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1.
J Prosthet Dent ; 2021 Apr 02.
Artículo en Inglés | MEDLINE | ID: mdl-33820631

RESUMEN

STATEMENT OF PROBLEM: Type IV hypersensitivity reactions (Type IV HR) are immune responses mediated by antigen-specific effector T cells. PURPOSE: The purpose of this clinical report and systematic review was to report the clinicopathological features of Type IV HR in the oral mucosa and to present a systematic literature review of case reports and case series of individuals with Type IV HR in the oral mucosa related to contact with dental materials. MATERIAL AND METHODS: The presented clinical lesions were melanotic macules with burning that affected the internal labial mucosa in contact with composite resin veneer crowns. Histopathological and immunohistochemical analysis of the lesion was performed. The systematic literature review was performed based on a search in 4 electronic databases (PubMed/MEDLINE, Scopus, Web of Science, and Ovid). RESULTS: Immunohistochemistry showed positivity for CD4, CD8, CD20, CD3, tryptase, and CD117. After conservative treatment, the patient reported improvement of symptoms, and a decrease in the number of inflammatory cells was verified. Twenty-one articles were included in the review. Unlike the present patient, the authors of all the articles recommended radical treatment with the removal of the dental material. CONCLUSIONS: Type IV HR in oral mucosa is rare, and the assessment of clinical and histopathological characteristics is essential to perform an accurate diagnosis and provide appropriate treatment.

2.
Arch Bronconeumol ; 2021 Mar 27.
Artículo en Inglés, Español | MEDLINE | ID: mdl-33895005

RESUMEN

INTRODUCTION: Idiopathic pulmonary fibrosis (IPF) is progressive and irreversible. Some discrepancies about IPF staging exists, especially in mild phases. Forced vital capacity (FVC) higher than 80% has been considered early or mild IPF even for the design of clinical trials. METHODS: Spanish multicentre, observational, retrospective study of IPF patients diagnosed between 2012 and 2016, based on the ATS/ERS criteria, which presented FVC greater or equal 80% at diagnosis. Clinical and demographic characteristics, lung function, radiological pattern, treatment, and follow-up were analyzed. RESULTS: 225 IPF patients were included, 72.9% were men. The mean age was 69.5 years. The predominant high-resolution computed tomography (HRCT) pattern was consistent usual interstitial pneumonia (UIP) (51.6%). 84.7% of patients presented respiratory symptoms (exertional dyspnea and/or cough) and 33.33% showed oxygen desaturation below 90% in the 6min walking test (6MWT). Anti-fibrotic treatment was initiated at diagnosis in 55.11% of patients. Median FVC was 89.6% (IQR 17) and 58.7% of patients had a decrease of diffusion lung capacity for carbon monoxide (DLCO) below 60% of theoretical value; most of them presented functional progression (61.4%) and higher mortality at 3 years (20.45%). A statistically significant correlation with the 3-years mortality was observed between DLCO <60% and consistent UIP radiological pattern. CONCLUSIONS: Patients with preserved FVC but presenting UIP radiological pattern and moderate-severe DLCO decrease at diagnosis associate an increased risk of progression, death or lung transplantation. Therefore, in these cases, preserved FVC would not be representative of early or mild IPF.

3.
Int J Mol Sci ; 22(3)2021 Jan 30.
Artículo en Inglés | MEDLINE | ID: mdl-33573134

RESUMEN

Angiogenesis pathway genes show substantial genetic variability causing inter-individual differences in responses to anti-angiogenic drugs. We examined 20 single nucleotide polymorphisms (SNPs) in 13 of these genes to predict tumour response and clinical outcome measured as progression free survival (PFS) and overall survival (OS) in 57 patients with metastatic colorectal cancer (mCRC) given bevacizumab plus chemotherapy. SNPs were detected (iPLEX® Assay) in genomic DNA extracted from formalin-fixed paraffin-embedded tumour specimens. The variant allele CD39 rs11188513 was associated with a good tumour response (p = 0.024). Patients homozygous for the wild-type allele FGF2 rs1960669 showed a median PFS of 10.95 months versus 5.44 months for those with at least one variant allele-A (HR 3.30; 95% CI: 1.52-7.14; p = 0.001). Patients homozygous for wild-type MMP9 rs2236416 and rs2274755 showed a median PFS of 9.48 months versus 6 and 6.62 months, respectively, for those with at least one variant allele (p = 0.022, p = 0.043, respectively). OS was also lengthened to 30.92 months (p = 0.034) in carriers of wild-type ANGPT1 rs2445365 versus 22.07 months for those carrying at least one variant allele-A. These gene variants were able to predict clinical outcome and tumour response in mCRC patients given bevacizumab-based therapy.

4.
Photodiagnosis Photodyn Ther ; 32: 102042, 2020 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-33321571

RESUMEN

BACKGROUND: Photodynamic therapy (PDT) is a treatment for the specific control of oral biofilms. However, its effects on maxillofacial prostheses have been barely explored. In this study, we evaluated the antimicrobial effect of PDT using methylene blue (MB) and laser against a Staphylococcus aureus biofilm developed on the surface of scleral acrylic resin. METHODS: Sixty-six specimens of acrylic resin designed for ocular prostheses were fabricated in a disk-shaped format (3 × 10 mm). S. aureus biofilm was grown on the surface of the specimens for 24 h and the disks were then treated with MB at different concentrations (25, 50, 75 or 100 µg/mL), with or without PDT (GaAlAs diode laser; 660 nm; 100 mW; 9 J; 321.4 J.cm-2; 3.5 W.cm-2 and 90 s). Control groups were treated with 2% chlorhexidine gluconate (CHX) or phosphate buffered saline. After the treatments, colony forming units (CFU) were counted and the samples were qualitatively evaluated by scanning electron microscopy (SEM). Data were analyzed descriptively and by nested ANOVA and the Tukey test (α = .05). RESULTS: PDT groups with MB concentrations at 75 and 100 µg/mL formed fewer CFU compared to the other groups (P < 0.001) and the 2% CHX group did not form any CFU. SEM images revealed that the surface of the polymers in these groups did not show bacterial colonies. CONCLUSIONS: PDT significantly reduced S. aureus biofilm in the scleral acrylic resin when associated with an MB dilution of 75 µg/mL or higher. Thus, PDT can be a promising candidate for disinfecting ocular prostheses.

5.
Respirology ; 2020 Nov 09.
Artículo en Inglés | MEDLINE | ID: mdl-33167075

RESUMEN

BACKGROUND AND OBJECTIVE: The relationship between IPF development and environmental factors has not been completely elucidated. Analysing geographic regions of idiopathic pulmonary fibrosis (IPF) cases could help identify those areas with higher aggregation and investigate potential triggers. We hypothesize that cross-analysing location of IPF cases and areas of consistently high air pollution concentration could lead to recognition of environmental risk factors for IPF development. METHODS: This retrospective study analysed epidemiological and clinical data from 503 patients registered in the Observatory IPF.cat from January 2017 to June 2019. Incident and prevalent IPF cases from the Catalan region of Spain were graphed based on their postal address. We generated maps of the most relevant air pollutant PM2.5 from the last 10 years using data from the CALIOPE air quality forecast system and observational data. RESULTS: In 2018, the prevalence of IPF differed across provinces; from 8.1 cases per 100 000 habitants in Barcelona to 2.0 cases per 100 000 in Girona. The ratio of IPF was higher in some areas. Mapping PM2.5 levels illustrated that certain areas with more industry, traffic and shipping maintained markedly higher PM2.5 concentrations. Most of these locations correlated with higher aggregation of IPF cases. Compared with other risk factors, PM2.5 exposure was the most frequent. CONCLUSION: In this retrospective study, prevalence of IPF is higher in areas of elevated PM2.5 concentration. Prospective studies with targeted pollution mapping need to be done in specific geographies to compile a broader profile of environmental factors involved in the development of pulmonary fibrosis.

6.
Bioengineering (Basel) ; 7(4)2020 Nov 08.
Artículo en Inglés | MEDLINE | ID: mdl-33171637

RESUMEN

Frequently, the oral cavity area can be affected by different diseases, so the patient needs to be submitted to surgery to remove a specific region of the mandibular. A complete or partial discontinuity of the mandibular bone can cause direct or indirect forces variations during the mastication. The dental prosthesis is an alternative to generate an aesthetic or functional solution for oral cavity lesions. However, they can be wrongly designed, or they can lose the adjustment during their useful life, deteriorating the patient's condition. In this work, the influence of the fixation components position for a dental prosthesis will be studied based on the finite element method. By means, it is possible to determine the area of the highest stress concentration generated on the mandibular structure. The temporomandibular image obtained by computational tomography was used as a 3D graphic whole model because in the medical area the morphological factors are extremely important. Vertical loads of 50, 100, 150 and 200 N were applied in three different regions: in the whole buccal cavity, simultaneously in the left and right laterals and only in the right lateral, to determine the values of von Mises stress in the mandible. These results were compared between three finite element software packages (Ansys®, SolidWorks® and Inventor®) and a meshless software (SimSolid®). They showed similar behaviors in the highest mechanical stress concentration in the same regions. Regarding the stress values, the percentage error between each software package was less than 10%. The use of SimSolid® software (meshless) proved to be better at identifying the higher stress generated by the dental prosthesis in the facial skeleton, so its computational efficiency, due to its geometric complexity, was highlighted.

7.
Viruses ; 12(11)2020 11 09.
Artículo en Inglés | MEDLINE | ID: mdl-33182268

RESUMEN

BACKGROUND: COVID-19 pathophysiology and the predictive factors involved are not fully understood, but lymphocytes dysregulation appears to play a role. This paper aims to evaluate lymphocyte subsets in the pathophysiology of COVID-19 and as predictive factors for severe disease. PATIENT AND METHODS: A prospective cohort study of patients with SARS-CoV-2 bilateral pneumonia recruited at hospital admission. Demographics, medical history, and data regarding SARS-CoV-2 infection were recorded. Patients systematically underwent complete laboratory tests, including parameters related to COVID-19 as well as lymphocyte subsets study at the time of admission. Severe disease criteria were established at admission, and patients were classified on remote follow-up according to disease evolution. Linear regression models were used to assess associations with disease evolution, and Receiver Operating Characteristic (ROC) and the corresponding Area Under the Curve (AUC) were used to evaluate predictive values. RESULTS: Patients with critical COVID-19 showed a decrease in CD3+CD4+ T cells count compared to non-critical (278 (485 IQR) vs. 545 (322 IQR)), a decrease in median CD4+/CD8+ ratio (1.7, (1.7 IQR) vs. 3.1 (2.4 IQR)), and a decrease in median CD4+MFI (21,820 (4491 IQR) vs. 26,259 (3256 IQR)), which persisted after adjustment. CD3+CD8+ T cells count had a high correlation with time to hospital discharge (PC = -0.700 (-0.931, -0.066)). ROC curves for predictive value showed lymphocyte subsets achieving the best performances, specifically CD3+CD4+ T cells (AUC = 0.756), CD4+/CD8+ ratio (AUC = 0.767), and CD4+MFI (AUC = 0.848). CONCLUSIONS: A predictive value and treatment considerations for lymphocyte subsets are suggested, especially for CD3CD4+ T cells. Lymphocyte subsets determination at hospital admission is recommended.

8.
PLoS One ; 15(10): e0240116, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-33044989

RESUMEN

The aim of this study was to evaluate the effect of disinfectants on the biofilm of Staphylococcus aureus and Staphylococcus epidermidis formed on the acrylic surface of ocular prostheses. In this study, 396 acrylic specimens were manufactured (50% for Staphylococcus epidermidis, and 50% for Staphylococcus aureus). For each bacterium, 66 specimens were subjected to biofilm formation on their surfaces for 24 hours, 66 specimens were subjected to biofilm formation on their surfaces for 48 hours, and 66 specimens were subjected to biofilm formation on their surfaces for 72 hours. Then, they were divided into groups according to disinfection method (n = 6): sterile distilled water for 10, 15, 30 min, and 6 hours (control); soap for 30 min (NES30); Opti-Free for 30 min (OPF30) and 6 h (OPF6); Efferdent for 15 min (EFF15); and 0.5%, 2%, and 4% chlorhexidine for 10 min (0.5% CHX10, 2% CHX10, and 4% CHX10). After the treatments, the specimens were vortexed to release the biofilm and the counting of bacterial colonies was performed (CFU/mL). Three-way ANOVA and the Tukey-Kramer HSD test were used (α = 0.05). For Staphylococcus epidermidis, there was no significant difference between NES30, OPF30, and OPF6 with their respective control groups; nor between NES30, OPF30, and OPF6 themselves, regardless of the biofilm development period (P >0.05). For Staphylococcus aureus, there was no significant difference between NES30 and OPF30 with their control group; nor between NES30 and OPF30 themselves, regardless of the biofilm development period (P >0.05). For Staphylococcus aureus, OPF6 showed a significant reduction in the number of CFU/mL when compared with its control group, NES30, and OPF30, regardless of the biofilm development period (P <0.05). For both bacteria, 0.5% CHX10, 2% CHX10,4% CHX10, and EFF15 showed a significant reduction in the number of CFU/mL when compared with their control groups, NES30, OPF30, and OPF6, regardless of the biofilm development period (P <0.05). Therefore, EFF15 and CHX (0.5%, 2% and 4%) were effective in reducing Staphylococcus epidermidis and Staphylococcus aureus on acrylic surfaces. NES30 and OPF (30 and 6) are not recommended.

9.
Arch Bronconeumol ; 2020 Sep 30.
Artículo en Inglés, Español | MEDLINE | ID: mdl-33069461

RESUMEN

INTRODUCTION: Serum autoantibodies support the diagnosis of interstitial lung disease (ILD) related to systemic autoimmune diseases (SAD-ILD). Nevertheless, their presence in the bronchoalveolar lavage (BAL) has not been explored. OBJECTIVES: To demonstrate the presence of autoantibodies in the BAL of ILD patients at onset of clinical evaluation, its relation with serum autoantibodies and to analyze clinical features of patients with autoantibodies in BAL. METHODS: Autoantibodies against extractable nuclear antigens (ENAs) were analyzed by immunoblot in the BAL of 155 patient with suspected diagnosis of ILD and 10 controls. RESULTS: Seven ENAs were detected in the BAL of 19 patients (Anti-Ro52, Anti-Ro60, CENP-B, Anti-La, Jo-1, Sm/RNP and Anti-SL70). The most frequent ENA was anti-Ro52 (13 patients; 68,4% of positives ones). Seven patients presented more than one ENAs. Fourteen were diagnosed of SAD-ILD, 3 of interstitial pneumonia with autoimmune features, one of non-specific idiopathic pneumonia and other of silicosis. In 10 cases (52%) IgA autoantibodies were also detected. The autoantibodies observed in BAL were also detected in the serum of 17 patients (90%). There were no significant clinical differences with the patients with SAD-ILD or interstitial pneumonia with autoimmune features with patients with negative BAL. CONCLUSION: The study of ENAs in BAL is feasible and can be a useful tool in the ILD initial algorithm, specifically sustaining the suspected diagnosis of SAD-ILD.

10.
World J Gastroenterol ; 26(16): 1979-1986, 2020 Apr 28.
Artículo en Inglés | MEDLINE | ID: mdl-32390708

RESUMEN

BACKGROUND: In metastatic colorectal cancer (mCRC), the anti-vascular endothelial growth factor drug bevacizumab (BVZ) plus chemotherapy significantly improves progression-free survival compared to chemotherapy (CT) alone. This benefit is not, however, observed in all patients. While increased chemokine CXCL5 gene expression promoting angiogenesis has been proposed as a prognostic mCRC biomarker, few studies have examined its relationship with drug efficacy. This study sought to analyze tumor CXCL5 gene expression in six patients with different efficacy of BVZ-containing CT in terms of the tumor response to treatment. CASE SUMMARY: We report six cases of stage IV KRAS-mutated mCRC. Patients were given first line treatment with BVZ-containing chemotherapy in University Hospital of Fuenlabrada. The six patients differed in terms of primary tumor location (right/left side), tumor burden (mostly hepatic and peritoneal disease) and clinical disease course. Before treatment onset, total RNA was isolated from paraffinated tumor biopsy specimens and CXCL5 gene expression quantified through conventional RT-qPCR procedures. Our main finding was that CXCL5 expression levels were several times higher in three patients with lower progression free survival (under 6 mo) from the start of treatment. CONCLUSION: A higher expression of CXCL5 was observed in the three patients showing worse tumor response to treatment.

11.
Asian Pac J Cancer Prev ; 21(5): 1227-1234, 2020 May 01.
Artículo en Inglés | MEDLINE | ID: mdl-32458626

RESUMEN

OBJECTIVE: This study aimed to evaluate the quality of life of patients with oral or oropharyngeal cancer by using specific questionnaires (QLQ-C30 and QLQ-HandN35), varying according to the location of the tumor (oral cavity or oropharynx) and the treatment performed (only surgery or surgery associated with radiotherapy). METHODS: Fifty patients were enrolled in this study and answered the EORTC QLQ-C30 and EORTC HandN35 questionnaires, before (baseline), at 1 week, and 3 months after treatment. Internal consistency reliability was calculated with the Cronbach coefficient. The Kruskal-Wallis and Wilcoxon tests were applied and P.

12.
BrJP ; 3(2): 147-152, Jan.-Mar. 2020. tab
Artículo en Inglés | LILACS-Express | LILACS | ID: biblio-1132000

RESUMEN

ABSTRACT BACKGROUND AND OBJECTIVES: The etiology of temporomandibular disorders includes local and systemic factors, with an emphasis on the occlusal condition, trauma, parafunctional activities, and emotional stress, deriving signs of anxiety and depression. These, in turn, are more likely to develop in the university population, due to the changes required when entering university and the demand for good performance. This study aimed to evaluate the correlation between anxiety and depression symptoms and the existence of symptoms associated with temporomandibular disorders in university students. METHODS: An epidemiological, randomized, and cross-sectional clinical study conducted with 100 university students. The Research Diagnostic Criteria for Temporomandibular Disorders: Axis II and the Hospital Anxiety and Depression Scale questionnaires were applied. For the statistical analysis, the Chi-square tests and the Logistic regression model were used. RESULTS: The results of the present study consisted of responses from 79 women and 21 men, with a mean age of 19 years. The following associations were observed: general health status and depression; anxiety and pain in the face/ clicking; habit of grinding/clenching teeth when sleeping, and a "yes" answer to anxiety; discomfort with your teeth and depression; state of anguished/worried about all anxiety issues; depression and thoughts about death, difficulty in breathing and feeling discouraged about the future. CONCLUSION: From the data obtained, it was possible to conclude that the presence of symptoms related to anxiety and depression interfere with the painful symptoms of temporomandibular disorders in the addressed population.


RESUMO JUSTIFICATIVA E OBJETIVOS: A etiologia das disfunções temporomandibulares engloba fatores locais e sistêmicos, destacando-se a condição oclusal, trauma, atividades parafuncionais e estresse emocional, derivando-se os sinais de ansiedade e de depressão. Esses, por sua vez, apresentam maior propensão em se desenvolver na população universitária devido às mudanças exigidas ao ingressar na universidade e a cobrança por um bom desempenho. O objetivo deste estudo foi avaliar a correlação de sintomas de ansiedade e de depressão e a existência de sintomas associados às disfunções temporomandibulares em estudantes universitários. MÉTODOS: Realizou-se um estudo clínico epidemiológico, aleatório e transversal, cuja amostra foi constituída por 100 estudantes universitários, aos quais foram aplicados os questionários Research Diagnostic Criteria for Temporomandibular Disorders: Eixo II e o Hospital Anxiety and Depression Scale. Para a análise estatística foram utilizados os testes Qui-quadrado e o Modelo de regressão logística. RESULTADOS: Os resultados do presente estudo foram constituídos pelas respostas de 79 mulheres e 21 homens, com média de idade de 19 anos. Foram observadas as seguintes associações: estado de saúde geral e depressão, ansiedade e dor na face/estalos, hábito de ranger/apertar os dentes ao dormir, e resposta "sim" para ansiedade, desconforto com seus dentes e depressão; estado de angustiado/preocupado com todas as questões de ansiedade; depressão e pensamentos sobre morte, dificuldade em respirar e sentir-se desanimado sobre o futuro. CONCLUSÃO: A partir dos dados obtidos foi possível concluir que a presença de sintomas relativos à ansiedade e depressão interferem nos sintomas dolorosos das disfunções temporomandibulares da população abordada.

13.
Pediatr. aten. prim ; 22(85): e13-e19, ene.-mar. 2020. tab, graf
Artículo en Español | IBECS | ID: ibc-193435

RESUMEN

INTRODUCCIÓN: el objetivo del estudio es describir los hallazgos electrocardiográficos y ecocardiográficos en mujeres adolescentes con anorexia nerviosa y correlacionarlos con parámetros clínicos. PACIENTES Y MÉTODOS: estudio observacional, retrospectivo, de casos y controles. Se estudiaron 98 mujeres adolescentes ingresadas en un hospital terciario por anorexia nerviosa restrictiva (ANR) durante los últimos 15 años, en las que se realizó valoración electrocardiográfica y ecocardiográfica al ingreso. RESULTADOS: la edad media fue similar en ambos grupos (14,6 ± 2,0 frente a 14,7 ± 2,0 años). Las pacientes con ANR presentaban menor frecuencia cardiaca (57 ± 12 frente a 72 ± 13 lpm), voltajes más bajos (rV5 = 1,1 ± 0,5 frente a 1,6 ± 0,4 mV) y menor masa ventricular izquierda (65,7 ± 14,8 frente a 90 ± 15,3 g/m2) que las pacientes controles. No se encontraron diferencias en la medición del QTc. En las pacientes con ANR, la bradicardia no se correlacionó con el peso (r = -0,20; p = 0,05), ni con el índice de masa corporal (IMC) (r = 0,02; p = 0,22) al ingreso. El grosor del septo interventricular y la masa del ventrículo izquierdo fueron significativamente menores en los pacientes con ANR (5,7 mm frente a 6,8 mm, p <0,001; 65,7 frente a 90 g/m2; p <0,001). La masa ventricular izquierda se correlacionó de forma significativa con el IMC (r = 0,21; p <0,001) y con la frecuencia cardiaca (FC) (r = -0,225; p <0,001). CONCLUSIONES: las alteraciones cardiacas fueron más prevalentes en pacientes con ANR. La bradicardia, los trastornos de la repolarización ventricular y la disminución de la masa cardiaca fueron los más frecuentemente identificados


INTRODUCTION: the aim of the study was to describe the electrocardiographic and echocardiographic findings in female adolescents with anorexia nervosa and to assess their correlation with clinical variables. PATIENTS AND METHODS: we conducted a retrospective observational case-control study. The analysis included 98 female adolescents admitted to a tertiary hospital due to anorexia nervosa over the last 15 years, all of who underwent an electrocardiographic and echocardiographic evaluation. RESULTS: the mean age was similar in both groups: 14.6 ± 2.0 years in cases vs. 14.7 ± 2.0 years in controls. Patients with anorexia had significantly lower heart rates (57 ± 12 vs. 72 ± 13 bpm), a smaller R-wave in V5 (1.1 ± 0.5 vs 1.6 ± 0.4 mV) and a lesser left ventricular mass (65.7 ± 14.8 vs 90 ± 15.3 g/m2) compared to controls. We found no differences in the QTc interval. In patients with anorexia, the presence of bradycardia was not correlated to weight (r = -0.20, p = 0.05) or body mass index (r = 0.02, p = 0.22) at admission. We found that the left ventricular mass was significantly correlated to the body mass index (r = 0.21, p <0.001,) and the heart rate (r = -0.225, p <0.001). CONCLUSIONS: cardiac abnormalities were more prevalent in patients with anorexia nervosa. Bradycardia, changes in ventricular repolarization, and a lesser left ventricular mass were the most frequent abnormalities in our sample


Asunto(s)
Humanos , Femenino , Adolescente , Anorexia Nerviosa/complicaciones , Electrocardiografía/estadística & datos numéricos , Ecocardiografía/estadística & datos numéricos , Bradicardia/epidemiología , Disfunción Ventricular Izquierda/epidemiología , Anorexia Nerviosa/epidemiología , Estudios Retrospectivos , Estudios de Casos y Controles , Pesos y Medidas Corporales/estadística & datos numéricos
14.
J Clin Exp Dent ; 12(2): e130-e138, 2020 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-32071694

RESUMEN

Background: The aim of the present study was to investigate pain perception and anxiety within the context of surgery for the placement of mandibular block bone and to evaluate the causality effect between theses variables. Material and Methods: A total of 13 patients were recruited for the study and were submitted to mandibular autogenous block bone surgery. Demographic data were collected and the anxiety level was determined using the State-Trait Anxiety Inventory (STAI). The STAI was administered on the day of surgery and on the 14th postoperative day. Pain was determined using the visual analogue scale (VAS) and limitation of daily activities and postoperative symptoms were also reported. Data were analyzed using parametric tests (α=0.05) and cross-lagged analysis was performed to verify a causality effect. Results: Few patients reported interference with daily activities or the presence of postoperative symptoms. A significant association of bad breath/taste with STAI-State was detected on the 14th postoperative day. No evidence of causality between STAI and VAS was detected. Conclusions: The patient's self-evaluation indicates that the pain and anxiety level felt during treatment was not directly associated with the clinical aspects of the surgical procedure or with postoperative activities/symptoms limitations. Key words:Anxiety pain, questionnaires, autogenous bone block, treatment, outcomes.

15.
Arch. bronconeumol. (Ed. impr.) ; 56(2): 99-105, feb. 2020. tab
Artículo en Español | IBECS | ID: ibc-197563

RESUMEN

El diagnóstico de la fibrosis pulmonar idiopática (FPI) es un proceso complejo que precisa la integración multidisciplinar de variables clínicas, radiológicas e histológicas. Cuando es preciso obtener muestras de parénquima pulmonar, la biopsia pulmonar quirúrgica ha sido el procedimiento recomendado por su rendimiento diagnóstico. Pero dada la morbimortalidad de esta técnica, se han explorado alternativas con menores riesgos. La más importante es la biopsia transbronquial con criosonda (criobiopsia transbronquial), que permite obtener tejido pulmonar con menor comorbilidad, con un rendimiento inferior a la biopsia quirúrgica pero superior a la biopsia transbronquial con pinza convencional. Por ello, en las recientes guías clínicas para el diagnóstico de la FPI se ha valorado esta opción, sin llegar a obtener una recomendación. En este artículo, resultado de un foro de discusión multidisciplinar, se pretende revisar la evidencia actual y hacer propuestas sobre el uso de la criobiopsia transbronquial para el diagnóstico de la FPI


The diagnosis of idiopathic pulmonary fibrosis (IPF) is a complex process that requires the multidisciplinary integration of clinical, radiological, and histological variables. Due to its diagnostic yield, surgical lung biopsy has been the recommended procedure for obtaining samples of lung parenchyma, when required. However, given the morbidity and mortality of this technique, alternative techniques which carry a lower risk have been explored. The most important of these is transbronchial cryobiopsy -transbronchial biopsy with a cryoprobe- which is useful for obtaining lung tissue with less comorbidity. Yield may be lower than surgical biopsy, but it is higher than with transbronchial biopsy with standard forceps. This option has been discussed in the recent clinical guidelines for the diagnosis of IPF, but the authors do not go so far as recommend it. The aim of this article, the result of a multidisciplinary discussion forum, is to review current evidence and make proposals for the use of transbronchial cryobiopsy in the diagnosis of IPF


Asunto(s)
Humanos , Fibrosis Pulmonar Idiopática/diagnóstico , Biopsia/métodos , Crioultramicrotomía , Algoritmos , Investigación Interdisciplinaria
16.
Arch Bronconeumol ; 56(2): 99-105, 2020 02.
Artículo en Inglés, Español | MEDLINE | ID: mdl-31420183

RESUMEN

The diagnosis of idiopathic pulmonary fibrosis (IPF) is a complex process that requires the multidisciplinary integration of clinical, radiological, and histological variables. Due to its diagnostic yield, surgical lung biopsy has been the recommended procedure for obtaining samples of lung parenchyma, when required. However, given the morbidity and mortality of this technique, alternative techniques which carry a lower risk have been explored. The most important of these is transbronchial cryobiopsy -transbronchial biopsy with a cryoprobe- which is useful for obtaining lung tissue with less comorbidity. Yield may be lower than surgical biopsy, but it is higher than with transbronchial biopsy with standard forceps. This option has been discussed in the recent clinical guidelines for the diagnosis of IPF, but the authors do not go so far as recommend it. The aim of this article, the result of a multidisciplinary discussion forum, is to review current evidence and make proposals for the use of transbronchial cryobiopsy in the diagnosis of IPF.

17.
Head Neck Pathol ; 14(1): 173-182, 2020 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-31011984

RESUMEN

The aim of this study was to describe a series with 66 cases of infected cemento-osseous dysplasia (COD) and to discuss the demographic distribution, clinicoradiographic features and treatment of this condition. A study looking back on the diagnoses made at a single Brazilian centre within a 28-year timeframe was performed. A literature review with searches across five databases was also conducted to identify reports on osteomyelitis/infected COD. Descriptive and statistical analyses were performed. The case series study showed a female/male ratio of 21:1. Affected individuals' mean age was 57.4 years. Mandible was the most affected site (95.5%) and florid subtype was the most frequent infected COD (62.1%). Tooth extraction was the main factor associated with the development of infection associated within a COD lesion. The literature review retrieved 30 studies reporting 46 cases of this condition. Asian women in their 40 s and 50 s were more affected. Surgery for removal/curettage of necrotic bone was acknowledged as an appropriate approach to the treatment of this infection. The clinicodemographic data of the study were similar to data collected across the literature. Clinicians, maxillofacial surgeons and oral rehabilitation providers should be alert to the diagnosis of COD, since infection is a frequent complication whose management is challenging.


Asunto(s)
Cementoma/complicaciones , Neoplasias Maxilomandibulares/complicaciones , Osteomielitis/complicaciones , Adulto , Anciano , Anciano de 80 o más Años , Brasil/epidemiología , Cementoma/epidemiología , Femenino , Humanos , Neoplasias Maxilomandibulares/epidemiología , Masculino , Persona de Mediana Edad , Osteomielitis/epidemiología , Prevalencia
18.
RGO (Porto Alegre) ; 68: e20200032, 2020. graf
Artículo en Inglés | LILACS-Express | LILACS, BBO - Odontología | ID: biblio-1136018

RESUMEN

ABSTRACT This clinical report describes the treatment of a patient dissatisfied with the esthetics of the smile due to the presence of narrow teeth, yellow and the presence of diastema between teeth 11 and 21. Clinical examination revealed absence of the disocclusion guides. The treatment plan consisted in obtaining study casts, assembly in a semi-adjustable articulator and diagnostic waxing, to evaluate the possibilities of a restorative treatment. After the approved the viability of the procedure, dental bleaching was started in-office with 38% hydrogen peroxide associated with at-home bleaching with 15% carbamide peroxide, in order to reduce the yellowing of the teeth. Afterwards, the functional evaluation of the restorative procedure was carried out through the prior preparation of the mock-up. After functional approval of the mock-up, lip frenectomy was performed, since the frenulum is the cause of the diastema between the teeth 11 and 21. After 4 weeks was carried out the restorative procedure of teeth 13 to 23, with direct composite resin, improving the aesthetics of the smile and restoring the disocclusion guides.


RESUMO Este relatório clínico descreve o tratamento de um paciente insatisfeito com a estética do sorriso devido à presença de dentes estreitos, amarelados e à presença de diastema entre os dentes 11 e 21. O exame clínico revelou ausência das guias de desoclusão. O plano de tratamento consistiu na obtenção de modelos de estudo, montagem em um articulador semi-ajustável e enceramento diagnóstico, para avaliar as possibilidades de um tratamento restaurador. Após a aprovação da viabilidade do procedimento, o clareamento dental foi iniciado em consultório, com 38% de peróxido de hidrogênio, associado ao clareamento caseiro, com 15% de peróxido de carbamida, a fim de reduzir o amarelamento dos dentes. Posteriormente, a avaliação funcional do procedimento restaurador foi realizada através da preparação prévia do mock-up. Após aprovação funcional do mock-up, foi realizada a frenectomia labial, uma vez que o freio era a causa do diastema entre os dentes 11 e 21. Após 4 semanas, foi realizado o procedimento restaurador dos dentes 13 ao 23, com resina composta direta, melhorando a estética do sorriso e restaurando as guias de desoclusão.

19.
Gen Dent ; 67(5): 72-76, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31454328

RESUMEN

The objective of this study was to evaluate the influence of the radiopacity of composite resin restorations on the interpretation of phantom radiographic images and to correlate the diagnosis with clinical management. Eighty healthy extracted human third molars were divided into 4 groups (n = 20 each): 3 restorative groups and 1 group of untreated teeth. The radiopacity of the materials was evaluated objectively using 10-mm discs of the composite resins SureFil SDR Flow (SDR), Filtek Bulk Fill Flowable Restorative (Filtek Bulk), and Filtek Z250 XT (Z250). Standard Class II cavities were prepared in the teeth. In the SDR and Filtek Bulk groups, the respective material was placed as a 2-mm base, and the remainder of the cavity was restored with Z250. In the Z250 group, the entire preparation was filled with Z250 composite resin. Ten phantoms of 6 teeth each were created; each phantom included 1 molar selected randomly from each of the 4 groups and 2 healthy premolars. Bitewing radiographs of the phantoms were obtained with a digital phosphor plate system and stored. For the subjective analysis, 5 examiners evaluated each of the molars on the radiographs and established the diagnosis and treatment plan. The radiopacity of the materials was statistically similar (P = 0.413), and there was no statistically significant difference between groups in the interpretation of the images. The radiopacity of the materials met ISO standard 4049/2009. Diagnosis and decision-making were influenced by the radiopacity of the materials. Filtek Z250, which had the lowest radiopacity, was diagnosed correctly more often than SDR, which had higher radiopacity. Filtek Bulk had the highest opacity and the highest percentage of correct diagnoses. In clinical practice, radiographic visualization of restorations and dental structures is essential for establishing a correct diagnosis and treatment plan. A restorative material may be within the established requirements for radiopacity, but on radiographic evaluation it might not be differentiated from mineralized dental tissues.


Asunto(s)
Resinas Compuestas , Caries Dental , Restauración Dental Permanente , Radiografía Dental Digital , Resinas Compuestas/química , Materiales Dentales/química , Humanos , Ensayo de Materiales
20.
BMC Pulm Med ; 19(1): 112, 2019 Jun 24.
Artículo en Inglés | MEDLINE | ID: mdl-31234826

RESUMEN

BACKGROUND: The respiratory microbiome is altered in COPD patients but its relationship with core components of the disease, such as the severity of airflow limitation, the frequency of exacerbations or the circulating levels of eosinophils, is unclear. METHODS: Cross-sectional study comprising 72 clinically stable COPD patients (mean age 68 [SD 7.9] years; FEV1 48.7 [SD 20.1]% of reference) who provided spontaneous sputum samples for 16S rRNA gene amplification and sequencing. The microbiome composition was analysed with QIIME. RESULTS: We observed that: (1) more severe airflow limitation was associated with reduced relative abundance (RA) of Treponema and an increase in Pseudomonas; (2) patients with ≥2 exacerbations the previous year showed a significantly different bacterial community with respect to non-exacerbators (p = 0.014), with changes in 13 genera, including an increase of Pseudomonas, and finally, (3) peripheral eosinophils levels ≥2% were associated with more diverse microbiome [Chao1 224.51 (74.88) vs 277.39 (78.92) p = 0.006; Shannon 3.94 (1.05) vs 4.54 (1.06) p = 0.020], and a significant increase in the RAs of 20 genera. CONCLUSION: The respiratory microbiome in clinically stable COPD patients varies significantly according to the severity of airflow limitation, previous history of exacerbations and circulating eosinophils levels.


Asunto(s)
Eosinófilos/citología , Microbiota , Enfermedad Pulmonar Obstructiva Crónica/sangre , Enfermedad Pulmonar Obstructiva Crónica/microbiología , Sistema Respiratorio/microbiología , Anciano , Estudios Transversales , Progresión de la Enfermedad , Femenino , Volumen Espiratorio Forzado , Humanos , Recuento de Leucocitos , Pulmón/fisiopatología , Masculino , Persona de Mediana Edad , Análisis Multivariante , Estudios Prospectivos , ARN Ribosómico 16S/genética , Índice de Severidad de la Enfermedad , Esputo/citología , Esputo/microbiología
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