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J Prosthodont ; 28(7): 757-765, 2019 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-29679427


PURPOSE: The present randomized clinical trial compared the oral health-related quality of life (OHRQoL), peri-implant parameters, mandible movements, and maxillary complete denture movement during chewing between wearers of single- (1-IOD) and wearers of two-implant overdentures (2-IODs) for a period of 12 months. MATERIALS AND METHODS: Twenty-one complete denture wearers were randomly allocated into two parallel groups: 1-IOD (n = 11) or 2-IODs (n = 10). The validated Brazilian version of the OHIP-EDENT was used to evaluate the OHRQoL. A kinesiograph recorded maxillary complete denture movement during chewing of hard food testing (polysulphide impression material) and soft food testing (bread). Peri-implant parameters were also recorded: plaque index (PI), bleeding on probing (BOP), and probing depth (PD). The Friedman test was used to compare the OHRQoL data and peri-implant parameters among periods; the Mann-Whitney test was performed to compare the groups (1- and 2-IODs). One-way ANOVA and the Bonferroni test were used to compare mandible movement during chewing among periods, and the t-test for independent samples was used to compare the groups. Maxillary complete denture movement was analyzed using three-way ANOVA followed by the Bonferroni test. All statistical analyses were performed at α = 0.05. RESULTS: Both treatments led to better general OHRQoL in comparison to conventional complete dentures (p < 0.001). Better OHRQoL was observed among 2-IOD patients at the 12-month follow up (p = 0.034). Peri-implant parameters were similar irrespective of the group and follow-up period. Vertical opening was significantly higher among 1-IOD patients at 3 months (p = 0.038). Decreased maxillary denture vertical intrusions were observed with complete dentures in comparison with overdentures (p = 0.006), regardless of the food test (p = 0.251); however, vertical intrusion was significantly higher among 1-IOD patients (p = 0.043). CONCLUSIONS: This study suggested that 1-IOD can improve patient OHRQoL and may be similar to 2-IODs in preservation of both peri-implant parameters and masticatory movements.

Prótesis de Recubrimiento , Calidad de Vida , Brasil , Prótesis Dental de Soporte Implantado , Retención de Dentadura , Dentadura Completa Inferior , Humanos , Mandíbula , Masticación , Salud Bucal , Satisfacción del Paciente
J Periodontol ; 88(12): 1244-1252, 2017 12.
Artículo en Inglés | MEDLINE | ID: mdl-28671507


BACKGROUND: The aim of the present study is to evaluate the periodontal clinical and microbiologic responses and possible adverse effects of clarithromycin (CLM) combined with periodontal mechanical therapy in the treatment of patients with generalized aggressive periodontitis. METHODS: Forty patients were selected and randomly assigned into one of two groups: 1) CLM (n = 20): one-stage full-mouth ultrasonic debridement (FMUD) associated with CLM (500 mg, every 12 hours for 3 days); and 2) placebo (n = 20): FMUD associated with placebo pills. Clinical and microbiologic parameters were evaluated at baseline and 3 and 6 months postoperatively. RESULTS: Both treatments presented statistically significant clinical and microbiologic improvements. However, the CLM group presented lower means of probing depth for pockets ≥7 mm at 6 months (4.0 ± 1.7 mm) compared with the placebo group (4.7 ± 1.3 mm) (P = 0.04). In addition, the CLM group also presented greater reduction of Porphyromonas gingivalis (Pg) DNA counts at 6 months (P = 0.0001). CONCLUSION: Results from this study suggest both treatments are effective; however, adjunct use of CLM to FMUD leads to better reduction of deep pockets and Pg at 6 months compared with FMUD alone.

Periodontitis Agresiva/terapia , Antibacterianos/uso terapéutico , Claritromicina/uso terapéutico , Desbridamiento Periodontal/métodos , Adulto , Antibacterianos/efectos adversos , Claritromicina/efectos adversos , Terapia Combinada , Femenino , Humanos , Masculino , Procedimientos Quirúrgicos Ultrasónicos/métodos , Adulto Joven
Gen Dent ; 63(5): 58-64, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-26325644


There is scarce evidence on suitable approaches for the treatment of unresponsive or residual periodontal sites in diabetic patients. This study assessed the effects of surgical debridement (SD) and nonsurgical debridement (NSD), associated with amoxicillin and metronidazole, on clinical and immunological outcomes of residual pockets and adjacent healthy sites in patients with type 2 diabetes. A split-mouth, randomized controlled trial was conducted in 21 patients presenting at least 2 residual pockets in contralateral quadrants 12 months after basic nonsurgical periodontal therapy. Patients received systemic antibiotics, and contralateral quadrants were assigned to receive SD or NSD. The changes in clinical parameters were evaluated from baseline to 12 months. Local levels of 14 cytokines and chemokines were measured with multiplex bead immunoassays at baseline and 3 and 12 months after therapy. There were no statistically significant differences between SD and NSD for changes in clinical parameters from baseline to 12 months (P > 0.05). There was a significantly greater increase in the levels of granulocyte-macrophage colony-stimulating factor and interleukin 6 from baseline to 3 months in the healthy sites adjacent to residual pockets receiving SD (P < 0.05). A significant decrease in the levels of monocyte chemoattractant protein-1 and macrophage inflammatory protein 1α occurred from baseline to 12 months in the residual pockets treated by SD (P < 0.05). In conclusion, SD and NSD resulted in similar clinical benefits at 12 months. The short-term increase in the levels of proinflammatory biomarkers in SD sites probably can be attributed to tissue trauma and healing, and the long-term decrease in the levels of chemotactic factors in residual pockets treated by surgery may reflect remission of infection and stable wound healing in these sites at 12 months.

Quimiocinas/análisis , Citocinas/análisis , Diabetes Mellitus Tipo 2/complicaciones , Desbridamiento Periodontal/métodos , Bolsa Periodontal/terapia , Adulto , Anciano , Amoxicilina/uso terapéutico , Antibacterianos/uso terapéutico , Biomarcadores/análisis , Quimiocina CCL2/análisis , Quimiocina CCL3/análisis , Factor Estimulante de Colonias de Granulocitos y Macrófagos/análisis , Humanos , Interleucina-6/análisis , Metronidazol/uso terapéutico , Persona de Mediana Edad , Bolsa Periodontal/cirugía , Periodoncio/química , Factores de Tiempo
Clin Oral Investig ; 17(1): 67-77, 2013 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-22373777


OBJECTIVES: It was previously reported the clinical results of placing subgingival resin-modified glass ionomer restoration for treatment of gingival recession associated with non-carious cervical lesions. The aim of this study was to evaluate the influence of this treatment on the subgingival biofilm and gingival crevicular fluid (GCF) inflammatory markers. MATERIALS AND METHODS: Thirty-four patients presenting the combined defect were selected. The defects were treated with either connective tissue graft plus modified glass ionomer restoration (CTG+R) or with connective tissue graft only (CTG). Evaluation included bleeding on probing and probing depth, 5 different bacteria targets in the subgingival plaque assessed at baseline, 45, and 180 days post treatments, and 9 inflammatory mediators were also assessed in the GCF. RESULTS: The levels of each target bacterium were similar during the entire period of evaluation (p > 0.05), both within and between groups. The highest levels among the studied species were observed for the bacterium associated with periodontal health. Additionally, the levels of all cyto/chemokines analyzed were not statistically different between groups (p > 0.05). CONCLUSION: Within the limits of the present study, it can be concluded that the presence of subgingival restoration may not interfere with the subgingival microflora and with GCF inflammatory markers analyzed. CLINICAL RELEVANCE: This approach usually leads to the placement of a subgingival restoration. There is a lack of information about the microbiological and immunological effects of this procedure. The results suggest that this combined approach may be considered as a treatment option for the lesion included in this study.

Restauración Dental Permanente/métodos , Encía/trasplante , Recesión Gingival/cirugía , Cementos de Ionómero Vitreo/química , Cementos de Resina/química , Cuello del Diente/microbiología , Desgaste de los Dientes/terapia , Adulto , Bacteroides/aislamiento & purificación , Biopelículas , Tejido Conectivo/trasplante , Placa Dental/microbiología , Femenino , Estudios de Seguimiento , Fusobacterium nucleatum/aislamiento & purificación , Líquido del Surco Gingival/inmunología , Líquido del Surco Gingival/microbiología , Hemorragia Gingival/inmunología , Hemorragia Gingival/microbiología , Recesión Gingival/inmunología , Recesión Gingival/microbiología , Humanos , Mediadores de Inflamación/análisis , Interleucinas/análisis , Masculino , Persona de Mediana Edad , Bolsa Periodontal/inmunología , Bolsa Periodontal/microbiología , Porphyromonas gingivalis/aislamiento & purificación , Prevotella intermedia/aislamiento & purificación , Streptococcus sanguis/aislamiento & purificación , Colgajos Quirúrgicos/trasplante , Cuello del Diente/inmunología , Desgaste de los Dientes/inmunología , Desgaste de los Dientes/microbiología , Adulto Joven