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Interventions (Lond) ; 22(5): 641-656, 2020 Feb 12.
Artículo en Inglés | MEDLINE | ID: mdl-32982570


The somatic effects of empire can be found in Tim Winton's "pneumatic materialism", an aesthetic preoccupation in his novels with moments of anoxia, or the deprivation of oxygen to the brain. This essay will consider how Winton's novel engage with pneumatic materialism in response to questions of uneven development traditionally associated with the Global South, thereby disrupting clear South-North distinctions. By blurring his concerns across the North-South divide, Winton shows a willingness to think of empire as a series of relations that are not bound by national or territorial borders so much as by substances in the air. He does this, I argue, in his use of the breath.

Med Humanit ; 2020 Jun 16.
Artículo en Inglés | MEDLINE | ID: mdl-32546553


This article considers the dynamics of shame and cynicism in A J Cronin's The Citadel (1937) and Samuel Shem's The House of God (1978). The protagonists of both novels are forced into shameful situations. Their response to these situations is increased cynicism. This results in a feedback loop: cynicism begets shame, which, in turn, causes more cynicism. Drawing on Bonnie Mann's work on shame-to-power conversion, the article suggests that the novels stage a shame-to-cynicism conversion, which anticipates possible links between cynicism and shame in medical education. The overwhelming success of both novels in shaping the popular imaginary of healthcare professionals means that this dynamic, far from being isolated to the novels, might speak to shared concerns in the education scholarship.

Med Humanit ; 45(3): 294-303, 2019 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-31371484


Health research is often bounded by disciplinary expertise. While cross-disciplinary collaborations are often forged, the analysis of data which draws on more than one discipline at the same time is underexplored. Life of Breath, a 5-year project funded by the Wellcome Trust to understand the clinical, historical and cultural phenomenology of the breath and breathlessness, brings together an interdisciplinary team, including medical humanities scholars, respiratory clinicians, medical anthropologists, medical historians, cultural theorists, artists and philosophers. While individual members of the Life of Breath team come together to share ongoing work, collaborate and learn from each other's approach, we also had the ambition to explore the feasibility of integrating our approaches in a shared response to the same piece of textual data. In this article, we present our pluralistic, interdisciplinary analysis of an excerpt from a single cognitive interview transcript with a patient with chronic obstructive pulmonary disease. We discuss the variation in the responses and interpretations of the data, why research into breathlessness may particularly benefit from an interdisciplinary approach, and the wider implications of the findings for interdisciplinary research within health and medicine.

Investigación Biomédica/métodos , Disnea , Relaciones Interprofesionales , Conducta Cooperativa , Interpretación Estadística de Datos , Humanos , Comunicación Interdisciplinaria
Chron Respir Dis ; 16: 1479973119847659, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31137961


Pulmonary rehabilitation (PR) is recommended for all individuals living with a lung condition and chronic breathlessness. This article considers how adopting an interdisciplinary, medical humanities approach to the term 'pulmonary rehabilitation' might unpack some of the misconceptions, misrepresentations or negative connotations surrounding it, which have been largely overlooked in explanations of the low uptake of this programme. Taking key insights from Wellcome Trust-funded Life of Breath project, including ethnographic research in community fitness groups in North East England and the 'Breath Lab' special interest group, this article outlines how the whole-body approach of PR is not easily understood by those with lung conditions; how experience can inform breath perception through the pacing of everyday life; and how stigma can impact rehabilitation. This article highlights the value of medical humanities in working through communicative challenges evident in the translation of PR between patient and clinical contexts and sets out two arts-based approaches (Singing for Lung Health and dance movement) as potential options that could be included in the PR referral. Finally, the article outlines the need for collaborative research exploring the communication and meaning of healthcare strategies and experiences at the interface of the arts, humanities and medical practice.

Terapia a traves de la Danza , Disnea/rehabilitación , Comunicación en Salud , Enfermedades Pulmonares/rehabilitación , Participación del Paciente , Terapia Respiratoria , Canto , Terminología como Asunto , Actitud Frente a la Salud , Enfermedad Crónica , Humanidades , Humanos , Estigma Social
Med Humanit ; 42(4): e31-e35, 2016 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-27542677


Breath has a realist function in most artistic media. It serves to remind the reader, the viewer or the spectator of the exigencies of the body. In science fiction (SF) literature and films, breath is often a plot device for human encounters with otherness, either with alien peoples, who may not breathe oxygen, or environments, where there may not be oxygen to breathe. But while there is a technoscientific quality to breath in SF, especially in its attention to physiological systems, concentrating on the technoscientific threatens to occlude other, more affective aspects raised by the literature. In order to supplement the tendency to read SF as a succession of technoscientific accounts of bodily experience, this paper recalls how SF texts draw attention to the affective, non-scientific qualities of breath, both as a metonym for life and as a metaphor for anticipation. Through an engagement with diverse examples from SF literature and films, this article considers the tension between technoscientific and affective responses to breath in order to demonstrate breath's co-determinacy in SF's blending of scientific and artistic discourses.

Drama , Emociones , Vida , Literatura , Metáfora , Películas Cinematográficas , Respiración , Humanos , Ciencia
J Cell Biol ; 194(3): 441-57, 2011 Aug 08.
Artículo en Inglés | MEDLINE | ID: mdl-21807882


In neurons, regulation of gene expression occurs in part through translational control at the synapse. A fundamental requirement for such local control is the targeted delivery of select neuronal mRNAs and regulatory RNAs to distal dendritic sites. The nature of spatial RNA destination codes, and the mechanism by which they are interpreted for dendritic delivery, remain poorly understood. We find here that in a key dendritic RNA transport pathway (exemplified by BC1 RNA, a dendritic regulatory RNA, and protein kinase M ζ [PKMζ] mRNA, a dendritic mRNA), noncanonical purine•purine nucleotide interactions are functional determinants of RNA targeting motifs. These motifs are specifically recognized by heterogeneous nuclear ribonucleoprotein A2 (hnRNP A2), a trans-acting factor required for dendritic delivery. Binding to hnRNP A2 and ensuing dendritic delivery are effectively competed by RNAs with CGG triplet repeat expansions. CGG repeats, when expanded in the 5' untranslated region of fragile X mental retardation 1 (FMR1) mRNA, cause fragile X-associated tremor/ataxia syndrome. The data suggest that cellular dysregulation observed in the presence of CGG repeat RNA may result from molecular competition in neuronal RNA transport pathways.

Proteína del Retraso Mental del Síndrome del Cromosoma X Frágil/metabolismo , Ribonucleoproteína Heterogénea-Nuclear Grupo A-B/genética , Ribonucleoproteína Heterogénea-Nuclear Grupo A-B/metabolismo , Neuronas/metabolismo , ARN Mensajero/metabolismo , Regiones no Traducidas 5' , Animales , Expansión de las Repeticiones de ADN , Dendritas/genética , Dendritas/metabolismo , Proteína del Retraso Mental del Síndrome del Cromosoma X Frágil/genética , Síndrome del Cromosoma X Frágil/genética , Regulación de la Expresión Génica , Conformación de Ácido Nucleico , ARN Mensajero/química , ARN Mensajero/genética , ARN Citoplasmático Pequeño , Ratas , Ratas Sprague-Dawley