Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 149
Filtrar
1.
J Transp Geogr ; 101: 103349, 2022 May.
Artículo en Inglés | MEDLINE | ID: mdl-35440861

RESUMEN

The Coronavirus Disease 2019 (COVID-19) epidemic is an unprecedented global health crisis and the effects may be related to environmental and socio-economic factors. In São Paulo, Brazil, the first death occurred in March 2020 and since then the numbers have grown to 175 new deaths per day in April 2021, positioning the city as the epicenter of the number of cases and deaths in Brazil. São Paulo is one of the largest cities in the world with more than 12 million inhabitants, a fleet of about 8 million vehicles and frequent pollutant concentrations above recommended values. Social inequalities are evident in the municipality, similarly to other cities in the world. This paper focuses on transportation activities related to air pollution and associated with cardiovascular and respiratory diseases especially on people who developed comorbidities during their whole life. This study relates travel trip data to air quality analysis and expanded to COVID-19 disease. This work studied the relationship of deaths in São Paulo due to COVID-19 with demographic density, with family income, with the use of public transport and with atmospheric pollution for the period between March 17th, 2020 and April 29th, 2021. The main results showed that generally passenger kilometers traveled, commuting times and air quality related diseases increase with residential distance from the city center, and thus, with decreasing residential density. PM2.5 concentrations are positively correlated with COVID-19 deaths, regions with high urban densities have higher numbers of deaths and long-distance frequent trips can contribute to spread of the disease.

2.
Ann Surg Oncol ; 29(5): 2773-2783, 2022 May.
Artículo en Inglés | MEDLINE | ID: mdl-35211857

RESUMEN

BACKGROUND: The purpose of this article is to summarize the opinions of the surgical oncology leaders from the Global Forum of Cancer Surgeons (GFCS) about the global impact of COVID-19 pandemic on cancer surgery. METHODS: A panel session (virtual) was held at the annual Society of Surgical Oncology 2021 International Conference on Surgical Cancer Care to address the impact of COVID-19 on cancer surgery globally. Following the virtual meeting, a questionnaire was sent to all the leaders to gather additional opinions. The input obtained from all the leaders was collated and analyzed to understand how cancer surgeons from across the world adapted in real-time to the impact of COVID-19 pandemic. RESULTS: The surgical oncology leaders noted that the COVID-19 pandemic led to severe disruptions in surgical cancer care across all domains of clinical care, education, and research. Several new changes/protocols associated with increased costs were implemented to deliver safe care. Leaders also noted that preexisting disparities in care were exacerbated, and the pandemic had a detrimental effect on well-being and financial status. CONCLUSIONS: The COVID-19 pandemic has led to severe disruptions in surgical cancer care globally. Leaders of the GFCS opined that new strategies need to be implemented to prepare for any future catastrophic events based on the lessons learned from the current events. The GFCS will embark on developing such a roadmap to ensure that surgical cancer care is preserved in the future regardless of any catastrophic global events.


Asunto(s)
COVID-19 , Neoplasias , Cirujanos , Oncología Quirúrgica , COVID-19/epidemiología , Humanos , Neoplasias/cirugía , Pandemias
3.
Injury ; 52(3): 633-637, 2021 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-33046249

RESUMEN

AIM: This study aimed to evaluate the clinical outcomes and the trans-syndesmotic screw frequency after trimalleolar ankle fractures with a posterior malleolus fracture involving <25% of the articular surface. MATERIAL AND METHODS: Retrospective comparative study. Patients with trimalleolar ankle fracture who underwent surgery between January 2011 and January 2018 were identified within the departments' fracture database. General demographics, treatment details, and fracture specific details (CT-scans) were assessed. Patients were grouped per the posterior malleolus fragment treatment: osteosynthesis (group 1) and non-osteosynthesis (group 2). RESULTS: 64 patients, 58.6 ± 17.8 years (range: 23-75), 68.8% female were eligible and follow up time was 43.1 ± 22.2 (range 24-96) months. The mean size of the posterior malleolus fragment was 14.7 ± 5.3% (range: 5-24). Posterior malleolus fragment treatment distribution: osteosynthesis (group 1) 31.2% and non- osteosynthesis (group 2) 68.8%. Group 1 showed significantly better clinical outcomes (p<0.05), AOOS (93.9 ± 5.79 (range: 73-99), AOFAS (91.5 ± 6.22 (range: 72-100) and VAS (0.8 ± 1.22 (range: 0-5) compared to Group 2, AOOS (84.25±8.34 (range: 63-100); AOFAS (84.75±8.05 (range: 58-100) and VAS (1.7 ± 1.38 (range: 0-6). Osteosynthesis of the posterior malleolus fragment significantly reduced the frequency of trans-syndesmotic screw (0%) compared to non-osteosynthesis posterior malleolus fragment (15.9%) (p < 0.05). The EQ-5D score was better in group 1 (1.08±0.27 (range: 1-2.2) compared to group 2 (1.27 ± 0.27 (range: 1-2.4) but with no statistical significance (p> 0.15). CONCLUSION: Posterior malleolus fragments (<25% of the articular surface) have significantly better clinical outcomes and significant decrease in trans-syndesmotic screw need following osteosynthesis.


Asunto(s)
Fracturas de Tobillo , Fracturas de Tobillo/diagnóstico por imagen , Fracturas de Tobillo/cirugía , Tornillos Óseos , Femenino , Fijación Interna de Fracturas , Humanos , Masculino , Rango del Movimiento Articular , Estudios Retrospectivos , Resultado del Tratamiento
5.
Environ Res ; 191: 110090, 2020 12.
Artículo en Inglés | MEDLINE | ID: mdl-32835679

RESUMEN

In Mediterranean area, Acacia melanoxylon biomass is an abundant waste material from non-native and invasive tree species control actions, requiring suitable disposal. Valorisation of such biomass residues requires its complete characterization to best approach the full potential of each plant material that could suit specific applications. This study compares mature and juvenile A. melanoxylon plant tissues (wood and bark) from two stands in different locations, regarding their chemical characteristics and organic growing media properties, such as mineral content and phytotoxicity effect for Lepidium sativum seeds. Juvenile bark (JB) showed greater total extractives (29%) extracted using solvents of increasing polarity (dichloromethane, ethanol, and water), followed by mature bark (MB) (21%). MB revealed the highest lignin content (>50%) suggesting material resistance to microbial biodegradation in horticultural applications. High barks phenolic content proved to be phytotoxic for cress seeds (null JB root index), although the toxic substances may be removed. After 1 week, ageing effect reduced MB phytototoxicity (root index > 60%) improving seed performance. Bark presented more mineral elements availability than wood. Wood high cellulose (>50%), low extractive (<9%) and moderate total lignin (<30%) contents can be attractive for pulp production, while bark growth medium profile may potentiate its application for horticultural uses. The future research on novel uses of A. melanoxylon plant residues can result in economic benefits that may alleviate management costs.


Asunto(s)
Acacia , Biomasa , Fenoles , Extractos Vegetales , Madera
6.
Exp Parasitol ; 216: 107939, 2020 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-32535115

RESUMEN

Gaucher disease is a lysosomal storage disease in which a genetic deficiency in ß-glucocerebrosidase leads to the accumulation of glycosphingolipids in lysosomes. Macrophages are amongst the cells most severely affected in Gaucher disease patients. One phenotype associated with Gaucher macrophages is the impaired capacity to fight bacterial infections. Here, we investigate whether inhibition of ß-glucocerebrosidase activity affects the capacity of macrophages to phagocytose and act on the early containment of human pathogens of the genus Leishmania. Towards our aim, we performed in vitro infection assays on macrophages derived from the bone marrow of C57BL/6 mice. To mimic Gaucher disease, macrophages were incubated with the ß-glucocerebrosidase inhibitor, conduritol B epoxide (CBE), prior to contact with Leishmania. This treatment guaranteed that ß-glucocerebrosidase was fully inhibited during the contact of macrophages with Leishmania, its enzymatic activity being progressively recovered along the 48 h that followed removal of the inhibitor. Infections were performed with L. amazonensis, L. infantum, or L. major, so as to explore potential species-specific responses in the context of ß-glucocerebrosidase inactivation. Parameters of infection, recorded immediately after phagocytosis, as well as 24 and 48 h later, revealed no noticeable differences in the infection parameters of CBE-treated macrophages relative to non-treated controls. We conclude that blocking ß-glucocerebrosidase activity during contact with Leishmania does not interfere with the phagocytic capacity of macrophages and the early onset of leishmanicidal responses.


Asunto(s)
Glucosilceramidasa/antagonistas & inhibidores , Leishmania/fisiología , Macrófagos/parasitología , Fagocitosis , Animales , Inhibidores Enzimáticos/farmacología , Citometría de Flujo , Enfermedad de Gaucher/complicaciones , Enfermedad de Gaucher/fisiopatología , Glucosilceramidasa/efectos de los fármacos , Glucosilceramidasa/genética , Inositol/análogos & derivados , Inositol/farmacología , Leishmania infantum/fisiología , Leishmania major/fisiología , Leishmania mexicana/fisiología , Lisosomas/efectos de los fármacos , Lisosomas/enzimología , Macrófagos/enzimología , Ratones , Ratones Endogámicos C57BL , Microscopía Fluorescente , Fagocitosis/efectos de los fármacos
7.
Phys Rev E ; 101(3-1): 032126, 2020 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-32289962

RESUMEN

We study, numerically, a system of active particles with either a single noise value or a mixture of equal proportions of particles with two noise values under the influence of an attractive periodic background potential, and we observe their diffusion regimes and trapping states. For the single noise system, we show that the slow diffusion is correlated to a significant particle trapping, while normal diffusion is seen for partial or no trapping. Our results indicate that low noise particles are less susceptible to the background, i.e., they have a smaller chance to be trapped as compared to higher noise particles for the same background, and that denser systems achieve a no-trapping state, unless for the largest noise value we studied. For the mixtures, we study the sorting of particles based on their noise value differences and observe that particles with distinct noises are trapped at distinct radii compared to a trap minimum, and, since these radii depend on the density, the latter should be well tuned in order to have an efficient sorting.

8.
Phys Rev E ; 101(2-1): 022135, 2020 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-32168676

RESUMEN

Recent experimental findings on anomalous diffusion have demanded novel models that combine annealed (temporal) and quenched (spatial or static) disorder mechanisms. The comb model is a simplified description of diffusion on percolation clusters, where the comblike structure mimics quenched disorder mechanisms and yields a subdiffusive regime. Here we extend the comb model to simultaneously account for quenched and annealed disorder mechanisms. To do so, we replace usual derivatives in the comb diffusion equation by different fractional time-derivative operators and the conventional comblike structure by a generalized fractal structure. Our hybrid comb models thus represent a diffusion where different comblike structures describe different quenched disorder mechanisms, and the fractional operators account for various annealed disorder mechanisms. We find exact solutions for the diffusion propagator and mean square displacement in terms of different memory kernels used for defining the fractional operators. Among other findings, we show that these models describe crossovers from subdiffusion to Brownian or confined diffusions, situations emerging in empirical results. These results reveal the critical role of interactions between geometrical restrictions and memory effects on modeling anomalous diffusion.

9.
Proc Nutr Soc ; 79(2): 246-251, 2020 05.
Artículo en Inglés | MEDLINE | ID: mdl-32090719

RESUMEN

Vitamin D is a fundamentally critical nutrient that the human body requires to function properly. It plays an important role in musculoskeletal health due to its involvement in the regulation of calcium and phosphorus. Having a low level of vitamin D in the body may be detrimental for a wide range of health outcomes, including risk of osteoporotic and stress fractures, risk of CVD and some cancers, and lowering of the capability of the immune system. Vitamin D is an unusual nutrient; it is not a vitamin, in the true sense of the word but a pro-hormone. The main source of vitamin D is UV exposure, not dietary intake. Interestingly, there are two forms of vitamin D, vitamin D2 and vitamin D3, both of which are metabolised into 25-hydroxyvitamin D (25(OH)D) in the liver, the biomarker of vitamin D status. Vitamin D deficiency is a global public health problem, especially amongst older people and ethnic minority groups. The newest publication from the UK Government's Public Health England Department recommends that vitamin D intake should be 10 µg daily and this recommendation compares well (albeit lower) with other guidelines such as the Institute of Medicine recommendation of 15 µg for those aged 1-70 years and 20 µg for those 70 years or over. Few countries, however, have a specific vitamin D policy to prevent deficiency in populations. Finland leads the way, demonstrating impressive results in reducing population-level vitamin D deficiency through mandatory food fortification programmes. Collaboration between academia, government and industry, including countries from varying latitudes, is essential to identify long-term solutions to the global issue of vitamin D deficiency. This paper provides a narrative review of the evidence related to the role of vitamin D deficiency in health outcomes, outlines controversies regarding setting levels of adequacy, identifies the prevalence of vitamin D deficiency across the globe, and identifies population-level strategies adopted by countries to prevent vitamin D deficiency.


Asunto(s)
Suplementos Dietéticos , Deficiencia de Vitamina D/epidemiología , Vitamina D/administración & dosificación , Vitamina D/fisiología , Variación Biológica Poblacional , Salud Global , Humanos , Estado Nutricional , Ingesta Diaria Recomendada , Vitamina D/análogos & derivados , Vitamina D/sangre , Deficiencia de Vitamina D/diagnóstico
10.
SLAS Discov ; 25(2): 176-185, 2020 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-31709883

RESUMEN

Protein kinases are intensely studied mediators of cellular signaling. While traditional biochemical screens are capable of identifying compounds that modulate kinase activity, these assays are limited in their capability of predicting compound behavior in a cellular environment. Here, we aim to bridge target engagement and compound-cellular phenotypic behavior by utilizing a bioluminescence resonance energy transfer (BRET) assay to characterize target occupancy within living cells for Bruton's tyrosine kinase (BTK). Using a diverse chemical set of BTK inhibitors, we determine intracellular engagement affinity profiles and successfully correlate these measurements with BTK cellular functional readouts. In addition, we leveraged the kinetic capability of this technology to gain insight into in-cell target residence time and the duration of target engagement, and to explore a structural hypothesis.


Asunto(s)
Agammaglobulinemia Tirosina Quinasa/aislamiento & purificación , Transferencia Resonante de Energía de Fluorescencia/métodos , Ensayos Analíticos de Alto Rendimiento/métodos , Inhibidores de Proteínas Quinasas/farmacología , Agammaglobulinemia Tirosina Quinasa/química , Agammaglobulinemia Tirosina Quinasa/genética , Humanos , Cinética , Fosforilación/efectos de los fármacos , Inhibidores de Proteínas Quinasas/química
11.
Proc Math Phys Eng Sci ; 475(2231): 20190432, 2019 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-31824219

RESUMEN

We investigate a connection between random walks and nonlinear diffusion equations within the framework proposed by Einstein to explain the Brownian motion. We show here how to properly modify that framework in order to handle different physical scenarios. We obtain solutions for nonlinear diffusion equations that emerge from the random walk approach and analyse possible connections with a generalized thermostatistics formalism. Finally, we conclude that fractal and fractional derivatives may emerge in the context of nonlinear diffusion equations, depending on the choice of distribution functions related to the spreading of systems.

12.
Phys Rev Lett ; 122(9): 090502, 2019 Mar 08.
Artículo en Inglés | MEDLINE | ID: mdl-30932510

RESUMEN

We demonstrate the use of shortcuts to adiabaticity protocols for initialization, read-out, and coherent control of dressed states generated by closed-contour, coherent driving of a single spin. Such dressed states have recently been shown to exhibit efficient coherence protection, beyond what their two-level counterparts can offer. Our state transfer protocols yield a transfer fidelity of ∼99.4(2)% while accelerating the transfer speed by a factor of 2.6 compared to the adiabatic approach. We show bidirectionality of the accelerated state transfer, which we employ for direct dressed state population read-out after coherent manipulation in the dressed state manifold. Our results enable direct and efficient access to coherence-protected dressed states of individual spins and thereby offer attractive avenues for applications in quantum information processing or quantum sensing.

13.
Sci Total Environ ; 668: 333-341, 2019 Jun 10.
Artículo en Inglés | MEDLINE | ID: mdl-30852210

RESUMEN

The knowledge of the allergen content in the atmosphere is a useful tool to stablish the risk allergy warnings for the sensitive people. In Portugal the main airborne allergenic pollen come from trees (such as Betula or Olea), grasses or weeds (mainly Urticaceae). The present study sought the quantification of the Bet v 1, Ole e 1, Lol p1 and Par j1-2 aeroallergen concentration as well as how weather variables influence in the pollen and allergen concentration in Porto city. Aerobiological study was carried out by a Hirst-type volumetric sampler for pollen collection and a Burkard Cyclone sampler for the aeroallergens. A regression analysis between pollen and allergens was conducted for the identification the allergenic risk days. High Pollen Allergen Potency in the atmosphere was observed considering the low levels of airborne pollen detected. A significant and positive correlation has been obtained between pollen and aeroallergen values with the temperatures whereas the correlation was negative with relative humidity, rainfall and wind speed. Back trajectory methodology was applied in order to analyse the discordances between pollen and allergen maximum concentrations. The analysis showed that when the pollen and allergen peaks were registered on the same day, air masses always comes from the continent. However, when the peaks do not coincide, the air mass comes from the continent in the case of the pollen peak and from the sea for the allergen peak. This behaviour can be a consequence of the high humidity in the air masses from the sea, which can benefit the allergen release from pollen grains. In our study it was observed that the available traditional information for allergenic Type I patients, corresponding to the amount of pollen grains in the bioaerosol, do not accurately identify the real allergenic load in the air.


Asunto(s)
Contaminantes Atmosféricos/análisis , Alérgenos/análisis , Monitoreo del Ambiente , Polen , Atmósfera , Ciudades , Humanos , Portugal
14.
Phys Rev E ; 99(1-1): 013311, 2019 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-30780266

RESUMEN

Imaging techniques are essential tools for inquiring a number of properties from different materials. Liquid crystals are often investigated via optical and image processing methods. In spite of that, considerably less attention has been paid to the problem of extracting physical properties of liquid crystals directly from textures images of these materials. Here we present an approach that combines two physics-inspired image quantifiers (permutation entropy and statistical complexity) with machine learning techniques for extracting physical properties of nematic and cholesteric liquid crystals directly from their textures images. We demonstrate the usefulness and accuracy of our approach in a series of applications involving simulated and experimental textures, in which physical properties of these materials (namely: average order parameter, sample temperature, and cholesteric pitch length) are predicted with significant precision. Finally, we believe our approach can be useful in more complex liquid crystal experiments as well as for probing physical properties of other materials that are investigated via imaging techniques.

15.
Waste Manag ; 79: 1-7, 2018 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-30343736

RESUMEN

The use of industrial Eucalyptus globulus bark residues for organic growing media formulation was studied. Hydrothermal treatments were tested using Response Surface Methodology approach. Model design consisted of twelve combinations of temperature (T: 60-140 °C) and residential time (t: 20-60') to evaluate the effect on bark properties. Temperature had a significant effect in C mineralization and N immobilization rates, where the lowest responses (111.8 mmol CO2 kg-1 d-1 and NIR = 4.1 mmol N kg-1 d-1, respectively) compared to IEB (214.6 mmol CO2 kg-1 d-1 and 8.9 N kg-1 d-1, respectively) were suggested after modeling at 40 °C during 70'. Industrial bark was phytotoxic and treatments were effective for phytotoxicity removal. Industrial bark presented high air content but low water availability; treatments had no effect on bark physical properties and the use of demineralized water may have leached nutrient content. Results from pot experiment recommend the use of 25% (v v-1) of treated barks in future growing media formulations.


Asunto(s)
Eucalyptus , Frío , Corteza de la Planta , Temperatura , Agua
16.
Mol Genet Metab ; 125(1-2): 161-167, 2018 09.
Artículo en Inglés | MEDLINE | ID: mdl-30030044

RESUMEN

Invariant natural killer T (iNKT) cells are a subset of T lymphocytes that recognize lipid antigens presented on CD1d molecules at the surface of antigen-presenting cells. GM2 is a glycosphingolipid abundant in cellular membranes and known to bind CD1d molecules, but the functional consequences of this binding are not completely clarified. Herein, we analyzed the effect of GM2 in iNKT cell activation. We found that culturing antigen-presenting cells or total peripheral blood mononuclear cells with GM2 did not induce activation of human iNKT cells, implying that this lipid is not antigenic for human iNKT cells. To investigate if this lipid could inhibit iNKT cell activation, we simultaneously incubated antigen-presenting cells with GM2 and the iNKT cell antigen α-Galactosylceramide (α-GalCer) and used them to stimulate iNKT cells. We found that GM2 reduced human iNKT cell activation in a dose-dependent manner. An explanation for this effect could be a direct competition of GM2 with antigenic lipids for CD1d binding. This was demonstrated by the use of an antibody (L363) that stains mouse CD1d:α-GalCer complexes, as in the presence of GM2 the amount of CD1d:α-GalCer complexes are reduced. We further explored the consequences of chronic GM2 overload on human iNKT cells by analyzing iNKT cells in patients diagnosed with GM2 gangliosidoses. We found that pediatric patients present a higher frequency of circulating CD4+ iNKT cells and concomitant lower frequency of CD4-CD8- iNKTs. A lower percentage of iNKT cells expressing the NK marker CD161 was also observed in these patients. In contrast, in two adult patients studied, no differences on iNKT cell phenotype were observed. Altogether, this study uncovers a new role for GM2 in the modulation of iNKT cell activation, thus strengthening the central role of lipid metabolism in iNKT cell biology.


Asunto(s)
Antígenos CD1d/genética , Galactosilceramidas/metabolismo , Gangliosidosis GM2/metabolismo , Glicoesfingolípidos/metabolismo , Animales , Antígenos CD1d/metabolismo , Humanos , Activación de Linfocitos/efectos de los fármacos , Ratones , Células T Asesinas Naturales/efectos de los fármacos , Células T Asesinas Naturales/metabolismo
17.
J Microencapsul ; 35(4): 344-356, 2018 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-29889598

RESUMEN

Pharmaceutical research has been focussed on developing improved delivery systems while exploring new ways of using approved excipients. The present work investigated the potential of starch nanocapsules (StNC) as a topical delivery platform for hydrophilic antimicrobial drugs using minocycline hydrochloride (MH) as a model drug. Thus, a quality by design approach was used to assess the role of different factors that affect the main pharmaceutical properties of StNC prepared using an emulsification-solvent evaporation method. Full characterisation was performed in terms of particle size, encapsulation efficiency, morphology and physical stability at 5 ± 3 °C. Results show the surfactant and lipid contents play a major role in StNC particle size distribution. The MH loading only promoted minor changes upon StNC properties. Formulations were stable without variations on physicochemical properties. All tested formulations presented a zeta-potential of +33.6 ± 6.7 mV, indicating a good physical stability and evidencing that StNC are suitable nanocarriers for topical use.


Asunto(s)
Antibacterianos/administración & dosificación , Minociclina/administración & dosificación , Nanocápsulas/química , Almidón/química , Administración Tópica , Antibacterianos/química , Composición de Medicamentos , Estabilidad de Medicamentos , Excipientes/química , Interacciones Hidrofóbicas e Hidrofílicas , Minociclina/química , Tamaño de la Partícula , Solubilidad , Tensoactivos/química
18.
J Transcat Intervent ; 26(supl. 1): 26-27, jun., 2018.
Artículo en Portugués | Sec. Est. Saúde SP, Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1046793

RESUMEN

INTRODUÇÃO: Recentemente, o conceito dos chamados balões farmacológicos tem sido testado no tratamento da reestenose intra stent, como uma alternativa de tratamento sem implante adicional de outra camada de metal no sítio previamente tratado. Ainda que os balões farmacológicos com paclitaxel tenham se mostrado eficazes para esta finalidade, esta tecnologia ainda apresenta alguns desafios: o paclitaxel é sabidamente menos efetivo e mais tóxico que outros fármacos anti-proliferativos, em especial quando comparado ao sirolimus e seus análogos/derivados. No presente estudo avaliamos um novo balão-farmacológico (Magic Touch), que utiliza sirolimus na dose de 1,27µg/mm2 , depositado em solução excipiente (nano partícula), na concentração de 1:1. MÉTODOS: Estudo prospectivo, multicêntrico, de braço único, incluindo pacientes com reestenose tanto de stents nãofarmacológicos como farmacológicos, tratados com balão Magic Touch. Não foram incluídas reestenoses do tipo oclusiva. Os pacientes foram submetidos a avaliação angiográfica e com ultrassom (USIC) aos seis meses. O desfecho primário foi a avaliação do grau de supressão neointinamal aos seis meses pela angiografia (perda luminal) e USIC (% de obstrução luminal). RESULTADO: Um total de 17 pacientes foram incluídos, sendo a maioria do sexo masculino (59%), com média de idade de 58 anos e com 60% de diabéticos. Metade da população tratada apresentava reestenose de stents farmacológicos e em 62% dos casos a reestenose era do tipo difusa/proliferativa. Sucesso angiográfico foi obtido em 100% dos casos. Aos 6 meses, a mediana da perda luminal tardia intra stent foi de 0,21mm [0,07; 0,51] ao passo que ao USIC, o% de obstrução luminal foi de 20% [18; 24]. Do ponto de vista clínico, ocorreu apenas um óbito, de causa não cardíaca. CONCLUSÃO: Neste estudo inicial em humanos, o balão farmacológico com sirolimus e nano partículas mostrou-se eficaz em reduzir a proliferação neointimal em pacientes com reestenose prévia de stents não-farmacológicos e/ou farmacológicos. (AU)


Asunto(s)
Humanos , Reestenosis Coronaria , Nanocompuestos , Stents Liberadores de Fármacos
19.
Nat Commun ; 9(1): 1221, 2018 03 23.
Artículo en Inglés | MEDLINE | ID: mdl-29572537

RESUMEN

The understanding of interactions between electrons and phonons in atomically thin heterostructures is crucial for the engineering of novel two-dimensional devices. Electron-phonon (el-ph) interactions in layered materials can occur involving electrons in the same layer or in different layers. Here we report on the possibility of distinguishing intralayer and interlayer el-ph interactions in samples of twisted bilayer graphene and of probing the intralayer process in graphene/h-BN by using Raman spectroscopy. In the intralayer process, the el-ph scattering occurs in a single graphene layer and the other layer (graphene or h-BN) imposes a periodic potential that backscatters the excited electron, whereas for the interlayer process the el-ph scattering occurs between states in the Dirac cones of adjacent graphene layers. Our methodology of using Raman spectroscopy to probe different types of el-ph interactions can be extended to study any kind of graphene-based heterostructure.

20.
Phys Rev Lett ; 120(4): 040505, 2018 Jan 26.
Artículo en Inglés | MEDLINE | ID: mdl-29437450

RESUMEN

Microwave squeezing represents the ultimate sensitivity frontier for superconducting qubit measurement. However, measurement enhancement has remained elusive, in part because integration with standard dispersive readout pollutes the signal channel with antisqueezed noise. Here we induce a stroboscopic light-matter coupling with superior squeezing compatibility, and observe an increase in the final signal-to-noise ratio of 24%. Squeezing the orthogonal phase slows measurement-induced dephasing by a factor of 1.8. This scheme provides a means to the practical application of squeezing for qubit measurement.

SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA
...