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1.
J Craniomaxillofac Surg ; 48(6): 555-559, 2020 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-32317138

RESUMEN

OBJECTIVE: To determine weight gain during treatment with the modified palatal plate (MPP) in infants with isolated and syndromic Pierre Robin Sequence (PRS) suffering from micrognathia, upper airway obstruction (UAO), and failure to thrive (FTT), the authors conducted a retrospective study of infants treated with the MPP. METHODS: The main outcome measure was infant weight (g) for up to three months after birth. Demographic and outcome data (associated syndromes, comorbidities, presence of cleft lip or palate, intubation attempts, tracheotomy and cleft repair) were collected. RESULTS: 14 children born January 2010 - December 2019 were included. The majority (86%) of infants showed highly significant weight gain (p < 0.001) within a 3-month period (mean pretreatment weight 3147 g with a SD of 425 g vs mean weight at three months 4435 g with a SD of 635 g). Syndromic PRS was found in 7% of infants. 43% of nonsyndromic PRS patients were found to have other congenital anomalies. Genetic testing showed normal karyotypes in 93% of infants and a microdeletion in 7% of infants. 21% of infants required tracheotomy, but no patients required mandibular distraction (MDO) or tongue-lip adhesion (TLA) to relieve UAO. CONCLUSION: PRS infants treated with the MPP showed highly significant weight gain within a 3-month period and did not require mandibular surgery for early airway management, but faster gain of weight might have implications for strategies to perform surgery at an earlier point in time.

2.
Swiss Dent J ; 128(9): 712-713, 2018 Sep 10.
Artículo en Francés, Alemán | MEDLINE | ID: mdl-30196691

RESUMEN

Platelet-rich fibrin (PRF) is a blood concentrate system derived from human peripheral blood. A solid and a liquid PRF-based matrix can be obtained by centrifugation in accordance with specific centrifugation protocols without the addition of anticoagulants or external chemicals. In dentistry, oral- and cranio-maxillo-facial surgery, PRF-based matrices are used on different subjects. The healing benefits of platelet-rich preparations together with the low risk profile and disposability of a simple preparation procedure should encourage more clinicians to incorporate PRF as a treatment option in their practice to accelerate healing, reduce adverse events, and improve patient outcomes.


Asunto(s)
Odontología , Fibrina Rica en Plaquetas , Flujo de Trabajo , Plaquetas , Humanos , Péptidos y Proteínas de Señalización Intercelular
3.
J Craniomaxillofac Surg ; 46(9): 1679-1690, 2018 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-30041850

RESUMEN

The innovative TriLock Bridging Plate System (Medartis AG, Switzerland) was developed to reduce common complications related to conventional mandibular reconstruction plates. The novelties regarding the plating system concern the cross-strut structure in the centerpiece, the bendable side elements and the reduction of the plate's thickness to 2.0 mm 4 different models are available, which cover lateral and central segmental mandibular defects. The plating system has only been introduced at selected maxillofacial units so far and clinical assessment is still lacking. Thus, the aim of the study was to analyze the novel Bridging Plate system in terms of its clinical applicability, rate of trimming and postoperative outcomes in a first investigation over 6 months. The study includes 25 patients with segmental mandibular resection, who underwent reconstruction with TriLock Bridging Plates. According to the assessment parameters, excellent clinical applicability was stated in 48%. The overall trimming rate was found to be 88%. Mostly adaptions to the distal bendable elements of lateral plates were performed. The occurrence of postoperative complications was 16%. Plate fracture occurred in 4%. With reference to the results, the novel plating system represents a viable method for segmental mandibular reconstruction, however, further evaluation is needed, for a more detailed analyzation.


Asunto(s)
Placas Óseas , Prótesis Mandibular , Reconstrucción Mandibular/instrumentación , Diseño de Prótesis , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Persona de Mediana Edad , Complicaciones Posoperatorias , Falla de Prótesis , Estudios Retrospectivos , Resultado del Tratamiento
4.
PLoS One ; 13(1): e0190183, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-29346397

RESUMEN

Localization microscopy has shown to be capable of systematic investigations on the arrangement and counting of cellular uptake of gold nanoparticles (GNP) with nanometer resolution. In this article, we show that the application of specially modified RNA targeting gold nanoparticles ("SmartFlares") can result in ring like shaped GNP arrangements around the cell nucleus. Transmission electron microscopy revealed GNP accumulation in vicinity to the intracellular membrane structures including them of the endoplasmatic reticulum. A quantification of the radio therapeutic dose enhancement as a proof of principle was conducted with γH2AX foci analysis: The application of both-SmartFlares and unmodified GNPs-lead to a significant dose enhancement with a factor of up to 1.2 times the dose deposition compared to non-treated breast cancer cells. This enhancement effect was even more pronounced for SmartFlares. Furthermore, it was shown that a magnetic field of 1 Tesla simultaneously applied during irradiation has no detectable influence on neither the structure nor the dose enhancement dealt by gold nanoparticles.


Asunto(s)
Neoplasias de la Mama/patología , Oro/química , Nanopartículas del Metal , ARN Neoplásico/efectos de los fármacos , Neoplasias de la Mama/genética , Línea Celular Tumoral , Humanos , Nanopartículas del Metal/química
5.
J Craniofac Surg ; 29(1): 237-242, 2018 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-29065044

RESUMEN

Crouzon syndrome is an autosomal-dominant congenital disease due to a mutation in the fibroblast growth factor receptor 2 protein. The purpose of this study is to evaluate wound-healing potential of Crouzon osteoblasts and adipose-derived stem cells (ADSCs) in a murine model. Parietal skull defects were created in Crouzon and mature wild-type (WT) CD-1 mice. One group of WT and Crouzon mice were left untreated. Another group was transplanted with both WT and Crouzon adipose-derived stem cells. Additional groups compared the use of a fibrin glue scaffold and periosteum removal. Skulls were harvested from each group and evaluated histologically at 8-week and/or 16-week periods. Mean areas of defect were quantified and compared via ANOVA F-test. The average area of defect after 8 and 16 weeks in untreated Crouzon mice was 15.37 ±â€Š1.08 cm and 16.69 ±â€Š1.51 cm, respectively. The average area of the defect in untreated WT mice after 8 and 16 weeks averaged 14.17 ±â€Š1.88 cm and 14.96 ±â€Š2.26 cm, respectively. WT mice with autologous ADSCs yielded an average area of 15.35 ±â€Š1.34 cm after 16 weeks while Crouzon mice with WT ADSCs healed to an average size of 12.98 ±â€Š1.89 cm. Crouzon ADSCs transplanted into WT mice yielded an average area of 15.47 ±â€Š1.29 cm while autologous Crouzon ADSCs yielded an area of 14.22 ±â€Š3.32 cm. ANOVA F-test yielded P = .415. The fibroblast growth factor receptor 2 mutation in Crouzon syndrome does not promote reossification of critical-sized defects in mature WT and Crouzon mice. Furthermore, Crouzon ADSCs do not possess osteogenic advantage over WT ADSCs.


Asunto(s)
Disostosis Craneofacial/genética , Disostosis Craneofacial/terapia , Osteoblastos/fisiología , Osteogénesis/genética , Células Madre/fisiología , Cicatrización de Heridas/genética , Tejido Adiposo/citología , Animales , Células Cultivadas , Modelos Animales de Enfermedad , Adhesivo de Tejido de Fibrina , Ratones , Hueso Parietal/lesiones , Hueso Parietal/fisiología , Receptor Tipo 2 de Factor de Crecimiento de Fibroblastos/genética , Trasplante de Células Madre
6.
Swiss Dent J ; 127(6): 538-539, 2017.
Artículo en Francés | MEDLINE | ID: mdl-28639683

RESUMEN

Oral lichen planus is a relatively common T-cell mediated inflammatory disease with potential malignant transformation. It may present itself with pain and oral lesions such as ulcers and Wickham’s striae. Treatment includes topical corticosteroids, preferably Clobetasol, immunosuppressive drugs and retinoids. Hyaluronic acid and aloe vera have been proven to be successful. If topical treatment fails, systemic therapy with corticosteroids may be needed. Because of the potential malignant transformation periodic follow-up is mandatory.


Asunto(s)
Liquen Plano Oral/diagnóstico , Liquen Plano Oral/tratamiento farmacológico , Administración Tópica , Corticoesteroides/uso terapéutico , Adulto , Aloe , Transformación Celular Neoplásica/efectos de los fármacos , Transformación Celular Neoplásica/patología , Clobetasol/uso terapéutico , Estudios Transversales , Humanos , Ácido Hialurónico/uso terapéutico , Inmunosupresores/uso terapéutico , Liquen Plano Oral/epidemiología , Liquen Plano Oral/patología , Persona de Mediana Edad , Retinoides/uso terapéutico
7.
Sci Total Environ ; 584-585: 1-10, 2017 Apr 15.
Artículo en Inglés | MEDLINE | ID: mdl-28131935

RESUMEN

Reliable gas measurements from supersaturated deep waters still remain a challenge. However, good information is mandatory to investigate the limnic carbon cycle, assess the endangerment through limnic eruptions and evaluate a potential source of exploitable energy. We addressed these three points in a heavily polluted mine pit lake in Germany. We quantified the ebullition of methane from deep waters and the sediment below. Exposed to continuous percolation of gas bubbles, the deep (monimolimnetic) water had accumulated high concentrations of gas: directly measured gas pressures indicated the proximity to spontaneous ebullition. Consequently, the possibility of a limnic eruption was assessed by initiating a self-sustained flow through a vertical pipe. Despite the high gas pressures, the flow was slow and the endangerment was considered low. A sampling strategy with bags was developed to achieve a reliable measurement of gas content and gas composition in the monimolimnion. As a result, directly measured gas pressures could be confirmed and were nearly exclusively attributed to methane and nitrogen. Contrary to lakes that had shown limnic eruptions, carbon dioxide played a much subordinate role, and hence the driving force for a violent outburst of gases was missing. Nevertheless the amount of dissolved methane was remarkably high. This investigation closes with some estimates of the commercial value of the deposit and limiting conditions for a possible exploitation.

8.
J Oral Maxillofac Surg ; 75(1): 197-206, 2017 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-27649463

RESUMEN

PURPOSE: Virtual surgical planning (VSP) using computer-aided design and manufacturing (CAD-CAM) has been reported to aid in craniofacial reconstruction. The reported improvements have been related mainly to operative performance, with limited evaluations of the position and function of the temporomandibular joint (TMJ). This study analyzed the radiographic detail of postoperative outcomes related to the TMJ. MATERIALS AND METHODS: Patients who underwent mandibular reconstruction with and without VSP were analyzed. All patients underwent preoperative computed tomography (CT) of their mandible. In the VSP group, CAD-CAM planning was performed preoperatively using CT Digital Imaging and Communications in Medicine (DICOM) data. Postoperative CT images from the 2 groups were quantitatively compared to evaluate the TMJ. CT images were digitized for 2- and 3-dimensional analysis using surgical planning software (Materialise, Leuven, Belgium). Anatomic landmarks and cephalometric relations were analyzed. RESULTS: Sixteen patients who underwent traditional planning or VSP for mandibular reconstruction were compared. Two groups (n = 8 each) were compared for positioning of the mandibular condyle in the glenoid fossa. Measurements of superior, anterior, and lateral movements were comparable in the pre- and postoperative groups for the traditional and VSP groups (P < .001 by analysis of variance). Subgroup analysis evaluating ipsilateral changes in the mandibular condyle position for traditional planning versus VSP noted decreased percentages of change in superior (22 vs 10%; P < .05), anterior (32 vs 15%; P < .05), and lateral (7 vs 1%, P < .01) shifts of the condyle for left mandibular reconstructions (n = 8). Ipsilateral right mandibular reconstructions (n = 6) showed changes in superior (62 vs 15%; P < .05) and anterior (5 vs 9%; not significant) shifts. CONCLUSION: These data showed comparable pre- and postoperative positions of the TMJ for traditional and VSP mandibular reconstructions. Evaluation of condyle movements showed differences in the ipsilateral position in the pre- and postoperative groups. VSP resulted in decreased superior and lateral shifts of the ipsilateral condyle and decreased changes in the condylar and condylar neck angles. This work shows that VSP can lead to increased precision in reconstruction leading to preserved normative anatomic relations.


Asunto(s)
Mandíbula/cirugía , Procedimientos Quirúrgicos Reconstructivos/métodos , Cirugía Asistida por Computador/métodos , Articulación Temporomandibular/cirugía , Adulto , Anciano , Anciano de 80 o más Años , Diseño Asistido por Computadora , Femenino , Humanos , Masculino , Mandíbula/diagnóstico por imagen , Persona de Mediana Edad , Articulación Temporomandibular/diagnóstico por imagen , Articulación Temporomandibular/fisiopatología , Tomografía Computarizada por Rayos X , Resultado del Tratamiento
9.
Swiss Dent J ; 126(12): 1160-1163, 2016.
Artículo en Alemán, Francés | MEDLINE | ID: mdl-28004379

RESUMEN

Reliable analgesia can nowadays be achieved with several techniques and different anesthetic solutions, but side effects may be encountered. Severe and potentially fatal cardiovascular reactions can be the result of an intravascular injection. An easy to use, effective and safe alternative is the periodontal ligament injection. Nerve damage or cardiovascular side effects are not to be expected. This type of anesthesia can be of advantage for many dental procedures. With new devices like the computer-controlled local anesthetic delivery system, the periodontal ligament injection is a convenient way of local anesthesia for both patient and dentist.


Asunto(s)
Anestesia Dental/métodos , Anestesia Local/métodos , Ligamento Periodontal/efectos de los fármacos , Anestesia Dental/instrumentación , Anestesia Local/instrumentación , Humanos , Inyecciones , Cirugía Asistida por Computador/instrumentación , Cirugía Asistida por Computador/métodos
10.
Swiss Dent J ; 126(10): 928-929, 2016.
Artículo en Alemán | MEDLINE | ID: mdl-27808350

RESUMEN

This script gives a pragmatic advice for dentists on pain control and anti-inflammation treatment considering current literature and state of the art of analgesic treatment. Naproxen seems to be the feasible anti-inflammatory painkiller as it has a lower cardio-vascular risk profile compared to other NSAID. The higher gastrointestinal bleeding risk can be mitigated using proton-pump inhibitors. Additionally, the duration of the drug effect of about 12–15 hours allows excellent patient compliance and comfort in comparison to other NSAID.


Asunto(s)
Antiinflamatorios no Esteroideos/uso terapéutico , Atención Odontológica , Manejo del Dolor/métodos , Antiinflamatorios no Esteroideos/efectos adversos , Humanos , Naproxeno/efectos adversos , Naproxeno/uso terapéutico
11.
Swiss Dent J ; 126(11): 1054-1055, 2016.
Artículo en Francés | MEDLINE | ID: mdl-27874917

RESUMEN

This script gives a pragmatic advice for dentists on pain control and anti-inflammation treatment considering current literature and state of the art of analgesic treatment. Naproxen seems to be the feasible anti-inflammatory painkiller as it has a lower cardio-vascular risk profile compared to other NSAID. The higher gastrointestinal bleeding risk can be mitigated using proton-pump inhibitors. Additionally, the duration of the drug effect of about 12–15 hours allows excellent patient compliance and comfort in comparison to other NSAID.


Asunto(s)
Antiinflamatorios no Esteroideos/efectos adversos , Antiinflamatorios no Esteroideos/uso terapéutico , Manejo del Dolor/métodos , Odontalgia/tratamiento farmacológico , Estudios de Factibilidad , Ibuprofeno/efectos adversos , Ibuprofeno/uso terapéutico , Ácido Mefenámico/efectos adversos , Ácido Mefenámico/uso terapéutico , Naproxeno/efectos adversos , Naproxeno/uso terapéutico
12.
Swiss Dent J ; 125(11): 1236-7, 2015.
Artículo en Francés | MEDLINE | ID: mdl-26631281

RESUMEN

Local anaesthetics are an integral part of most dental procedures and are therefore widely used and safely applied. Though rare, complications may occur and can be categorized as local or systemic. In the majority they are of minor nature but there is a potential for severe and possibly lethal side effects. Local complications are nerve damage (mainly the lingual and the inferior alveolar nerve), lesions of vascular structures, hematoma formation, temporary palsy of the facial nerve and post injection pain being the most common local complication. Examples for systemic complications are allergic reactions, cardiovascular complications, intoxication and psychogenic reactions.

13.
Br J Oral Maxillofac Surg ; 53(10): 1021-6, 2015 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-26602443

RESUMEN

In dentomaxillofacial radiology, cone-beam computed tomography (CT) is used to give fast and high-resolution 3-dimensional images of bone with a low dose of radiation. However, its use for quantitative measurement of bone density based on absolute values (Hounsfield units, HU) as in multidetector CT is still controversial. We know of no in vivo study of 3-dimensional merging software that will reliably match identical bone areas of cone-beam and multidetector CT datasets. We studied 19 multidetector, and 19 cone-beam, CT scans of the skull. The two datasets were fused, corresponding points were identified for measurement, and we compared mean density. We used linear regression to analyse the relation between the two different scanning methods, and studied a total of 4180 measurements. The mean time interval between scans was 5.2 (4.7) months. Mean R(2) over all measurements was 0.63 (range 0.22 - 0.79) with a mean internal consistency (Cronbach's α) of 0.86 (range 0.61 - 0.93). The strongest linearity, seen at the left mastoid, was R(2)=0.79 with high internal consistency (Cronbach's α 0.89), and the weakest was at the left zygomatic bone with R(2)=0.22 and Cronbach's α=0.61. Measurements of bone density based on cone-beam and multidetector CT scans generated in vivo showed high and reproducible internal consistency but poor linearity.


Asunto(s)
Tomografía Computarizada Multidetector , Tomografía Computarizada de Haz Cónico , Cintigrafía , Programas Informáticos
14.
Swiss Dent J ; 125(10): 1116-7, 2015.
Artículo en Alemán | MEDLINE | ID: mdl-26470804

RESUMEN

Local anaesthetics are an integral part of most dental procedures and are therefore widely used and safely applied. Though rare, complications may occur and can be categorized as local or systemic. In the majority they are of minor nature but there is a potential for severe and possibly lethal side effects. Local complications are nerve damage (mainly the lingual and the inferior alveolar nerve), lesions of vascular structures, hematoma formation, temporary palsy of the facial nerve and post injection pain being the most common local complication. Examples for systemic complications are allergic reactions, cardiovascular complications, intoxication and psychogenic reactions.

15.
Swiss Dent J ; 125(7-8): 830-831, 2015.
Artículo en Alemán | MEDLINE | ID: mdl-26345398

RESUMEN

Chlorhexidine, one of the most frequently prescribed medications, belongs to a group of medicines called antiseptic antibacterial agents. It is indicated as a mouthwash in the treatment of gingivitis, as it cleans the skin after injury and can be used to clean hands before a procedure. Chlorhexidine works by killing or preventing the growth of bacteria on the mucosa or skin. It should not be used in individuals who are known to be hypersensitive to Chlorhexidine gluconate or other ingredients. It may cause some reversible tooth discoloration or an increase in tartar formation.

16.
Swiss Dent J ; 125(9): 982-3, 2015.
Artículo en Francés | MEDLINE | ID: mdl-26400000

RESUMEN

Chlorhexidine, one of the most frequently prescribed medications, belongs to a group of medicines called antiseptic antibacterial agents. It is indicated as a mouthwash in the treatment of gingivitis, as it cleans the skin after injury and can be used to clean hands before a procedure. Chlorhexidine works by killing or preventing the growth of bacteria on the mucosa or skin. It should not be used in individuals who are known to be hypersensitive to Chlorhexidine gluconate or other ingredients. It may cause some reversible tooth discoloration or an increase in tartar formation.

17.
Swiss Dent J ; 125(5): 612-3, 2015.
Artículo en Alemán | MEDLINE | ID: mdl-26169977

RESUMEN

Solcoseryl® is a protein-free haemodialysate, containing a broad spectrum of low molecular components of cellular mass and blood serum obtained from veal calves. Solcoseryl® improves the transport of oxygen and glucose to cells that are under hypoxic conditions. It increases the synthesis of intracellular ATP and contributes to an increase in the level of aerobic glycolysis and oxidative phosphorylation. It activates the reparative and regenerative processes in tissues by stimulating fibroblast proliferation and repair of the collagen vascular wall. The formulations of Solcoseryl® are infusion, injection, gel and ointment, and it is also available as a dental paste for inflammatory processes of the mouth cavity, gums and lips.

18.
Swiss Dent J ; 125(6): 740-1, 2015.
Artículo en Francés | MEDLINE | ID: mdl-26179567

RESUMEN

Solcoseryl® is a protein-free haemodialysate, containing a broad spectrum of low molecular components of cellular mass and blood serum obtained from veal calves. Solcoseryl® improves the transport of oxygen and glucose to cells that are under hypoxic conditions. It increases the synthesis of intracellular ATP and contributes to an increase in the level of aerobic glycolysis and oxidative phosphorylation. It activates the reparative and regenerative processes in tissues by stimulating fibroblast proliferation and repair of the collagen vascular wall. The formulations of Solcoseryl® are infusion, injection, gel and ointment, and it is also available as a dental paste for inflammatory processes of the mouth cavity, gums and lips.

19.
Artículo en Inglés | MEDLINE | ID: mdl-26085840

RESUMEN

BACKGROUND: A significant proportion of patients admitted to hospital with multiple traumas exhibit facial injuries. The aim of this study is to evaluate the incidence and cause of facial injuries in severely injured patients and to examine the role of plastic and maxillofacial surgeons in treatment of this patient collective. METHODS: A total of 67 patients, who were assigned to our trauma room with maxillofacial injuries between January 2009 and December 2010, were enrolled in the present study and evaluated. RESULTS: The majority of the patients were male (82 %) with a mean age of 44 years. The predominant mechanism of injury was fall from lower levels (<5 m) and occurred in 25 (37 %) cases. The median ISS was 25, with intracranial bleeding found as the most common concomitant injury in 48 cases (72 %). Thirty-one patients (46 %) required interdisciplinary management in the trauma room; maxillofacial surgeons were involved in 27 cases. A total of 35 (52 %) patients were treated surgically, 7 in emergency surgery, thereof. CONCLUSION: Maxillofacial injuries are often associated with a risk of other serious concomitant injuries, in particular traumatic brain injuries. Even though emergency operations are only necessary in rare cases, diagnosis and treatment of such concomitant injuries have the potential to be overlooked or delayed in severely injured patients.

20.
J Plast Reconstr Aesthet Surg ; 68(5): 615-21, 2015 May.
Artículo en Inglés | MEDLINE | ID: mdl-25863706

RESUMEN

BACKGROUND: Unicoronal synostosis (UCS) results in nasal root deviation toward the fused side of the face, resulting in an apparent nasal dorsal deviation to the non-fused side. The impact of the altered radix position on the osteocartilaginous vault and nasal soft tissue has not been analyzed. The purpose of this study is to morphometrically assess the nasal structure and deviation in UCS. We hypothesize the proximal etiology exerts an impact on the distal nasal form, compared to controls. METHODS: Demographic data were tabulated and computed tomographic information recorded. Three-dimensional reconstruction was created and analyzed digitally (using Surgi Case). Morphometric landmarks were determined and used to perform measurements on the nasal soft tissue and osseous skull surface to evaluate nasal deviation within a midsaggital plane (MSP). RESULTS: Forty three-dimensional CT scans of 20 UCS patients and 20 control subjects were analyzed. The deviation angle of the nose to the non-fused side was 6.6 ± 2.9° in the bony layer. In the soft-tissue layer, the deviation angle of the nasal dorsum line to the non-fused side was 5.4 ± 3.4°. The tip of the nose showed a significant deviation to the non-fused side (2.2 ± 1.2 mm). Paired landmarks (alares, inferior lateral nostril bases) related to the MSP showed a greater distance on the non-fused side. Paired landmarks related to an intrinsic nasal midline (Nsup-ANS; tip-columella line (TCL)) did not show any significant differences. CONCLUSION: UCS confers osteocartilaginous and soft-tissue nasal deviation, with the distal nose toward the non-fused side. The nasal root inclination underpins this asymmetry across the midsaggital reference plane. However, the nose in isolation exhibits balanced side-side proportions.


Asunto(s)
Craneosinostosis/complicaciones , Craneosinostosis/patología , Deformidades Adquiridas Nasales/diagnóstico por imagen , Deformidades Adquiridas Nasales/etiología , Plagiocefalia/diagnóstico por imagen , Plagiocefalia/etiología , Antropometría , Craneosinostosis/diagnóstico por imagen , Femenino , Humanos , Lactante , Masculino , Intensificación de Imagen Radiográfica/métodos , Tomografía Computarizada por Rayos X
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