, litter and rhizospheric soil, was between 0.459 and 0.714 kg N ha-1 yr-1. Our results highlight the importance of ANF in the phyllosphere for the N input in the Amazon forest, and suggest that changes in the patterns of ANF driven by large scale climatic events may impact total N inputs and likely alter forest productivity.

3.
J Prosthet Dent ; 2020 Dec 16.
Artículo en Inglés | MEDLINE | ID: mdl-33341254

RESUMEN

This article introduced a digital workflow by using data merging and a computer-aided design and computer-aided manufacturing (CAD-CAM) milled surgical guide for an esthetic crown lengthening procedure. The superimposition of intraoral scanning, digital photographs, cone beam computed tomography, and a CAD-CAM surgical guide should increase the predictability of esthetic crown lengthening surgery.

4.
Artículo en Inglés | MEDLINE | ID: mdl-33225616

RESUMEN

INTRODUCTION: The infringement of supracrestal tissue attachment by subgingival restorative margins, extensive caries, and root fractures, can compromise the periodontal health, resulting in inflammation and loss of periodontal supporting tissues. This report describes a case of a root fracture on the upper left central incisor that was successfully treated using a conservative approach, by applying the Restorative alveolar interface (RAI) management combined with tunnel technique and a subepithelial connective tissue graft (SCTG). CASE PRESENTATION: A 24-year-old male patient presented with a provisional single-unit fixed prosthesis on his upper left central incisor, in function for 4 years, with the chief complaint of prosthesis discoloration. After clinical and radiographic examination, a diagnosis of root fracture was established. Following the removal of the provisional prosthesis, a full-thickness flap was elevated creating a tunnel. The elimination of the fracture line/angle, root recontouring and planning was then performed with the aid of a conical long diamond bur and periodontal curettes. Additionally, a SCTG was placed buccally into the tunnel. The final zirconia layered with E-max crown was placed at 6 month after surgery. At 12 and 24-month follow-up the periodontal tissues presented healthy aspect, no bleeding on probing and a 4 mm probing pocket depth. CONCLUSION: Surgically repositioning of the restorative margin can be an alternative and conservative treatment approach to compromised teeth with subgingival fracture line/angle. However, case selection should be carefully considered and restorability assessed as limitations might apply. This article is protected by copyright. All rights reserved.

5.
J Prosthet Dent ; 2020 Nov 04.
Artículo en Inglés | MEDLINE | ID: mdl-33160619

RESUMEN

This clinical report describes a ceramic complete-mouth rehabilitation with screw-retained implant abutment crowns, optimizing esthetics by combining the properties of ceramic materials. The abutments connected a titanium insert to a computer-aided design and computer-aided manufacturing (CAD-CAM) monolithic zirconia framework, offering improved esthetics and biologic response without negatively affecting the implant abutment interface. Lithium disilicate crowns were cemented extraorally on the abutments, resulting in a screw-retained restoration.

6.
Odontology ; 2020 Nov 11.
Artículo en Inglés | MEDLINE | ID: mdl-33175280

RESUMEN

The aims of this study were to (i) evaluate the bone alterations following maxillary molar extraction and (ii) identify the factors associated with bone alterations using a tomographic analysis. Cone Beam Computer Tomographies (CBCTs) of 17 subjects with 25 maxillary molars were analyzed, before and, in average, 12 months following extraction. Fifty CBCTs were segmented as 3D models that were used as reference for analysis. Cross-sectional planes were established to measure the dimensional changes in the vertical, horizontal aspects, and the area of the alveolar bone. Associations between root divergence, initial bone location related to the maxillary sinus, and the thickness of buccal and palatal bone at baseline was assessed using mixed-effect models. Overall, the average reduction in vertical bone height was 35.23% (2.61 ± 1.76 mm). The mean reduction of area of alveolar process and horizontal bone width were 18.89% (56.08 ± 44.23 mm2) and 65.10% (8.33 ± 4.51 mm), respectively. There was a marginal significant association between horizontal bone changes and the thickness of palatal bone (p = 0.05). The results of the present study indicated that following maxillary molar extraction, significant dimensional changes occur in both the vertical and horizontal directions. The vertical changes were mainly attributed to remodeling on the coronal aspect of the alveolar ridge and sinus pneumatization was rare.

8.
Artículo en Inglés | MEDLINE | ID: mdl-33073043

RESUMEN

Although researchers have been trying to harness the immune system for over 100 years, the advent of immune checkpoint blockers (ICB) marks an era of significant clinical outcomes in various metastatic solid tumors, characterized by complete and durable responses. ICBs are monoclonal antibodies that target either of a pair of transmembrane molecules in tumors or T-cells involved in immune evasion. Currently 2 ICBs targeting the checkpoint program death 1 (PD-1), nivolumab and pembrolizumab, and one cytotoxic lymphocyte antigen-4 (CTLA-4) inhibitor (ipilimumab) are approved in gastrointestinal malignancies. We review herein the current evidence on predictive biomarkers for ICB response in gastrointestinal tumors. A review of literature based on the National Cancer Institute list of FDA-approved drugs for neoplasms and FDA-approved therapies at the FDA website was performed. An initial literature review was based on the American Association for Clinical Research meeting 2019, the American Society of Clinical Oncology meeting 2019 and the European Society of Medical Oncology 2019 proceedings. A systematic search of PubMed was performed involving MeSH browser terms such as biomarkers, immunotherapy, gastrointestinal diseases and neoplasms. When appropriate, American and British terms were used in the search. The most relevant predictor of response to ICBs is microsatellite instability (MSI) and the data is strongest for colorectal cancer. At least 3 prospective trials show evidence of PD-L1 as a predictive biomarker for ICB response in gastroesophageal malignancies. At least one prospective trial has described tumor mutational burden high (TMB-H), independent of MSI, as predictive of response in anal and biliary tract carcinomas. DNA Polymerase Epsilon (POLE) or delta (POL-D) mutations have been implicated in a subset of MSS colorectal cancer with TMB-H but this biomarker requires prospective validation. There is evolving data based on retrospective observations that gene alterations predicting acquired resistance and hyper-progression. Ongoing clinical research is assessing the role of the human microbiome and RNA-editing complex mutations as predictive biomarkers of response to ICBs. MSI has the strongest predictive power among current biomarkers for ICB response in gastrointestinal cancers. Data continue to accumulate from ongoing clinical trials and new biomarkers are emerging from pre-clinical studies, suggesting that drug combinations targeting pathways complimentary to the PD-1/PD-L1 axis inhibition will define a robust field of clinical research.

9.
Bull Environ Contam Toxicol ; 105(5): 711-714, 2020 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-33001235

RESUMEN

The dusky grouper Epinephelus marginatus is predator fish subjected to be impacted due to the contamination of their habitats. A viable source of metal contamination, i.e., copper (Cu), in this species is the ingestion of contaminated food. The objective of this work was to verify the toxic effects of Cu contaminated feed in dusky grouper. A 15 days trial was conducted with three treatments: control, 1 g and 2 g Cu/kg of fish feed. After the trial, the gut was analyzed for Cu concentration and the liver for SOD and GST activity. The Cu concentration in the intestinal tract was significantly greater in fish from contaminated treatments when compared with control. The SOD was significantly lower in contaminated fish, and the GST did not show differences among treatments. Copper showed to be toxic for the species, as evidenced by gut accumulation and suggested by SOD response.


Asunto(s)
Alimentación Animal , Cobre/toxicidad , Contenido Digestivo/química , Perciformes/metabolismo , Contaminantes Químicos del Agua/toxicidad , Animales , Cobre/análisis , Ecosistema , Hígado/efectos de los fármacos , Hígado/enzimología , Modelos Teóricos , Alimentos Marinos , Superóxido Dismutasa/metabolismo , Contaminantes Químicos del Agua/análisis
10.
Compend Contin Educ Dent ; 41(9): e5-e9, 2020 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-33001661

RESUMEN

This article describes the case of a partially edentulous patient who had undergone template-guided implant placement and was treated using a triple digital scanning protocol that allowed for CAD/CAM prosthodontic rehabilitation in a complete digital workflow. At the impression appointment, the provisional implant-supported screw-retained prosthesis was digitally scanned both intraorally (first scan) and, after removal, extraorally (second scan). After the second scan, scan bodies were placed intraorally and an implant-level digital impression was taken (third scan). The three standard tessellation language (STL) files derived from the three digital scans were imported in a CAD software and superimposed into one file that contained all of the information from the implant 3D position, prosthesis contours, and transmucosal part of the peri-implant soft tissues. The superimposition of the three STL files led to one master file to serve as a blueprint for the definitive prosthesis. The definitive monolithic zirconia prosthesis was CAM copy-milled, externally stained, and inserted. The patient was satisfied with both the esthetic and functional outcome and the minimally invasive, time-efficient, two-visit restorative protocol. In summary, this case report illustrates a technique for a complete digital workflow in an implant rehabilitation for the replacement of multiple missing teeth in the esthetic zone in two visits.


Asunto(s)
Implantes Dentales , Flujo de Trabajo , Diseño Asistido por Computadora , Prótesis Dental de Soporte Implantado , Estética Dental , Humanos
11.
Av. enferm ; 38(3): 325-334, 01 Sep. 2020.
Artículo en Portugués | LILACS, BDENF - Enfermería, COLNAL | ID: biblio-1141277

RESUMEN

Objetivo: avaliar o efeito do extrato das folhas da Passiflora edulis na cicatrização da pele em ratos, especificamente na área da lesão e na proliferação de fibroblastos. Materiais e método: estudo experimental realizado com 54 ratos da linhagem Wistar, machos, adultos, divididos igualmente em três grupos. A indução das lesões em formato circular na região dorso-cervical foi realizada com o auxílio de um punch trepano de 8 mm. As lesões do grupo de controle foram higienizadas diariamente com água filtrada e sabonete vegetal glicerinado de pH neutro. Os outros dois grupos, além da higienização diária, receberam tratamento com creme contendo extrato a 20 % das folhas da Passiflora edulis, e creme base sem extrato a 20 % das folhas da Passiflora edulis, respectivamente. No 1o, 4o, 7o e 14o dia de tratamento foram obtidas imagens para cálculo da área de lesão. No 4o, 7o e 14o dia de tratamento foram coletados espécimes para análises histológicas. Resultados: não foram encontradas diferenças estatisticamente significativas entre os grupos experimentais com relação à comparação de médias da área de lesão e de proliferação de fibroblastos. Conclusões: o uso tópico do extrato a 20 % das folhas da Passiflora edulis não apresentou efeito na área de lesão e na proliferação de fibroblastos na cicatrização da pele em ratos.


Objetivo: evaluar el efecto del extracto de hoja de Passiflora edulis en la curación de la piel en ratas, específicamente el área de la lesión y de la proliferación de fibroblastos. Materiales y método: estudio experimental con 54 ratas Wistar macho adultas, divididas por igual en tres grupos. La inducción de lesiones de forma circular en la región dorsocervical se realizó con la ayuda de un punzón de 8 mm. Las lesiones del grupo de control se limpiaron diariamente con agua filtrada y jabón vegetal glicerinado con pH neutro. Los otros dos grupos, además de la limpieza diaria, recibieron tratamiento con crema que contenía extracto al 20 % de las hojas de Passiflora edulis, y crema base sin extracto al 20 % de las hojas de Passiflora edulis, respectivamente. Los días 1, 4, 7 y 14 de tratamiento, se obtuvieron imágenes para calcular el área de la lesión. Los días 4, 7 y 14 de tratamiento, se recolectaron muestras para análisis histológicos. Resultados: no se encontraron diferencias estadísticamente significativas entre los grupos experimentales con respecto a la comparación de las medias del área de la lesión y la proliferación de fibroblastos. Conclusiones: el uso tópico del extracto al 20 % de las hojas de Passiflora edulis no tuvo efecto en el área de la lesión y de la proliferación de fibroblastos en la curación de la piel en ratas.


Objective: To evaluate the effect of Passiflora edulis leaf extract on skin healing in rats, specially the lesion area and on fibroblast proliferation. Materials and method: Experimental study with 54 male adult Wistar rats equally divided into three groups. The induction of circular-shaped lesions in the dorso cervical region was performed with the aid of an 8 mm climbing punch. Control group lesions were daily cleaned with filtered water and neutral pH glycerinated vegetable soap. The other two groups, in addition to daily cleansing, received treatment with cream containing 20 % extract of Passiflora edulis leaves and base cream without this extract, respectively. On day 1, 4, 7 and 14 of treatment, images were obtained to calculate the lesion area. On day 4, 7 and 14 of treatment, specimens were collected for histological analysis. Results: No statistically significant differences were found between the experimental groups regarding the comparison of means of lesion area and fibroblast proliferation. Conclusion: Topical use of the 20 % extract of Passiflora edulis leaves had no effect on the affected area and the proliferation of fibroblasts on skin healing in rats.


Asunto(s)
Animales , Ratas , Cicatrización de Heridas , Enfermería , Passiflora , Experimentación Animal
12.
Am Soc Clin Oncol Educ Book ; 40: e319-e332, 2020 May.
Artículo en Inglés | MEDLINE | ID: mdl-32479115

RESUMEN

Genomic characterization of metastatic castration-resistant prostate cancer (mCRPC) has been remodeling the treatment landscape of this disease in the past decade. The emergence of molecularly defined subsets of mCRPC is altering the treatment paradigm from therapeutics with nonspecific activity across the spectrum, including androgen receptor (AR)-directed treatments, docetaxel, and cabazitaxel, to targeted approaches directed at molecular subsets of disease. The meaningful benefit of PARP inhibitors in mCRPC carrying mutations in DNA repair genes demonstrated in a phase III trial epitomizes this transition in the treatment paradigm of mCRPC and brings new challenges related to how to sequence and integrate the targeted therapies on top of the treatments with broad activity in all mCRPC. To enable and sustain the advance of precision oncology in the management of mCRPC, genomic characterization is required, including somatic and germline testing, for all patients with the ultimate goal of longitudinal molecular profiling guiding treatment decisions and sequential treatments of this lethal disease. This article reviews the emerging molecular subtypes of mCRPC that are driving the evolution of mCRPC treatment.

13.
J Therm Biol ; 89: 102535, 2020 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-32364980

RESUMEN

High mountains are harsh environments in which colder temperatures and higher levels of UV-B radiation are common. These abiotic conditions strongly affect animals' biology, often constraining their survival and reproduction. As a result, adaptations to live in such habitats are expected to evolve. Body color is thought to be adaptive to the environment that animals experience. Tegument melanization improves heat gain and provides photoprotection. Therefore, at high elevation, ectotherms are expected to be darker (well-melanized). We test this prediction in the paper wasp Agelaia pallipes (Hymenoptera: Vespidae), a species distributed across an elevational gradient in the Colombian Andes. We used Malaise traps and sampled a total of 146 wasps along nine elevations, ranging from 2,600-3,380 m above sea level. Standard digital photography was used to measure the body luminance and colour patterning in different body parts of dry-preserved specimens. There was striking variation in body luminance (darker and lighter), color patterning (patched, smoothed, homogeneous) and surface texture (shiny and matte), but the kind and degree of variation depended on the body part examined. Wasps from higher elevations had darker thoraces, confirming our prediction. Besides, at high elevation, the frequency of wasps with a matte rather than a shiny face strongly increased. Overall, our findings support the thermal melanism hypothesis and suggest that intraspecific color variation might be an adaptation to the environment of paper wasps.

14.
R I Med J (2013) ; 103(3): 20-24, 2020 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-32236156

RESUMEN

Our current understanding of the genetic mechanisms that underly cancer pathogenesis is rapidly expanding. Hereditary cancer predisposition syndromes are important to recognize for diagnostic and treatment decision-making but also for family members so they will benefit from surveillance and treatment options. This brief review gives primary care and oncology caregivers a summary of the evolution of hereditary cancer predisposition syndromes, indications for consideration of testing and therapy of patients and families.


Asunto(s)
Manejo de la Enfermedad , Predisposición Genética a la Enfermedad , Pruebas Genéticas , Neoplasias/genética , Asesoramiento Genético , Humanos , Oncología Médica , Neoplasias/terapia , Selección de Paciente , Rol del Médico , Medición de Riesgo , Estados Unidos
16.
J Oral Rehabil ; 47(3): 403-415, 2020 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-31846097

RESUMEN

PURPOSE: To analyse randomised controlled clinical trials (RCTs) and prospective cohort studies reporting on the survival and failure rates of functionally loaded short implants (SI) based on the actual length of time in function. MATERIALS AND METHODS: This meta-analysis was conducted according to PRISMA guidelines for systematic reviews. Electronic and manual searches were conducted to identify RCTs and prospective cohort studies reporting survival and complication rates of short dental implants (≤6 mm) based on the time in function. Secondary outcomes included the location (maxilla or mandible), type of restoration (single crown [SC] versus fixed dental prosthesis [FDP]) and marginal bone loss (MBL). RESULTS: A total of 20 studies (11 RCTs and 9 prospective) fulfilled the inclusion criteria and featured a total of 1238 SI placed in 747 patients. The overall (early and late) mean percentage of short implant failure was 4%. SI with up to 1-year follow-up presented failure rate of 2%, while SI followed up for >3 years showed a failure rate of 10%. SI restored with SC presented a late failure rate of 4% while SI restored with FPD 2%. The late failure rate did not differ in terms of location (maxilla or mandible) both with 3%. CONCLUSION: Short implants in function for more than 3 years presented higher failure rates compared to SI in function for <3 years. Splinting crowns supported by SIs in the posterior area should be considered. However, SI is a valid option for selected cases given their relatively high long-term survival rates.


Asunto(s)
Pérdida de Hueso Alveolar , Implantes Dentales , Coronas , Implantación Dental Endoósea , Diseño de Prótesis Dental , Prótesis Dental de Soporte Implantado , Fracaso de la Restauración Dental , Humanos , Estudios Prospectivos , Ensayos Clínicos Controlados Aleatorios como Asunto
17.
Micron ; 127: 102757, 2019 12.
Artículo en Inglés | MEDLINE | ID: mdl-31574380

RESUMEN

The sperm morphology of the parasitoid Elasmus polistis (Eulophidae) has been investigated with light and transmission electron microscopy. The sperm were filiform and spiraled, with 165.6 (± 4.6) µm in length, and showed a distinctive head, formed by a one-layered small acrosome and a nucleus, and a flagellar region. An extracellular sheath from which many long filaments radiated out covered the acrosome and part of the nucleus. The spiral nucleus, with 24.1 (± 1.3) µm in length, was filled with homogeneously compact chromatin. In the nucleus-flagellum transition, the centriole adjunct extended posteriorly from the nuclear base in a spiral around the basal body, which has two central microtubules, and axoneme for approximately 1.1 µm. The two mitochondrial derivatives began roughly at the same level and at the base of the centriole adjunct. In cross-section, they were symmetrical, with a slightly oval shape and a smaller diameter in comparison to the axoneme. The latter, also spiraled, consisted of 9 + 9 + 2 microtubules that was formed from the basal body situated just below and aligned with the nucleus. The E. polistis sperm showed the same basic structures and morphological characteristics as observed in other Chalcidoidea. However, it was possible to distinguish the sperm of this species from those of other Eulophidae by (i) the long length of the centriole adjunct on the flagellum, and (ii) the presence of two central microtubules within the basal body. The sperm characteristics suggest that Eulophidae is closely related to Trichogrammatidae and both families are more similar to Eurytomidae, Pteromalidae, and Torymidae than Agaonidae.


Asunto(s)
Espermatozoides/ultraestructura , Avispas/ultraestructura , Acrosoma/ultraestructura , Animales , Axonema/ultraestructura , Flagelos/ultraestructura , Masculino , Microscopía Electrónica de Transmisión , Microtúbulos/ultraestructura
18.
Cancer Biol Ther ; 20(8): 1047-1056, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-30975030

RESUMEN

As a kinase at the crossroads of numerous metabolic and cell growth signaling pathways, glycogen synthase kinase-3 beta (GSK-3ß) is a highly desirable therapeutic target in cancer. Despite its involvement in pathways associated with the pathogenesis of several malignancies, no selective GSK-3ß inhibitor has been approved for the treatment of cancer. The regulatory role of GSK-3ß in apoptosis, cell cycle, DNA repair, tumor growth, invasion, and metastasis reflects the therapeutic relevance of this target and provides the rationale for drug combinations. Emerging data on GSK-3ß as a mediator of anticancer immune response also highlight the potential clinical applications of novel selective GSK-3ß inhibitors that are entering clinical studies. This manuscript reviews the preclinical and early clinical results with GSK-3ß inhibitors and delineates the developmental therapeutics landscape for this potentially important target in cancer therapy.


Asunto(s)
Antineoplásicos/uso terapéutico , Glucógeno Sintasa Quinasa 3 beta/antagonistas & inhibidores , Inmunomodulación/efectos de los fármacos , Terapia Molecular Dirigida , Neoplasias/tratamiento farmacológico , Neoplasias/etiología , Inhibidores de Proteínas Quinasas/uso terapéutico , Animales , Antineoplásicos/farmacología , Biomarcadores de Tumor , Regulación Neoplásica de la Expresión Génica/efectos de los fármacos , Glucógeno Sintasa Quinasa 3 beta/genética , Glucógeno Sintasa Quinasa 3 beta/metabolismo , Humanos , Terapia Molecular Dirigida/efectos adversos , Terapia Molecular Dirigida/métodos , Neoplasias/metabolismo , Neoplasias/patología , Especificidad de Órganos , Inhibidores de Proteínas Quinasas/farmacología
19.
J Craniofac Surg ; 30(4): 1272-1274, 2019 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-30839462

RESUMEN

PROPOSE: This paper aims to describe a modification of the Wolford technique by replacing the Mitek anchors with bone screws. TECHNICAL DESCRIPTION: Two intermaxillary fixation screws locking screws, with 2.0 mm in diameter and 8 mm in length, are used in each temporomandibular joint, one of which is fixed to the root of the zygomatic arch and another to the lateral pole of the mandibular condyle. Ethibond 2-0 thread is passed through the holes in the 2 ipsilateral screws, thus acting as an artificial ligament limiting the range of the mouth opening. CONCLUSION: The technique described was effective in preventing mandibular dislocation while allowing satisfactory mouth opening range. This technique has easy handling and low cost.


Asunto(s)
Tornillos Óseos , Luxaciones Articulares/cirugía , Traumatismos Mandibulares/cirugía , Humanos , Mandíbula/cirugía , Cóndilo Mandibular/cirugía , Recurrencia , Articulación Temporomandibular/cirugía , Cigoma/cirugía
20.
Sci Total Environ ; 658: 895-900, 2019 Mar 25.
Artículo en Inglés | MEDLINE | ID: mdl-30583184

RESUMEN

Precision agriculture requires faster and automatic responses for fertility parameters, especially regarding soil organic matter (SOM). In Brazil, the standard methodology for SOM determination is a wet procedure based on the oxidation of the sample by an excess of potassium dichromate based on Walkley-Black method. This methodology has serious drawbacks, since, at a national level, generates approximately 600,000 L/year of toxic acid waste containing Cr3+ and possibly Cr6+, besides time consuming and expensive. Herein, we present a faster green methodology that can eliminate the generation of these hazardous wastes and reduces the costs of analysis by approximately 80%, democratizing the soil fertility information and increasing the productivity. The methodology is based on the use of a national near infrared spectral library with approximately 43,000 samples and learning machine data analysis based on a random forest algorithm. The methodology was validated by submitting the prediction results of 12 blind soil samples to a proficiency assay used for fertility soil laboratories qualification, receiving the maximum quality excellence index, indicating that it is suitable for use in routine analysis.

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