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Trials ; 24(1): 70, 2023 Jan 31.
Artículo en Inglés | MEDLINE | ID: mdl-36721259


BACKGROUND: Prophylactic dressings are increasingly used to prevent pressure injuries in hospitalised patients. However, evidence regarding the effectiveness of these dressings is still emerging. This trial aims to determine the clinical and cost-effectiveness of a prophylactic silicone foam border dressing in preventing sacral pressure injuries in medical-surgical patients. METHODS: This is a multicentre, pragmatic, parallel group, randomised controlled trial. A sample size of 1320 was calculated to have >90% power to detect a 5% difference in the primary outcome at an alpha of 0.05. Adult patients admitted to participating medical-surgical wards are screened for eligibility: ≥18 years, admitted to hospital within the previous 36 h, expected length of stay of ≥24 h, and assessed high risk for hospital-acquired pressure injury. Consenting participants are randomly allocated to either prophylactic silicone foam dressing intervention or usual care without any dressing as the control group via a web-based randomisation service independent of the trial. Patients are enrolled across three Australian hospitals. The primary outcome is the cumulative incidence of patients who develop a sacral pressure injury. Secondary outcomes include the time to sacral pressure injury, incidence of severity (stage) of sacral pressure injury, cost-effectiveness of dressings, and process evaluation. Participant outcomes are assessed daily for up to 14 days by blinded independent outcome assessors using de-identified, digitally modified sacral photographs. Those who develop a sacral pressure injury are followed for an additional 14 days to estimate costs of pressure injury treatment. Analysis of clinical outcomes will be based on intention-to-treat, per-protocol, and sensitivity analyses. DISCUSSION: This trial aims to provide definitive evidence on the effect prophylactic dressings have on the development of hospital-acquired sacral pressure injuries in medical-surgical patients. A parallel economic evaluation of pressure injury prevention and treatment will enable evidence-informed decisions and policy. The inclusion of a process evaluation will help to explain the contextual factors that may have a bearing on trial results including the acceptability of the dressings to patients and staff. The trial commenced 5 March 2020 and has been significantly delayed due to COVID-19. TRIAL REGISTRATION: ANZCTR ACTRN12619000763145. Prospectively registered on 22 May 2019.

COVID-19 , Sordera , Úlcera por Presión , Adulto , Humanos , Úlcera por Presión/etiología , Úlcera por Presión/prevención & control , Australia , Vendajes , Siliconas
Clin Toxicol (Phila) ; 50(8): 781-7, 2012 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-22889059


CONTEXT: High volume surges in health care are uncommon and unpredictable events. Their impact on health system performance and capacity is difficult to study. OBJECTIVES: To identify time periods that exhibited very busy conditions at a poison control center and to determine whether cases and communication during high volume call periods are different from cases during low volume periods. METHODS: Call data from a US poison control center over twelve consecutive months was collected via a call logger and an electronic case database (Toxicall®).Variables evaluated for high call volume conditions were: (1) call duration; (2) number of cases; and (3) number of calls per staff member per 30 minute period. Statistical analyses identified peak periods as busier than 99% of all other 30 minute time periods and low volume periods as slower than 70% of all other 30 minute periods. Case and communication characteristics of high volume and low volume calls were compared using logistic regression. RESULTS: A total of 65,364 incoming calls occurred over 12 months. One hundred high call volume and 4885 low call volume 30 minute periods were identified. High volume periods were more common between 1500 and 2300 hours and during the winter months. Coded verbal communication data were evaluated for 42 high volume and 296 low volume calls. The mean (standard deviation) call length of these calls during high volume and low volume periods was 3 minutes 27 seconds (1 minute 46 seconds) and 3 minutes 57 seconds (2 minutes 11 seconds), respectively. Regression analyses revealed a trend for fewer overall verbal statements and fewer staff questions during peak periods, but no other significant differences for staff-caller communication behaviors were found. CONCLUSION: Peak activity for poison center call volume can be identified by statistical modeling. Calls during high volume periods were similar to low volume calls. Communication was more concise yet staff was able to maintain a good rapport with callers during busy call periods. This approach allows evaluation of poison exposure call characteristics and communication during high volume periods.

Comunicación , Modelos Estadísticos , Centros de Control de Intoxicaciones/estadística & datos numéricos , Teléfono/estadística & datos numéricos , Bases de Datos Factuales , Humanos , Modelos Logísticos , Centros de Control de Intoxicaciones/normas , Análisis de Regresión , Factores de Tiempo , Estados Unidos
Transplant Proc ; 37(8): 3262-3, 2005 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-16298566


Renal transplantation is established as the best form of renal replacement therapy, but demand for kidneys exceeds supply from cadaveric donations. It is therefore important to make the best use of the pool of potential cadaveric organ donors. Donation rates are to a large extent dependent on public opinions, which may be influenced by external events. In northeast England from 1986 to 2003, there was a potential pool of 1170 brain stem-dead donors, of whom 190 (16%) could not be retrieved due to relatives' objections. From 1998 to 2003 we were referred 90 potential non-heart-beating donors, of whom relatives refused donation in 10 (11%). A major reason for not retrieving organs from a potential donor has been lack of consent from the relatives. Refusals appear to vary year by year and are consistently lower for non-heart-beating donors. This therefore raises the possibility that negative or positive media publicity plays a role in this variation.

Donantes de Tejidos/estadística & datos numéricos , Actitud Frente a la Muerte , Inglaterra , Geografía , Humanos , Consentimiento Informado , Opinión Pública , Recolección de Tejidos y Órganos/estadística & datos numéricos
Clin Chim Acta ; 268(1-2): 85-99, 1997 Dec 10.
Artículo en Inglés | MEDLINE | ID: mdl-9495573


This study reports on the ability of myocrisin to mediate in the production and detoxification of oxidants (principally hydrogen peroxide) in the monocyte in-vivo and in-vitro. The hydrogen peroxide produced by the monocyte derived from rheumatoid arthritis patients being treated with myocrisin was found to be 14.9 +/- 1.6 nmoles/10(6) cells and is elevated above levels found in monocytes obtained from patients either being treated with non-steroidal anti-inflammatory drugs (NSAIDs) (11.3 +/- 0.4 nmoles/10(6) cells; P < 0.01) or normal healthy volunteers (11.2 +/- 1.2 nmoles/10(6) cells; P < 0.01). A comparative study on glutathione (GSH) oxidation indicated that levels of monocyte GSH were elevated in myocrisin-treated patients (2.4 +/- 0.49 mmol/l) over normal healthy volunteers (0.83 +/- 0.18 mM; P < 0.01) and that levels of monocyte diglutathione (GSSG) were depressed (myocrisin, 0.97 +/- 0.41 micromol/l; normal, 5.71 +/- 0.73 micromol/l; P < 0.01). The non-inhibition of glutathione reductase and the inhibition of glutathione peroxidase by gold provides the link between these two observations. Thus, gold therapy would seem to elevate monocyte hydrogen peroxide, increase monocyte reduced glutathione and decrease plasma glutathione peroxidase activity. Subsequently, the data from this small group of patients (n = 10) provides an indication that, in-vivo, myocrisin contributes to an increase in oxidative stress.

Antirreumáticos/farmacología , Artritis Reumatoide/sangre , Tiomalato Sódico de Oro/farmacología , Estrés Oxidativo , Antiinflamatorios no Esteroideos/uso terapéutico , Antirreumáticos/uso terapéutico , Artritis Reumatoide/tratamiento farmacológico , Femenino , Glutatión/sangre , Glutatión Peroxidasa/antagonistas & inhibidores , Tiomalato Sódico de Oro/uso terapéutico , Humanos , Peróxido de Hidrógeno/metabolismo , Persona de Mediana Edad , Monocitos/metabolismo
Hospitals ; 66(4): 42-3, 45-9, 51, 1992 Feb 20.
Artículo en Inglés | MEDLINE | ID: mdl-1735546


While construction budgets appear to be tighter in the wake of Medicare's fold-in of inpatient capital payment, hospitals are going ahead with ambitious plans for expansion and renovation. But construction planning is increasingly becoming more interwined with overall strategic planning.

Necesidades y Demandas de Servicios de Salud , Arquitectura y Construcción de Hospitales/tendencias , Planificación Hospitalaria/normas , Recolección de Datos , Diseño Interior y Mobiliario , Servicio Ambulatorio en Hospital , Técnicas de Planificación , Estados Unidos