Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 50
Filtrar
1.
Am Soc Clin Oncol Educ Book ; 38: 249-261, 2018 May 23.
Artículo en Inglés | MEDLINE | ID: mdl-30231398

RESUMEN

Esophageal cancer and gastric cancer are aggressive diseases for which treatment approaches are facing a new era. Some molecular pathways, such as VEGF, EGFR, fibroblast growth factor receptor, PIK3CA, and PARP-1, have been studied, and novel targeted drugs are presumed to be developed in the near future. From The Cancer Genome Atlas report, 80% of Epstein-Barr virus tumors and 42% of tumors with microsatellite instability have PIK3CA mutations, suggesting that this pathway could be reevaluated as a possible target for new systemic treatment of gastric cancer. Notably, higher PARP-1 expression can be found in gastric cancer, which might be related to more advanced disease and worse prognosis. In addition, PD-L1 expression, high microsatellite instability, and mismatch repair deficiency can be found in gastric cancer, thus suggesting that immunotherapy may also play a role in those patients. We discuss trends related to the potential of novel therapies for patients with esophageal and gastric cancers in the near future.


Asunto(s)
Neoplasias Esofágicas/terapia , Neoplasias Gástricas/terapia , Biomarcadores , Biomarcadores de Tumor , Neoplasias Esofágicas/diagnóstico , Neoplasias Esofágicas/genética , Neoplasias Esofágicas/mortalidad , Humanos , Inestabilidad de Microsatélites , Repeticiones de Microsatélite , Mutación , Neoplasias Gástricas/diagnóstico , Neoplasias Gástricas/genética , Neoplasias Gástricas/mortalidad , Resultado del Tratamiento
3.
J Clin Exp Dent ; 10(1): e61-e65, 2018 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-29670717

RESUMEN

Background: The search for the ideal, healthy and reproducible position of the condyles is of utmost importance for dental diagnosis and treatment. Thus, the objective of this laboratory cross-sectional study was to verify the relationship between the posterior joint space and the mandibular lateral movements. Material and Methods: Dental casts from 15 women and 15 men with normal mastication, 28 natural teeth and no history of temporomandibular disorders or pain, were fabricated and mounted on a fully adjustable articulator. From the maximum intercuspal position, condylar displacement was evaluated and measured on the working and nonworking sides during mandibular lateral movement, both to the right and left sides. Results: The correlation between the measures of interest was assessed with the Pearson correlation coefficient (α=.05). Condylar displacement on the working side and nonworking side condyle was 0.88±0.71 mm and 3.57±1.11 mm (right mandibular lateral movement); and 0.91±0.58 mm and 3.51±0.78mm (left mandibular lateral movement), respectively. No significant correlation in the condylar displacement between the working side condyles on the right and on the left sides was observed (r=.22; P=.248). The condylar poles of the articulator moved posteriorly, simulating the functional movements of the mandible during mastication. In all cases, condylar displacement during mandibular lateral movement both to the right and left occurred posteriorly on the working side condyle. Conclusions: The condylar poles of the articulator moved posteriorly simulating the functional movements of the mandible during mastication. Moreover, left and right working condyles may require slightly different spaces to function, suggesting minor anatomical asymmetries. Key words:Mastication, dental occlusion, prosthodontics.

4.
Future Oncol ; 14(6): 567-575, 2018 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-29417838

RESUMEN

The global burden of lung cancer has been increasing over the past years, and is still a major threat to public health worldwide, leading to disabilities and premature mortality. Despite multifactorial cause, smoking remains as the major etiological factor, followed by occupational exposure to carcinogens, genetic predisposition and other concomitant diseases. In order to reduce the individual and social burden due to the direct and indirect costs related to the lung cancer treatment, accurate methods of screening are needed. Among those, x-ray with cytological analysis of sputum was first proposed. Nowadays, more sensitive methods such as low-dose computed tomography are being used to improve the early detection. In the future, molecular biomarkers may complement low-dose computed tomography and improve the robustness of early lung cancer detection.


Asunto(s)
Neoplasias Pulmonares/epidemiología , Algoritmos , Biomarcadores de Tumor , Costo de Enfermedad , Análisis Costo-Beneficio , Diagnóstico por Imagen , Detección Precoz del Cáncer , Humanos , Neoplasias Pulmonares/diagnóstico , Neoplasias Pulmonares/etiología , Tamizaje Masivo/métodos , Vigilancia de la Población , Pronóstico , Factores de Riesgo
5.
Clin Implant Dent Relat Res ; 20(2): 229-242, 2018 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-29205768

RESUMEN

BACKGROUND: Findings in regenerative medicine applied to the sinus lift procedures. PURPOSE: Evaluate the effectiveness of regenerative medicine in sinus lift. MATERIALS AND METHODS: An extensive search for manuscripts were performed by using different combinations of keywords and MeSH terms (Pub-med; Embase; Scopus; Web of Science Core Collection; Medline; Current Contents Connect; Derwent Innovations Index; Scielo Citation Index; Cochrane library). The full text selected articles are written in English, Portuguese, Spanish, Italian, German, or French, and published until 28 of November 2016. Inclusion criteria were: implant osteointegration, radiographic, histologic, and/or histomorphometric analysis, clinical studies in humans using of regenerative medicine. This systematic review was performed by selecting only randomized controlled clinical trials and controlled clinical trials. RESULTS: Eighteen published studies (11 CT and 7 RCT) were considered eligible for inclusion in the present systematic review. These studies demonstrated considerable variation of biomaterial and cell technics used, study design, sinus lift technic, outcomes, follow-up, and results. CONCLUSION: Only few studies have demonstrated potential of regenerative medicine in sinus lift; further randomized clinical trials are needed to achieve more accurate results.


Asunto(s)
Regeneración Ósea , Medicina Regenerativa , Elevación del Piso del Seno Maxilar/métodos , Ingeniería de Tejidos/métodos , Aumento de la Cresta Alveolar/métodos , Humanos , Seno Maxilar/cirugía
6.
Oncotarget ; 8(46): 81679-81685, 2017 Oct 06.
Artículo en Inglés | MEDLINE | ID: mdl-29113423

RESUMEN

Lung cancer (LC) is a serious public health problem responsible for the majority of cancer deaths and comorbidities in developed countries. Tobacco smoking is considered the main risk factor for LC; however, only a few smokers will be affected by this cancer. Current screening methods are focused on identifying the early stages of this malignancy. Thus, new data concerning the roles of microRNA alterations in inflammation, epithelial-mesenchymal transition and lung disease have increased hope about LC pathogenesis, diagnosis, treatment and prognosis. MicroRNA mechanisms include angiogenesis promotion, cell cycle regulation by modulating cellular proliferation and apoptosis, and migration and invasion inhibition. In this context, this manuscript reviews the current information about many important microRNAs as they relate to the initiation and progression of LC.

7.
J Prosthodont Res ; 61(3): 283-289, 2017 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-27866879

RESUMEN

PURPOSE: Due to the bite force importance in functionality of the masticatory system, this study aimed to characterize it in dolichofacial and brachyfacial individuals. METHODS: A sample comprised by 190 patients was divided into two groups: 90 severe dolichofacial, and 100 severe brachyfacial individuals classified according to the VERT index and the face height ratio (Jarabak quotient). Bite force was measured by using an adjusted digital dynamometer and proper methodology. RESULTS: The sample met the parametric assumptions and presented statistical significance when right and left sides of dolichofacial and brachyfacial individuals were compared. However, within the same group, no differences between the left and right sides were found. Generally, bite force was higher for male, left masticator, age between 41-50 years, weighing over 100kg and between 1.81 and 1.90m tall. CONCLUSIONS: Based on the results of this cross-sectional study, it was possible to conclude that the bite force in severe brachyfacial individuals was significantly higher than in severe dolichofacial individuals, being influenced by gender, weight and height.


Asunto(s)
Fuerza de la Mordida , Estatura , Peso Corporal , Cara/anatomía & histología , Masticación/fisiología , Caracteres Sexuales , Adolescente , Adulto , Estudios Transversales , Femenino , Humanos , Masculino , Dimensión Vertical , Adulto Joven
8.
Indian J Med Res ; 143(3): 297-302, 2016 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-27241642

RESUMEN

BACKGROUND & OBJECTIVES: There are many difficulties in generating and testing orofacial pain in animal models. Thus, only a few and limited models that mimic the human condition are available. The aim of the present research was to develop a new model of trigeminal pain by using a spared nerve injury (SNI) surgical approach in the rat face (SNI-face). METHODS: Under anaesthesia, a small incision was made in the infraorbital region of adult male Wistar rats. Three of the main infraorbital nerve branches were tightly ligated and a 2 mm segment distal to the ligation was resected. Control rats were sham-operated by exposing the nerves. Chemical hyperalgesia was evaluated 15 days after the surgery by analyzing the time spent in face grooming activity and the number of head withdrawals in response to the orofacial formalin test. RESULTS: SNI-face rats presented a significant increase of the formalin-induced pain-related behaviours evaluated both in the acute and tonic phases (expected biphasic pattern), in comparison to sham controls. INTERPRETATION & CONCLUSIONS: The SNI-face model in the rat appears to be a valid approach to evaluate experimental trigeminal pain. Ongoing studies will test the usefulness of this model to evaluate therapeutic strategies for the treatment of orofacial pain.


Asunto(s)
Traumatismos Faciales/fisiopatología , Traumatismos del Nervio Facial/fisiopatología , Dolor Facial/fisiopatología , Dimensión del Dolor , Adulto , Animales , Modelos Animales de Enfermedad , Humanos , Masculino , Ratas , Ratas Sprague-Dawley
9.
J Oral Facial Pain Headache ; 30(2): 134-8, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-27128477

RESUMEN

AIMS: To investigate the possible relationship between the orthodontic treatment of Class II malocclusion and the development of temporomandibular disorders (TMD). METHODS: A total of 40 patients was evaluated at four time points: the day before the start of treatment employing bilateral Class II elastics (baseline), as well as at 24 hours, 1 week, and 1 month after the start of treatment. The development of TMD pain complaints in the orofacial region and changes in the range of mouth opening were assessed at these times. Shapiro-Wilk, McNemar, and Friedman tests with 5% significance level were used to analyze the data. RESULTS: The treatment produced pain of a transitory, moderate intensity, but there was no significant change from baseline after 1 month. There were no restrictions in the range of jaw motion or any evidence of limitations in mouth opening. CONCLUSION: Orthodontic treatment with bilateral Class II elastics does not cause significant orofacial pain or undesirable changes in the range of mouth opening. Furthermore, this modality of orthodontic treatment was not responsible for inducing TMD.


Asunto(s)
Trastornos de la Articulación Temporomandibular/etiología , Técnicas de Movimiento Dental/métodos , Adolescente , Adulto , Dolor Facial/etiología , Femenino , Estudios de Seguimiento , Cefalea/etiología , Humanos , Masculino , Maloclusión de Angle Clase II/terapia , Masticación/fisiología , Aparatos Ortodóncicos , Dimensión del Dolor/métodos , Estudios Prospectivos , Rango del Movimiento Articular/fisiología , Articulación Temporomandibular/fisiología , Técnicas de Movimiento Dental/instrumentación , Adulto Joven
10.
Pharmacogenomics ; 16(3): 257-71, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-25712189

RESUMEN

HER2-targeted therapies have radically changed the prognosis of HER2-positive breast cancer over the last few years. However, resistance to these therapies has been a constant, leading to treatment-failure and new tumor progression. Recently, the kinase-impaired HER3 emerged as a pivotal player in oncogenic signaling, with an important role in both non-treated progression and treatment response. HER2/HER3 dimerization is required for full signaling potential and constitutes the key oncogenic unit. Also, when inhibiting PI3K/AKT pathway (as with anti-HER2 drugs) feedback mechanisms lead to a rebound in HER3 activity, which is one of the main roads to resistance. As current strategies to treat HER2-positive breast cancer are unable to inhibit this feedback response, two great promises emerged: the combination of targeted-therapies and drugs targeting HER3. In this article HER2 and HER3-targeted drugs and possible combinations between them, as well as the biomarkers to predict and monitor these drugs effect, are reviewed.


Asunto(s)
Neoplasias de la Mama/genética , Neoplasias de la Mama/terapia , Genes erbB-2 , Terapia Molecular Dirigida/métodos , Biomarcadores de Tumor/genética , Biomarcadores de Tumor/metabolismo , Neoplasias de la Mama/secundario , Resistencia a Antineoplásicos , Femenino , Humanos , Terapia Molecular Dirigida/tendencias , Inhibidores de Proteínas Quinasas/uso terapéutico , Receptor ErbB-2/antagonistas & inhibidores , Receptor ErbB-2/genética , Receptor ErbB-3/antagonistas & inhibidores , Receptor ErbB-3/genética , Transducción de Señal , Trastuzumab/uso terapéutico
11.
J Contemp Dent Pract ; 15(4): 500-5, 2014 Jul 01.
Artículo en Inglés | MEDLINE | ID: mdl-25576120

RESUMEN

AIM: To report on a patient with Eagle's syndrome with a complete and very large ossification of the stylohyoid complex on the right side that to our best knowledge has never been published previously. BACKGROUND: Eagle's syndrome is characterized by a set of symptoms that are caused by the irritation of the neurovascular and soft-tissues caused by an elongated styloid process or ossification of stylohyoid ligament. CASE DESCRIPTION: Because of the high discomfort and pain degree as well as limitations of mandibular and head mobility and also the thickness of the ossifed stylohyoid chain, the patient was treated surgically by removing the hypertrophic segment. CONCLUSION: These symptoms subsided completely after the surgical excision of the anomaly. The elongated styloid process on the left side was symptom free. CLINICAL SIGNIFICANCE: Eagle's syndrome symptoms are not specific and can mimic those of other disorders, the syndrome must be included in the differential diagnosis of patients with pain in the orofacial, pharyngeal and cervical area.


Asunto(s)
Osificación Heterotópica/diagnóstico , Hueso Temporal/anomalías , Trastornos de Deglución/diagnóstico , Diagnóstico Diferencial , Dolor de Oído/diagnóstico , Dolor Facial/diagnóstico , Humanos , Imagenología Tridimensional/métodos , Ligamentos/patología , Masculino , Persona de Mediana Edad , Dolor de Cuello/diagnóstico , Síndrome de la Disfunción de Articulación Temporomandibular/diagnóstico , Tomografía Computarizada por Rayos X/métodos
12.
J Orofac Pain ; 27(3): 271-5, 2013.
Artículo en Inglés | MEDLINE | ID: mdl-23882460

RESUMEN

AIMS: To translate the Pictorial Representation of Illness and Self Measure (PRISM) instrument from German to Portuguese (Brazilian) and adapt it to the Brazilian cultural context, and then assess its reliability and validity in orofacial pain patients. METHODS: The PRISM was translated to Portuguese then back-translated to German. The translated PRISM was evaluated by a multidisciplinary committee and administered as a pre-test to 30 Portuguese-speaking orofacial pain patients. Psychometric properties were obtained after testing 116 orofacial pain patients. Validity was obtained through correlation analyses of scores obtained from PRISM and other psychometric tests, including the Numerical Pain Scale (NPS), Insomnia Severity Index (ISI), and Hospital Anxiety and Depression Scale (HAD). RESULTS: The adapted instrument showed high levels of reliability, proven by means of the test-retest procedure, and calculation of the Intraclass Correlation Coefficient (ICC = 0.991). Significant correlations were found between PRISM and the other tests. Correlation with NPS was moderate (-0.42), whereas correlations with ISI (-0.24), HAD-anxiety (-0.25), and HAD-depression (-0.22) were weak. CONCLUSION: The cross-cultural adaptation process of PRISM was successful and the adapted version offers reliable and valid psychometric properties in the Brazilian context.


Asunto(s)
Comparación Transcultural , Autoevaluación Diagnóstica , Dolor Facial/diagnóstico , Pruebas Psicológicas , Adulto , Brasil , Estudios Transversales , Dolor Facial/psicología , Femenino , Humanos , Lenguaje , Masculino , Persona de Mediana Edad , Dimensión del Dolor , Fotograbar , Estudios Prospectivos , Psicometría , Calidad de Vida , Índice de Severidad de la Enfermedad , Estadísticas no Paramétricas , Estrés Psicológico
13.
Mol Med Rep ; 6(1): 163-6, 2012 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-22576742

RESUMEN

The retinoblastoma (Rb) and p53 genes play a fundamental role in cell cycle mechanisms, and their deregulation is related to many steps of oral cancer carcinogenesis. This study was conducted to evaluate the expression of the p53 and Rb proteins in malignant and pre-malignant oral cavity lesions. This retrospective study was conducted at the Federal University of Bahia, Salvador, Brazil, and the Molecular Biology Laboratory of the Otorhinolaryngology Department at the University of Heidelberg, Heidelberg, Germany. Excisional biopsy samples of oral cavities were collected from patients with suspected oral lesions. The samples were processed by immunohistochemistry to be classified by a semi-quantitative score: samples with a ≤ 10% positivity were considered to have weak/negative expression (-); those with 11-50% positivity, moderate expression (+); and those with >50% positivity, high expression (++). Seventy-one patients were studied (75% male; median age, 52 years; range, 24-84). Of the samples studied, 59.4% were oral squamous cell carcinoma (OSCC) and 40.6% were pre-neoplastic lesions (leukoplakia and actinic cheilitis). OSCC presented higher expression of Rb protein compared to pre-malignant lesions: 75 vs. 25% (p<0.001). Pre-neoplastic lesions presented higher expression of p53 protein compared to OSCC lesions: 55.2 vs. 44.8% (p = 0.030). Despite the small number of samples, the expression of these cell cycle biomarkers (p53 and Rb protein) in excisional biopsies suggests that molecular lesion assessment can determine pre-malignant lesions, and that its use may improve the clinical and surgical treatment of early lesions. Thus, p53 protein expression may be related to the early steps of carcinogenesis in OSCC. Finally, a higher Rb expression was also observed in malignant lesions.


Asunto(s)
Carcinoma de Células Escamosas/metabolismo , Queilitis/metabolismo , Leucoplasia Bucal/metabolismo , Neoplasias de la Boca/metabolismo , Proteína de Retinoblastoma/metabolismo , Proteína p53 Supresora de Tumor/metabolismo , Adulto , Anciano , Anciano de 80 o más Años , Carcinoma de Células Escamosas/patología , Femenino , Humanos , Inmunohistoquímica , Leucoplasia Bucal/patología , Masculino , Persona de Mediana Edad , Neoplasias de la Boca/patología , Clasificación del Tumor , Adulto Joven
14.
Neurosignals ; 19(4): 210-21, 2011.
Artículo en Inglés | MEDLINE | ID: mdl-21912089

RESUMEN

Activating transcription factor 3 (ATF-3) expression has been associated with several signaling pathways implicated in cellular stress response in many cell types and is usually regarded as a neuronal damage marker in dorsal root ganglia (DRG). We investigated ATF-3 expression in primary afferents in the monoarthritic (MA) model of chronic inflammatory joint pain. Immunohistochemistry revealed that ATF-3 is highly induced mainly in small and medium neurons, especially at 2 and 4 days of MA in L(5) DRGs. Colocalization with calcitonin gene-related peptide (CGRP) and isolectin B4 (IB4) demonstrated that ATF-3-immunoreactive cells are mainly peptidergic. The lack of significant differences in ATF-3 and pAkt colocalization indicated that ATF-3 is probably not involved in a pAkt-mediated survival pathway. Anti-inflammatory (ketoprofen) administration failed to reverse ATF-3 induction in MA rats, but significantly increased CGRP expression. These data suggest that ATF-3 expression is definitely involved in MA, actually marking injured neurons. Some degree of neuronal damage seems to occur right from the first days of disease, mainly affecting small-to-medium peptidergic neurons. The intra-articular injection of complete Freund's adjuvant and the generation of a neuroinflammatory environment seem to be the plausible explanation for the local nerve damage.


Asunto(s)
Factor de Transcripción Activador 3/metabolismo , Artritis Experimental/metabolismo , Neuronas Aferentes/metabolismo , Animales , Artritis Experimental/patología , Biomarcadores , Péptido Relacionado con Gen de Calcitonina/metabolismo , Modelos Animales de Enfermedad , Ganglios Espinales/metabolismo , Glicoproteínas/metabolismo , Inmunohistoquímica , Lectinas/metabolismo , Masculino , Neuronas Aferentes/citología , Neuronas Aferentes/patología , Proteínas Proto-Oncogénicas c-akt/metabolismo , Ratas
15.
Med. oral patol. oral cir. bucal (Internet) ; 16(2): 225-230, mar. 2011. ilus, tab
Artículo en Inglés | IBECS | ID: ibc-92991

RESUMEN

Objectives: To investigate apicectomies performed using burs, a CO2 laser or an Er:YAG laser and to evaluate thefollowing aspects: morphology of apicectomized surfaces, presence of failures at the dentin/obturation materialinterface (marginal fit) of the apical portions of the root canals, and the proportions of chemical elements in theapicectomized surfaces.Study design: Twenty-four teeth were divided into three groups of eight and each group underwent apicectomy byone of three different ablation techniques: bur, CO2 laser or Er:YAG laser. The morphology of the apicectomizedsurfaces was then analyzed using scanning electron microscopy and their chemical composition was analyzed byenergy dispersive spectroscopy.Results: Surfaces produced with ablation by bur exhibited less surface irregularities and better marginal fit, whileablation with the CO2 laser caused intense surface carbonization and failures in obturation material fit.Conclusions: Our results suggest that, taking into consideration their clinical application, ablation of tooth apicesusing burs proved to be the best option among those tested here (AU)


Asunto(s)
Humanos , Apicectomía/métodos , Terapia por Láser/métodos , Láseres de Estado Sólido , Láseres de Gas , Microscopía Electrónica de Rastreo
16.
Med Oral Patol Oral Cir Bucal ; 16(2): e225-30, 2011 Mar 01.
Artículo en Inglés | MEDLINE | ID: mdl-20711132

RESUMEN

OBJECTIVES: To investigate apicectomies performed using burs, a CO2 laser or an Er:YAG laser and to evaluate the following aspects: morphology of apicectomized surfaces, presence of failures at the dentin/obturation material interface (marginal fit) of the apical portions of the root canals, and the proportions of chemical elements in the apicectomized surfaces. STUDY DESIGN: Twenty-four teeth were divided into three groups of eight and each group underwent apicectomy by one of three different ablation techniques: bur, CO2 laser or Er:YAG laser. The morphology of the apicectomized surfaces was then analyzed using scanning electron microscopy and their chemical composition was analyzed by energy dispersive spectroscopy. RESULTS: Surfaces produced with ablation by bur exhibited less surface irregularities and better marginal fit, while ablation with the CO2 laser caused intense surface carbonization and failures in obturation material fit. CONCLUSIONS: Our results suggest that, taking into consideration their clinical application, ablation of tooth apices using burs proved to be the best option among those tested here.


Asunto(s)
Técnicas de Ablación , Ápice del Diente/anatomía & histología , Ápice del Diente/cirugía , Adulto , Humanos , Láseres de Gas , Láseres de Estado Sólido , Persona de Mediana Edad
17.
RFO UPF ; 15(2)maio-ago. 2010.
Artículo en Portugués | LILACS, BBO - Odontología | ID: lil-568347

RESUMEN

Diferentes metodologias para verificar o sucesso de materiais odontológicos em apicoplastias com retro-obturaçãotêm sido utilizadas em estudos de infiltração marginal por corante. Apicoplastia é o aplainamento de umápice radicular sem a necessidade de sua amputação, com sua plástica correta. Objetivo: Esta pesquisa objetivou avaliar os resultados de infiltração da rodamina B a 1 por cento num grupo experimental, comparando-se a profundidadede penetração do corante com a sua área de impregnação nas mesmas amostras em apicoplastias comretro-obturação. Métodos: Para tanto utilizaram-se doze caninos humanos superiores tratados endodonticamentee retro-obturados com MTA. Na análise das amostras utilizou-se o software Image Tool® para realizar a morfometriacomputadorizada. Resultados: Os resultados demonstraram um desvio-padrão baixo (4,79) para a mensuração da área e alto (15,05) para mensuração da profundidade de penetração do corante. O teste Mann- Whitney demonstrou diferenças estatisticamente significativas entre os grupos, com p < 0,0001. Conclusão: A utilização da área impregnada por corante, em substituiçãoà profundidade de sua penetração, apresentouse como uma melhor alternativa para mensuração dos escores de infiltração marginal, considerando-se os parâmetros metodológicos utilizados nesta pesquisa.


Asunto(s)
Filtración Dental , Obturación Retrógrada
18.
RFO UPF ; 15(2): [160-164], maio-ago. 2010. ilus, graf, tab
Artículo en Portugués | LILACS, BBO - Odontología | ID: biblio-874358

RESUMEN

Diferentes metodologias para verificar o sucesso de materiais odontológicos em apicoplastias com retro-obturaçãotêm sido utilizadas em estudos de infiltração marginal por corante. Apicoplastia é o aplainamento de umápice radicular sem a necessidade de sua amputação, com sua plástica correta. Objetivo: Esta pesquisa objetivou avaliar os resultados de infiltração da rodamina B a 1 por cento num grupo experimental, comparando-se a profundidadede penetração do corante com a sua área de impregnação nas mesmas amostras em apicoplastias comretro-obturação. Métodos: Para tanto utilizaram-se doze caninos humanos superiores tratados endodonticamentee retro-obturados com MTA. Na análise das amostras utilizou-se o software Image Tool® para realizar a morfometriacomputadorizada. Resultados: Os resultados demonstraram um desvio-padrão baixo (4,79) para a mensuração da área e alto (15,05) para mensuração da profundidade de penetração do corante. O teste Mann- Whitney demonstrou diferenças estatisticamente significativas entre os grupos, com p < 0,0001. Conclusão: A utilização da área impregnada por corante, em substituiçãoà profundidade de sua penetração, apresentouse como uma melhor alternativa para mensuração dos escores de infiltração marginal, considerando-se os parâmetros metodológicos utilizados nesta pesquisa


Asunto(s)
Filtración Dental , Obturación Retrógrada
19.
Pain ; 148(3): 492-502, 2010 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-20106595

RESUMEN

The role of mu-opioid receptors (MORs) in the inflammatory pain processing mechanisms within the ventrobasal complex of the thalamus (VB) is not well understood. This study investigated the effect of modulating MOR activity upon nociception, by stereotaxically injecting specific ligands in the VB. Nociceptive behaviour was evaluated in two established animal models of inflammatory pain, by using the formalin (acute and tonic pain) and the ankle-bend (chronic monoarthritic pain) tests. Control (saline intra-VB injection) formalin-injected rats showed acute and tonic pain-related behaviours. In contrast, intrathalamic administration of [D-Ala(2), N-Me-Phe(4), Gly(5)-ol]-enkephalin acetate (DAMGO), a MOR-specific agonist, induced a statistically significant decrease of all tonic phase pain-related behaviours assessed until 30-35min after formalin hind paw injection. In the acute phase only the number of paw-jerks was affected. In monoarthritic rats, there was a noticeable antinociceptive effect with approximately 40min of duration, as denoted by the reduced ankle-bend scores observed after DAMGO injection. Intra-VB injection of D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH(2) (CTOP), a specific MOR antagonist, or of CTOP followed, 10min after, by DAMGO had no effects in either formalin or ankle-bend tests. Data show that DAMGO-induced MOR activation in the VB has an antinociceptive effect in the formalin test as well as in chronic pain observed in MA rats, suggesting an important and specific role for MORs in the VB processing of inflammatory pain.


Asunto(s)
Inflamación/fisiopatología , Dolor/fisiopatología , Receptores Opioides mu/fisiología , Núcleos Talámicos Ventrales/metabolismo , Analgésicos Opioides/farmacología , Analgésicos Opioides/uso terapéutico , Análisis de Varianza , Animales , Tobillo/inervación , Tobillo/fisiopatología , Conducta Animal , Modelos Animales de Enfermedad , Interacciones Farmacológicas , Encefalina Ala(2)-MeFe(4)-Gli(5)/farmacología , Encefalina Ala(2)-MeFe(4)-Gli(5)/uso terapéutico , Inflamación/tratamiento farmacológico , Masculino , Antagonistas de Narcóticos/farmacología , Dolor/tratamiento farmacológico , Dimensión del Dolor/efectos de los fármacos , Dimensión del Dolor/métodos , Umbral del Dolor/efectos de los fármacos , Ratas , Ratas Wistar , Tiempo de Reacción/efectos de los fármacos , Receptores Opioides mu/agonistas , Receptores Opioides mu/antagonistas & inhibidores , Somatostatina/administración & dosificación , Somatostatina/análogos & derivados , Factores de Tiempo , Núcleos Talámicos Ventrales/efectos de los fármacos
20.
J Appl Oral Sci ; 17(6): 596-9, 2009.
Artículo en Inglés | MEDLINE | ID: mdl-20027433

RESUMEN

OBJECTIVES: CO(2), Er:YAG and Nd:YAG lasers have been used in endodontic surgery. This in vitro study evaluated 1% Rhodamine B dye penetration using computer-assisted morphometry (ImageTool Software) of 108 endodontically treated human permanent canines. MATERIAL AND METHODS: Teeth were divided into 9 groups according to the technique used: A: 90-degree apicoectomy with bur, root-end cavity preparation with ultrasound and filled with MTA; B: 90-degree apicoectomy with bur, root-end cavity prepared with ultrasound and filled with MTA, and treatment of apical surface with CO(2) laser (1 W, CW/CW); C: 90-degree apicoectomy with bur, and treatment of apical surface with Nd:YAG laser (150 mJ, 10 Hz); D: 90-degree apicoectomy with bur, and treatment of apical surface with CO(2) laser,(1 W, CW/CW); E: apicoectomy with Er:YAG laser (400 mJ, 10 Hz), root-end cavity prepared with ultrasound and filled with MTA; F: apicoectomy with Er:YAG laser (400 mJ, 10 Hz) and treatment of apical surface with Nd:YAG laser (150 mJ, 10Hz); G: apicoectomy with CO(2) laser (5W, CW/SP), root-end cavity prepared with ultrasound and filled with MTA; H: irradiation of apical end with CO(2) laser (1 W, CW/CW); I: irradiation of apical end with Nd:YAG laser (150 mJ, 10 Hz). RESULTS: Dye penetration was found in all specimens at different rates, the lowest penetration occurring in groups C (16.20%), B (17.24%) and F (17.84%). CONCLUSIONS: Groups B, C and F represent the best technical sequences to perform endodontic surgery.


Asunto(s)
Apicectomía/métodos , Terapia por Láser/métodos , Láseres de Gas/uso terapéutico , Láseres de Estado Sólido/uso terapéutico , Ápice del Diente/patología , Compuestos de Aluminio/uso terapéutico , Apicectomía/instrumentación , Compuestos de Calcio/uso terapéutico , Diente Canino/patología , Diente Canino/cirugía , Filtración Dental/clasificación , Dentina/patología , Combinación de Medicamentos , Colorantes Fluorescentes , Humanos , Procesamiento de Imagen Asistido por Computador , Óxidos/uso terapéutico , Obturación Retrógrada/métodos , Rodaminas , Materiales de Obturación del Conducto Radicular/uso terapéutico , Preparación del Conducto Radicular/instrumentación , Preparación del Conducto Radicular/métodos , Silicatos/uso terapéutico , Terapia por Ultrasonido/métodos
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA