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1.
Clin Rheumatol ; 2021 Feb 24.
Artículo en Inglés | MEDLINE | ID: mdl-33629203

RESUMEN

Drug-induced sarcoidosis-like reaction (DISR) is a condition almost indistinguishable from sarcoidosis, both clinically and microscopically, consisting of granulomatous tissue reaction associated with a specific therapy. Commonly affected sites are the lungs, hilar lymph nodes, and skin. This report aimed to describe a very uncommon case of DISR with an unique involvement of the oral cavity. A 63-year-old female with a history of rheumatoid arthritis, who was treated with a TNF-α antagonist (adalimumab), presented multiple ulcerative nodules on the hard palate. Laboratory tests and imaging studies failed to show any other alterations. The biopsy specimen demonstrated multiple noncaseating granulomas. Histochemical reactions were negative for acid-fast bacilli and fungi, and immunohistochemical assessment highlighted the presence of normal lymphocytes and histiocytes. With the diagnosis of DISR, adalimumab was discontinued, and complete clinical resolution of the lesions was achieved after 14 months. Although uncommon, DISR should be considered in differential diagnoses of oral granulomatous reactions, especially in cases where the patient is being treated with TNF-α antagonists.

2.
Support Care Cancer ; 2021 Jan 07.
Artículo en Inglés | MEDLINE | ID: mdl-33411048

RESUMEN

PURPOSE: To identify and summarize the evidence on the cost-effectiveness of photobiomodulation (PBM) therapy for the prevention and treatment of cancer treatment-related toxicities. METHODS: This systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement (PRISMA) and Meta-analysis Of Observational Studies in Epidemiology (MOOSE). Scopus, MEDLINE/PubMed, and Embase were searched electronically. RESULTS: A total of 1490 studies were identified, and after a two-step review, 4 articles met the inclusion criteria. The included studies analyzed the cost-effectiveness of PBM therapy used in the context of lymphedema for breast cancer and oral mucositis (OM) induced by chemotherapy and radiotherapy. Better outcomes were associated with PBM therapy. The incremental cost-effectiveness ratio ranged from 3050.75 USD to 5592.10 USD per grade 3-4 OM case prevented. PBM therapy cost 21.47 USD per percentage point reduction in lymphedema in comparison with 80.51 USD for manual lymph drainage and physical therapy. CONCLUSION: There is limited evidence that PBM therapy is cost-effective in the prevention and treatment of specific cancer treatment-related toxicities, namely, OM and breast cancer-related lymphedema. Studies may have underreported the benefits due to a lack of a comprehensive cost evaluation. This suggests a wider acceptance of PBM therapy at cancer treatment centers, which has thus far been limited by the number of robust clinical studies that demonstrate cost-effectiveness for the prevention and treatment of toxicities.

3.
Clin Oral Investig ; 2021 Jan 07.
Artículo en Inglés | MEDLINE | ID: mdl-33409696

RESUMEN

OBJECTIVE: A systematic review and meta-analysis was carried out to verify evidence regarding the efficacy and safety of the clinical applicability of natural products in the prevention and treatment of oral mucositis induced by chemotherapy and/or radiotherapy. METHODOLOGY: An electronic research according to the PICOS strategy, using the terms "natural products" and "oral mucositis," was carried out at Pubmed, Cochrane, Embase, and "gray literature." The stages of eligibility, data extraction, and quality assessment of the studies were carried out independently and in duplicate. RESULTS: The number of studies identified as eligible was 151, including 47 randomized controlled trials, reporting a total of 3075 participants undergoing some therapy with natural products on oral mucositis. The included clinical trials covered a variety of 31 types of natural products. Considering the risk of bias of the clinical trials, 24 studies (51.1%) were considered to have a low overall risk of bias, nine (19.1%) were at moderate risk, and 14 clinical trials (29.8%) were at high risk of bias. Honey was the most assessed natural agent. Fourteen studies (3.4%) reported that natural agents reduced pain. CONCLUSION: The results of the meta-analysis support a positive effect of honey and Aloe vera in reducing mucositis in patients receiving cancer therapy. CLINICAL RELEVANCE: The results found add relevant information to the scientific community regarding the prevention and treatment of mucositis. Graphical abstract.

4.
Oral Dis ; 2020 May 31.
Artículo en Inglés | MEDLINE | ID: mdl-32475006

RESUMEN

Coronaviridae is a family of single-stranded positive enveloped RNA viruses. This article aimed to review the history of these viruses in the last 60 years since their discovery to understand what lessons can be learned from the past. A review of the PubMed database was carried out, describing taxonomy, classification, virology, genetic recombination, host adaptation, and main symptoms related to each type of virus. SARS-CoV-2 is responsible for the ongoing global pandemic, and SARS-CoV and MERS-CoV were responsible for causing severe respiratory illness and regional epidemics in the past while the four other strains of CoVs (229-E OC43, NL63, and HKU1) circulate worldwide and normally only cause mild upper respiratory tract infections. Given the enormous diversity of coronavirus viruses in wildlife and their continuous evolution and adaptation to humans, future outbreaks would undoubtedly occur. Restricting or banning all trade in wild animals in wet markets would be a necessary measure to reduce future zoonotic infections.

5.
Einstein (Sao Paulo) ; 18: eAO4978, 2020.
Artículo en Portugués, Inglés | MEDLINE | ID: mdl-32428062

RESUMEN

Objective To determine the prevalence of syphilis and the associated risk factors in a female prison unit. Methods This was a cross-sectional study including 113 women whom data were collected in two stages: first, blood test to check for syphilis seropositivity; and then collection of information through a form to assess risk situations for sexually transmitted infections. Results Overall, syphilis prevalence was found to be 22.1% among the female prison population (n=25) and 28.6% among pregnant women. A statistically significant relationship was found between syphilis infection and previous history of sexually transmitted infections (p=0.04). However, most participants diagnosed with the disease were unaware of a history of sexually transmitted infection in the last 12 months (n=20/80.0%). The use of condom with fixed partners was considered to be a protective factor (odds ratio of 0.76; 95% of confidence interval 0.68-0.85). Conclusion The prevalence of syphilis among the female prison population was high, particularly among pregnant women. Preventive and therapeutic measures as well as appropriate prenatal care can minimize the impact of syphilis in prison systems and, consequently, improve such health outcomes nationwide.


Asunto(s)
Sífilis/epidemiología , Adolescente , Adulto , Brasil/epidemiología , Condones/estadística & datos numéricos , Estudios Transversales , Femenino , Humanos , Persona de Mediana Edad , Prevalencia , Factores de Riesgo , Sífilis/prevención & control , Adulto Joven
6.
Oral Dis ; 26(2): 457-464, 2020 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-31742839

RESUMEN

OBJECTIVE: To describe oral alterations in children with congenital Zika syndrome (CZS). METHODS: This was a case series, whose research instrument was a structured questionnaire, associated with the use of medical record data and extra and intraoral clinical examination. RESULTS: Thirty-two children were evaluated, the majority male (18/32%-56.3%), mean age 22 months (SD = 2.71). It was also observed that the majority of the patients (19/32%-59.4%) presented a low family income. All the children had a mean head circumference of 29.43 cm (SD = 1.42). Regarding the alterations, an ogival-shaped palate was observed in 14 children (43.7%), and delayed chronology of eruption was observed in 15 children (46.9%), of whom 7 children (21.9%) did not present eruption of the upper left lateral incisor (p = .0002) and upper right lateral incisor (p = .002) until the moment of analysis. Additionally, 03 children with yellowish dental pigmentation were identified in erupted teeth after the onset of phenobarbital use. Enamel hypoplasia was identified in 9 children (28.1%) and only one child with ankyloglossia. CONCLUSION: CZS may present delayed chronology of eruption, ankyloglossia, ogival-shaped palate, and enamel hypoplasia, requiring dental follow-up aimed at prevention, promotion, and rehabilitation of the health of these children.


Asunto(s)
Hipoplasia del Esmalte Dental/virología , Anomalías Dentarias/virología , Erupción Dental , Infección por el Virus Zika/complicaciones , Humanos , Incisivo/patología , Lactante , Masculino , Virus Zika
7.
Einstein (Säo Paulo) ; 18: eAO4978, 2020. tab
Artículo en Inglés | LILACS-Express | LILACS | ID: biblio-1133734

RESUMEN

ABSTRACT Objective To determine the prevalence of syphilis and the associated risk factors in a female prison unit. Methods This was a cross-sectional study including 113 women whom data were collected in two stages: first, blood test to check for syphilis seropositivity; and then collection of information through a form to assess risk situations for sexually transmitted infections. Results Overall, syphilis prevalence was found to be 22.1% among the female prison population (n=25) and 28.6% among pregnant women. A statistically significant relationship was found between syphilis infection and previous history of sexually transmitted infections (p=0.04). However, most participants diagnosed with the disease were unaware of a history of sexually transmitted infection in the last 12 months (n=20/80.0%). The use of condom with fixed partners was considered to be a protective factor (odds ratio of 0.76; 95% of confidence interval 0.68-0.85). Conclusion The prevalence of syphilis among the female prison population was high, particularly among pregnant women. Preventive and therapeutic measures as well as appropriate prenatal care can minimize the impact of syphilis in prison systems and, consequently, improve such health outcomes nationwide.


RESUMO Objetivo Determinar a prevalência de sífilis e fatores de risco associados no sistema prisional feminino. Métodos Foi realizado estudo transversal com 113 mulheres. A coleta de dados ocorreu em duas etapas: a primeira etapa correspondeu à coleta de sangue para verificar a soropositividade à sífilis e a segunda a um formulário para avaliar situações de risco para infecções sexualmente transmissíveis. Resultados A prevalência da doença foi de 22,1% (n=25). Quanto às gestantes, identificou-se prevalência de 28,6%. Foi verificada relação estatisticamente significativa entre a infecção pela sífilis e a história prévia de infecções sexualmente transmissíveis (p=0,04). Entretanto, a maioria das participantes diagnosticadas com a doença desconhecia um histórico de infecção sexualmente transmissível nos últimos 12 meses (n=20/80,0%). O uso de preservativo com parceiros fixos foi considerado fator de proteção (odds ratio de 0,76; intervalo de confiança de 95% de 0,68-0,85). Conclusão Foi alta a prevalência de sífilis na população carcerária feminina estudada, principalmente entre as gestantes. Medidas preventivas e de tratamento da doença, bem como cuidados pré-natais adequados, podem minimizar o impacto da sífilis nos sistemas prisionais e, consequentemente, melhorar esse indicador de saúde no país.

8.
Braz J Microbiol ; 50(3): 663-668, 2019 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-31001794

RESUMEN

Polymorphisms in the structural gene MBL-2 (mannose-binding lectin-2) may result in low MBL serum concentration, associated with greater susceptibility to infection. The study evaluated the effects of MBL-2 polymorphisms with the oral manifestations of the HSV in human immunodeficiency virus (HIV)-infected patients. An observational case-control study was carried out, with the sample comprising 64 HIV+ and 65 healthy individuals. The signs and symptoms of HSV oral infection were evaluated, and oral mucosa buccal smears were collected. Polymorphisms of the MBL-2 gene and HSV-1 DNA were amplified through real-time PCR. The data revealed that of 64 HIV+, 29.6% presented signs and symptoms of HSV oral infection. Of these, the HSV-1 DNA was detected through real-time PCR in 21% of cases, and in 13.3% of asymptomatic individuals. There was no statistically significant difference between the symptomatic (p = 1) and the asymptomatic (p = 0.52) individuals, HIV+ and HIV-. Different genotypes (AA, A0, or 00) did not contribute to the oral manifestation of HSV in the HIV+ patients (p = 0.81) or HIV- (p = 0.45). There was no statistically significant difference in either group (p = 0.52). No significant association was identified between the MBL-2 gene polymorphisms in the oral manifestation of HSV infection. However, further studies are recommended with larger population groups before discarding this interrelationship.


Asunto(s)
Infecciones por VIH/complicaciones , Herpes Simple/genética , Herpesvirus Humano 1/fisiología , Lectina de Unión a Manosa/genética , Boca/virología , Polimorfismo de Nucleótido Simple , Adolescente , Adulto , Estudios de Casos y Controles , Femenino , Predisposición Genética a la Enfermedad , Genotipo , Infecciones por VIH/genética , VIH-1/genética , VIH-1/aislamiento & purificación , VIH-1/fisiología , Herpes Simple/etiología , Herpes Simple/virología , Herpesvirus Humano 1/genética , Herpesvirus Humano 1/aislamiento & purificación , Humanos , Masculino , Persona de Mediana Edad , Adulto Joven
9.
Braz Dent J ; 30(2): 146-151, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-30970057

RESUMEN

The present study was to investigate the action of a toothpaste made from the extract of Rosmarinus officinalis Linn. (rosemary) in a clinical randomized, controlled, open and double-blind trial. One hundred and ten volunteers fulfilled the inclusion criteria and were randomly separated into two groups according to the toothpastes used: Group A (experimental) and Group B (control). They were assessed at baseline and 30 days after the study using the gingival bleeding index (GBI) and the plaque index (PI). Data analysis was conducted to calculate the effects of the two toothpastes on gingival bleeding and plaque, using measurements such as the excess relative risk (ERR), the Relative Risk Reduction (RRR), the Absolute Risk Reduction (ARR) and the Number Needed for Treatment (NNT). The two toothpastes provided similar results in terms of the reduction in the risk of gingival bleeding (relative and absolute): a reduction of 38% in Group A, ERR=0.38; a reduction of 29.3% in Group B, ERR=0.293; A and B reduced by 18% ARR=0.18). The reductions in bacterial plaque were also similar (22.7% reduction in Group A, RRR=0.227; 28% reduction in Group B, RRR= 0.28). The number needed for treatment values for bleeding and plaque were A and B NNT=5 and A and B NNT=7, respectively. The rosemary-based toothpaste effectively treated gingival bleeding and reduced bacterial plaque, when compared with conventional toothpaste.


Asunto(s)
Gingivitis , Rosmarinus , Pastas de Dientes , Índice de Placa Dental , Método Doble Ciego , Humanos
10.
Braz. dent. j ; 30(2): 146-151, Mar.-Apr. 2019. tab, graf
Artículo en Inglés | LILACS-Express | LILACS | ID: biblio-1001432

RESUMEN

Abstract The present study was to investigate the action of a toothpaste made from the extract of Rosmarinus officinalis Linn. (rosemary) in a clinical randomized, controlled, open and double-blind trial. One hundred and ten volunteers fulfilled the inclusion criteria and were randomly separated into two groups according to the toothpastes used: Group A (experimental) and Group B (control). They were assessed at baseline and 30 days after the study using the gingival bleeding index (GBI) and the plaque index (PI). Data analysis was conducted to calculate the effects of the two toothpastes on gingival bleeding and plaque, using measurements such as the excess relative risk (ERR), the Relative Risk Reduction (RRR), the Absolute Risk Reduction (ARR) and the Number Needed for Treatment (NNT). The two toothpastes provided similar results in terms of the reduction in the risk of gingival bleeding (relative and absolute): a reduction of 38% in Group A, ERR=0.38; a reduction of 29.3% in Group B, ERR=0.293; A and B reduced by 18% ARR=0.18). The reductions in bacterial plaque were also similar (22.7% reduction in Group A, RRR=0.227; 28% reduction in Group B, RRR= 0.28). The number needed for treatment values for bleeding and plaque were A and B NNT=5 and A and B NNT=7, respectively. The rosemary-based toothpaste effectively treated gingival bleeding and reduced bacterial plaque, when compared with conventional toothpaste.


Resumo O presente estudo investigou a ação de uma pasta de dente feita a partir do extrato de Rosmarinus officinalis Linn. (Alecrim) em um ensaio clínico randomizado, controlado, aberto e duplo-cego. Cento e dez voluntários preencheram os critérios de inclusão e foram separados aleatoriamente em dois grupos de acordo com as pastas usadas: Grupo A (experimental) e Grupo B (controle). Eles foram avaliados no início e 30 dias após o estudo usando o índice de sangramento gengival (GBI) e o índice de placa (PI). A análise dos dados foi realizada para calcular os efeitos das duas pastas dentárias sobre sangramento gengival e placa, usando medidas como o excesso de risco relativo (ERR), a Redução do Risco Relativo (RRR), a Redução do Risco Absoluto (ARR) e o Número Necessário para Tratamento (NNT). As duas pastas de dentes proporcionaram resultados semelhantes em termos de redução do risco de sangramento gengival (relativo e absoluto): redução de 38% no Grupo A, ERR=0,38; Uma redução de 29,3% no Grupo B, ERR=0,293; A e B reduziram-se em 18% ARR=0,18). As reduções na placa bacteriana também foram semelhantes (redução de 22,7% no Grupo A, RRR=0,227, redução de 28% no Grupo B, RRR=0,28). O número necessário para tratamento de sangramento e placa foi A e B NNT=5 e A e B NNT=7, respectivamente. A pasta de dente à base de alecrim tratou efetivamente o sangramento gengival e reduziu a placa bacteriana, quando comparada à pasta dentífrica convencional.

11.
Artículo en Inglés | MEDLINE | ID: mdl-28229898

RESUMEN

OBJECTIVES: The aim of this study was to characterize the histomorphometric features of subgemmal neurogenous plaques (SNPs) to better understand their relationship to surrounding microanatomy included in the tissue biopsy samples of the tongue. STUDY DESIGN: A 12-year retrospective study on the files of 3 oral pathology centers yielded 28 SNPs. Hematoxylin and eosin-stained sections were used for histologic analysis, and immunohistochemical staining for S100 protein was performed to better characterize the neural structures. Slides were scanned and histomorphometric analysis carried out using ImageScope software. RESULTS: Twenty-one women (75%) and 6 men (21.4%) comprised the sample (mean age 46.4 and 49 years, respectively). Twenty cases (71.4%) were juxtaposed to the tongue epithelium and 16 cases (57.1%) were associated with lymphoid tissue. The mean area of the SNPs was 0.160 mm2, and the mean distance to the overlying epithelium was 0.312 mm. CONCLUSIONS: SNPs are normal neural structures located on the posterior border of the tongue that represent a non-neoplastic regional anatomic variation. In some cases, signs or symptoms may be present, and further investigation should be performed. Pathologists should be aware of this entity to avoid confusion with neural lesions.


Asunto(s)
Lengua/anatomía & histología , Diagnóstico Diferencial , Femenino , Humanos , Inmunohistoquímica , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Papilas Gustativas/anatomía & histología , Lengua/inervación
12.
Gen Dent ; 64(6): 66-70, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-27814258

RESUMEN

Lasers demonstrate excellent therapeutic action and are often employed in dentistry for the treatment of diverse clinical conditions. The aim of this study was to compare the efficacy of neodymium-doped yttrium-aluminum-garnet (Nd:YAG) laser, gallium-aluminum-arsenide (GaAlAs) laser, and 2% neutral fluoride gel in the treatment of dentinal hypersensitivity. Twenty-three patients were evaluated, involving a total of 48 quadrants with at least 1 tooth with dentinal hypersensitivity (89 teeth total). Pain intensity was recorded on a visual analog scale at the time of clinical examination (baseline), immediately after treatment, and 1 week posttreatment. Teeth were treated with 60 seconds of 2% neutral fluoride gel application or 60 seconds of laser treatment-Nd:YAG laser at a distance of 0.5 cm (unfocused; 1 W and 10 Hz for 60 seconds, perpendicular to the cervical surfaces) or GaAlAs laser in contact (40 mW; 4 J/cm²; spot: 0.028 cm²; 15 seconds per point on 4 points [mesial, medial, distal, and apical])-as well as sham treatments so that patients remained blind to their treatment group. All treatments provided adequate pain reduction immediately posttreatment, but laser treatments resulted in significantly greater reductions in pain intensity.


Asunto(s)
Sensibilidad de la Dentina/cirugía , Láseres de Semiconductores/uso terapéutico , Adulto , Anciano , Sensibilidad de la Dentina/tratamiento farmacológico , Femenino , Fluoruros/administración & dosificación , Fluoruros/uso terapéutico , Geles , Humanos , Láseres de Estado Sólido/uso terapéutico , Masculino , Persona de Mediana Edad , Dimensión del Dolor , Método Simple Ciego , Resultado del Tratamiento , Adulto Joven
13.
Lasers Med Sci ; 31(9): 1855-1862, 2016 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-27638147

RESUMEN

The aim of this study was to evaluate the influence of low-level laser therapy (LLLT) with different parameters and wavelengths on nitric oxide (NO) release and cell viability. Irradiation was performed with Ga-Al-As laser, continuous mode and wavelengths of 660 and 808 nm at different energy and power densities. For each wavelength, powers of 30, 50, and 100 mW and times of 10, 30, and 60 s were used. NO release was measured using Griess reaction, and cell viability was evaluated by mitochondrial reduction of bromide 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) to formazan. LLLT promoted statistically significant changes in NO release and MTT value only at the wavelength of 660 nm (p < 0.05). LLLT also promoted an increase in the NO release and cell viability when the energy densities 64 (p = 0.04) and 214 J/cm2 (p = 0.012), respectively, were used. LLLT has a significant impact on NO release without affecting cell viability, but the significance of these findings in the inflammatory response needs to be further studied.


Asunto(s)
Láseres de Semiconductores/uso terapéutico , Terapia por Luz de Baja Intensidad/métodos , Macrófagos/efectos de la radiación , Óxido Nítrico/metabolismo , Supervivencia Celular/efectos de la radiación , Humanos
14.
Recurso Educacional Abierto en Portugués | CVSP - Brasil | ID: una-2659

RESUMEN

O vídeo foi produzido para o curso "Atenção e cuidado da saúde bucal da pessoa com deficiência". Orienta a realização do exame físico em odontologia.


Asunto(s)
Salud Bucal , Atención Dental para Personas con Discapacidades
15.
J Oral Pathol Med ; 44(9): 746-51, 2015 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-25345344

RESUMEN

INTRODUCTION: Oral mucositis (OM) has been described as the oral complication most frequently associated with antineoplastic therapy. However, the influence on the quality of life of affected patients is still unclear. OBJECTIVE: To evaluate the impact of OM on the oral-health-related quality of life (OHRQoL) of patients diagnosed with cancer, who developed chemotherapy- and/or radiotherapy-induced OM. METHODS: This is a cross-sectional evaluation of QoL using oral health impact profile-14 (OHIP-14). The study group comprised a sample of 60 patients diagnosed with cancer, who developed OM during the treatment. The instrument (OHIP-14) composed of seven dimensions was used: functional limitation, physical pain, psychological discomfort, physical deficiency, psychological deficiency, social incapacity, and deficiency. RESULTS: The internal consistency of OHIP-14 measured by the Cronbach's α coefficient was of 0.76. Physical pain attained the highest score (worst quality of life) among the studied dimensions 60.8% (292/480), followed by physical limitation 52.7% (253/480), and psychological discomfort 50.8% (244/480). The dimension 'social limitation' obtained the lowest score 27.2% (131/480). There was statistically significant difference as regards gender (P = 0.021) for physical pain, with greater impact among patients of the male gender. CONCLUSION: Oral-health-related quality of life is significantly affected by OM in individuals diagnosed with cancer.


Asunto(s)
Neoplasias/complicaciones , Salud Bucal , Calidad de Vida , Perfil de Impacto de Enfermedad , Estomatitis/etiología , Adolescente , Estudios Transversales , Evaluación de la Discapacidad , Femenino , Humanos , Masculino , Dolor/etiología , Dimensión del Dolor , Estomatitis/psicología , Encuestas y Cuestionarios , Adulto Joven
16.
J Med Virol ; 85(4): 636-45, 2013 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-23417616

RESUMEN

Studies were conducted to determine whether HHV-8 hyperactivity could be the consequence of the propensity of the host to multiple HHV-8 infection. The aim of the present work was to investigate HHV-8 intrahost genetic variability. HHV-8 subgenomic DNA was amplified by PCR from patients infected with HIV, health care workers (HCW) and bone marrow transplant recipients (BMT), and from oral lesional tissues of AIDS-Kaposi's sarcoma (KS) patients. As controls, blood from HIV-negative health care workers, and the cell lines BC-1, BC-2, and BCP-1 were used. Clones derived from amplicons originating from DNA fragments in open reading frame (ORF) 26 and ORF K1 were isolated. For each ORF, intra-specimen nucleotide sequence differences were determined. The extent of HHV-8 variation in clones derived from blood of patients infected with HIV was significantly higher than in blood from health care workers or post-bone marrow transplantation patients or in AIDS-KS tissue. Among the clones derived from the latter three categories of specimens, sequence variations were not significant. It is concluded that HIV-infected individuals can have multiple of HHV-8, but AIDS-KS lesions are associated with infection by a single HHV-8 variant or a small group of related variants.


Asunto(s)
Variación Genética , Infecciones por Herpesviridae/virología , Herpesvirus Humano 8/clasificación , Herpesvirus Humano 8/genética , Adolescente , Adulto , Análisis por Conglomerados , Femenino , Genotipo , Infecciones por VIH/complicaciones , Personal de Salud , Herpesvirus Humano 8/aislamiento & purificación , Humanos , Masculino , Persona de Mediana Edad , Sistemas de Lectura Abierta , Filogenia , Reacción en Cadena de la Polimerasa , Análisis de Secuencia de ADN , Trasplante , Adulto Joven
17.
Rev. cir. traumatol. buco-maxilo-fac ; 12(4): 45-52, Out.-Dez. 2012. ilus, graf
Artículo en Portugués | LILACS-Express | LILACS | ID: lil-792271

RESUMEN

O ameloblastoma multicístico é uma lesão de origem odontogênica, que acomete, principalmente, pacientes entre a terceira e a quinta década de vida. Apesar de ser um tumor benigno, muitas vezes, apresenta-se com comportamento agressivo, o que pode exigir intervenções terapêuticas radicais. Casos de ressecções extensas podem representar a perda de uma grande porção de segmento ósseo, produzindo graves sequelas estéticas e funcionais, além da diminuição da qualidade de vida do doente. A reconstrução mandibular representa um importante estágio na reabilitação de pacientes submetidos à exérese de tumores extensos. A utilização de próteses de titânio se traduz numa alternativa confiável, mas ainda inacessível à grande maioria dos pacientes devido ao seu alto custo. Para tanto, o estudo de materiais alternativos viáveis se faz necessário. Nosso trabalho apresenta o caso de um paciente do sexo masculino, 56 anos, que compareceu ao ambulatório de CTBMF do Hospital da Restauração, com queixa de dor e aumento de volume em hemiface direita há mais ou menos dois anos, sendo submetido à hemimandibulectomia após firmado diagnóstico de ameloblastoma musticístico e reabilitação imediata feita por prótese personalizada, confeccionada em resina acrílica. As necessidades do paciente percebidas e o ganho em qualidade de vida foram analisados antes e após o tratamento por meio da aplicação do questionário "perfil de impacto de saúde bucal" (Oral Health Impact Profile - OHIP-14), por se tratar de um dos instrumentos mais amplamente utilizados na avaliação da qualidade de vida. A utilização de materiais alternativos na reabilitação de pacientes, como a resina acrílica, traduz-se numa alternativa segura, rápida e com menor custo, podendo levar ao paciente funcionalidade satisfatória, numa melhora considerável em sua qualidade de vida em todos os âmbitos.


The multicystic ameloblastoma is an odontogenic lesion that mainly affects patients aged 20 to 49 years. Despite being a benign tumor it often presents an aggressive behavior that may require radical interventional therapy. Cases of extensive resections may represent the loss of a large portion of bone segment, producing severe aesthetic and functional sequelae, in addition to a diminished quality of life for the patient. Mandibular reconstruction represents an important stage in the rehabilitation of patients undergoing resection of large tumors. The use of titanium prostheses is a clinically reliable alternative, but is still inaccessible to most patients due to its high cost. It is therefore necessary to examine the use of affordable alternative materials. This paper presents a case of a 56-year-old male patient who came to the outpatient clinic of Oral and Maxillofacial Surgery of Hospital Restauração, complaining of pain and swelling on the right hemiface for about two years. The patient underwent a hemimandibulectomy following the diagnosis of ameloblastoma, followed by immediate rehabilitation with a custom prosthesis made of acrylic resin. The perceived needs of the patient, and the gain in quality of life were assessed before and after treatment using the questionnaire Oral Health Impact Profile - OHIP-14, because it is one of the most widely used instruments in the assessment of quality of life. The use of alternative materials such as acrylic resin in the rehabilitation of patients represents a safe, rapid and low-cost alternative option that may afford the patient a satisfactory functionality and a considerable improvement in quality of life in all areas.

18.
Gen Dent ; 60(4): 316-21, 2012.
Artículo en Inglés | MEDLINE | ID: mdl-22782044

RESUMEN

Soft tissue infections are characterized by acute inflammation, diffuse edema, and suppuration, and are often associated with symptoms such as malaise, fever, tachycardia, and chills. Necrotizing fasciitis is a destructive bacterial infection affecting subcutaneous tissue and superficial fascia and is associated with high rates of mortality. It usually involves the abdomen and extremities, but it also can occur in the head and neck. Early diagnosis is critical and the most commonly accepted treatment includes radical surgical intervention and administration of broad-spectrum antibiotics. This article reports and discusses the case of a patient with odontogenic cervicofacial necrotizing fasciitis, and emphasizes the importance of early and effective treatment.


Asunto(s)
Fascitis Necrotizante/etiología , Infección Focal Dental/complicaciones , Cuello/patología , Absceso Periodontal/complicaciones , Pérdida de Hueso Alveolar/etiología , Antibacterianos/uso terapéutico , Terapia Combinada , Desbridamiento/métodos , Diagnóstico Precoz , Humanos , Infecciones por Klebsiella/diagnóstico , Klebsiella pneumoniae/aislamiento & purificación , Masculino , Persona de Mediana Edad , Cicatrización de Heridas/fisiología
19.
Imaging Sci Dent ; 42(2): 99-103, 2012 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-22783479

RESUMEN

Osteoma is a benign osteogenic tumor composed of cancellous or compact bone, classified as peripheral, central, or extraskeletal. Peripheral osteomas are uncommon. Excluding the maxillary sinuses, the maxilla is a rare site for osteomas. The purpose of this report was to describe clinicopathological and radiological features of two peripheral osteomas occurring in the jaws, one located in the mandible and another in the edentulous maxillary alveolar ridge. The tumors were asymptomatic and were fully excised without any complications or recurrence. The lesions were submitted to histopathological analysis and diagnosed as peripheral osteoma, compact type.

20.
Braz Dent J ; 23(1): 82-6, 2012.
Artículo en Inglés | MEDLINE | ID: mdl-22460321

RESUMEN

Injuries in the parotid and masseter region can cause serious impairment secondary to damage of important anatomical structures. Sialocele is observed as facial swelling associated with parotid duct rupture due to trauma. The aim of this paper is to report a case of a giant traumatic sialocele in the parotid gland, secondary to a knife lesion in a 40-year-old woman. Conservative measures could not promote clinical resolution and a surgical intervention for the placement of a vacuum drain was selected. Under local anesthesia, a small incision was performed adjacent to parotid duct papilla, followed by muscular divulsion and draining of significant amount of saliva. An active vacuum suction drain was placed for 15 days, aiming to form a new salivary duct. This technique was shown to be a safe, effective and low-cost option, leading to complete resolution and no recurrence after 28 months of follow up.


Asunto(s)
Cara/cirugía , Traumatismos Faciales/complicaciones , Enfermedades de las Parótidas/cirugía , Glándula Parótida/lesiones , Conductos Salivales/cirugía , Enfermedades de las Glándulas Salivales/cirugía , Adulto , Drenaje/métodos , Traumatismos Faciales/cirugía , Femenino , Estudios de Seguimiento , Humanos , Glándula Parótida/cirugía
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