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Artículo en Inglés | MEDLINE | ID: mdl-32231082


Peri-implant soft tissues play a role of paramount importance, not only on the esthetic appearance, but also on the maintenance and long-term stability of implants. The present report presents the conclusions from the Consensus Conference of the South European North African Middle Eastern Implantology & Modern Dentistry Association (SENAME) (4-6 November 2016, Cairo, Egypt). The conference focused on the topic of the soft tissue around dental implants, and in particular, on the influence of implant configurations on the marginal soft tissues, soft tissue alterations after immediate, early or delayed implant placement and immediate loading, the long-term outcomes of soft tissue stability around dental implants, and soft tissue augmentation around dental implants. Thirty world experts in this field were invited to take part in this two-day event; however, only 29 experts were in the final consensus voting process.

Implantes Dentales , Mucosa Bucal , Consenso , Egipto , Humanos
J Biophotonics ; 8(8): 681-6, 2015 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-25237005


High-definition optical coherence tomography (HD-OCT) scanners have recently been developed. We assessed micromorphological HD-OCT correlates of benign naevi (BN) and malignant melanoma (MM). 28 BN and 20 MM were studied using HD-OCT and histology. Epidermal honeycomb/cobblestone pattern, regular junctional cell nests, and edged papillae are more often observed in BN, whereas fusion of rete ridges, pagetoid cells and junctional and/or dermal nests with atypical cells are more frequently seen in MM. A high overlap of HD-OCT features in BN and MM was observed and in 20% of MM we did not find evidence for malignancy in OCT images at all. Using HD-OCT it is possible to visualize architectural and cellular alterations of melanocytic skin lesions. The overlap of HD-OCT features seen in BN and MM and the absence of suspicious HD-OCT features in some MM represents an important limitation of HD-OCT affecting the sensitivity of HD-OCT in diagnosing MM. High-definition optical coherence tomography and the corresponding vertically sectioned histology of a compound naevus.

Melanoma/diagnóstico , Nevo Pigmentado/diagnóstico , Tomografía de Coherencia Óptica , Humanos , Melanoma/patología , Nevo Pigmentado/patología
Implant Dent ; 23(1): 37-43, 2014 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-24384743


PURPOSE: The aim of this study was to evaluate the effect of a biphasic synthetic bone graft material composed of ß-tricalcium phosphate (ß-TCP) and calcium sulfate (CS) in 12 New Zealand rabbits. MATERIALS AND METHODS: A circular bicortical critical-size cranial defect was created in each of 12 rabbits. The defects were grafted with ß-TCP/CS. Animals were euthanized at 3 and 6 weeks. Harvested tissue specimens were evaluated histologically and histomorphometrically. Parameters associated with new bone formation and graft resorption were measured and calculated. The results were statistically analyzed using the Mann-Whitney test. RESULTS: Our data demonstrated the biocompatibility of synthetic ß-TCP/CS, as no inflammatory response was observed, and no fibrosis was developed between the graft particles and the newly formed bone. Moreover, ß-TCP/CS acted as an osteoconductive scaffold that allowed a significant bone regeneration and graft biodegradation with time. CONCLUSION: In this animal model, synthetic ß-TCP/CS proved to be a biocompatible, osteoconductive, and bioresorbable bone graft substitute.

Regeneración Ósea , Sustitutos de Huesos , Trasplante Óseo/métodos , Fosfatos de Calcio , Sulfato de Calcio , Animales , Regeneración Ósea/efectos de los fármacos , Masculino , Conejos , Cráneo/cirugía , Andamios del Tejido
Implant Dent ; 21(5): 399-405, 2012 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-22971979


PURPOSE: To evaluate the effect of autologous platelet-rich plasma (PRP) on the early phases of osteoinduction by allogenic demineralized bone matrix (DBM) in rabbit intramuscular positions. MATERIALS AND METHODS: Allogenic DBM was produced from bones of 3 healthy rabbits. In each of 6 experimental animals, 0.3 mL autologous PRP was prepared and 2 muscle pouches were created, where 250 mg DBM + PRP (experimental sites) and 250 mg DBM without PRP (control sites) were randomly implanted. Animals were euthanized 3 weeks postoperatively. RESULTS: Histologic examination revealed uneventful healing in all cases, whereas remineralization of the periphery of the bone graft particles was a constant finding. In both control and experimental sites, fibroblasts and other mesenchymal cells (probably osteoprogenitor cells and preosteoblasts) were observed. The main histological difference was the recolonization of the empty lacunae of the bone graft particles by osteocytes at the control sites. The degradation of the graft at the control sites was statistically significantly quicker, although a statistically significant difference regarding the amount of the newly formed fibrous connective tissue was not observed. CONCLUSION: The present study demonstrated that in this experimental model, the addition of PRP to DBM had a negative effect on the early phases of osteoinduction at 3 weeks of observation.

Regeneración Ósea , Sustitutos de Huesos , Trasplante Óseo/efectos adversos , Rechazo de Injerto , Plasma Rico en Plaquetas , Animales , Matriz Ósea/trasplante , Regeneración Ósea/efectos de los fármacos , Masculino , Conejos , Distribución Aleatoria