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1.
Front Immunol ; 10: 495, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-30949168

RESUMEN

Leprosy is an infectious disease caused by the intracellular bacillus Mycobacterium leprae that mainly affects the skin and peripheral nerves. One of the most intriguing aspects of leprosy is the diversity of its clinical forms. Paucibacillary patients are characterized as having less than five skin lesions and rare bacilli while the lesions in multibacillary patients are disseminated with voluminous bacilli. The chronic course of leprosy is often interrupted by acute episodes of an inflammatory immunological response classified as either reversal reaction or erythema nodosum leprosum (ENL). Although ENL is considered a neutrophilic immune-complex mediated condition, little is known about the direct role of neutrophils in ENL and leprosy disease overall. Recent studies have shown a renewed interest in neutrophilic biology. One of the most interesting recent discoveries was that the neutrophilic population is not homogeneous. Neutrophilic polarization leads to divergent phenotypes (e.g., a pro- and antitumor profile) that are dynamic subpopulations with distinct phenotypical and functional abilities. Moreover, there is emerging evidence indicating that neutrophils expressing CD64 favor systemic inflammation during ENL. In the present review, neutrophilic involvement in leprosy is discussed with a particular focus on ENL and the potential of neutrophils as clinical biomarkers and therapeutic targets.


Asunto(s)
Lepra/inmunología , Neutrófilos/inmunología , Animales , Eritema Nudoso/inmunología , Humanos , Piel/inmunología , Enfermedades de la Piel/inmunología
2.
J Med Microbiol ; 60(Pt 10): 1441-1446, 2011 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-21596907

RESUMEN

We performed genotyping of Mycobacterium leprae present in skin biopsy samples that were collected during the first and the second disease occurrences from eight leprosy patients, seven of whom were diagnosed as suffering from disease relapse. Sequence analysis of part of the M. leprae rpoB, folP1, gyrB and gyrA genes did not show genetic change that supported the presence of drug-resistant bacilli. However, we observed a synonymous nucleotide change at position 297 of gyrA among five of these patients, one presenting C to T (CgyrAT) and four presenting T to C (TgyrAC) at this position. Additional genotyping by analysis of the four short tandem repeats GAA, GTA9, AT17 and TA18 showed that the gyrA single nucleotide polymorphism change was accompanied by a change in short tandem repeat genotype. Our data suggest that leprosy relapse in these patients, living in an area endemic for leprosy, could be caused by M. leprae with a genotype different from the one that caused initial disease.


Asunto(s)
Lepra/epidemiología , Lepra/microbiología , Tipificación Molecular , Mycobacterium leprae/clasificación , Mycobacterium leprae/genética , Adulto , Anciano , Proteínas Bacterianas/genética , Biopsia , Brasil/epidemiología , Femenino , Genotipo , Humanos , Masculino , Persona de Mediana Edad , Mycobacterium leprae/aislamiento & purificación , Recurrencia , Secuencias Repetitivas de Ácidos Nucleicos , Análisis de Secuencia de ADN , Piel/microbiología
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