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1.
Maedica (Bucur) ; 17(4): 856-861, 2022 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-36818257

RESUMEN

Introduction: To evaluate the role of single dose of intravitreal recombinant tissue plasminogen activator (RTPA) in patients with vitreomacular traction (VMT) and macular edema. Methodology: Eighteen eyes of 18 patients with VMT and macular edema, as evidenced by spectral domain optical coherence tomography (SD-OCT), were selected in our Malda Medical College. After proper history taking and required systemic examinations, each patient underwent detailed ophthalmic examination, including best corrected visual acuity (BCVA), intraocular pressure, slit lamp examination, fundal evaluation by indirect ophthalmoscopy, 78D, 90D lens. All patients underwent SD-OCT examination to evaluate central macular thickness (CMT). Then, after proper informed consent, intravitreal injections with 50 micrograms of RTPA were administered to each patient and all baseline examinations were repeated one month and three months after injection. Results:Postoperatively, 16 patients had complete posterior vitreous detachment (PVD) and 14 resolution of VMT. All participants showed an improvement in BCVA and reduction in CMT. Conclusion:Intravitreal RTPA might be a useful agent in resolution of VMT associated with macular edema.

2.
Maedica (Bucur) ; 16(4): 615-619, 2021 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-35261663

RESUMEN

Aim: To evaluate the role of intravitreal Ranibizumab injection at monthly interval for six doses along with single dose of intravitreal dexamethasone implant at first sitting of Ranibizumab in patients with refractory diabetic macular edema (DME). Methodology: Thirty eyes of 30 patients were selected in our Malda medical college with refractory DME. After proper history taking and required systemic examinations, each patient underwent detailed ophthalmic examination, including best corrected visual acuity (BCVA), intraocular pressure measurement, slit lamp examination, fundal evaluation by indirect ophthalmoscopy, 78D, 90D lens. Spectral domain optical coherence tomography (SD-OCT) has been used to evaluate central macular thickness (CMT) in each patient. After proper informed consent, 0.05 mg Ranibizumab along with 0.7 mg dexamethasone implant were injected intravitreally in each patient at first sitting, followed by intravitreal Ranibizumab for five more doses at one month interval, and all baseline investigations were repeated at one month after the first sitting as well as one month after the last dose of intravitreal Ranibizumab. Results:Postoperatively, 21 patients out of 30 had shown encouraging results as far as both improvement in BCVA and reduction in central macular thickness (CMT) were concerned. Conclusion:Intravitreal Ranibizumab combined with intravitreal dexamethasone implant might be a useful tool to deal with refractory diabetic macular edema (DME).

3.
Maedica (Bucur) ; 16(4): 656-662, 2021 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-35261668

RESUMEN

Aim: To study the ultrastructural, histochemical, cytological features of retina in aborted fetuses of different gestational age and its probable implication in the disease process of retinitis pigmentosa. Methodology: This is a prospective randomized cross sectional study that has been carried out in AIIMS Bhubaneswar from June 2017 to May 2019, jointly by the Department of Anatomy and Obstetrics and Gynaecology, AIIMS, Bhubaneswar, India, after proper institutional approval. Three fetuses from each trimester were taken into the present study; their retina was collected and subsequently sent for cytological, immunohistochemical and ultrastructural explorations. Detailed information from all explorations were collected and properly documented. Results:Fetuses whose retinas that have been shown to contain very few to no rod cells and short-sized cone cells might tend to develop retinitis pigmentosa after birth. Moreover, those cone cells have been shown to contain melanolysosome, phagosomes, autophagic vacuoles, and membranous whorls.

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