Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 7 de 7
Filtrar
Más filtros










Base de datos
Intervalo de año de publicación
1.
Cancer Chemother Pharmacol ; 84(3): 513-520, 2019 09.
Artículo en Inglés | MEDLINE | ID: mdl-30997533

RESUMEN

PURPOSE: This study analyzes the effect of oxaliplatin treatment on the facial nerve. The facial nerve is the most commonly paralyzed cranial motor nerve because it advances through a long, curved bone canal. Electroneurography and blink reflex are the electrophysiological measurements used for evaluating facial nerve function. Oxaliplatin is a cytotoxic agent used in adjuvant or palliative systemic therapy for colorectal cancer treatment. METHODS: This study was performed on 20 individuals who were at least 18 years old at Hacettepe University Ear Nose Throat Department, Audiology and Speech Disorders Unit, and Neurology Division EMG Laboratory as they received oxaliplatin treatment from Hacettepe University Oncology Hospital. Electroneurography and blink-reflex values were recorded and examined. The parameters taken during the second and fourth months were compared for this purpose. RESULTS: This study shows that the prolongation of distal latencies of compound muscle action potential is statistically significant, the amplitudes showed no difference. The ENoG results were analyzed, the prolongation of latency measurements between pre-treatment and the fourth month after treatment were statistically significant. The blink-reflex results showed that comparison with the baseline values, the prolongation of latencies in R1 measurements between pre-treatment, the second month, and the fourth month were significant. CONCLUSIONS: The facial nerve is affected asymptomatically by oxaliplatin treatment. During oxaliplatin treatment, the evaluation of facial nerve function could be beneficial for patients by improving their quality of life. Electroneurography and blink-reflex tests can be used in the early evaluations of different medicines to determine their neurotoxicity.


Asunto(s)
Antineoplásicos/efectos adversos , Parpadeo/efectos de los fármacos , Neoplasias Colorrectales/tratamiento farmacológico , Nervio Facial/patología , Parálisis Facial/patología , Oxaliplatino/efectos adversos , Calidad de Vida , Adulto , Anciano , Neoplasias Colorrectales/patología , Electrofisiología , Nervio Facial/efectos de los fármacos , Parálisis Facial/inducido químicamente , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Proyectos Piloto , Pronóstico
2.
J Craniofac Surg ; 29(1): e100-e103, 2018 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-28212126

RESUMEN

Submucous cleft palate (SMCP) is a relatively rare variant of the common pathology of cleft palate with specific anatomic and clinical features. Even though there are many surgical options defined previously to correct the SMCP, correction of the velopharyngeal insufficiency and obtaining ideal speech results remains as a challenge. The aim of this article was to compare the speech benefits of Furlow double opposing Z plasty and posterior pharyngeal flap operation combined with intravelar veloplasty for the correction of SMCP using objective assessment tools. This study reviewed 29 patients who underwent either superiorly based posterior pharyngeal flap combined with intravelar veloplasty or Furlow palatoplasty for submucous cleft palate repair between years 2005 and 2011. The mean standard deviation age at palate repair was 123.6 ±â€Š65.8 months and the mean follow-up period was 31.2 ±â€Š15.9 months. The postoperative results demonstrated that in both groups significantly correction has been achieved in means of velopharygeal closure (P values for Furlow and pharyngeal flap groups are 0.012 and 0.001 respectively). The correction of the nasalance scores obtained depending on the surgical procedure for /sa/ and /ka/ syllables demonstrated significantly more benefit with pharyngeal flap combined with intravelar veloplasty than Furlow palatoplasty (P = 0.026 for each). In the treatment of submucous clefts, both Furlow palatoplasty and pharyngeal flap procedure combined with intravelar veloplasty appear to be effective whereas for the patients having significant signs of hypernasality, contribution of pharyngeal flap may be taken into consideration.


Asunto(s)
Injerto de Hueso Alveolar , Fisura del Paladar/cirugía , Paladar Blando/cirugía , Complicaciones Posoperatorias , Trastornos del Habla , Insuficiencia Velofaríngea , Injerto de Hueso Alveolar/efectos adversos , Injerto de Hueso Alveolar/métodos , Preescolar , Femenino , Humanos , Lactante , Masculino , Evaluación de Procesos y Resultados en Atención de Salud , Faringe/cirugía , Complicaciones Posoperatorias/diagnóstico , Complicaciones Posoperatorias/etiología , Procedimientos Quirúrgicos Reconstructivos/efectos adversos , Procedimientos Quirúrgicos Reconstructivos/métodos , Estudios Retrospectivos , Trastornos del Habla/diagnóstico , Trastornos del Habla/etiología , Colgajos Quirúrgicos , Resultado del Tratamiento , Insuficiencia Velofaríngea/diagnóstico , Insuficiencia Velofaríngea/etiología
3.
J Craniomaxillofac Surg ; 45(6): 891-896, 2017 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-28381372

RESUMEN

PURPOSE: The purpose of this study was to evaluate the speech results of posterior pharyngeal wall augmentation (PPWA) with fat grafting both in the early and late postoperative period, and to clarify the impact of the procedure concomitant with speech therapy. MATERIALS AND METHODS: This is a prospective case-control study. The study involved 87 cleft palate ± cleft lip patients with velopharyngeal insufficiency (VPI) who has been treated with PPWA. Patients were separated into two groups according to age; the first group consisted of 49 pediatric participants between 6 and 12 years of age and the second group consisted of 38 adolescent participants between 13 and 18 years of age. Preoperative velopharyngeal function and articulation were compared postoperatively at the following time points: the 3rd month, 12th month, 18th month and 24th month. The velopharyngeal function was evaluated with regards to the velopharyngeal closure type and velopharyngeal closure amount, by using the pediatric flexible nasoendoscopy and the nasometer methods. In the nasometer evaluation, nasalance sores were measured by using nonsense syllables and meaningful sentences. The Ankara Articulation Test (AAT) (Ege et al., 2004) was used to detect compensatory articulation products secondary to VPI. Consonant production error types and frequencies were determined according the guidelines stated in the study of Hardin-Jones et al. (2009). These were Pharyngeal Fricatives - Posterior Nasal Fricatives/Stop Production, Glottal Stop Production, Middorsum Palatal Stop Production, Nasal Frictional Production, Posterior Nasal Frictional Production/Phoneme Specific Nasal Emission, use of Nasal Consonants for Oral Consonants, and Replacement of Trills. All the participants received concurrent speech therapy four times, twice in the post-operative period between 1 and 3 months and twice between 3 and 6 months. RESULTS: PPWA improved the speech performance from the 18th month to 24th month of the postoperative period. AAT assessment of the first group after 24 months comparing the post-PPWA with the preoperative data showed a highly significant decrease with regard to compensatory production errors and hypernasality; however, in the second group, the same comparison revealed a highly significant decrease in regard to the degree of hypernasality and a significant difference in terms of glottal articulation and pharyngealization of fricatives. A circular closure pattern was observed in 17 individuals with cleft palate at a rate of 70.6%. CONCLUSION: PPWA with concurrent speech therapy is an acceptable surgical method to correct VPI and to improve speech performance.


Asunto(s)
Tejido Adiposo/trasplante , Trastornos de la Articulación/rehabilitación , Fisura del Paladar/cirugía , Faringe/cirugía , Insuficiencia Velofaríngea/cirugía , Adolescente , Estudios de Casos y Controles , Niño , Femenino , Humanos , Masculino , Estudios Prospectivos , Resultado del Tratamiento
4.
J Craniofac Surg ; 28(2): 413-417, 2017 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-28033190

RESUMEN

Velopharyngeal insufficiency (VPI) is certainly one of the most important problems confronted after cleft palate repairs. In this study, it was aimed to evaluate the preoperative and postoperative speaking results of patients who underwent modified superior-based pharyngeal flap. Sixty-six children who underwent modified superiorly based pharyngeal flap for treatment of VPI between 2005 and 2013 were retrospectively reviewed. The study population was evaluated in 2 distinctive groups depending on their preoperative velopharyngeal closure pattern as: coronal closure pattern or noncoronal closure patterns (ie, circular, sagittal with or without the presence of a Passavant ridge). The speech outcome of the patients was evaluated using the objective assessment tools of nasopharyngoscopy and nasometer. Coronal closure pattern was determined in 24 patients (36.4%) and noncoronal closure pattern in 42 patients (63.6%). The mean follow-up period was 14.67 ±â€Š3.90 and 13.74 ±â€Š3.53 months in the coronal and noncoronal groups, respectively. The results demonstrated that the postoperative nasalance scores of all syllables except (m) and (n) were found to be significantly lower compared to those of the preoperative period (P < 0.001). However, no significant difference between the preoperative and postoperative results was observed in means of closure pattern. The surgical approach of modified superior-based pharyngeal flap for treatment of VPI appears to be effective regardless of the preoperatively determined closure pattern.


Asunto(s)
Fisura del Paladar/cirugía , Complicaciones Posoperatorias/cirugía , Colgajos Quirúrgicos , Insuficiencia Velofaríngea , Preescolar , Endoscopía , Femenino , Estudios de Seguimiento , Humanos , Lactante , Masculino , Procedimientos Quirúrgicos Orales/efectos adversos , Procedimientos Quirúrgicos Orales/métodos , Evaluación de Procesos y Resultados en Atención de Salud , Faringe/cirugía , Estudios Retrospectivos , Resultado del Tratamiento , Insuficiencia Velofaríngea/etiología , Insuficiencia Velofaríngea/cirugía , Esfínter Velofaríngeo/cirugía , Técnicas de Cierre de Heridas
5.
Eur J Orthod ; 39(4): 440-445, 2017 Aug 01.
Artículo en Inglés | MEDLINE | ID: mdl-27507127

RESUMEN

Objective: The aim of this study was to compare the effects of two retainer types (Essix and Hawley) on speech performance. Subjects and methods: The speech articulation of 30 patients was evaluated prospectively. Five patients did not appear during the follow-up periods. The patients were randomly divided into retention groups by treatment allocation cards as Essix and Hawley. The Essix group included 13 participants with a mean age of 15.3±2.4 years; the Hawley group included 12 participants with a mean age of 16.3±2.56 years. Speech sound assessments were performed on the first day and 1 week, 4 weeks, and 3 months later. On the first day, the assessments were conducted prior to inserting the retainers, immediately after maxillary and mandibular retainer application, individually, and with both retainers applied. The acoustic analyses were obtained using spectral and temporal parameters. Results: Statistical analyses were performed with IBM SPSS for Windows, version 20. A P value less than 0.05 was considered statistically significant. The most apparent changes were found in the [a] vowel in the Hawley group, the [e] vowel in the Essix group, and the [u] vowel in both groups (P < 0.05). While the number of affected consonant-vowel couples in the Essix group was low, alterations were common in the Hawley group. There was a statistically significant difference (P < 0.05) in voice onset time of the [d] sound between the groups. Limitations: The trial had a small sample size and a short follow-up period. Conclusions: The Hawley retainer affected articulatory movements in consonant-vowel combinations more prominently than the Essix retainer did. Voice onset time of the consonant [d] in the Hawley group was shorter than normal, indicating rapid articulatory movement in the alveolar region.


Asunto(s)
Retenedores Ortodóncicos/efectos adversos , Acústica del Lenguaje , Trastornos del Habla/etiología , Adolescente , Niño , Femenino , Humanos , Masculino , Mandíbula , Maxilar , Movimiento/fisiología , Diseño de Aparato Ortodóncico , Procesamiento de Señales Asistido por Computador , Habla/fisiología , Pruebas de Articulación del Habla , Trastornos del Habla/diagnóstico
6.
J Craniomaxillofac Surg ; 43(10): 2112-5, 2015 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-26545930

RESUMEN

PURPOSE: The aim of the study is to compare long term otoscopic and audiological findings of cleft palate patients with or without early grommet insertion. METHODS: Cleft palate patients followed-up in Hacettepe University between 2008 and 2013 were included in the study. Age, gender, cleft types and palate surgery data, grommet tube insertion history and otological - audiological evaluations of the patients were recorded. Patients were evaluated in three groups according to grommet insertion history: A-early routine grommet insertion, B-grommet insertion during follow-up, C-no grommet insertion. Otological and audiological findings were compared. RESULTS: There were 154 patients in the study, with a median age of 7.7 years. There were 67 patients in group A (43.5%), 22 patients in group B (14.3%) and 65 patients in group C (42.2%). OME was identified significantly higher in group A and normal otoscopic examination findings were higher in group C. Complications showed a higher rate than other otoscopic findings in group B patients. There was no significant difference for any frequencies in between the groups in terms of mean air-bone gap (ABG) values. There were 20 grade I, 25 grade II, 77 grade III and 32 grade IV patients in the study according to the Veau classification. CONCLUSION: Prophylactic grommet insertion may not be applied as some cleft palate patients with no OME. Wait and see protocol can be recommended for these patients, and they should be followed-up up closely to avoid complications. If the effusion does not recover or tympanic membrane changes occur in follow-up, grommet insertion should be considered.


Asunto(s)
Fisura del Paladar/complicaciones , Ventilación del Oído Medio/métodos , Otitis Media con Derrame/cirugía , Niño , Humanos
7.
Angle Orthod ; 82(1): 14-21, 2012 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-21761988

RESUMEN

OBJECTIVE: To assess (1) whether Hawley retainers cause speech disturbance and (2) the duration of speech adaptation to Hawley retainers with objective and subjective tests. MATERIALS AND METHODS: Twelve adolescents, aged 11.11 to 18.03 years, were included in this study. The assessment of speech sounds were done subjectively using an articulation test and objectively using acoustic analysis before and after Hawley retainer application. RESULTS: After wearing Hawley retainers, patients showed statistically significant speech disturbances on consonants [s] and [z]. Regarding the vowels, statistically significant changes were recorded with [i], while F1 increased and F2 and F3 decreased. CONCLUSIONS: The tongue changes its target position with the application of a foreign body within the mouth; however, in time it adapts to that new situation.


Asunto(s)
Trastornos de la Articulación/diagnóstico , Retenedores Ortodóncicos/efectos adversos , Pruebas de Articulación del Habla , Adaptación Fisiológica , Adolescente , Trastornos de la Articulación/etiología , Femenino , Humanos , Masculino
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA