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1.
Clin Oral Investig ; 2021 Jan 07.
Artículo en Inglés | MEDLINE | ID: mdl-33409696

RESUMEN

OBJECTIVE: A systematic review and meta-analysis was carried out to verify evidence regarding the efficacy and safety of the clinical applicability of natural products in the prevention and treatment of oral mucositis induced by chemotherapy and/or radiotherapy. METHODOLOGY: An electronic research according to the PICOS strategy, using the terms "natural products" and "oral mucositis," was carried out at Pubmed, Cochrane, Embase, and "gray literature." The stages of eligibility, data extraction, and quality assessment of the studies were carried out independently and in duplicate. RESULTS: The number of studies identified as eligible was 151, including 47 randomized controlled trials, reporting a total of 3075 participants undergoing some therapy with natural products on oral mucositis. The included clinical trials covered a variety of 31 types of natural products. Considering the risk of bias of the clinical trials, 24 studies (51.1%) were considered to have a low overall risk of bias, nine (19.1%) were at moderate risk, and 14 clinical trials (29.8%) were at high risk of bias. Honey was the most assessed natural agent. Fourteen studies (3.4%) reported that natural agents reduced pain. CONCLUSION: The results of the meta-analysis support a positive effect of honey and Aloe vera in reducing mucositis in patients receiving cancer therapy. CLINICAL RELEVANCE: The results found add relevant information to the scientific community regarding the prevention and treatment of mucositis. Graphical abstract.

2.
Med. oral patol. oral cir. bucal (Internet) ; 26(1): e14-e20, ene. 2021. tab
Artículo en Inglés | IBECS-Express | IBECS | ID: ibc-ET6-1980

RESUMEN

BACKGROUND: Head and neck radiotherapy is typically associated with toxicities that can have profound effects on the patient's quality of life. Xerostomia, which may or may not be related to hypofunction of the salivary gland, leading to negative consequences, mainly in quality of life, leaving patients more susceptible to the development of oral mucositis, dental caries, oral infection and difficulties in speech is one of the most common side effects of such treatment. The aim of the present study was to evaluate salivary function of patients in treatment with radiotherapy for head and neck cancer submitted to photobiomodulation. MATERIAL AND METHODS: A cross-sectional study with a quantitative approach was carried out in the Dentistry Department of the Hospital de Câncer de Pernambuco between February and September 2019. RESULTS: The study sample comprised 23 patients of both genders, treated with radiotherapy for cancer in the head and neck region. The patients were submitted to photobiomodulation with infrared laser, as intraoral applications in order to prevent mucositis and extraoral applications to stimulate salivary glands. The applications were undertaken three times a week on alternate days throughout the radiotherapy period. The following parameters were used: Intraoral 15mW, 12J / cm2, 10s / point, 2.4 J / point, and extraoral 30mW, 7.5J / cm2, 10s / point, 0.3J / point, both with a wavelength of 830nm and area of 0.028cm². Subjective and objective symptoms were evaluated by measuring the unstimulated salivary flow (USF) using the spitting technique before, during and after radiotherapy treatment. For statistical analysis, a significance level of 5% was adopted. Most patients were male (70%) with 60 years of age on average. At the beginning of treatment, 22 patients had USF > 0.2 ml / min (grade 1), at the end of which 15 patients remained unchanged and only 3 patients progressed to grade 3. As for the subjective classification, most (52%) remained in grade 1 (absence of disability) throughout the treatment. CONCLUSION: Based upon the results of this study it was possible to conclude that the use of photobiomodulation did not significantly interfere with the xerostomia complaint of patients in treatment with radiotherapy, however, it does seem to prevent patients from reaching higher degrees of xerostomia taking into account salivary flow measures


No disponible

4.
Support Care Cancer ; 2020 Oct 27.
Artículo en Inglés | MEDLINE | ID: mdl-33106977

RESUMEN

BACKGROUND: The aim of the present study was to evaluate the efficacy of pentoxifylline and tocopherol for the management of osteoradionecrosis of the jaws. METHODS: Twenty-five patients diagnosed with osteoradionecrosis of the jaws treated with pentoxifylline 400 mg + tocopherol 400 mg three times daily (tid) were evaluated. Clinical records and image tests were reviewed. All patients were previously submitted to head and neck radiation therapy and presented with a clinical and radiographic diagnosis of osteoradionecrosis of the jaws. RESULTS: Following therapy with pentoxifylline and tocopherol, 76% (19/25) of the patients showed complete mucosal healing, in which 47.3% (9/19) did not undergo sequestrectomy. From this particular group, 77.7% (7/9) were in stage I and 33.3% (3/9) used the protocol for up to 3 months. Among those who underwent to sequestrectomy, complete mucosal healing was observed in 52.7% (10/19). Among these, 60% (6/10) were in stage I and 100% of the patients were using the protocol for more than 3 months. In all other patients, partial healing of the mucosa was observed since they presented advanced disease. These represented 24% of the sample (6/25), 66.6% (4/6) were in stage III, and 60% (4/6) used the protocol for over 6 months. CONCLUSION: Pentoxifylline and tocopherol may provide effective management of osteoradionecrosis of the jaws, and the association with sequestrectomy may avoid major surgical procedures.

6.
Support Care Cancer ; 2020 Jul 09.
Artículo en Inglés | MEDLINE | ID: mdl-32642953

RESUMEN

OBJECTIVE: The aim of this study was to evaluate the efficacy of photobiomodulation therapy (PBMT) on the mucosal healing of patients submitted to simple dental extractions after head and neck radiation therapy (HNRT). METHODS: Forty surgical procedures were randomly assigned into two groups: G1: dental extraction + PBMT (n = 19) and G2: dental extraction + sham-PBMT (n = 21). All patients received antibiotic therapy and the surgical alveolotomy to promote primary closure of the surgical site. Group 1 was submitted to PMBT according to the following parameters: 808 nm, 40 mW, 100 J/cm2, 70 s, 2.8 J/point, 14 J/session, and area of 0.028cm2. The primary outcome was complete mucosal lining at 14 days, and the secondary outcomes were the presence of infection, postoperative pain, and analgesics intake at 7 days. The patients were evaluated every 7 days until 28 days. RESULTS: Alveolar mucosal lining was faster in G1, and at 14 postoperative days, 94.7% patients evolved with complete alveolar mucosal lining compared to no patient from G2 (p < 0.001). Patients from G1 reported postoperative pain less frequently (G1 = 4, 21.1% × G2 = 14, 66.7%, p = 0.005), and also reported lower intake of analgesic pills at D7 (21.1% × 66.7%, p = 0.005%). PBMT had a significant positive impact on both postoperative pain (NNT = 2.192, CI95% = 1.372-5.445) and mucosal healing (NNT = 1.056, CI95% = 0.954-1.181). CONCLUSIONS: This preliminary study strongly supports the use of PMBT to promote surgical alveolar mucosal lining in a shorter time and with less postoperative pain.

7.
Med. oral patol. oral cir. bucal (Internet) ; 25(4): e541-e548, jul. 2020. tab, graf
Artículo en Inglés | IBECS | ID: ibc-196508

RESUMEN

BACKGROUND: Oral rehabilitation of atrophic maxillae features high complexity, for which there are several therapeutic modalities reported on scientific literature. Zygomatic implant placement is a viable option that features low morbidity and allows immediate prosthetic loading. The purpose of the present study was to determine the methodological quality of systematic reviews that assessed the effectiveness of zygomatic implants placed in atrophic maxillae. MATERIAL AND METHODS: Searches were conducted on Medline via Pubmed, LILACS, Dare Cochrane, Scopus, and Sigle via Open Grey up to June 2019. RESULTS: Seven systematic reviews were eligible for Overview and comprised a total of 2313 patients, 4812 zygomatic implants, and a 96,72% success rate. Common surgical complications, in decreasing order, were: maxillary sinusitis, peri-implant mucositis, prosthetic fracture, and infections. Methodological quality was assessed using the AMSTAR 2 tool, which revealed that six systematic reviews showed critically low methodological quality and one review was assessed as of low methodological quality. CONCLUSIONS: Zygomatic implants seem to be an adequate option for atrophic maxilla rehabilitation, however, new studies with a higher methodological rigor are needed to provide more reliable results to professionals and patients undergoing this modality of oral rehabilitation


No disponible


Asunto(s)
Humanos , Revisiones Sistemáticas como Asunto , Implantación Dental Endoósea/métodos , Cigoma/cirugía , Enfermedades Maxilares/cirugía , Resultado del Tratamiento
8.
Oral Dis ; 2020 May 31.
Artículo en Inglés | MEDLINE | ID: mdl-32475006

RESUMEN

Coronaviridae is a family of single-stranded positive enveloped RNA viruses. This article aimed to review the history of these viruses in the last 60 years since their discovery to understand what lessons can be learned from the past. A review of the PubMed database was carried out, describing taxonomy, classification, virology, genetic recombination, host adaptation, and main symptoms related to each type of virus. SARS-CoV-2 is responsible for the ongoing global pandemic, and SARS-CoV and MERS-CoV were responsible for causing severe respiratory illness and regional epidemics in the past while the four other strains of CoVs (229-E OC43, NL63, and HKU1) circulate worldwide and normally only cause mild upper respiratory tract infections. Given the enormous diversity of coronavirus viruses in wildlife and their continuous evolution and adaptation to humans, future outbreaks would undoubtedly occur. Restricting or banning all trade in wild animals in wet markets would be a necessary measure to reduce future zoonotic infections.

11.
Einstein (Sao Paulo) ; 18: eAO4978, 2020.
Artículo en Portugués, Inglés | MEDLINE | ID: mdl-32428062

RESUMEN

Objective To determine the prevalence of syphilis and the associated risk factors in a female prison unit. Methods This was a cross-sectional study including 113 women whom data were collected in two stages: first, blood test to check for syphilis seropositivity; and then collection of information through a form to assess risk situations for sexually transmitted infections. Results Overall, syphilis prevalence was found to be 22.1% among the female prison population (n=25) and 28.6% among pregnant women. A statistically significant relationship was found between syphilis infection and previous history of sexually transmitted infections (p=0.04). However, most participants diagnosed with the disease were unaware of a history of sexually transmitted infection in the last 12 months (n=20/80.0%). The use of condom with fixed partners was considered to be a protective factor (odds ratio of 0.76; 95% of confidence interval 0.68-0.85). Conclusion The prevalence of syphilis among the female prison population was high, particularly among pregnant women. Preventive and therapeutic measures as well as appropriate prenatal care can minimize the impact of syphilis in prison systems and, consequently, improve such health outcomes nationwide.


Asunto(s)
Sífilis/epidemiología , Adolescente , Adulto , Brasil/epidemiología , Condones/estadística & datos numéricos , Estudios Transversales , Femenino , Humanos , Persona de Mediana Edad , Prevalencia , Factores de Riesgo , Sífilis/prevención & control , Adulto Joven
12.
J Oral Pathol Med ; 49(7): 693-700, 2020 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-32428250

RESUMEN

INTRODUCTION: The role of viral infections in the pathogenesis of autoimmune diseases has long been suggested, but little evidence is available. OBJECTIVE: This study aimed to evaluate an association between EBV and CMV and the presence of rheumatoid arthritis and its association with Sjögren's Syndrome. PATIENTS AND METHOD: A case-control study was performed with 227 patients divided in RA (n = 99), RA/SS (n = 20), and C (n = 128). Resting salivary flow rate and Schirmer's test were performed; minor salivary gland biopsy was indicated in the case of suspected Sjögren's syndrome. CMV and EBV viral loads were quantified in peripheral blood, and their presence in glandular tissue samples was evaluated by in situ hybridization (EBV) and immunohistochemistry (CMV). RESULTS: EBV was more frequent in RA and RA/SS than in C (P < .000007). No correlation with clinical markers (P > .05) or between RA and RA/SS was found (P > .05). A higher number of EBV/DNA copies were found in RA (158.52 copies/µL) and RA/SS (99.24 copies/µL) (P = .739). EBV/DNA was associated with the Schirmer test (P = .0231). CMV was detected in one patient of the RA group. None of the viruses were detected in biopsies of minor salivary glands. CONCLUSIONS: Detection of EBV/DNA in peripheral blood was associated with RA regardless of the presence of SS.


Asunto(s)
Artritis Reumatoide/virología , Infecciones por Citomegalovirus/complicaciones , Infecciones por Virus de Epstein-Barr/complicaciones , Síndrome de Sjögren/virología , Carga Viral , Artritis Reumatoide/complicaciones , Estudios de Casos y Controles , ADN Viral/sangre , Herpesvirus Humano 4 , Humanos , Síndrome de Sjögren/complicaciones
13.
Oral Dis ; 26(2): 457-464, 2020 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-31742839

RESUMEN

OBJECTIVE: To describe oral alterations in children with congenital Zika syndrome (CZS). METHODS: This was a case series, whose research instrument was a structured questionnaire, associated with the use of medical record data and extra and intraoral clinical examination. RESULTS: Thirty-two children were evaluated, the majority male (18/32%-56.3%), mean age 22 months (SD = 2.71). It was also observed that the majority of the patients (19/32%-59.4%) presented a low family income. All the children had a mean head circumference of 29.43 cm (SD = 1.42). Regarding the alterations, an ogival-shaped palate was observed in 14 children (43.7%), and delayed chronology of eruption was observed in 15 children (46.9%), of whom 7 children (21.9%) did not present eruption of the upper left lateral incisor (p = .0002) and upper right lateral incisor (p = .002) until the moment of analysis. Additionally, 03 children with yellowish dental pigmentation were identified in erupted teeth after the onset of phenobarbital use. Enamel hypoplasia was identified in 9 children (28.1%) and only one child with ankyloglossia. CONCLUSION: CZS may present delayed chronology of eruption, ankyloglossia, ogival-shaped palate, and enamel hypoplasia, requiring dental follow-up aimed at prevention, promotion, and rehabilitation of the health of these children.


Asunto(s)
Hipoplasia del Esmalte Dental/virología , Anomalías Dentarias/virología , Erupción Dental , Infección por el Virus Zika/complicaciones , Humanos , Incisivo/patología , Lactante , Masculino , Virus Zika
14.
Einstein (Säo Paulo) ; 18: eAO4978, 2020. tab
Artículo en Inglés | LILACS-Express | LILACS | ID: biblio-1133734

RESUMEN

ABSTRACT Objective To determine the prevalence of syphilis and the associated risk factors in a female prison unit. Methods This was a cross-sectional study including 113 women whom data were collected in two stages: first, blood test to check for syphilis seropositivity; and then collection of information through a form to assess risk situations for sexually transmitted infections. Results Overall, syphilis prevalence was found to be 22.1% among the female prison population (n=25) and 28.6% among pregnant women. A statistically significant relationship was found between syphilis infection and previous history of sexually transmitted infections (p=0.04). However, most participants diagnosed with the disease were unaware of a history of sexually transmitted infection in the last 12 months (n=20/80.0%). The use of condom with fixed partners was considered to be a protective factor (odds ratio of 0.76; 95% of confidence interval 0.68-0.85). Conclusion The prevalence of syphilis among the female prison population was high, particularly among pregnant women. Preventive and therapeutic measures as well as appropriate prenatal care can minimize the impact of syphilis in prison systems and, consequently, improve such health outcomes nationwide.


RESUMO Objetivo Determinar a prevalência de sífilis e fatores de risco associados no sistema prisional feminino. Métodos Foi realizado estudo transversal com 113 mulheres. A coleta de dados ocorreu em duas etapas: a primeira etapa correspondeu à coleta de sangue para verificar a soropositividade à sífilis e a segunda a um formulário para avaliar situações de risco para infecções sexualmente transmissíveis. Resultados A prevalência da doença foi de 22,1% (n=25). Quanto às gestantes, identificou-se prevalência de 28,6%. Foi verificada relação estatisticamente significativa entre a infecção pela sífilis e a história prévia de infecções sexualmente transmissíveis (p=0,04). Entretanto, a maioria das participantes diagnosticadas com a doença desconhecia um histórico de infecção sexualmente transmissível nos últimos 12 meses (n=20/80,0%). O uso de preservativo com parceiros fixos foi considerado fator de proteção (odds ratio de 0,76; intervalo de confiança de 95% de 0,68-0,85). Conclusão Foi alta a prevalência de sífilis na população carcerária feminina estudada, principalmente entre as gestantes. Medidas preventivas e de tratamento da doença, bem como cuidados pré-natais adequados, podem minimizar o impacto da sífilis nos sistemas prisionais e, consequentemente, melhorar esse indicador de saúde no país.

15.
Med. oral patol. oral cir. bucal (Internet) ; 24(6): e770-e775, nov. 2019. tab, graf
Artículo en Inglés | IBECS | ID: ibc-192238

RESUMEN

BACKGROUND: The aim of the present work was to evaluate the impact of xerostomia on the quality of life of patients who underwent radiotherapy in the head and neck region. MATERIAL AND METHODS: This was a cross-sectional, quantitative study. The sample comprised 40 patients whose xerostomia was classified through the xerostomia inventory and the quality of life evaluated through the oral health impact profile questionnaire (OHIP). RESULTS: The majority of participants were male (75%), mean age 58.7 years. According to the degree of severity of the xerostomia, the average score among the participants was 36 points, this being considered moderate xerostomia. A significant impact was observed, with the median score 11 points, with the highest scores in the domains related to functional limitation, physical pain and physical disability. The majority of the participants (97.5%) had reduced salivary flow after the end of radiotherapy. There was a significant positive correlation between the degree of xerostomia and reduced quality of life, Pearson correlation 0.5421, (p < 0.05). CONCLUSION: Based upon the results it is concluded that xerostomia has a negative impact on the quality of life of patients who undergo radiotherapy in the head and neck region


No disponible


Asunto(s)
Humanos , Masculino , Femenino , Persona de Mediana Edad , Anciano , Neoplasias de Cabeza y Cuello/radioterapia , Radioterapia/efectos adversos , Xerostomía/psicología , Xerostomía/etiología , Calidad de Vida , Índice de Severidad de la Enfermedad , Encuestas y Cuestionarios , Estudios Transversales
16.
J. health sci. (Londrina) ; 21(3): https://seer.pgsskroton.com/index.php/JHealthSci/article/view/6441, 24/09/2019.
Artículo en Inglés | LILACS-Express | LILACS | ID: biblio-1051484

RESUMEN

Men and women seem to have different susceptibilities to disease and dissimilar responses to pain. These differences are not well understood. Understanding those variations between men and women from the perspective of gender identity can contribute to disparities observed in the health field. Since 1980, efforts have been made to develop instruments that can help to categorize individuals according to their own gender perception. One of these, recently developed, is the Traditional Masculinity and Femininity Scale (TMFs). The advantage of this scale is to allow the gender self-identification without the need for attributes. The aim of this study is to present the process of cross-cultural adaptation of the TMFs for applicability in studies in the Brazilian population. The cross-cultural adaptation followed the steps: 1) authorization by the authors; 2) initial translation into Portuguese; 3) cultural, conceptual, experimental and idiomatic adaptation to the target population; 4) retroversion; 5) assessment by a revision committee; and 6) pretest. The equivalence of measurement, corresponding to the psychometric properties to a gold standard, is in progress. In conclusion, the original version of the TMF scale, having been translated, culturally adapted, and validated into Brazilian Portuguese has proven to be a reliable instrument that is easy to use, and can be used in both clinical practice and clinical trials in the evaluation of gender identity. (AU)


Homens e mulheres parecem ter diferentes suscetibilidades às doenças e respostas diferentes à dor. Essas disparidades não são bem compreendidas. A compreensão dessas variações entre homens e mulheres na perspectiva da identidade de gênero pode contribuir para as disparidades observadas no campo da saúde. Desde a década de 1980, esforços têm sido feitos para desenvolver instrumentos que possam ajudar a categorizar os indivíduos de acordo com sua própria percepção de gênero. Uma delas, recentemente desenvolvida, é a Escala de Masculinidade e Feminilidade Tradicionais (TMFs). A vantagem desta escala é permitir a auto identificação do gênero sem a necessidade de atributos. O objetivo deste estudo é apresentar o processo de adaptação transcultural dos TMFs para aplicabilidade em estudos na população brasileira. A adaptação transcultural seguiu os passos: 1) autorização dos autores; 2) tradução inicial para o português; 3) adaptação cultural, conceitual, experimental e idiomática à população-alvo; 4) retroversão; 5) avaliação por um comitê de revisão; e 6) pré-teste. A equivalência de medida, correspondente às propriedades psicométricas de um padrão-ouro, está em andamento. Em conclusão, a versão original da escala TMF, traduzida, adaptada culturalmente e validada para o português brasileiro, mostrou-se um instrumento confiável e de fácil utilização, podendo ser utilizada tanto na prática clínica quanto nas pesquisas para a avaliação da identidade de gênero. (AU)

17.
Oral Dis ; 25(8): 1995-2002, 2019 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-31407451

RESUMEN

OBJECTIVE: The aim of this study was to evaluate the orofacial parameters of systemic sclerosis (SSc) and its related systemic features. SUBJECTS AND METHODS: A descriptive case-control study was performed from November 2015 to October 2016. Ninety-three individuals were included and divided into SSc group (n = 50) and healthy controls (C, n = 43). RESULTS: Systemic sclerosis individuals were mostly women (43/50, 86%), with a mean age of 46 years (±11.6 years). Telangiectasia (42/50, 84%) and reduced mouth opening (35/50, 70%) were the most frequent orofacial findings. The periodontitis frequency was much higher in SSc individuals than in healthy controls (90.7% × 48.83%; p < .001). In addition, SSc individuals presented a distinctive pattern of periodontitis, with low probing pocket depth (2 ± 0.65 mm × 2 ± 0.24; p < .001), higher gingival recession (4 ± 2.13 × 0.14 ± 0,22; p < .001), higher periodontal attachment loss (6 ± 1.34 mm × 2 ± 0.43, p < .001), and lower gingival bleeding index values (7.05 ± 7.25 × 21.57 ± 15.66; p < .001). CONCLUSIONS: Orofacial manifestations were common in SSc and included a unique pattern of periodontal manifestation, characterized by lower gingival bleeding index, higher periodontal attachment loss, and low probing depth.


Asunto(s)
Hemorragia Gingival/epidemiología , Pérdida de la Inserción Periodontal , Enfermedades Periodontales/epidemiología , Periodontitis/epidemiología , Esclerodermia Sistémica/complicaciones , Xerostomía/epidemiología , Adulto , Anciano , Brasil/epidemiología , Estudios de Casos y Controles , Índice de Placa Dental , Femenino , Estado de Salud , Humanos , Masculino , Persona de Mediana Edad , Enfermedades Periodontales/complicaciones , Enfermedades Periodontales/diagnóstico , Esclerodermia Sistémica/epidemiología
18.
Braz J Microbiol ; 50(3): 663-668, 2019 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-31001794

RESUMEN

Polymorphisms in the structural gene MBL-2 (mannose-binding lectin-2) may result in low MBL serum concentration, associated with greater susceptibility to infection. The study evaluated the effects of MBL-2 polymorphisms with the oral manifestations of the HSV in human immunodeficiency virus (HIV)-infected patients. An observational case-control study was carried out, with the sample comprising 64 HIV+ and 65 healthy individuals. The signs and symptoms of HSV oral infection were evaluated, and oral mucosa buccal smears were collected. Polymorphisms of the MBL-2 gene and HSV-1 DNA were amplified through real-time PCR. The data revealed that of 64 HIV+, 29.6% presented signs and symptoms of HSV oral infection. Of these, the HSV-1 DNA was detected through real-time PCR in 21% of cases, and in 13.3% of asymptomatic individuals. There was no statistically significant difference between the symptomatic (p = 1) and the asymptomatic (p = 0.52) individuals, HIV+ and HIV-. Different genotypes (AA, A0, or 00) did not contribute to the oral manifestation of HSV in the HIV+ patients (p = 0.81) or HIV- (p = 0.45). There was no statistically significant difference in either group (p = 0.52). No significant association was identified between the MBL-2 gene polymorphisms in the oral manifestation of HSV infection. However, further studies are recommended with larger population groups before discarding this interrelationship.


Asunto(s)
Infecciones por VIH/complicaciones , Herpes Simple/genética , Herpesvirus Humano 1/fisiología , Lectina de Unión a Manosa/genética , Boca/virología , Polimorfismo de Nucleótido Simple , Adolescente , Adulto , Estudios de Casos y Controles , Femenino , Predisposición Genética a la Enfermedad , Genotipo , Infecciones por VIH/genética , VIH-1/genética , VIH-1/aislamiento & purificación , VIH-1/fisiología , Herpes Simple/etiología , Herpes Simple/virología , Herpesvirus Humano 1/genética , Herpesvirus Humano 1/aislamiento & purificación , Humanos , Masculino , Persona de Mediana Edad , Adulto Joven
19.
Braz Dent J ; 30(2): 146-151, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-30970057

RESUMEN

The present study was to investigate the action of a toothpaste made from the extract of Rosmarinus officinalis Linn. (rosemary) in a clinical randomized, controlled, open and double-blind trial. One hundred and ten volunteers fulfilled the inclusion criteria and were randomly separated into two groups according to the toothpastes used: Group A (experimental) and Group B (control). They were assessed at baseline and 30 days after the study using the gingival bleeding index (GBI) and the plaque index (PI). Data analysis was conducted to calculate the effects of the two toothpastes on gingival bleeding and plaque, using measurements such as the excess relative risk (ERR), the Relative Risk Reduction (RRR), the Absolute Risk Reduction (ARR) and the Number Needed for Treatment (NNT). The two toothpastes provided similar results in terms of the reduction in the risk of gingival bleeding (relative and absolute): a reduction of 38% in Group A, ERR=0.38; a reduction of 29.3% in Group B, ERR=0.293; A and B reduced by 18% ARR=0.18). The reductions in bacterial plaque were also similar (22.7% reduction in Group A, RRR=0.227; 28% reduction in Group B, RRR= 0.28). The number needed for treatment values for bleeding and plaque were A and B NNT=5 and A and B NNT=7, respectively. The rosemary-based toothpaste effectively treated gingival bleeding and reduced bacterial plaque, when compared with conventional toothpaste.


Asunto(s)
Gingivitis , Rosmarinus , Pastas de Dientes , Índice de Placa Dental , Método Doble Ciego , Humanos
20.
Braz. dent. j ; 30(2): 146-151, Mar.-Apr. 2019. tab, graf
Artículo en Inglés | LILACS-Express | LILACS | ID: biblio-1001432

RESUMEN

Abstract The present study was to investigate the action of a toothpaste made from the extract of Rosmarinus officinalis Linn. (rosemary) in a clinical randomized, controlled, open and double-blind trial. One hundred and ten volunteers fulfilled the inclusion criteria and were randomly separated into two groups according to the toothpastes used: Group A (experimental) and Group B (control). They were assessed at baseline and 30 days after the study using the gingival bleeding index (GBI) and the plaque index (PI). Data analysis was conducted to calculate the effects of the two toothpastes on gingival bleeding and plaque, using measurements such as the excess relative risk (ERR), the Relative Risk Reduction (RRR), the Absolute Risk Reduction (ARR) and the Number Needed for Treatment (NNT). The two toothpastes provided similar results in terms of the reduction in the risk of gingival bleeding (relative and absolute): a reduction of 38% in Group A, ERR=0.38; a reduction of 29.3% in Group B, ERR=0.293; A and B reduced by 18% ARR=0.18). The reductions in bacterial plaque were also similar (22.7% reduction in Group A, RRR=0.227; 28% reduction in Group B, RRR= 0.28). The number needed for treatment values for bleeding and plaque were A and B NNT=5 and A and B NNT=7, respectively. The rosemary-based toothpaste effectively treated gingival bleeding and reduced bacterial plaque, when compared with conventional toothpaste.


Resumo O presente estudo investigou a ação de uma pasta de dente feita a partir do extrato de Rosmarinus officinalis Linn. (Alecrim) em um ensaio clínico randomizado, controlado, aberto e duplo-cego. Cento e dez voluntários preencheram os critérios de inclusão e foram separados aleatoriamente em dois grupos de acordo com as pastas usadas: Grupo A (experimental) e Grupo B (controle). Eles foram avaliados no início e 30 dias após o estudo usando o índice de sangramento gengival (GBI) e o índice de placa (PI). A análise dos dados foi realizada para calcular os efeitos das duas pastas dentárias sobre sangramento gengival e placa, usando medidas como o excesso de risco relativo (ERR), a Redução do Risco Relativo (RRR), a Redução do Risco Absoluto (ARR) e o Número Necessário para Tratamento (NNT). As duas pastas de dentes proporcionaram resultados semelhantes em termos de redução do risco de sangramento gengival (relativo e absoluto): redução de 38% no Grupo A, ERR=0,38; Uma redução de 29,3% no Grupo B, ERR=0,293; A e B reduziram-se em 18% ARR=0,18). As reduções na placa bacteriana também foram semelhantes (redução de 22,7% no Grupo A, RRR=0,227, redução de 28% no Grupo B, RRR=0,28). O número necessário para tratamento de sangramento e placa foi A e B NNT=5 e A e B NNT=7, respectivamente. A pasta de dente à base de alecrim tratou efetivamente o sangramento gengival e reduziu a placa bacteriana, quando comparada à pasta dentífrica convencional.

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