Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 49
Filtrar
1.
MMWR Morb Mortal Wkly Rep ; 73(2): 44-48, 2024 Jan 18.
Artículo en Inglés | MEDLINE | ID: mdl-38236779

RESUMEN

Since May 2022, approximately 2,500 mpox cases have been reported in Los Angeles County (LAC), California. Beginning in May 2023, the LAC Department of Public Health observed a consistent increase in mpox cases after a prolonged period of low incidence. A total of 56 cases were identified during May 4-August 17, 2023. A minority of mpox patients were fully vaccinated (29%). One patient was hospitalized; no deaths were reported. Two cases of reinfection occurred, both of which were associated with mild illness. The increasing number of cases during this period was significant, as few other health departments in the United States reported an increase in mpox cases during the same period. The outbreak spread similarly to the 2022 U.S. mpox outbreak, mainly through sexual contact among gay, bisexual, and other men who have sex with men. Vaccination against mpox became available in June 2022 and has been shown to be effective at preventing mpox disease. This outbreak was substantially smaller than the 2022 mpox outbreak in LAC (2,280 cases); possible explanations for the lower case count include increased immunity provided from vaccination against mpox and population immunity from previous infections. Nonetheless, mpox continues to spread within LAC, and preventive measures, such as receipt of JYNNEOS vaccination, are recommended for persons at risk of Monkeypox virus exposure.


Asunto(s)
Minorías Sexuales y de Género , Masculino , Humanos , Homosexualidad Masculina , Los Angeles/epidemiología , Brotes de Enfermedades
2.
J Infect Dis ; 2023 Nov 23.
Artículo en Inglés | MEDLINE | ID: mdl-37995310

RESUMEN

The Los Angeles County Department of Public Health established a surveillance system to identify complicated (advanced HIV or hospitalized) mpox cases. From August 1st to November 30th, 2022, we identified 1,581 mpox cases of which 134 were complicated (8.5%). A subset of eight cases did not recover after either initiating or completing a course of oral tecovirimat. All eight patients were HIV positive and had advanced HIV (CD4 <200 cells/mm3). We identified eight distinct mutations previously associated with tecovirimat resistance in specimens collected from six patients. Ongoing surveillance of viral evolution requires close coordination between health departments and front-line providers.

4.
Emerg Infect Dis ; 29(12): 2520-2523, 2023 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-37856215

RESUMEN

Reports of tecovirimat-resistant mpox have emerged after widespread use of antiviral therapy during the 2022 mpox outbreak. Optimal management of patients with persistent infection with or without suspected resistance is yet to be established. We report a successfully treated case of severe mpox in California, USA, that had suspected tecovirimat resistance.


Asunto(s)
Humanos , Estados Unidos , Huésped Inmunocomprometido , Benzamidas , Brotes de Enfermedades
5.
Lancet ; 402(10402): 608-609, 2023 08 19.
Artículo en Inglés | MEDLINE | ID: mdl-37597882

Asunto(s)
Humanos , /transmisión
8.
J Clin Virol ; 164: 105493, 2023 07.
Artículo en Inglés | MEDLINE | ID: mdl-37220710

RESUMEN

BACKGROUND: Despite the sharp increase in mpox (formerly monkeypox) incidence and the wide geographic spread of mpox during the 2022 outbreak, the community prevalence of infection remains poorly characterized. This study is a retrospective epidemiologic survey to estimate mpox prevalence. METHODS: Samples obtained for sexually transmitted infection (STI) testing from April to September 2022 in the public hospital and clinic system of San Mateo County, California were screened for mpox virus (MPXV) using polymerase chain reaction. RESULTS: 16/1,848 samples from 11/1,645 individuals were positive for MPXV by qPCR. 4/11 individuals with positive MPXV testing were cisgender women, 2 of whom were pregnant at the time of sample collection. Both deliveries were complicated by chorioamnionitis. Anorectal and oropharyngeal samples were the most likely to be positive for MPXV (4/60 anorectal samples and 4/66 oropharyngeal samples compared with 5/1,264 urine samples and 3/445 vaginal samples). CONCLUSIONS: Our study is one of the first epidemiologic surveys for MPXV infection outside of sexual health/STI clinic settings. Relatively high rates of MPXV from oropharyngeal and anorectal samples reinforces the importance of MPXV testing at various anatomic sites, particularly if patients are presenting with non-lesional symptoms (pharyngitis, proctitis). However, the United States Food and Drug Administration (FDA) has not yet authorized non-lesional MPXV testing. The identification of MPXV in women in our cohort suggests that the rates of mpox in women may have previously been underestimated and highlights the risk of pregnancy complications associated with mpox.


Asunto(s)
Embarazo , Humanos , Femenino , Prevalencia , Estudios Retrospectivos , Instituciones de Atención Ambulatoria , California/epidemiología , Virus de la Viruela de los Monos
9.
Emerg Infect Dis ; 29(4): 848-850, 2023 04.
Artículo en Inglés | MEDLINE | ID: mdl-36918374

RESUMEN

We retrospectively screened oropharyngeal and rectal swab samples originally collected in California, USA, for Chlamydia trachomatis and Neisseria gonorrhoeae testing for the presence of monkeypox virus DNA. Among 206 patients screened, 17 (8%) had samples with detectable viral DNA. Monkeypox virus testing from mucosal sites should be considered for at-risk patients.


Asunto(s)
Infecciones por Chlamydia , Gonorrea , Humanos , California/epidemiología , Infecciones por Chlamydia/diagnóstico , Infecciones por Chlamydia/epidemiología , Chlamydia trachomatis/genética , Chlamydia trachomatis/aislamiento & purificación , ADN , Gonorrea/diagnóstico , Virus de la Viruela de los Monos/genética , Virus de la Viruela de los Monos/aislamiento & purificación , Neisseria gonorrhoeae/genética , Neisseria gonorrhoeae/aislamiento & purificación , Estudios Retrospectivos , /diagnóstico
10.
BMJ ; 380: 489, 2023 03 01.
Artículo en Inglés | MEDLINE | ID: mdl-36858452
11.
Am J Trop Med Hyg ; 108(3): 592-594, 2023 03 01.
Artículo en Inglés | MEDLINE | ID: mdl-36716741

RESUMEN

Mpox (formally monkeypox) is an Orthopoxvirus associated with both zoonotic and person-to-person spread. Human mpox classically presents with rash and systemic symptoms. Although sporadic outbreaks of mpox have occurred worldwide, the 2022 outbreak is the first of pandemic significance. Thousands of geographically dispersed cases were reported beginning in May 2022. The clinical presentations and outcomes of mpox infection have varied greatly based on viral clade. Further guidance is needed for clinicians to diagnose and treat this emerging infection. We present five clinical vignettes of confirmed cases diagnosed in June and July 2022 in northern California to demonstrate the range of mpox disease, including myocarditis, pharyngitis, epididymitis, and proctitis. We note a significant overlap with HIV infection and a high rate of concurrent sexually transmitted infection. Given the heterogenous presentations of mpox disease, clinicians should maintain a high degree of suspicion in patients with oropharyngeal or genital lesions, proctitis, or new rash.


Asunto(s)
Exantema , Infecciones por VIH , Proctitis , Masculino , Humanos , Brotes de Enfermedades
13.
Emerg Infect Dis ; 29(2): 435-437, 2023 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-36469326

RESUMEN

Risk for transmission of monkeypox virus (MPXV) (clade IIb) to healthcare workers (HCWs) is low. Although many cases have been reported among HCW, only a few have been occupationally acquired. We report a case of non-needle stick MPXV transmission to an HCW in the United States.


Asunto(s)
Virus de la Viruela de los Monos , Humanos , /epidemiología , California/epidemiología , Personal de Salud
16.
Emerg Infect Dis ; 28(10): 2121-2123, 2022 10.
Artículo en Inglés | MEDLINE | ID: mdl-35971952

RESUMEN

We report human monkeypox in a man who returned to the United States from the United Kingdom and reported no sexual contact. He had vesicular and pustular skin lesions but no anogenital involvement. The potential modes of transmission may have implications for the risk of spread and for epidemic control.


Asunto(s)
California , Brotes de Enfermedades , Humanos , Masculino , /epidemiología , Virus de la Viruela de los Monos , Reino Unido/epidemiología , Estados Unidos/epidemiología
18.
BMJ ; 376: o631, 2022 03 10.
Artículo en Inglés | MEDLINE | ID: mdl-35587391
19.
BMJ ; 377: o976, 2022 04 13.
Artículo en Inglés | MEDLINE | ID: mdl-35418446
20.
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA
...