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1.
Res Involv Engagem ; 7(1): 12, 2021 Mar 01.
Artículo en Inglés | MEDLINE | ID: mdl-33648588

RESUMEN

Background Continual improvements to health systems, products, and services are necessary for improvements in health. However, many of these improvements are not incorporated into everyday practice. When designing new health systems, products, and services, involving members of the healthcare community and the public with personal healthcare experience can help to make sure that improvements will be useful and relevant to others like them. Methods Together with healthcare workers and family members with healthcare experience, we developed and applied a step-by-step guide to involving those with personal experience in the design of health system improvements. Results Our guide has three phases- 'Pre-Design', 'Co-Design', and 'Post-Design'. This paper describes each of these phases and illustrates how we applied them to our own project, which is to use virtual healthcare methods to improve care for children with chronic healthcare conditions and their families. In our own work, we found that healthcare workers and family members with personal healthcare experiences were able to use their knowledge and creativity to help us imagine how to improve care for children with chronic healthcare conditions and their families. We have created action items from these family member- and healthcare worker-identified needs, which we will use to shape our virtual healthcare system. Conclusions This paper may be useful for those seeking to involve members of the healthcare community and the public in the creation of better healthcare systems, products, and services. Background Challenges with the adoption, scale, and spread of health innovations represent significant gaps in the evidence-to-practice cycle. In the health innovation design process, a lack of attention paid to the needs of end-users, and subsequent tailoring of innovations to meet these needs, is a possible reason for this deficit. In the creative field of health innovation, which includes the design of healthcare products, systems (governance and organization mechanisms), and services (delivery mechanisms), a framework for both soliciting the needs of end-users and translating these needs into the design of health innovations is needed. Methods To address this gap, our team developed and applied a seven-step methodological framework, called A Generative Co-Design Framework for Healthcare Innovation. This framework was developed by an interdisciplinary team that included patient partners. Results This manuscript contributes a framework and applied exemplar for those seeking to engage end-users in the creative process of healthcare innovation. Through the stages of 'Pre-Design', 'Co-Design', and 'Post-Design', we were able to harness the creative insights of end-users, drawing on their experiences to shape a future state of care. Using an expository example of our own work, the DigiComp Kids project, we illustrate the application of each stage of the Framework. Conclusions A Generative Co-Design Framework for Healthcare Innovation provides healthcare innovators, applied health science researchers, clinicians, and quality improvement specialists with a guide to eliciting and incorporating the viewpoints of end-users while distilling practical considerations for healthcare innovation and design.

2.
World J Urol ; 38(2): 343-350, 2020 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-31062122

RESUMEN

OBJECTIVES: To evaluate the effect of intensified treatment parameters on safety, functional outcomes, and PSA after MR-Guided Transurethral Ultrasound Ablation (TULSA) of prostatic tissue. PATIENTS AND METHODS: Baseline and 6-month follow-up data were collected for a single-center cohort of the multicenter Phase I (n = 14/30 at 3 sites) and Pivotal (n = 15/115 at 13 sites) trials of TULSA in men with localized prostate cancer. The Pivotal study used intensified treatment parameters (increased temperature and spatial extent of ablation coverage). The reporting site recruited the most patients to both trials, minimizing the influence of physician experience on this comparison of adverse events, urinary symptoms, continence, and erectile function between subgroups of both studies. RESULTS: For Phase I and TACT patients, median age was 71.0 and 67.0 years, prostate volume 41.0 and 44.5 ml, and PSA 6.7 and 6.7 ng/ml, respectively. All 14 Phase I patients had low-risk prostate cancer, whereas 7 of 15 TACT patients had intermediate-risk disease. Baseline IIEF, IPSS, quality of life, and pad use were similar between groups. Pad use at 1 month and quality of life at 3 months favored Phase I patients. At 6 months, there were no significant differences in functional outcomes or adverse events. CONCLUSION: TULSA demonstrated acceptable clinical safety in Phase I trial. Intensified treatment parameters in the TACT Pivotal trial increased ablation coverage from 90 to 98% of the prostate without affecting 6-month adverse events or functional outcomes. Long-term follow-up and 12-month biopsies are needed to evaluate oncological safety.


Asunto(s)
Próstata/diagnóstico por imagen , Próstata/cirugía , Neoplasias de la Próstata/diagnóstico por imagen , Neoplasias de la Próstata/cirugía , Resección Transuretral de la Próstata/métodos , Anciano , Ensayos Clínicos Fase I como Asunto , Endosonografía , Estudios de Factibilidad , Humanos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Estudios Multicéntricos como Asunto , Cirugía Asistida por Computador , Resultado del Tratamiento , Ultrasonografía Intervencional
3.
Eur J Clin Microbiol Infect Dis ; 38(1): 171-176, 2019 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-30374685

RESUMEN

Children with medical complexity (CMC) are vulnerable to respiratory illness hospitalization (RIH) and respiratory syncytial virus (RSV)-related hospitalization (RSVH) due to multisystem disorders and compromised airways. It is unknown whether RSV prophylaxis is effective, or if RSVH is associated with significant morbidities in CMC. The study objectives were to (1) determine the incidence of RSV-related infection in prophylaxed CMC during the first 3 years of life and (2) assess the burden of illness following RSVH. A single tertiary center, retrospective study, was conducted of CMC who received palivizumab during the 2012-2016 RSV seasons. Fifty-four subjects were enrolled; most received one (38.9%, n = 21) or two (57.4%, n = 31) seasons of prophylaxis (mean = 4.2 [SD = 1.24], palivizumab doses per season). The cohort comprised children with multiple medical conditions (n = 22, 40.8%), tracheostomy (n = 18, 33.3%), and invasive (n = 10, 18.5%) or non-invasive (n = 4, 7.4%) ventilation. Of the CMC, 24 were hospitalized 47 times for a viral-related respiratory illness. RSV incidence in the first 3 years of life was 7.4%. Viral-related RIH and RSVH rates were 44.4% (n = 24/54) and 1.9% (n = 1/54), respectively. Of the four RSV-positive children, one was ventilated for 9 days, two acquired nosocomial RSV that was managed on the ward, and one was discharged home under close complex care supervision. All four RSV-positive cases required additional oxygen during their illness. CMC experience a high viral-related RIH rate and palivizumab likely minimizes RSV-related events and associated morbidities. The efficacy of palivizumab in CMC, especially in those ≤ 3 years, should be prospectively evaluated.


Asunto(s)
Infecciones por Virus Sincitial Respiratorio/complicaciones , Infecciones por Virus Sincitial Respiratorio/epidemiología , Virus Sincitial Respiratorio Humano , Profilaxis Antibiótica , Antivirales/uso terapéutico , Preescolar , Comorbilidad , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Palivizumab/uso terapéutico , Infecciones por Virus Sincitial Respiratorio/tratamiento farmacológico , Infecciones por Virus Sincitial Respiratorio/virología , Estudios Retrospectivos , Resultado del Tratamiento
4.
World J Urol ; 37(7): 1415-1420, 2019 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-30341450

RESUMEN

PURPOSE: To analyze and compare preoperative patient characteristics and postoperative results in men with stress urinary incontinence (SUI) selected for an adjustable male sling system or an artificial urinary sphincter (AUS) in a large, contemporary, multi-institutional patient cohort. METHODS: 658 male patients who underwent implantation between 2010 and 2012 in 13 participating institutions were included in this study (n = 176 adjustable male sling; n = 482 AUS). Preoperative patient characteristics and postoperative outcomes were analyzed. For statistical analysis, the independent T test and Mann-Whitney U test were used. RESULTS: Patients undergoing adjustable male sling implantation were less likely to have a neurological disease (4.5% vs. 8.9%, p = 0.021), a history of urethral stricture (21.6% vs. 33.8%, p = 0.024) or a radiation therapy (22.7% vs. 29.9%, p = 0.020) compared to patients that underwent AUS implantation. Mean pad usage per day (6.87 vs. 5.82; p < 0.00) and the ratio of patients with a prior incontinence surgery were higher in patients selected for an AUS implantation (36.7% vs. 22.7%; p < 0.001). At maximum follow-up, patients that underwent an AUS implantation had a significantly lower mean pad usage during daytime (p < 0.001) and nighttime (p = 0.018). Furthermore, the patients' perception of their continence status was better with a subjective complete dry rate of 57.3% vs. 22.0% (p < 0.001). CONCLUSIONS: Patients selected for an AUS implantation showed a more complex prior history and pathogenesis of urinary incontinence as well as a more severe grade of SUI. Postoperative results reflect a better continence status after AUS implantation, favoring the AUS despite the more complicated patient cohort.


Asunto(s)
Cabestrillo Suburetral , Incontinencia Urinaria de Esfuerzo/cirugía , Esfínter Urinario Artificial , Procedimientos Quirúrgicos Urológicos Masculinos/métodos , Anciano , Estudios de Cohortes , Humanos , Masculino , Medición de Resultados Informados por el Paciente , Selección de Paciente , Radioterapia/estadística & datos numéricos , Estudios Retrospectivos , Índice de Severidad de la Enfermedad , Resultado del Tratamiento , Estrechez Uretral/epidemiología
5.
World J Urol ; 35(12): 1841-1847, 2017 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-28861691

RESUMEN

PURPOSE: To investigate the influence of different postoperative radiotherapy (RT) regimes on post-prostatectomy continence and QoL. METHODS: Men after prostatectomy (RP) and RT were assigned in adjuvant (ART), early salvage (ESRT) and salvage radiotherapy (SRT) groups depending on time of initiation, indication and pre-RT-PSA (≤/>0.5 ng/ml). Continence and QoL outcomes were evaluated by validated questionnaire. Statistical analysis included students t test, Chi square, Fisher's test, ROC- and McNemar-Bowker-Analyses. RESULTS: The mean follow-up was 5.1 years. 33.5, 38.2 and 28.3% received ART, ESRT and SRT, respectively. Mean time to RT was 0.3 (±0.4), 1.8 (±2.5) and 3.3 (±3.6) years respectively. Differences in age at RP (p = 0.54) and RT (p = 0.47) between groups were not significant. Mean-RT-dose was similar (p = 0.70). Differences in continence distribution between groups before (p = 0.56) and after RT (p = 0.38) were not significant. No significant differences were observed for frequency (p = 0.58) or amount (p = 0.88) of urine loss, impact on QoL (p = 0.13) and ICIQ-SF scores (p = 0.69) between groups. Even though no significant difference in post-RT-continence (p = 0.89) was observed in the direct comparison between groups, a significant worsening of long-term continence was observed in all groups (p < 0.001). We found no cutoff and no time-point after RP at which this negative effect of RT on continence became insignificant (AUC = 0.474). A subgroup with apparent local recurrence showed no differences for ICIQ-SF-score (p = 0.155), QoL (0.077), incontinence grade (p = 0.387), frequency (p = 0.182) and amount (p = 0.415) of urine loss. Proportionally more men in this subgroup remembered deterioration of continence after RT (p = 0.029). CONCLUSION: Postoperative RT adversely affects long-term continence; this negative effect is irrespective of time of initiation or indication for RT. These results suggest a need for innovative strategies of prostate cancer therapy with lasting oncological, functional and QoL outcomes.


Asunto(s)
Efectos Adversos a Largo Plazo , Prostatectomía/métodos , Neoplasias de la Próstata/cirugía , Calidad de Vida , Radioterapia Ayuvante , Incontinencia Urinaria , Anciano , Estudios de Seguimiento , Alemania/epidemiología , Humanos , Efectos Adversos a Largo Plazo/diagnóstico , Efectos Adversos a Largo Plazo/etiología , Efectos Adversos a Largo Plazo/psicología , Masculino , Persona de Mediana Edad , Dosificación Radioterapéutica , Radioterapia Ayuvante/efectos adversos , Radioterapia Ayuvante/métodos , Terapia Recuperativa/efectos adversos , Terapia Recuperativa/métodos , Encuestas y Cuestionarios , Incontinencia Urinaria/diagnóstico , Incontinencia Urinaria/etiología , Incontinencia Urinaria/psicología
6.
J Anim Sci ; 95(2): 866-874, 2017 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-28380577

RESUMEN

The objectives of this experiment were to determine the effects of follicular wave (first or second) on diameter of the dominant follicle, concentrations of progesterone and estradiol and the hepatic enzymes that inactivate them, thickness of the endometrium, and pregnancy rates to AI. Beef heifers ( = 101) and cows ( = 106) were randomly assigned to 1 of 2 treatments: insemination to the first follicular wave (FFW) or insemination to the second follicular wave (SFW). Estrous cycles of females were synchronized to ensure appropriate timing for the treatments. The MIXED procedure of SAS was used for analysis. A similar proportion of females in each treatment responded to presynchronization; however, females in the FFW group ovulated in response to the first injection of GnRH of the CO-Synch protocol more frequently. Only females ( = 94) that properly responded to ovulation synchronization were included in further analyses. Cows in the FFW group tended ( 0.06) to have larger ovulatory follicles 36 h post-PGF of the CO-Synch protocol compared to cows in the SFW group (14.22 ± 0.42 and 11.83 ± 0.49, respectively), whereas heifers were similar between treatment groups. Three d prior to AI, circulating concentrations of progesterone were lesser ( 0.01) in females in the FFW (3.63 ± 0.80 ng/mL) than in the SFW (7.12 ± 0.83 ng/mL), whereas concentrations of estradiol tended ( 0.08) to be greater in those in the FFW (82.72 ± 6.48 pg/mL) than in the SFW (65.55 ± 6.74 pg/mL). Concentrations of cytochrome P450 1A in the liver were lesser ( 0.01) in females in the FFW than those in the SFW (0.68 ± 0.08 vs. 0.96 ± 0.06, respectively). Endometrial thicknesses were similar between treatments but were thicker ( < 0.0001) in cows (9.73 ± 0.24 mm) than heifers (7.22 ± 0.26 mm). When considering all females or only those that were properly presynchronized, pregnancy rates were similar between treatments. However, when evaluating females that ovulated to the assigned follicular wave, there was a treatment by parity interaction ( = 0.04) with heifers in the FFW having a lesser pregnancy rate (25.9%) than heifers in the SFW (72.0%) while cows in both treatment groups were intermediate (45.4% in FFW and 50.0% in SFW). The differences in concentrations of steroids between treatment groups may affect fertility of heifers; however, additional research is necessary.


Asunto(s)
Bovinos/fisiología , Folículo Ovárico/efectos de los fármacos , Ovulación/efectos de los fármacos , Animales , Endometrio , Estradiol/farmacología , Ciclo Estral/efectos de los fármacos , Sincronización del Estro/métodos , Femenino , Fertilidad/efectos de los fármacos , Hormona Liberadora de Gonadotropina/farmacología , Inseminación Artificial/veterinaria , Folículo Ovárico/fisiología , Ovulación/fisiología , Embarazo , Índice de Embarazo , Progesterona/farmacología
7.
BMC Urol ; 17(1): 5, 2017 Jan 11.
Artículo en Inglés | MEDLINE | ID: mdl-28077116

RESUMEN

BACKGROUND: To evaluate quality of life, functional and oncological outcome after infravesical desobstruction and HIFU treatment for localized prostate cancer. METHODS: One hundred thirty-one patients, treated with TURP and HIFU in a single institution were followed up for oncological and functional outcome. Oncological outcome was quantified by biochemical recurrence free survival using the Stuttgart and Phoenix criteria. Quality of life was assessed by usage of standardized QLQ-C30 and QLQ-PR25 questionnaires. In addition, functional questionnaires such as IPSS and IIEF-5 were used. Complications were assessed by the Clavien-Dindo classification. RESULTS: One hundred thirty-one patients with a mean age of 72.8 years (SD: 6.0) underwent HIFU for prostate cancer (29.0% low risk, 58.8% intermediate risk, 12.2% high risk). PSA nadir was 0.6 ng/ml (SD: 1.2) after a mean of 4.6 months (SD: 5.7). Biochemical recurrence free survival defined by Stuttgart criteria was 73.7%, 84.4% and 62.5% for low-, intermediate- and high-risk patients after 22.2 months. Complications were grouped according to Clavien-Dindo and occurred in 10.7% (grade II) and 11.5% (grade IIIa) of cases. 35.1% of patients needed further treatment for bladder neck stricture. Regarding incontinence, 14.3%, 2.9% and 0% of patients had de novo urinary incontinence grade I°, II° and III° and 3.8% urge incontinence due to HIFU treatment. Patients were asked for the ability to have intercourse: 15.8%, 58.6% and 66.7% of patients after non-, onesided and bothsided nervesparing procedure were able to obtain sufficient erection for intercourse, respectively. Regarding quality of life, mean global health score according to QLQ-C30 was 69.4%. CONCLUSION: HIFU treatment for localized prostate cancer shows acceptable oncological safety. Quality of life after HIFU is better than in the general population and ranges within those of standard treatment options compared to literature. HIFU seems a safe valuable treatment alternative for patients not suitable for standard treatment.


Asunto(s)
Neoplasias de la Próstata/cirugía , Calidad de Vida , Resección Transuretral de la Próstata , Ultrasonido Enfocado Transrectal de Alta Intensidad , Obstrucción del Cuello de la Vejiga Urinaria/cirugía , Anciano , Humanos , Masculino , Estudios Prospectivos , Neoplasias de la Próstata/complicaciones , Recuperación de la Función , Resultado del Tratamiento , Obstrucción del Cuello de la Vejiga Urinaria/etiología
8.
Nat Commun ; 7: 12168, 2016 07 07.
Artículo en Inglés | MEDLINE | ID: mdl-27385262

RESUMEN

Van der Waals assembly of two-dimensional crystals continue attract intense interest due to the prospect of designing novel materials with on-demand properties. One of the unique features of this technology is the possibility of trapping molecules between two-dimensional crystals. The trapped molecules are predicted to experience pressures as high as 1 GPa. Here we report measurements of this interfacial pressure by capturing pressure-sensitive molecules and studying their structural and conformational changes. Pressures of 1.2±0.3 GPa are found using Raman spectrometry for molecular layers of 1-nm in thickness. We further show that this pressure can induce chemical reactions, and several trapped salts are found to react with water at room temperature, leading to two-dimensional crystals of the corresponding oxides. This pressure and its effect should be taken into account in studies of van der Waals heterostructures and can also be exploited to modify materials confined at the atomic interfaces.

9.
World J Urol ; 34(1): 113-20, 2016 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-25991601

RESUMEN

PURPOSE: To identify predictive factors for immediate continence after radical prostatectomy. PATIENTS AND METHODS: A total of 1553 patients underwent radical prostatectomy in a single institution (670 RRP, 883 RARP), had complete perioperative data and follow-up for urinary continence and were included in this prospective analysis. Immediate continence was defined as no pad usage after catheter removal. Evaluated parameters included age, body mass index, ECOG performance status, erectile function, prostate volume, PSA, Gleason score, tumor stage and D'Amico risk groups, as well as surgical approach (RRP, RARP), surgeon volume, nerve-sparing, lymphadenectomy, blood transfusions and duration of catheterization. RESULTS: A total of 240 men (15.5 %) did not require any pads 1 day or later after removal of the transurethral catheter. Correlation of parameters with immediate continence revealed significance for age (p < 0.001), ECOG-score (p = 0.025), erectile function (p = 0.001), nerve-sparing (p = 0.022), Gleason score (p = 0.002) and surgeon volume (p ≤ 0.022). Multivariate analyses identified IIEF-score >21 (p = 0.031), ECOG (p < 0.05), bilateral nerve-sparing (p = 0.049), Gleason score <3 + 4 (p ≤ 0.028), less blood transfusion (p ≤ 0.044) and surgeon volume (p ≤ 0.042) as the remaining prognostic parameters for immediate continence after radical prostatectomy. The type of surgical approach (robotic vs. open radical prostatectomy) did not yield significant influence. CONCLUSION: Evaluating continence in a contemporary prospective cohort revealed 15.5 % of patients never requiring a pad postoperatively. Predictive parameters for immediate continence were erectile function, ECOG, bilateral nerve-sparing, less blood transfusion and Gleason score. Furthermore, the surgeon's experience but not his operative technique had a significant impact on immediate postoperative continence.


Asunto(s)
Escisión del Ganglio Linfático/métodos , Complicaciones Posoperatorias/epidemiología , Prostatectomía , Neoplasias de la Próstata/cirugía , Recuperación de la Función , Incontinencia Urinaria/epidemiología , Adulto , Anciano , Anciano de 80 o más Años , Transfusión Sanguínea/estadística & datos numéricos , Estudios de Cohortes , Técnicas de Apoyo para la Decisión , Disfunción Eréctil/epidemiología , Humanos , Masculino , Persona de Mediana Edad , Clasificación del Tumor , Estadificación de Neoplasias , Pelvis , Estudios Prospectivos , Procedimientos Quirúrgicos Robotizados , Factores de Tiempo , Cateterismo Urinario/estadística & datos numéricos
10.
Urologe A ; 54(6): 800-3, 2015 Jun.
Artículo en Alemán | MEDLINE | ID: mdl-25758237

RESUMEN

Advanced clear cell renal cell carcinoma is characterized by extensive intratumoral genomic heterogeneity and branched as well as convergent evolutionary traits with genomically different subclones evolving in parallel in the same tumor. Distinct driver mutations can be found in spatially separated subclones, which may hinder the development of novel targeted therapies. However, truncal mutations of the VHL tumor suppressor gene and chromosome 3p loss were ubiquitously detected and will hence continue to be a focus of future drug development. Nevertheless, genomic instability, enhanced tumor genome plasticity and intratumoral heterogeneity are likely to represent major challenges towards biomarker development and personalized patient care.


Asunto(s)
Carcinoma de Células Renales/genética , Plasticidad de la Célula/genética , Neoplasias Renales/genética , Proteínas de Neoplasias/genética , /tendencias , Animales , Carcinoma de Células Renales/terapia , Evolución Molecular , Predisposición Genética a la Enfermedad/genética , Terapia Genética/tendencias , Inestabilidad Genómica , Humanos , Neoplasias Renales/terapia , Terapia Molecular Dirigida/tendencias , Polimorfismo de Nucleótido Simple/genética
11.
Urologe A ; 54(9): 1256-60, 2015 Sep.
Artículo en Alemán | MEDLINE | ID: mdl-25503899

RESUMEN

Biomedical research plays an important role in the development of novel diagnostic procedures, drugs and treatment strategies with regard to cancerous and chronic inflammatory diseases. Biobanks are essential tools in this process. The complex structures and benefits of biobanks are presented in this article.


Asunto(s)
Bancos de Muestras Biológicas/organización & administración , Biomarcadores de Tumor/análisis , Investigación Biomédica/organización & administración , Neoplasias Urológicas/diagnóstico , Urología/organización & administración , Alemania , Humanos , Modelos Organizacionales , Neoplasias Urológicas/genética , Neoplasias Urológicas/metabolismo
12.
Adv Urol ; 2012: 702412, 2012.
Artículo en Inglés | MEDLINE | ID: mdl-22924039

RESUMEN

We prospectively investigated whether routine evaluation of the vesicourethral anastomosis (VUA) after radical prostatectomy can be waived. Primary integrity of the VUA was analysed by an intraoperative methylene-blue test (IMBT) and postoperatively by conventional cystography. Data on the IMBT, contrast extravasation and prostate volume as well as pad usage were collected prospectively. Significantly more patients with a primary watertight anastomosis demonstrated by the MBT had no leakage in the postoperative cystography (P < 0.001). In a multivariate logistic regression with adjustment for prostate size and surgeon, the positive correlation between IMBT and postoperative cystography remained statistically significant (P = 0.001). The IMBT is easy to perform, inexpensive, and timesaving. With it postoperative evaluation of VUA for integrity can be waived in a significant number of patients. Following our algorithm, the Foley can be removed without further testing of the VUA, whenever the IMBT detected no leakage.

13.
Transplant Proc ; 44(5): 1287-92, 2012 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-22664002

RESUMEN

PURPOSE: To evaluate the general applicability of robotic-assisted laparoscopic radical prostatectomy (RALP) in renal transplant recipients and potential surgical modifications due to the position of the transplanted kidney in the iliac fossa, as RALP has proven to be an effective and safe treatment option for prostate cancer (PCa) removal. PROCEDURES: A 71-year-old patient who had undergone renal transplantation was diagnosed with biopsy-proven localized Gleason 7a PCa. The prostate-specific antigen value was 12.4 ng/mL. RALP was performed by a transperitoneal approach using six ports. By partial mobilization of the bladder, the working space for the radical prostatectomy was created, while leaving the renal transplant and ureter untouched. Lymph node dissection was performed only on the contralateral side of the transplanted kidney. RESULTS: The procedure concluded after 220 minutes and the estimated blood loss was 300 mL. The perioperative clinical course was uneventful. The kidney function remained normal with a creatinine value of 1.2 mg/dL. A complete extirpation of the prostate with negative surgical margins was achieved. After catheter removal, the patient was completely continent. CONCLUSIONS: RALP in renal transplant recipients is feasible and can be achieved with favorable oncological and functional outcome. No modifications to the standard RALP technique are required in these patients, except from a partial dissection of the bladder from the abdominal wall and a one-sided lymph node dissection.


Asunto(s)
Adenocarcinoma/cirugía , Trasplante de Riñón , Laparoscopía , Prostatectomía/métodos , Neoplasias de la Próstata/cirugía , Robótica , Cirugía Asistida por Computador , Adenocarcinoma/sangre , Adenocarcinoma/patología , Anciano , Disección , Humanos , Trasplante de Riñón/efectos adversos , Escisión del Ganglio Linfático , Imagen por Resonancia Magnética , Masculino , Clasificación del Tumor , Antígeno Prostático Específico/sangre , Neoplasias de la Próstata/sangre , Neoplasias de la Próstata/patología , Resultado del Tratamiento , Vejiga Urinaria/cirugía
14.
J Acoust Soc Am ; 130(5): 3431-7, 2011 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-22088017

RESUMEN

Twin inverted pulse sonar (TWIPS) is here deployed in the wake of a moored rigid inflatable boat (RIB) with propeller turning, and then in the wake of a moving tanker of 4580 dry weight tonnage (the Whitchallenger). This is done first to test its ability to distinguish between scatter from the wake and scatter from the seabed, and second to test its ability to improve detectability of the seabed through the wake, compared to conventional sonar processing techniques. TWIPS does this by distinguishing between linear and nonlinear scatterers and has the further property of distinguishing those nonlinear targets which scatter energy at the even-powered harmonics from those which scatter in the odd-powered harmonics. TWIPS can also, in some manifestations, require no range correction (and therefore does not require the a priori environment knowledge necessary for most remote detection technologies).


Asunto(s)
Modelos Lineales , Ruido del Transporte , Dinámicas no Lineales , Navíos , Procesamiento de Señales Asistido por Computador , Ultrasonido , Simulación por Computador , Diseño de Equipo , Sedimentos Geológicos , Movimiento (Física) , Análisis Numérico Asistido por Computador , Océanos y Mares , Presión , Dispersión de Radiación , Espectrografía del Sonido , Factores de Tiempo , Ultrasonido/instrumentación , Agua
15.
Aktuelle Urol ; 42(5): 306-10, 2011 Sep.
Artículo en Alemán | MEDLINE | ID: mdl-21769764

RESUMEN

Radical prostatectomy is the most common cause of male urinary incontinence. Up to 90% of the patients are incontinent in the early postoperative phase. This rate reduces to 3-23% approximately 12 months after prostatectomy. Male slings and the ProACT™-Ballon system are preferred minimal invasive therapeutic options for mild to moderate incontinence. Mid-term continence rates of 50-80% can be achieved with bone anchored and adjustable slings or the adjustable ProACT™-Ballon system. The results after radiation therapy are significantly poorer. Randomised controlled trials with longer follow-ups are necessary in order to evaluate the effectiveness of these options for continence therapy. Considering the high continence rates of 73-92% in long-term follow-ups, the artificial urinary sphincter (AUS) still remains the gold standard in the therapy for incontinence in men with normal dexterity and mental status. In cases where continence cannot be achieved by implantation of an AUS, a urinary diversion can be taken into consideration.


Asunto(s)
Cabestrillo Suburetral , Incontinencia Urinaria de Esfuerzo/cirugía , Esfínter Urinario Artificial , Humanos , Masculino , Complicaciones Posoperatorias/etiología , Complicaciones Posoperatorias/cirugía , Prostatectomía/efectos adversos , Reoperación , Incontinencia Urinaria de Esfuerzo/etiología
16.
Urologe A ; 49(4): 498-503, 2010 Apr.
Artículo en Alemán | MEDLINE | ID: mdl-20376652

RESUMEN

Urinary incontinence in men most commonly occurs after radical prostatectomy. Of these patients, 3-23% remain incontinent a year after prostatectomy. Data on conservative therapy for postoperative incontinence is contradictory. Nonetheless, conservative treatment strategies must generally be attempted before any operative technique. Early pelvic floor muscle training with or without biofeedback therapy and duloxetine seem to have a positive effect on continence. Further randomised controlled studies are necessary to accurately assess other conservative therapeutic options such as extracorporeal magnetic innervation and electrical stimulation therapy.


Asunto(s)
Complicaciones Posoperatorias/terapia , Prostatectomía , Incontinencia Urinaria de Esfuerzo/terapia , Inhibidores de Captación Adrenérgica/uso terapéutico , Biorretroalimentación Psicológica , Terapia Combinada , Clorhidrato de Duloxetina , Terapia por Estimulación Eléctrica , Terapia por Ejercicio , Humanos , Magnetoterapia , Masculino , Tiofenos/uso terapéutico
17.
Urologe A ; 49(4): 515-24, 2010 Apr.
Artículo en Alemán | MEDLINE | ID: mdl-20300726

RESUMEN

The artificial urinary sphincter (AUS) has been successfully implanted in the last 40 years. Continuous improvement of the AUS and increasing experience with the device has led to its widespread acceptance. The major indication is still post-prostatectomy incontinence. In this collective patient satisfaction was reported in over 90%. In a number of patients with neurogenic bladder dysfunction and congenital or acquired anatomical disorders of the urethra, an AUS can be an alternative to urinary diversion. Nonetheless, complications such as infections and erosions are still a problem, leading to revisions and secondary procedures in up to 20% of the cases. Therefore, operative expertise and precise execution of aseptic rules are basic prerequisites.


Asunto(s)
Incontinencia Urinaria/cirugía , Esfínter Urinario Artificial , Niño , Terapia Combinada , Humanos , Masculino , Prótesis de Pene , Complicaciones Posoperatorias/fisiopatología , Complicaciones Posoperatorias/cirugía , Prostatectomía , Neoplasias de la Próstata/radioterapia , Neoplasias de la Próstata/cirugía , Diseño de Prótesis , Falla de Prótesis , Implantación de Prótesis/métodos , Radioterapia Ayuvante , Reoperación , Uretra/anomalías , Vejiga Urinaria Neurogénica/etiología , Vejiga Urinaria Neurogénica/fisiopatología , Vejiga Urinaria Neurogénica/cirugía , Incontinencia Urinaria/etiología , Incontinencia Urinaria/fisiopatología , Urodinámica/fisiología
18.
Urologe A ; 48(5): 510-5, 2009 May.
Artículo en Alemán | MEDLINE | ID: mdl-19421801

RESUMEN

Pelvic organ prolapse is a widespread condition that especially affects women. There are a number of conservative and surgical therapeutic options. The choice of therapy should be individually made, depending on factors such as the grade of prolapse and concomitant secondary disorders as well as the age and general condition of the patient. This article presents current surgical options, analyzes recent studies, and offers future perspectives for reconstructive pelvic surgery.


Asunto(s)
Diafragma Pélvico/cirugía , Incontinencia Urinaria de Esfuerzo/cirugía , Prolapso Uterino/cirugía , Terapia Combinada , Estudios Transversales , Femenino , Humanos , Laparoscopía , Complicaciones Posoperatorias/etiología , Complicaciones Posoperatorias/cirugía , Recurrencia , Reoperación , Sacro/cirugía , Cabestrillo Suburetral , Mallas Quirúrgicas , Suturas , Incontinencia Urinaria de Esfuerzo/diagnóstico , Incontinencia Urinaria de Esfuerzo/epidemiología , Prolapso Uterino/diagnóstico , Prolapso Uterino/epidemiología , Vagina/cirugía
19.
Adv Urol ; : 650135, 2008.
Artículo en Inglés | MEDLINE | ID: mdl-18989369

RESUMEN

Objective. The great possibility of variations in the clinical presentation of hypospadia, makes its therapy challenging. This has led to the development of a number of techniques for hypospadia repair. This article assesses past and present concepts and operative techniques with the aim of broadening our understanding of this malformation. Materials and Methods. The article not only reviews hypospadia in general with its development and clinical presentation as well as historical and current concepts in hypospadiologie on the basis of available literature, but it is also based on our own clinical experience in the repair of this malformation. Results and Conclusion. The fact that there are great variations in the presentation and extent of malformations existent makes every hypospadia individual and a proposal of a universal comprehensive algorithm for hypospadia repair difficult. The Snodgrass technique has found wide popularity for the repair of distal hypospadias. As far as proximal hypospadias are concerned, their repair is more challenging because it not only involves urethroplasty, but can also, in some cases, fulfil the dimensions of a complex genital reconstruction. Due to the development of modern operating materials and an improvement in current surgical techniques, there has been a significant decrease in the complication rates. Nonetheless, there still is room and, therefore, need for further improvement in this field.

20.
Urologe A ; 45(10): 1289-90, 1292, 2006 Oct.
Artículo en Alemán | MEDLINE | ID: mdl-16953453

RESUMEN

Conservative therapeutic options are considered the gold standard in therapy of overactive bladder syndrome. However, surgery may be beneficial in selected cases. Neuromodulation is well established in clinical practice. If conservative or minimally invasive therapy fails, augmentation techniques or urinary diversion may be considered. This review presents the current knowledge about surgical treatment options for idiopathic overactive bladder.


Asunto(s)
Cistectomía/métodos , Procedimientos Quirúrgicos Mínimamente Invasivos/métodos , Procedimientos Quirúrgicos Reconstructivos/métodos , Vejiga Urinaria Hiperactiva/cirugía , Incontinencia Urinaria/cirugía , Humanos , Síndrome
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