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1.
Artículo en Inglés | MEDLINE | ID: mdl-35523130

RESUMEN

Although commercial treatment planning systems (TPSs) can automatically solve the optimization problem for treatment planning, human planners need to define and adjust the planning objectives/constraints to obtain clinically acceptable plans. Such a process is labor-intensive and time-consuming. In this work, we show an end-to-end study to train a deep reinforcement learning (DRL) based virtual treatment planner (VTP) that can behave like a human to operate a dose-volume constrained treatment plan optimization engine following the parameters used in Eclipse TPS for high-quality treatment planning. We considered the prostate cancer IMRT treatment plan as the testbed. The VTP took the dose-volume histogram (DVH) of a plan as input and predicted the optimal strategy for constraint adjustment to improve the plan quality. The training of VTP followed the state-of-the-art Q-learning framework. Experience replay was implemented with epsilon-greedy search to explore the impacts of taking different actions on a large number of automatically generated plans, from which an optimal policy can be learned. Since a major computational cost in training was to solve the plan optimization problem repeatedly, we implemented a graphical processing unit (GPU)-based technique to improve the efficiency by 2-fold. Upon the completion of training, the established VTP was deployed to plan for an independent set of 50 testing patient cases. Connecting the established VTP with the Eclipse workstation via the application programming interface, we tested the performance the VTP in operating Eclipse TPS for automatic treatment planning with another two independent patient cases. Like a human planner, VTP kept adjusting the planning objectives/constraints to improve plan quality until the plan was acceptable or the maximum number of adjustment steps was reached under both scenarios. The generated plans were evaluated using the ProKnow scoring system. The mean plan score (± standard deviation) of the 50 testing cases were improved from 6.18 ± 1.75 to 8.14 ± 1.27 by the VTP, with 9 being the maximal score. As for the two cases under Eclipse dose optimization, the plan scores were improved from 8 to 8.4 and 8.7 respectively by the VTP. These results indicated that the proposed DRL-based VTP was able to operate the in-house dose-volume constrained TPS and Eclipse TPS to automatically generate high-quality treatment plans for prostate cancer IMRT.

2.
Stem Cell Res ; 62: 102798, 2022 May 02.
Artículo en Inglés | MEDLINE | ID: mdl-35537242

RESUMEN

Epilepsy of infancy with migrating focal seizures (EIMFS) is a kind of epileptic encephalopathy with high genetic heterogeneity. The most common pathogenic gene for EIMFS is potassium sodium-activated channel subfamily T member 1 (KCNT1). Using Sendai virus-mediated reprogramming, we established an induced pluripotent stem cell (iPSC) line from the peripheral blood mononuclear cells (PBMCs) of a five-month-old Chinese girl with heterozygous missense mutation (c.2800 G>A) in the KCNT1 gene. The iPSCs were stable during amplification, expressed pluripotent genes, maintained a normal karyotype, and showed characteristics of the three germs layers in an in vitro differentiation assay.

3.
Chem Commun (Camb) ; 2022 May 03.
Artículo en Inglés | MEDLINE | ID: mdl-35502741

RESUMEN

Durable Cu/NiFe(OH)x electrocatalyst was designed for hydrogen evolution reaction in alkaline media. The in situ generated Cu nanodendrites protect the NiFe(OH)x from being hydrogenated, giving it a > 1000 h lifetime for high-performance water splitting (1.51 V, 10 mA cm-2 in 1 M KOH) when coupled with a NiFe-layered double hydroxide anode.

4.
Front Neurol ; 13: 818335, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35528737

RESUMEN

Background: Assessing rupture risk in patients with unruptured intracranial aneurysms (UIAs) remains challenging. Hemodynamics plays an important role in the natural history of intracranial aneurysms. This study aimed to compare aneurysmal hemodynamic features between patients with different rupture risk as determined by PHASES score. Methods: We retrospectively examined 238 patients who harbored a solitary saccular UIA. Patients were stratified by rupture risk into low-, intermediate-, and high-risk groups according to PHASES score. Flow simulations were performed to compare differences in hemodynamics among the groups. Results: Aneurysmal time-averaged wall shear stress (WSSa) and normalized WSS (WSSn) decreased progressively as PHASES score increased. WSSa and WSSn significantly differed among the low-, intermediate-, and high-risk groups (p < 0.001). WSSa was significantly lower in the high-risk group than the low-risk group (p < 0.001) and the intermediate-risk group (p = 0.004). WSSn was also significantly lower in the high-risk group than the low-risk group (p < 0.001) and the intermediate-risk group (p = 0.001). Conclusions: Low WSS was significantly associated with higher risk of intracranial aneurysm rupture as determined by PHASES score, indicating that hemodynamics may play an important role in aneurysmal rupture. In the future, a multidimensional rupture risk prediction model that includes hemodynamic parameters should be investigated.

5.
Korean J Orthod ; 2022 May 10.
Artículo en Inglés | MEDLINE | ID: mdl-35535016

RESUMEN

Objective: This cross-sectional study aimed to investigate the characteristics of malocclusions in scoliotic patients through clinical examinations. Methods: Fifty-eight patients with idiopathic scoliosis (IS) and 48 patients with congenital scoliosis (CS) participated in the study. A randomly selected group of 152 orthopedically healthy children served as the control group. Standardized orthodontic and orthopedic examination protocols were used to record the occlusal patterns and type of scoliosis. Assessments were made by three experienced orthodontists and a spinal surgery team. The differences in the frequency distribution of occlusal patterns were evaluated by the chi-squared test. Results: In comparison with patients showing IS, patients with CS showed a higher incidence of Cobb angle ≥ 45° (p = 0.020) and included a higher proportion of patients receiving surgical treatments (p < 0.001). The distribution of the Angle Class II subgroup was significantly higher in the IS (p < 0.001) and CS (p = 0.031) groups than in the control group. In comparison with the healthy controls, the CS and IS groups showed significantly higher (p < 0.05) frequencies of asymmetric molar and asymmetric canine relationships, upper and lower middle line deviations, anterior deep overbite, unilateral posterior crossbite, and canted occlusal plane, with the frequencies being especially higher in CS patients and to a lesser extent in IS patients. Conclusions: Patients with scoliosis showed a high frequency of malocclusions, which were most obvious in patients with CS.

6.
Integr Med Res ; 11(3): 100864, 2022 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-35535308

RESUMEN

Background: The number of systematic reviews meta-analyses (SRs/MAs) on the effectiveness of acupuncture for angina pectoris (AP) is increasing. Due to the inconsistent conclusions and unknown quality of these SRs/MAs, this overview aimed to systematically evaluate and synthesize the existing SRs/MAs, attempting to provide more reliable evidence for the effectiveness and safety of acupuncture in the treatment of AP. Methods: SRs/MAs were searched via eight databases from inception to March 14, 2022. The risk of bias was evaluated using the Risk of Bias in Systematic reviews (ROBIS) tool. The quality of the methodology, reporting, and evidence were assessed by the Assess Systematic Reviews 2 (AMSTAR-2), the Preferred Reporting Item for Systematic Review and Meta-analysis for Acupuncture (PRISMA-A), and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system, respectively. Results: Sixteen SRs/MAs were included and fifteen SRs/MAs were considered being of critically low quality according to AMSTAR-2. Only three SRs/MAs were rated at low risk of bias. No study reported all the items listed in the PRISMA-A checklist. No high-quality evidence with GRADE assessment was found. With the low-quality evidence, acupuncture combined with other interventions was superior to monotherapy (medications or Chinese medicine) in the angina symptom and electrocardiogram recovery. No adverse effects owing to acupuncture were reported. Conclusions: Owing to the lack of high-quality evidence provided by the current SRs/MAs, the effectiveness of acupuncture for AP still warrants further proof. Further researches with more critical design and methodology are needed for providing more convincing evidence. Registration: This review was registered at PROSPERO (www.crd.york.ac.uk/prospero/): CRD42021219367.

7.
Chem Commun (Camb) ; 2022 May 10.
Artículo en Inglés | MEDLINE | ID: mdl-35536555

RESUMEN

Crystal engineering is an important way to improve the catalytic performance of transition-metal phosphides. In this work, we propose a strategy for constructing multi-dimensional defects induced by hexamethylenetetramine, which effectively introduces grain boundaries, N doping and P vacancies into Co2P nanosheets, and improves the activity and stability of the catalyst. Due to the synergistic effect of the multi-dimensional defects, the Co2P nanosheets exhibit excellent HER catalytic performance, especially at a large current density of 100 mA cm-2 with an overpotential of only 159 mV. Under 1 M KOH electrolyte and current density of 10 mA cm-2, the long-term test for 36 h shows that the catalyst maintains a very high stability.

8.
Sci Total Environ ; 836: 155625, 2022 May 01.
Artículo en Inglés | MEDLINE | ID: mdl-35508233

RESUMEN

Excessive human activities destroy the structure and function of ecosystem and threaten sustainable development. As a typical resource-based area, Shanxi Province is facing an increasingly serious contradiction between ecosystem and sustainable development, with the overexploitation of resources. In view of this, the coupling coordination degree model was used to measure the association between sustainable development and ecosystem services (SDESs), and geographically and temporally weighted regression model was used to explore the correlation between SDESs and measure the correlation between ecosystem services (ESs) and sustainable development at the county level from 2000 to 2015 in Shanxi Province. The results showed an increase in the sustainable development level and all ESs except soil retention. The coupling coordination degree (CCD) of soil retention and sustainable development decreased, while other services increased. Habitat quality had the strongest negative correlation with sustainable development. There were obvious spatiotemporal heterogeneities in the CCD and correlation of SDESs, which is helpful for promoting regional sustainable development and optimize ecosystem decision-making.

9.
J Affect Disord ; 309: 266-273, 2022 Apr 29.
Artículo en Inglés | MEDLINE | ID: mdl-35490875

RESUMEN

OBJECTIVE: To investigate the impact of 10 common foods (including staple foods, fruits, vegetables, sugar, meat, fish, eggs, beans, salt-preserved vegetables, and garlic) on cognitive function in Chinese older adults. METHODS: Cross-sectional data on demographic characteristics, lifestyle, and dietary habits were taken from the 2018 Chinese Longitudinal Healthy Longevity Survey (CLHLS). Cognition was assessed using the Mini-Mental State Examination (MMSE). Food consumption was measured by participants reporting the frequency of their food consumption. Association between food groups and cognitive function was evaluated using mixed-effect regression model analysis. RESULTS: Compared with those who rarely or never consumed vegetables, meat, fruits, beans, and garlic, older adults who consumed these foods almost daily were 56%, 30%, 23%, 34%, and 29% less likely to have cognitive impairment, respectively. No associations between staple foods, sugar, fish, and eggs consumption and cognitive impairment were found. Low-frequency consumption of salt-preserved vegetables may be associated with cognitive function. Regular vegetables consumption had the greatest associated risk reduction of all food types. Interactions indicated that the co-ingestion of vegetables and beans or sugar, meat and beans may have antagonistic effect, while the co-ingestion of salt-preserved vegetables and garlic may have synergistic effect. Subgroup analyses showed that sex and age were the significant effect modifiers for meat and fish, respectively. CONCLUSIONS: Cognitive function of Chinese older adults may be related to food groups. Future research should measure food types and consumption level with greater granularity.

10.
CNS Neurosci Ther ; 2022 May 04.
Artículo en Inglés | MEDLINE | ID: mdl-35506354

RESUMEN

AIMS: Cigarette smoking is a modifiable risk factor for Alzheimer's disease (AD), and controlling risk factors may curb the progression of AD. However, the underlying neural mechanisms of the effects of smoking on cognition remain largely unclear. Therefore, we aimed to explore the interaction effects of smoking × cognitive status on cortico-striatal circuits, which play a crucial role in addiction and cognition, in individuals without dementia. METHODS: We enrolled 304 cognitively normal (CN) non-smokers, 44 CN smokers, 130 mild cognitive impairment (MCI) non-smokers, and 33 MCI smokers. The mixed-effect analysis was performed to explore the interaction effects between smoking and cognitive status (CN vs. MCI) based on functional connectivity (FC) of the striatal subregions (caudate, putamen, and nucleus accumbens [NAc]). RESULTS: The significant interaction effects of smoking × cognitive status on FC of the striatal subregions were detected in the left inferior parietal lobule (IPL), bilateral cuneus, and bilateral anterior cingulate cortex (ACC). Specifically, increased FC of right caudate to left IPL was found in CN smokers compared with non-smokers. The MCI smokers showed decreased FC of right caudate to left IPL and of right putamen to bilateral cuneus and increased FC of bilateral NAc to bilateral ACC compared with CN smokers and MCI non-smokers. Furthermore, a positive correlation between FC of the NAc to ACC with language and memory was detected in MCI smokers. CONCLUSIONS: Cigarette smoking could affect the function of cortico-striatal circuits in patients with MCI. Our findings suggest that quitting smoking in the prodromal stage of AD may have the potential to prevent disease progression.

11.
Artículo en Inglés | MEDLINE | ID: mdl-35522403

RESUMEN

The healthy development of biodiversity has been threatened frequent water eutrophication. In recent years, photocatalytic technology, which has attracted researchers' attention, not only showed increasing potential in the field of organic pollutant degradation, but also many kinds of photocatalysts were used in the field of red tide pollution control at present, which showed superior ability to inactivate harmful algae and degrade algal toxins. Researches have also explored the mechanisms of photocatalytic algae inhibition. In this study, the current research progress in the field of photocatalytic algae inhibition was systematically discussed from several aspects, such as common types of photocatalysts, modification methods of photocatalysts, types of tested algae for photocatalytic algae inhibition, and action mechanism of inactivated algae cells, so as to provide a certain theoretical basis for further application research of photocatalysts in the field of algae removal in the later period.

12.
Food Chem X ; 14: 100310, 2022 Jun 30.
Artículo en Inglés | MEDLINE | ID: mdl-35492251

RESUMEN

The objective of this study was to develop an effective recovery technology of odor-active compounds (OACs) to improve the flavor quality of instant Pu-erh tea (IPT) based on their released behaviors. Salting-out re-distillation (SRD) combined with sensory-directed analysis was developed. The contributing factors, including the soaking time of tea, recovery volume of condensed water of first distillation, amount of sodium chloride, recovery volume of condensed water of SRD, and re-use times of sodium chloride, were studied systematically. Under optimized conditions, 41 OACs were recovered in the first distillation, and the total recovery rate was 83.94%. Forty-one OACs were recovered via SRD, and the total recovery rate reached 72.29%, significantly better than membrane method (33.46%). The IPT prepared by adding OACs that recovered via SRD showed strong aroma attributes intensities and good coordination. This developed method can provide a more effective scheme to improve the flavor quality of IPT.

13.
Front Med (Lausanne) ; 9: 839787, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35492310

RESUMEN

Background: The main aim of this study was to evaluate the effect of oxygen saturation on mortality in critically ill patients with mechanical ventilation according to obesity status. Methods: We conducted an observational study in mechanically ventilated patients admitted to the ICU retrospectively. Demographic, arterial blood gas, ventilator setting, interventions, and peripheral oxygen saturation (Spo2) during the first 24 h were recorded and analyzed between non-obese and obese patients. The main exposure included Spo2, time-weighted mean Spo2 (TWM-Spo2), and proportion of time spent in different Spo2 (PTS-Spo2) levels. The primary outcome was hospital mortality. We used multivariable logistic regression models to assess the relationship between Spo2 and mortality, as well as the interaction between PTS-Spo2 and obesity status. Results: A total of 25,100 patients were included, of which 10,564 (42%) were obese patients. After adjusting for confounders, compared with TWM-Spo2 of 94-98%, TWM-Spo2 of < =88% (OR 3.572; CI [2.343, 5.455]; p < 0.001) and of 89-93% (OR 1.514; CI [1.343, 1.706]; p < 0.001) were both associated with higher risk of mortality. PTS-Spo2 of 99-100% was associated with increased risk of mortality for obese patients (OR 1.028; 95% CI 1.010-1.046; p = 0.002; Pinteraction = 0.001), while PTS-Spo2 of 89-93% was associated with increased risk of mortality (OR 1.089; 95% CI 1.051-1.128; p < 0.001; Pinteraction = 0.001) for non-obese patients. Conclusions: For obese and non-obese critically ill patients with mechanical ventilation, the impact of oxygen saturation on hospital mortality is different.

14.
Front Aging Neurosci ; 14: 865558, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35493944

RESUMEN

Mild Cognitive Impairment (MCI) is an early stage of dementia, which may lead to Alzheimer's disease (AD) in older adults. Therefore, early detection of MCI and implementation of treatment and intervention can effectively slow down or even inhibit the progression of the disease, thus minimizing the risk of AD. Currently, we know that published work relies on an analysis of awake EEG recordings. However, recent studies have suggested that changes in the structure of sleep may lead to cognitive decline. In this work, we propose a sleep EEG-based method for MCI detection, extracting specific features of sleep to characterize neuroregulatory deficit emergent with MCI. This study analyzed the EEGs of 40 subjects (20 MCI, 20 HC) with the developed algorithm. We extracted sleep slow waves and spindles features, combined with spectral and complexity features from sleep EEG, and used the SVM classifier and GRU network to identify MCI. In addition, the classification results of different feature sets (including with sleep features from sleep EEG and without sleep features from awake EEG) and different classification methods were evaluated. Finally, the MCI classification accuracy of the GRU network based on features extracted from sleep EEG was the highest, reaching 93.46%. Experimental results show that compared with the awake EEG, sleep EEG can provide more useful information to distinguish between MCI and HC. This method can not only improve the classification performance but also facilitate the early intervention of AD.

15.
Front Neurosci ; 16: 872609, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35495065

RESUMEN

Traumatic brain injury (TBI) is a common source of morbidity and mortality among civilians and military personnel. Initial routine neuroimaging plays an essential role in rapidly assessing intracranial injury that may require intervention. However, in the context of TBI, limitations of routine neuroimaging include poor visualization of more subtle changes of brain parenchymal after injury, poor prognostic ability and inability to analyze cerebral perfusion, metabolite and mechanical properties. With the development of modern neuroimaging techniques, advanced neuroimaging techniques have greatly boosted the studies in the diagnosis, prognostication, and eventually impacting treatment of TBI. Advances in neuroimaging techniques have shown potential, including (1) Ultrasound (US) based techniques (contrast-enhanced US, intravascular US, and US elastography), (2) Magnetic resonance imaging (MRI) based techniques (diffusion tensor imaging, magnetic resonance spectroscopy, perfusion weighted imaging, magnetic resonance elastography and functional MRI), and (3) molecular imaging based techniques (positron emission tomography and single photon emission computed tomography). Therefore, in this review, we aim to summarize the role of these advanced neuroimaging techniques in the evaluation and management of TBI. This review is the first to combine the role of the US, MRI and molecular imaging based techniques in TBI. Advanced neuroimaging techniques have great potential; still, there is much to improve. With more clinical validation and larger studies, these techniques will be likely applied for routine clinical use from the initial research.

16.
Front Cardiovasc Med ; 9: 860346, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35498029

RESUMEN

Background: Coronary perfusion pressure (CPP) and coronary artery stenosis are responsible for myocardial perfusion. However, how CPP-related survival outcome affects revascularization is unclear. Objective: The aim of this study is to investigate the prognostic role of CPP in patients with left ventricular systolic dysfunction (LVSD) undergoing percutaneous coronary intervention (PCI) with complete revascularization (CR) or reasonable incomplete revascularization (RIR). Methods: We retrospectively screened 6,076 consecutive patients in a registry. The residual synergy between percutaneous coronary intervention with Taxus and cardiac surgery (SYNTAX) score (rSS) was used to define CR (rSS = 0) and RIR (0 42 mmHg. Moreover, 101 pairs of RIR and CR were present in patients with CPP ≤ 42 mmHg. In patients with CPP > 42 mmHg, RIR was not significantly different from CR in long-term mortality [hazard ratio (HR) 1.20; 95% confidence interval (CI):0.70-2.07; p = 0.513]; However, in patients with CPP≤42 mmHg, RIR had a significantly higher mortality risk than CR (HR 2.39; 95% CI: 1.27-4.50; p = 0.007). Conclusions: The CPP had a risk stratification role in selecting different revascularization strategies in patients with LVSD. When patients with LVSD had CPP > 42 mmHg, RIR was equivalent to CR in survival. However, when patients with LVSD had CPP ≤ 42 mmHg, RIR had a significantly higher mortality risk than CR.

17.
Artículo en Inglés | MEDLINE | ID: mdl-35379120

RESUMEN

BACKGROUND: RNA-binding proteins (RBPs) are crucial factors that function in the post-transcriptional modification process and are significant in cancer. OBJECTIVE: This research aimed for a multigene signature to predict the prognosis and immunotherapy response of patients with colon adenocarcinoma (COAD) based on the expression profile of RNA-binding proteins (RBPs). METHODS: COAD samples retrieved from the TCGA and GEO datasets were utilized for a training dataset and a validation dataset. Totally, 14 shared RBP genes with prognostic significance were identified. Non-negative matrix factorization clusters defined by these RBPs could stratify COAD patients into two molecular subtypes. Cox regression analysis and identification of 8-gene signature acted to categorize COAD patients into high- and low-risk populations with significantly different prognosis and immunotherapy responses. RESULTS: Our prediction signature was superior to another five well-established prediction models. A nomogram was generated to quantificationally predict the overall survival (OS) rate, which was validated by calibration curves. Our findings also indicated that high-risk populations possessed an enhanced immune evasion capacity and low-risk population might be beneficial for immunotherapy, especially for the joint combination of PD-1 and CTLA4 immunosuppressants. DHX15 and LARS2 were detected with significantly different expression in both datasets, which were further confirmed by qRT-PCR and immunohistochemical staining. CONCLUSION: Our observations supported an eight-RBp-related signature that could be applied for survival prediction and immunotherapy response of patients with COAD.

19.
Stroke Vasc Neurol ; 2022 Apr 06.
Artículo en Inglés | MEDLINE | ID: mdl-35387893

RESUMEN

OBJECTIVES: The aim of this study was to compare complications and outcomes between intracranial aneurysms treated with the Pipeline embolisation device (PED) alone or with PED combined with coiling for different-sized aneurysms. METHOD: Patients with aneurysms treated by PED were collected from the PED in China postmarket multicentre registry study. We performed a propensity match analysis to compare the efficacy and safety between PED alone and PED combined with coiling treatment, and then aneurysms were organised into three groups based on their size: small (≤7 mm), medium (≤15 mm to >7 mm) and large/giant (>15 mm). Complications and aneurysm occlusion rates in the aneurysm size groups were compared between PED alone and PED combined with coiling patients. RESULT: A total of 1171 patients with 1322 aneurysms were included. All patients received clinical follow-up, while angiographic follow-up was available in 967 aneurysms. For small aneurysms, there was no difference in the aneurysm occlusion rate between two groups (79.1% vs 88.4%, respectively), while there was a significant increase in the ischaemic complication rate (8.3% vs 19.3%, respectively, p=0.0001). For medium and large/giant saccular aneurysms, PED combined with coiling significantly improved the occlusion rate (medium aneurysms: 74.7% vs 88.8%, respectively, p<0.0001; large/giant saccular aneurysms: 72.9% vs 86.9%, respectively, p=0.018), while there were no differences in the total complication rate. For large/giant non-saccular aneurysms, two groups showed no differences. CONCLUSION: Use of the PED with adjunctive coils can significantly improve the occlusion rate of medium aneurysms, without increasing the total complication rate.

20.
J Med Entomol ; 2022 Apr 07.
Artículo en Inglés | MEDLINE | ID: mdl-35388896

RESUMEN

Ornithoica aequisenta Maa 1966 (Diptera: Hippoboscidae) is recorded for the first time from a rodent from China. An updated checklist of louse flies including 21 genera and 52 species of Hippoboscoidea (Hippoboscidae, Nycteribiidae, and Streblidae) is presented for mainland China and Taiwan, including collection records and host species.

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