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1.
Nat Commun ; 12(1): 3132, 2021 05 25.
Artículo en Inglés | MEDLINE | ID: mdl-34035246

RESUMEN

The COVID-19 pandemic has demonstrated the need for massively-parallel, cost-effective tests monitoring viral spread. Here we present SARSeq, saliva analysis by RNA sequencing, a method to detect SARS-CoV-2 and other respiratory viruses on tens of thousands of samples in parallel. SARSeq relies on next generation sequencing of multiple amplicons generated in a multiplexed RT-PCR reaction. Two-dimensional, unique dual indexing, using four indices per sample, enables unambiguous and scalable assignment of reads to individual samples. We calibrate SARSeq on SARS-CoV-2 synthetic RNA, virions, and hundreds of human samples of various types. Robustness and sensitivity were virtually identical to quantitative RT-PCR. Double-blinded benchmarking to gold standard quantitative-RT-PCR performed by human diagnostics laboratories confirms this high sensitivity. SARSeq can be used to detect Influenza A and B viruses and human rhinovirus in parallel, and can be expanded for detection of other pathogens. Thus, SARSeq is ideally suited for differential diagnostic of infections during a pandemic.


Asunto(s)
Técnicas de Laboratorio Clínico , Ensayos Analíticos de Alto Rendimiento , Infecciones del Sistema Respiratorio/diagnóstico , Virus/aislamiento & purificación , COVID-19/diagnóstico , Diagnóstico Diferencial , Secuenciación de Nucleótidos de Alto Rendimiento , Humanos , Reacción en Cadena de la Polimerasa , ARN Viral/genética , Infecciones del Sistema Respiratorio/virología , SARS-CoV-2/genética , SARS-CoV-2/aislamiento & purificación , Saliva/virología , Sensibilidad y Especificidad , Proteínas Virales/genética , Virus/clasificación , Virus/genética
2.
Arch Cardiol Mex ; 89(1): 93-99, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31702734

RESUMEN

The Editors' Network of the European Society of Cardiology (ESC) provides a dynamic forum for editorial discussions and endorses the recommendations of the International Committee of Medical Journal Editors (ICMJE) to improve the scientific quality of biomedical journals. Authorship confers credit and important academic rewards. Recently, however, the ICMJE emphasized that authorship also requires responsibility and accountability. These issues are now covered by the new -(fourth) criterion for authorship. Authors should agree to be accountable and ensure that questions regarding the accuracy and integrity of the entire work will be appropriately addressed. This review discusses the implications of this paradigm shift on authorship requirements with the aim of increasing awareness on good scientific and editorial practices.


Asunto(s)
Autoria , Políticas Editoriales , Edición/ética , Responsabilidad Social
3.
Rev Port Cardiol (Engl Ed) ; 38(7): 519-525, 2019 Jul.
Artículo en Inglés, Portugués | MEDLINE | ID: mdl-31492459

RESUMEN

The Editors' Network of the European Society of Cardiology (ESC) provides a dynamic forum for editorial discussions and endorses the recommendations of the International Committee of Medical Journal Editors (ICMJE) to improve the scientific quality of biomedical journals. Authorship confers credit and important academic rewards. Recently, however, the ICMJE emphasized that authorship also requires responsibility and accountability. These issues are now covered by the new (fourth) criterion for authorship. Authors should agree to be accountable and ensure that questions regarding the accuracy and integrity of the entire work will be appropriately addressed. This review discusses the implications of this paradigm shift on authorship requirements with the aim of increasing awareness on good scientific and editorial practices.


Asunto(s)
Autoria , Investigación Biomédica/métodos , Cardiología , Políticas Editoriales , Difusión de la Información/métodos , Humanos
4.
Rev. urug. cardiol ; 34(2): 11-36, ago. 2019.
Artículo en Español | LILACS-Express | LILACS | ID: biblio-1014545

RESUMEN

Resumen: La Red de Editores de la Sociedad Europea de Cardiología (ESC, por su sigla en inglés) constituye un foro dinámico dedicado a discusiones editoriales y respalda las recomendaciones del Comité Internacional de Editores de Revistas Médicas (ICMJE, por su sigla en inglés) destinadas a mejorar la calidad científica de las revistas biomédicas. La paternidad literaria confiere crédito, además de importantes recompensas académicas. Recientemente, sin embargo, el ICMJE ha destacado que la autoría también exige que los autores sean responsables y se hagan cargo de lo que publican. Estas cuestiones ahora están cubiertas por el nuevo (cuarto) criterio para la autoría. Los autores deben aceptar hacerse responsables de lo que escriben y garantizar un adecuado enfoque de las cuestiones concernientes a la precisión e integridad de todo el trabajo. Esta revisión analiza las implicancias de este cambio de paradigma en los requisitos de autoría con el objetivo de aumentar la conciencia sobre las buenas prácticas científicas y editoriales.


Summary: The Editors´ Network of the European Society of Cardiology provides a dynamic forum for editorial discussions and endorses the recommendations of the International Committee of Medical Journal Editors to improve the scientific quality of biomedical journals. Authorship confers credit and important academic rewards. Recently, however, the International Committee of Medical Journal Editors emphasized that authorship also requires responsibility and accountability. These issues are now covered by the new (fourth) criterion for authorship. Authors should agree to be accountable and ensure that questions regarding the accuracy and integrity of the entire work will be appropriately addressed. This review discusses the implications of this paradigm shift on authorship requirements with the aim of increasing awareness on good scientific and editorial practices.


Resumo: A Rede de Editores da Sociedade Europeia de Cardiologia é um fórum dinâmico para discussões editoriais e apoia as recomendações do Comitê Internacional de Editores de Revistas Médicas, visando melhorar a qualidade científica das revistas biomédicas. A autoria confere crédito, além de importantes recompensas acadêmicas. Recentemente, no entanto, o Comitê Internacional de Editores de Revistas Médicas enfatizou que a autoria também requer que os autores sejam responsáveis do que escrevem e se encarreguem do que publicam. Essas questões agora estão cobertas pelo novo (quarto) critério de autoria. Os autores devem concordar em ser responsáveis e garantir que as questões relativas à precisão e integridade de todo o trabalho sejam abordadas de maneira apropriada. Esta revisão discute as implicações dessa mudança de paradigma nos requisitos de autoria, com o objetivo de aumentar a conscientização sobre as boas práticas científicas e editoriais.

5.
Arch Cardiol Mex ; 89(2): 105-111, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31314006

RESUMEN

The Editors' Network of the European Society of Cardiology (ESC) provides a dynamic forum for editorial discussions and endorses the recommendations of the International Committee of Medical Journal Editors (ICMJE) to improve the scientific quality of biomedical journals. Authorship confers credit and important academic rewards. Recently, however, the ICMJE emphasized that authorship also requires responsibility and accountability. These issues are now covered by the new -(fourth) criterion for authorship. Authors should agree to be accountable and ensure that questions regarding the accuracy and integrity of the entire work will be appropriately addressed. This review discusses the implications of this paradigm shift on authorship requirements with the aim of increasing awareness on good scientific and editorial practices.

7.
Arch. cardiol. Méx ; 89(2): 105-111, Apr.-Jun. 2019.
Artículo en Español | LILACS-Express | LILACS | ID: biblio-1149066

RESUMEN

Abstract The Editors’ Network of the European Society of Cardiology (ESC) provides a dynamic forum for editorial discussions and endorses the recommendations of the International Committee of Medical Journal Editors (ICMJE) to improve the scientific quality of biomedical journals. Authorship confers credit and important academic rewards. Recently, however, the ICMJE emphasized that authorship also requires responsibility and accountability. These issues are now covered by the new (fourth) criterion for authorship. Authors should agree to be accountable and ensure that questions regarding the accuracy and integrity of the entire work will be appropriately addressed. This review discusses the implications of this paradigm shift on authorship requirements with the aim of increasing awareness on good scientific and editorial practices.

8.
Anatol J Cardiol ; 21(5): 281-286, 2019 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-31062751

RESUMEN

The Editors´ Network of the European Society of Cardiology (ESC) provides a dynamic forum for editorial discussions and endorses the recommendations of the International Committee of Medical Journal Editors (ICMJE) to improve the scientific quality of biomedical journals. Authorship confers credit and important academic rewards. Recently, however, the ICMJE emphasized that authorship also requires responsibility and accountability. These issues are now covered by the new (fourth) criterion for authorship. Authors should agree to be accountable and ensure that questions regarding the accuracy and integrity of the entire work will be appropriately addressed. This review discusses the implications of this paradigm shift on authorship requirements with the aim of increasing awareness on good scientific and editorial practices.


Asunto(s)
Autoria , Responsabilidad Social , Cardiología , Políticas Editoriales , Europa (Continente) , Humanos , Turquia
9.
Clin Res Cardiol ; 108(7): 723-729, 2019 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-31041501

RESUMEN

The Editors' Network of the European Society of Cardiology provides a dynamic forum for editorial discussions and endorses the recommendations of the International Committee of Medical Journal Editors (ICMJE) to improve the scientific quality of biomedical journals. Authorship confers credit and important academic rewards. Recently, however, the ICMJE emphasized that authorship also requires responsibility and accountability. These issues are now covered by the new (fourth) criterion for authorship. Authors should agree to be accountable and ensure that questions regarding the accuracy and integrity of the entire work will be appropriately addressed. This review discusses the implications of this paradigm shift on authorship requirements with the aim of increasing awareness on good scientific and editorial practices.


Asunto(s)
Autoria , Investigación Biomédica/métodos , Cardiología , Responsabilidad Social , Sociedades Médicas , Europa (Continente) , Humanos
10.
Basic Res Cardiol ; 114(3): 23, 2019 04 08.
Artículo en Inglés | MEDLINE | ID: mdl-30963299

RESUMEN

The Editors' Network of the European Society of Cardiology provides a dynamic forum for editorial discussions and endorses the recommendations of the International Committee of Medical Journal Editors (ICMJE) to improve the scientific quality of biomedical journals. Authorship confers credit and important academic rewards. Recently, however, the ICMJE emphasized that authorship also requires responsibility and accountability. These issues are now covered by the new (fourth) criterion for authorship. Authors should agree to be accountable and ensure that questions regarding the accuracy and integrity of the entire work will be appropriately addressed. This review discusses the implications of this paradigm shift on authorship requirements with the aim of increasing awareness on good scientific and editorial practices.


Asunto(s)
Autoria/normas , Cardiología/organización & administración , Políticas Editoriales , Responsabilidad Social
11.
Med Glas (Zenica) ; 14(2): 211-217, 2017 Aug 01.
Artículo en Inglés | MEDLINE | ID: mdl-28786966

RESUMEN

Aim To investigate biosynthesis in nitric oxide (NO) during normal pregnancy and in pregnancies complicated by preeclampsia. Methods This prospective cross-sectional study included 80 patients hospitalized at the Department of Women's Health, Neonatology and Perinatology Cantonal Hospital in Zenica. Serum NO concentration in 20 non-pregnant women, 40 healthy pregnant women and 20 pregnant women with preeclampsia aged 17-40 years were measured. The group of healthy pregnant women were divided into 4 subgroups by gestational age. For each woman with preeclampsia, a healthy pregnant control was matched for age, parity and gestational age. Serum NO concentrations were determined after reduction of nitrates to nitrites using the Griess reaction. Results NO concentrations during second trimester of pregnancy (37.2±1.7µM; p<0.05) and third trimester of pregnancy (40.9±2.8µM; p<0.05) were significantly higher in healthy pregnant women than in non-pregnant women (29.3±1.7µM). Serum NO concentrations were lower in preeclamptic women (30.7±1.8µM) compared to matched healthy pregnant women of the third and the late third trimester (35.1±2.2µM), without significant differences. Mean NO concentrations in pre-eclamptic women was positively correlated with systolic blood pressure (r=0.58; p<0.01), diastolic blood pressure (r=0.45; p<0.05), creatinine clearance (r=0.48; p<0.05), uric acid (r=0.49; p<0.05), and negatively correlated with platelet count (r=-0.57; p<0.05). Conclusion NO production was increased with gestational age during normal pregnancy and slightly decreased in preeclampsia suggesting that NO may modulate the cardiovascular changes during normal pregnancy and pregnancy complicated by preeclampsia.


Asunto(s)
Óxido Nítrico/sangre , Preeclampsia/sangre , Adolescente , Adulto , Análisis de Varianza , Presión Sanguínea/fisiología , Estudios de Casos y Controles , Estudios Transversales , Femenino , Humanos , Óxido Nítrico/biosíntesis , Preeclampsia/fisiopatología , Embarazo , Segundo Trimestre del Embarazo , Estudios Prospectivos , Adulto Joven
12.
Acta Inform Med ; 24(1): 12-5, 2016 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-27046941

RESUMEN

AIM: The aims of this study were to compare ultrasound fetoplacental parameters and to calculate Hepato-Cephalic Index (HCI) as a new predictor of IUGR. METHODS AND MATERIAL: A clinical prospective study was conducted and included 120 pregnant women divided in two groups: non IUGR group included healthy pregnant women (n=60) and IUGR group included pregnant women with preeclampsia and IUGR (n=60). Outcome measures were following ultrasound fetoplacental parameters in fetuses with IUGR and non IUGR: Fetal Liver Length (FLL), Femur Length (FL), Biparietal Diameter (BPD), Placental Maturation by Grannum, Amniotic Fluid Index (AFI) and Hepato-Cephalic Index (HCI). Sonography was carried out by probe 3.5 Mhz type MINDRAY DC 7. RESULTS: The mean of maternal age was 30.0±6.1 years in women with preeclampsia and IUGR and 28.1±5.1 years in healthy pregnant women, p > 0.05. There was a statistically significant difference in values of: FLL (p < 0.001), FL (p = 0.004), BPD (p < 0.001), AFI (p < 0.001), HCI (p < 0.001) between IUGR and non IUGR groups. The most of women with preeclampsia and IUGR had grade III of placental maturation (48.3%). There is a significant association between the placental maturation and the diagnosis, p < 0.001. There was a statistically significant difference in body mass of newborns between IUGR and non IUGR groups, p < 0.001. CONCLUSION: In a fetus with IUGR in preeclampsia there is a reduction in FLL, FL, BPD, AFI and HCI and there is a early maturation of the placenta. By measurement of fetoplacental ultrasonic parameters of liver, pregnant women will experience prediction of risk pregnancy (preeclampsia with IUGR) due to hypoxia.

13.
Med Arch ; 70(1): 44-7, 2016 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-26980931

RESUMEN

AIM: The aim of this study was to evaluate biochemical parameters in serum of women with preeclampsia and IUGR. MATERIAL AND METHODS: A clinical prospective study was conducted and included 120 pregnant women divided in two groups: non IUGR group included healthy pregnant women (n=60) and IUGR group included pregnant women with preeclampsia and IUGR (n=60). Outcome measures were following values of biochemical parameters in serum of mother and fetuses: aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), bilirubin (indirect and direct) and cholesterol. A blood for analysis was drawn from the cubital vein of mothers and the umbilical vein of the fetuses during delivery period. RESULTS: The mean of maternal age was 30.0±6.1 years in women with preeclampsia and IUGR and 28.1±5.1 years in healthy pregnant women, p > 0.05. The most of women with preeclampsia and IUGR had grade III of placental maturation (48.3%). There is a significant association between the placental maturation and the diagnosis, p < 0.001. There was a statistically significant difference in body mass of newborns between IUGR and non IUGR groups, p < 0.001. There was a significant statistically difference in serum value of AST, ALT, LDH and total cholesterol between women with preeclampsia and IUGR and healthy pregnant women (all p < 0.001). CONCLUSION: Measurement of AST, ALT, LDH, and total cholesterol in serum of pregnant women and newborns with IUGR allows the differentiation and threatening risk of perinatal complications due to hypoxia.


Asunto(s)
Alanina Transaminasa/sangre , Aspartato Aminotransferasas/sangre , Retardo del Crecimiento Fetal/sangre , Retardo del Crecimiento Fetal/diagnóstico , L-Lactato Deshidrogenasa/sangre , Preeclampsia/sangre , Preeclampsia/diagnóstico , Adulto , Bilirrubina/sangre , Biomarcadores/sangre , Peso al Nacer , Índice de Masa Corporal , Colesterol/sangre , Femenino , Humanos , Recién Nacido , Valor Predictivo de las Pruebas , Embarazo , Pronóstico , Estudios Prospectivos , Sensibilidad y Especificidad
14.
Mater Sociomed ; 27(3): 185-7, 2015 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-26244044

RESUMEN

INTRODUCTION: Infertility or sterility or barrenness is defined as a state of inability to conceive after a year of unprotected intercourse. Ovulation problems, uterine tube problems, endometriosis, uterine etiology problems, chromosomal problems which are not so rare, spermatogenesis disorders and azoospermia are stated as the most common causes of infertility. OBJECTIVE: Main objective of this research is to present most common causes of marital infertility in Bosnia-Herzegovina population. MATERIAL AND METHODS: Retrospective, descriptive- epidemiological study has been published at Bahceci IVF center in Sarajevo (Bosnia and Herzegovina). The research covered a time-period of two years. During the time-period in question, 826 marital couples from Bosnia and Herzegovina diagnosed with marital sterility approached the Center. RESULTS: Analysis of female patients as per age groups determined that the largest number of respondents belonged to the 36 - 39 age group with a total number of 293 patients, followed by 30 - 35 age group with a total number of 245 patients, and the third most frequent age group included those of ≥ 40 years of age with 179 patients in total, followed by 25-29 age group with 98 respondents. In 42% (n=350) of the couples diagnosed with marital infertility, female sterility was established as the reason, while in 36 % (n=294) of the couples, male sterility was the reason. Both marital spouses were infertile in 11% of the couples (n=92), while in remaining 11% of the couples, no diagnosis was determined and they belonged in the group of unexplainable sterility. The most common cause of sterility in women is diminished ovarian reserve (DOR), as was the case in 38.57% of respondents. This diagnosis is in direct correlation with the age of a woman. Among causes of sterility of organic and functional origin, the most common is ovarian tube problem - in 31.4% of the cases, then ovulatory problems - in 12.86% of the cases, and polycystic ovary syndrome in 6% of the cases. Other causes such as endometrioma, endometriosis and genetic factors are present in less than 2% of respondents. Regarding male sterility, problems with spermatogenesis are prevailing (decreased number and mobility of sperm cells and problems with morphology of sperm cells), oligoasthenoteratozoospermia in 81.61% of the patients. In 14.19% of the cases, azoospermia was present. CONCLUSION: All of this contributes to the negative demographic trend in Bosnia and Herzegovina. In 2008, European Parliament warned of importance of infertility treatment. In collaboration with ESHRE (European Society of Human Reproduction and Embryology), main guidelines to alleviate this problem were provided.

15.
Med Arch ; 69(3): 196-9, 2015 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-26261391

RESUMEN

INTRODUCTION: To present results of MicroTese procedure in treatment of male infertility in patients with azoospermia at Bahçeci BIH IVF Center during two-year period of 2013-2014. METHODS: In the stated time-period, 55 MicroTese surgeries were performed. In 52.7% of the cases, sperm cells were isolated after MicroTese surgery, and in 47.3% of the cases, there was a negative outcome of the procedure. Obtained sperm cells were subjected to cryopreservation. Furthermore, ICSI procedure was performed by use of the obtained sperm cells. RESULTS: Of 29 positive MicroTese surgeries, 21 (72.4%) resulted in clinical pregnancies. Biggest percentage of negative MicroTese procedures happened in patients with cryptorchidism and orchidopexy. CONCLUSION: MicroTese is the most precise and successful method of retrieving sperm cells surgically in men with azoospermia. Our results are within scope of results in referent world centers.


Asunto(s)
Azoospermia/cirugía , Adulto , Bosnia y Herzegovina , Humanos , Masculino , Inyecciones de Esperma Intracitoplasmáticas , Espermatozoides , Testículo/cirugía
16.
Mater Sociomed ; 26(3): 186-7, 2014 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-25126013

RESUMEN

AIM: The main goal of this research is to correlate anthropometric characteristics of newborns in pregnant women who consume cigarettes during pregnancy. The study was conducted at the Obstetrics Clinic of the Clinical Center, University of Sarajevo. METHODS: The retrospective study covered a period of two years. Main inclusion criteria for the study was that pregnant women consume cigarettes during pregnancy. The research included respondents who had a singleton pregnancy, without pathological conditions that can affect the outcome and duration of pregnancy. RESULTS: At the Obstetrics Clinic, Clinical Center University of Sarajevo in the period from January 1, 2012 to December 31, 2013. In that period 393 pregnant women completed labor who in the personal history had data on smoking during pregnancy. Of the total number of subjects enrolled in this study 38.17% smoked up to 10 cigarettes a day, 33.08 % smoked up to 20 cigarettes a day, while up to 30 cigarettes per day smoked 28.75 % of respondents. CONCLUSION: There was a significant difference in the average values of all anthropometric parameters, in relation to the number of cigarettes consumed by the subjects during the day. We also found negative correlation in the average values of anthropometric measures and the number of cigarettes consumed (p <0.05).

17.
Med Arch ; 68(1): 61-4, 2014.
Artículo en Inglés | MEDLINE | ID: mdl-24783917

RESUMEN

Among the priority basic human rights, without a doubt, are the right to life and health-social protection. The process of implementation of human rights in the everyday life of an ordinary citizen in the post-war recovery of Bosnia and Herzegovina faces huge objective and subjective difficulties. Citizens need to be affordable adequate healthcare facilities that will be open to all on equal terms. The term hospital activity implies a set of measures, activities and procedures that are undertaken for the purpose of treatment, diagnosis and medical rehabilitation of patients in the respective health institutions. Principles of hospital care should include: Comprehensiveness (Hospital care is available to all citizens equally); Continuity (Provided is continuous medical care to all users); Availability (Provided approximately equal protection of rights for all citizens). Education of health professionals: The usual threats to patient safety include medical errors, infections occurred in the hospital, unnecessary exposure to high doses of radiation and the use of the wrong drug. Everyday continuing education in the profession of a doctor is lifelong.


Asunto(s)
Cuerpo Médico , Derechos del Paciente , Rol del Médico , Humanos , Garantía de la Calidad de Atención de Salud
18.
Mater Sociomed ; 26(1): 53-4, 2014 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-24757404

RESUMEN

INTRODUCTION: Caesarean section is obstetrical surgery by which through incision of the abdominal wall and the lower uterine segment performs extraction of the fetus in the advanced stages of pregnancy and childbirth ends by abdominal myomectomy. Because of its significance it is one of the most important surgical procedures performed in gynecology and obstetrics. MATERIAL AND METHODS: The goal of this study is to show the incidence of cesarean section in the Public Hospital in Travnik during 2012, and the most frequent indications for surgical completion of delivery. During 2012 at the Department of Gynecology and Obstetrics of Cantonal Hospital Travnik there was 927 deliveries. RESULTS: Of the total number of births, in 115 (12.41%) of cases a caesarean section was performed, while in 812 (87.59%) delivery was completed vaginally. Descriptive analysis reveals that 55 (5.93%) women had repeated cesarean section after a previous cesarean section, while in 60 (6.47%) cases in 2012 for the first time underwent cesarean section. As the most common indications in 7.33% of the women was reported cefalopelvinea disproportion and breech presentation. At 6.67% of the women caesarean section was performed due to asphyxia and 4% due to preeclampsia. The incidence of other indications such as abruption, placenta previa, multiple pregnancy and other was less than 3%. CONCLUSION: On the basis of the data we conclude that in the maternity hospital Travnik vaginal birth is most common. However, although the percentage of cesarean sections was much lower than in the regional maternity hospitals, we cannot ignore that the rate of caesarean sections is slowly increasing and requires that obstetricians in their practice make professional triage when setting indications for cesarean section so that a trend of surgically completed births should not reach epidemic proportions.

19.
Int J Prev Med ; 4(12): 1347-58, 2013 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-24498489

RESUMEN

BACKGROUND: Prevention of diseases in gynecology can be improved by better understanding of health promotion and management of diseases. Management is "the art of performing jobs by or with other people" Mary Parker Follet. METHODS: A descriptive analysis was performed on scientific studies in several published articles in medical journals and books. RESULTS: THERE ARE FIVE PRIMARY FUNCTIONS OF MANAGEMENT AS: Anticipate and plan, organize, command, coordinate and control. If we introduce the following definition in the sense of medical science and apply it to the medical practice that would mean way of recognizing, managing and resolving issues of diagnosis and therapy of diseases (in this case gynecology diseases) according to certain guidelines and treatment algorithms. Treatment of family doctors is an important aspect in the quality-of-life of women and their reproductive health as well as a significant issue in public, environmental and social problems. CONCLUSIONS: It is very important to deal with it on the primary care level and in addition to promote the primary and secondary prevention of diseases, which is sometimes more important than the curative procedures. The primary prevention involves regular gynecological examinations and screening. The doctors have also a duty to educate women about the risk factors for malignant diseases, as well as proposing some of the qualitative preventive measures.

20.
Med Arch ; 67(6): 431-4, 2013 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-25568515

RESUMEN

INTRODUCTION: Postmenopausal uterine bleeding is a "cancer until proven otherwise". Endometrial cancer is a typical disease among postmenopause woman, because every bleeding in this age etiology associated with endometrial cancer (10-30%). The lifespan of women today has been extended and post menopause today last one third of a woman's life. Early diagnosis of endometrial cancer has a very high cure rate. Screening for this cancer has limits in practice and is necessary given the definition of high-risk groups would be subject to primary and secondary prevention. GOAL: Primary to evaluate the leading causes of postmenopausal uterine bleeding among patients at risk for endometrial cancer (diabetes, obesity, nulliparity, late menopause (after 55 years) and compared them with the causes of postmenopausal uterine bleeding patients without this risk. MATERIAL AND METHODS: A retrospective, descriptive study with a targeted sample of 50 consecutive patients who had registered postmenopausal uterine bleeding in high-risk groups (cohorts) and the same number of patients with postmenopausal uterine bleeding that does not belong to the risk group (control group). Each patient underwent clinical examination, then fractionated curettements and its histopathological verification and assessment of treated clinical stage of disease with PH analysis of the resected specimens. RESULTS: The patients of the studied risk group were significantly affected by endometrial cancer compared with the control group (RR=2.45, 95% CI 1.2 4.6, p=0.005). Endocervical pathology did not differ between groups. Clinical forms of bleeding: for those that are profuse bleeding cancer was present in 54.6% of cases. With intermittent bleeding cancer is verified in the 33.3% of patients. Risk patient groups with cancer frequently suffer from clinically more advanced stages of histologically aggressive endometrial cancer (serous adenocarcinoma-type II, low differentiated cancer).


Asunto(s)
Detección Precoz del Cáncer , Neoplasias Endometriales/diagnóstico , Endometrio/patología , Posmenopausia/fisiología , Hemorragia Uterina/patología , Neoplasias Uterinas/diagnóstico , Anciano , Femenino , Humanos , Persona de Mediana Edad , Tamaño de los Órganos , Estudios Retrospectivos , Factores de Riesgo , Ultrasonografía , Hemorragia Uterina/etiología
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