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1.
Curr Cardiol Rev ; 2019 Dec 02.
Artículo en Inglés | MEDLINE | ID: mdl-31797762

RESUMEN

BACKGROUND: Pulmonary arterial hypertension (PAH) is a severe and progressive disease of pulmonary arterioles. This pathology is characterized by elevation of the pulmonary vascular resistance and pulmonary arterial pressure, leading to right heart failure and death. Studies have demonstrated that resveratrol possesses a protective effect in the mechanisms related to the genesis of the PAH-induced by different models. OBJECTIVE: This study aimed to investigate the dose-related effects of resveratrol in different models of pulmonary arterial hypertension. METHODS: To identify eligible papers, we performed a systematic literature search on Scielo, PubMed, and Scholar Google. The research was limited to articles written in English in the last 10 years. We use the following descriptors to search: Pulmonary Arterial Hypertension and Resveratrol, OR Resveratrol, and Animal models of Pulmonary Arterial Hypertension, OR Resveratrol, and in vitro models of Pulmonary Arterial Hypertension. RESULTS: 1724 studies were identified through the descriptors employed, fifty-five studies with different models of pulmonary arterial hypertension were selected for the full review, forty-four were excluded after application of exclusion and inclusion criteria, totalizing eleven studies included in this systematic review. CONCLUSION: The results showed that resveratrol, at low and high doses, protects in a dose-dependent manner against the development of PAH induced through monocrotaline, normoxia and hypoxia models. In addition to having chemopreventive, anti-inflammatory, antioxidant and antiproliferative properties. In the case of PAH-related myocardial injury, resveratrol protects cells from apoptosis, thus working as an antiapoptotic agent.

2.
Respir Physiol Neurobiol ; 263: 31-37, 2019 05.
Artículo en Inglés | MEDLINE | ID: mdl-30853602

RESUMEN

OBJECTIVES: We aimed to evaluate the effect a regular inspiratory muscle training program on autonomic modulation measured by heart rate variability, exercise capacity and respiratory function in chronic obstructive pulmonary disease subjects (COPD). DESIGN: Single-center controlled study, with balanced randomization (1:1 for two arms). SETTING: A COPD reference hospital localized in Sao Luís, Brazil. PARTICIPANTS: 22 COPD subjects joined the study. INTERVENTIONS: Three times a week for four weeks inspiratory muscle training (IMT) at 30% of PImax. MAIN OUTCOME MEASURES: Pulmonary capacities and inspiratory pressure, total six-minute walk test and, cardiac autonomic modulation. RESULTS: The intervention group showed improvements in the cardiac autonomic modulation, with increased vagal modulation (total variability and HF [ms2; adjusted p < 0.05]); increased expiratory and inspiratory capacities and, increased distance in the 6-min walk test. CONCLUSION: 12 weeks of IMT at 30% of the maximal inspiratory pressure increased cardiac autonomic modulation, expiratory and inspiratory and exercise capacity in COPD subjects.


Asunto(s)
Sistema Nervioso Autónomo/fisiopatología , Ejercicios Respiratorios/métodos , Tolerancia al Ejercicio/fisiología , Ejercicio Físico/fisiología , Enfermedad Pulmonar Obstructiva Crónica/fisiopatología , Enfermedad Pulmonar Obstructiva Crónica/rehabilitación , Músculos Respiratorios/fisiología , Anciano , Femenino , Frecuencia Cardíaca/fisiología , Humanos , Masculino , Persona de Mediana Edad , Espirometría , Resultado del Tratamiento
3.
Int J Sports Med ; 40(3): 209-217, 2019 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-30703844

RESUMEN

We aimed to analyze the effect of an exercise training program in autonomic modulation, and exercise tolerance of hemodialysis and kidney-transplanted patients. 4 groups of exercised and non-exercised patients undergoing hemodialysis and kidney-transplanted subjects had their biochemical tests, and heart rate variability evaluations analyzed. Also, sleep quality, anxiety and depression questionnaires were evaluated. Both exercised groups showed improvements in cardiovascular autonomic modulation, biochemical markers, and exercise tolerance after the exercise training program. The exercised kidney-transplanted patients group showed better improvements in cardiovascular autonomic modulation, biochemical markers, and exercise tolerance when compared to the exercised hemodialysis patients group. Both groups showed improvements in sleep quality, anxiety, and depression. The group of kidney-transplanted patients show better results in the cardiovascular autonomic modulation than subjects undergoing hemodialysis. However, the patients undergoing hemodialysis showed improvements in blood pressure, HDL, hemoglobin and phosphorus, changes not observed in the kidney-transplanted group. Exercise is beneficial for both hemodialysis and kidney-transplanted patients groups. However, exercise programs should be focused mainly in improving cardiovascular risk factors in the HD patients.


Asunto(s)
Terapia por Ejercicio , Enfermedades Renales/terapia , Trasplante de Riñón , Diálisis Renal , Adulto , Ansiedad/etiología , Enfermedades Cardiovasculares/prevención & control , Estudios de Casos y Controles , Enfermedad Crónica , Depresión/etiología , Tolerancia al Ejercicio , Femenino , Tasa de Filtración Glomerular , Frecuencia Cardíaca , Humanos , Enfermedades Renales/fisiopatología , Enfermedades Renales/psicología , Enfermedades Renales/cirugía , Masculino , Persona de Mediana Edad , Consumo de Oxígeno , Factores de Riesgo , Sueño , Prueba de Paso
4.
J Health Psychol ; 24(3): 299-308, 2019 03.
Artículo en Inglés | MEDLINE | ID: mdl-28810362

RESUMEN

The aim of this study was to compare the sleep quality, depression, anxiety, and autonomic function of a group of kidney-transplanted recipients who joined a combined exercise program (KTRt) or remained sedentary (KTRs). A total of 20 kidney-transplanted recipients, split into two groups (10 KTRt and 10 KTRs), joined the study. Heart rate variability, cardiorespiratory capacity, depression, and sleep questionnaires were evaluated. KTRt presented lower Pittsburgh Sleep Quality Index and greater entropy, and increased parasympathetic and decreased sympathetic modulation than KTRs. Anxiety level was minimal and depression was absent in both groups. KTRt group presented better sleep quality and better autonomic modulation than KTRs.

5.
Motriz (Online) ; 25(2): e101904, 2019. tab, graf
Artículo en Inglés | LILACS-Express | ID: biblio-1020086

RESUMEN

Abstract Aim: The aim of the present study was to evaluate the effect of an exercise session prescribed by the Sworkit® Personal Trainer application on hemodynamic and autonomic responses. Methods: The sample consisted of 11 men classified as sedentary according to IPAQ. The exercises were randomly selected by the app Sworkit® Personal Trainer, using the pre-built program "Light Warm-Up Cardio" (see supplementary material). Heart rate and perceived exertion data were collected every minute during an exercise session. Blood pressure and heart rate variability were measured Pre, Post, 30 min, 12h, 24 h, and 48h after exercise. Heart rate and rate of perceived exertion were collected during the 30 minutes exercise. Results: Hemodynamic responses showed differences in heart rate and systolic blood pressure: Post, 12 h and 24 h compared to Pre. We also found significant statistical differences in the heart rate variability indexes when comparing Post, 30min to 48h versus Pre, indicating modifications in the autonomic modulation post-exercise. The perceived exertions scale remained between 13-14 during the exercise. Heart rate was 149 ± 5.26 (80 ± 5% of HRmax) during the 30min exercise, indicating a moderate to vigorous intensity. Conclusion: We concluded that a single exercise session guided by the Sworkit® Personal Trainer application could generate autonomic changes in up to 12 hours, presenting a moderate to vigorous intensity in 30 minutes of exercise for sedentary men.

6.
Motriz (Online) ; 24(1): e1018132, 2018. tab, graf
Artículo en Inglés | LILACS | ID: biblio-895056

RESUMEN

Aim: We aimed to evaluate the effect of low and vigorous levels of physical activity in body composition, hemodynamics and autonomic modulation in subjects with Down syndrome (DS). METHODS: We evaluated 13 healthy subjects without DS (control group), 15 sedentary subjects with DS, (SED DS group), nine with DS with low intensity levels of physical activity (LIDS) and 12 with DS with vigorous levels of physical activity (VIDS). The physical activity level was measured using the IPAQ questionnaire. Body composition, hemodynamics and autonomic modulation were also evaluated. RESULTS The VIDS showed lower BMI than the control and SED DS group. Body fat (%) was lower in LIDS and VIDS than in the control and SED DS group. The systolic and diastolic arterial pressure values were similar among the groups. When normalized, the frequency domain showed higher LF/HF, higher LF (nu) and lower HF (nu) component of heart rate variability in sedentary DS than in the control group. However, LIDS and VIDS groups showed similar values in LF (nu), HF (nu) and LF/HF than the control group. The symbolic analysis showed greater 0V and lower values in 2LV in sedentary DS group when compared to the control group. However, the LIDS and VIDS did not show difference in 0V when compared to the control group. The 2LV was lower in LIDS and VIDS than in the control group, but 2UV was higher in VIDS than in the control group. CONCLUSION: We conclude that, regardless of the intensity, exercise can promote positive adaptations in the autonomic modulation of DS patients.(AU)


Asunto(s)
Humanos , Masculino , Adulto , Composición Corporal/fisiología , Síndrome de Down , Ejercicio Físico/fisiología , Frecuencia Cardíaca , Hemodinámica/fisiología
7.
J Exerc Rehabil ; 13(5): 599-607, 2017 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-29114536

RESUMEN

The present study aimed to investigate the impact of a short-term exercise training (ET) on the cardiorespiratory fitness and autonomic modulation of women with breast cancer who were receiving adjuvant radiotherapy, chemotherapy or hormonotherapy. Eighteen women previously diagnosed with breast cancer receiving adjuvant radiotherapy, chemotherapy or hormone therapy were randomly allocated into breast cancer nonexercise (BC) and exercise groups (BC+Ex). Moreover, nine healthy physically inactive volunteers were recruited to compose the noncancer control group (CG). The BC+Ex group was underwent to a combined ET program, which was based on resistance, aerobic and flexibility exercises. ET was performed 3 times a week, on nonconsecutive days, for 4 weeks at the hospital room under the professional supervision. In turn, BC and CG remained without be engaged in physical exercise programs. Volunteers were evaluated regarding their cardiorespiratory fitness and autonomic modulation (i.e., time, frequency domains, and nonlinear [symbolic analysis]) before and after the end of the ET program. A priori, data indicate that women patients with breast cancer showed impaired exercise tolerance, as well as autonomic dysfunction in comparison with age-matched healthy control subjects. However, a 1-month combined ET program could reverse such impairments, so that after the intervention, BC+Ex and CG showing similar results in the cardiorespiratory test and heart rate variability analysis. In conclusion, data of the current study indicate that 1 month of ET is able to reverse impaired cardiorespiratory fitness and autonomic modulation in women with breast cancer receiving adjuvant therapy.

8.
Games Health J ; 6(3): 159-164, 2017 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-28628383

RESUMEN

PURPOSE: We aimed to analyze the acute autonomic response of obese and eutrophic prepubertal boys to an exergame (EXG) session. MATERIALS AND METHOD: Nine eutrophic (8.89 ± 2.71 years of age and 16.42% ± 6.30% body fat) and nine obese boys (8.70 ± 1.16 years of age and 40.76% ± 4.2% body fat) participated. Nutritional state was determined using World Health Organization guidelines. Variables were collected at rest, immediately post (IP), and 60 minutes after a 20 minutes EXG session. Autonomic nervous system (ANS) activity was assessed using heart rate variability in time and frequency domains, and data were analyzed using Shapiro-Wilk and ANOVA tests with Tukey post hoc. RESULTS: The obese group demonstrated an increased sympathetic activity at rest when compared with the eutrophic group (P < 0.05). The obese group also demonstrated an increased parasympathetic activity 60 minutes after the EXG session when compared with the eutrophic group (P < 0.05). CONCLUSION: We concluded that an acute session of EXG promoted ANS super compensation. We encourage research on chronic ANS response to EXG.


Asunto(s)
Fenómenos Fisiológicos Cardiovasculares , Terapia por Ejercicio/métodos , Obesidad/terapia , Obesidad Pediátrica/terapia , Juegos de Video/normas , Niño , Terapia por Ejercicio/psicología , Terapia por Ejercicio/normas , Femenino , Frecuencia Cardíaca/fisiología , Humanos , Masculino , Monitoreo Fisiológico/métodos , Obesidad/psicología , Obesidad Pediátrica/psicología , Juegos de Video/psicología
9.
Sci. med. (Porto Alegre, Online) ; 26(1): 22380, jan-mar 2016.
Artículo en Portugués | LILACS-Express | ID: biblio-836861

RESUMEN

OBJETIVOS: Analisar os efeitos de uma corrida de 15 km ao ar livre em ambiente de alta temperatura na modulação da leucocitose em homens saudáveis treinados em corrida. MÉTODOS: A amostra foi composta por 14 homens que participavam de um grupo de corrida recreativo. Foram incluídos voluntários que declarassem ser capazes de percorrer a distância mínima de 15 km, não estivessem tomando nenhum medicamento imunossupressor e não tivessem nenhuma doença infecciosa. Os critérios de exclusão foram hipertensão arterial em repouso antes da corrida, histórico de doenças osteomioarticulares, metabólicas e/ou cardiovasculares, e não completar o percurso da corrida. Amostras de sangue venoso antes e após a corrida foram coletadas para determinação do hematócrito e contagem de células imunes por imunocitoquímica. RESULTADOS: Observou-se aumento no número de leucócitos totais e neutrófilos no momento pós corrida (9,31±2,4×10³ células/µL e 7,64±3,4×10³ células/µL respectivamente) em comparação ao momento pré corrida (5,52±0.2×10³ células/µL e 2,90±0,6×10³ células/µL respectivamente) (p<0,05). Houve diminuição no número de linfócitos e eosinófilos no momento pós corrida (1,34±0,3×10³ e 0,36±0,2×10³ células/µL respectivamente) comparado ao pré corrida (1,67±0,3×10³ e 0,22±0,1×10³ células/µL respectivamente) (p<0,05). Não foram observadas diferenças significativas no número de monócitos e basófilos no momento pós corrida (0,45±0,1×10³ e 0,9±0,3×10³ células/µL respectivamente) comparado ao pré corrida (0,40±0,08×10³ e 0,8±0,3×10³ células/µL respectivamente) (p>0,05). CONCLUSÕES: A corrida de 15 km ao ar livre, em ambiente de alta temperatura, induziu a uma cinética leucocitária típica, com leucocitose às custas do aumento no número de neutrófilos, assim como queda no número de linfócitos e eosinófilos, em homens saudáveis com prévio treinamento em corrida. Estes resultados ajudam a compreender melhor a leucocitose induzida pelo exercício e podem indicar a intensidade do estresse promovido pelo exercício em condições ambientais extremas.


AIMS: To assess the effects of an outdoor race of 15 km in a hot environment on leukocyte kinetics in healthy trained men. METHODS: The sample consisted of 14 men who participated in a recreational race group. Volunteers who said they were able to run a minimum distance of 15 km, were not taking any immunosuppressants, and had no infectious disease were included in the study. The exclusion criteria were the following: hypertension at rest before the race, history of musculoskeletal, metabolic and/or cardiovascular diseases, and failure to finish the race. Venous blood samples were collected before and after the race for determination of hematocrit levels and immune cell count by immunocytochemistry. RESULTS: An increase in total leukocyte and neutrophil count was observed after the race (9.31±2.4×10³ cells/µL and 7.64±3.4×10³ cells/µL, respectively) compared to the pre-race period (5.52±0.2×10³ cells/µL and 2.90±0.6×103 cells/µL, respectively), (p<0.05). There was a decrease in lymphocyte and eosinophil count after the race (1.34±0.3×10³ and 0.36±0.2×10³ cells/µL, respectively) compared to the pre-race period (1.67±0.3×10³ and 0.22±0.1×10³ cells/µL, respectively) (p<0.05). There was no statistically significant difference in monocyte and basophil count after the race (0.45±0.1×10³ and 0.9±0.3×10³ cells/µL, respectively) compared to the pre-race period (0.40±0.08×10³ and 0.8±0.3×10³cells/µL, respectively) (p>0.05). CONCLUSIONS: The 15-km outdoor race in a hot environment led to a typical leukocyte kinetics, resulting in leukocytosis owing to the increase in neutrophil count as well as to a decrease in lymphocyte and eosinophil count in healthy trained men. These findings shed some further light upon exercise-induced leukocytosis and may indicate the level of stress produced by exercise under extreme environmental conditions.

10.
Clin Exp Pharmacol Physiol ; 42(12): 1239-44, 2015 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-26284458

RESUMEN

Modulation of the autonomic nervous system on heart rate can be compromised in chronic kidney disease and may result in changes in the frequency and duration of the cardiac cycle. The aim of this study was to evaluate autonomic modulation in active and sedentary renal transplant recipients. Twenty renal-transplanted individuals were analyzed at the Centro de Prevenção de Doenças Renais (Kidney Disease Education Centre), in the academic hospital of Universidade Federal do Maranhão, and were divided into the active group (AG) and the sedentary group (SG). The AG comprised of six men and four women (age 43.10 ± 13.02) and was in regular concurrent training intervention for 8 weeks, while the SG was composed of three men and seven women (age 36.8 ± 9.26). Analysis of heart rate (HR) variability in time and frequency domain demonstrated that HR mean values in the SG and AG were 787.32 ± 79.60 and 870 ± 106.66 ms, respectively. Differences were observed in the time domain and frequency domain. The total index of low frequency and high frequency showed no differences between the SG and AG. Biochemical variables presented significantly lower levels after 8 weeks of training. Higher heart rate variability in the time domain and greater vagal modulation was observed in the AG. The AG ad greater vagal modulation when compared to the SG, with removal of the sympathetic and increased parasympathetic in the behaviour was confirmed by sympatho-vagal balance. The AG also presented significant improvements in the frequency domain.


Asunto(s)
Sistema Nervioso Autónomo/fisiopatología , Ejercicio Físico , Conducta Sedentaria , Adulto , Femenino , Frecuencia Cardíaca , Humanos , Trasplante de Riñón , Masculino , Insuficiencia Renal Crónica/metabolismo , Insuficiencia Renal Crónica/fisiopatología , Insuficiencia Renal Crónica/terapia
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