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World J Clin Cases ; 9(18): 4627-4636, 2021 Jun 26.
Artículo en Inglés | MEDLINE | ID: mdl-34222429


BACKGROUND: The main clinical manifestation of Alzheimer's disease (AD) is memory loss, which can be accompanied by neuropsychiatric symptoms at different stages of the disease. Amygdala is closely related to emotion and memory. AIM: To evaluate the diagnostic value of amygdala on structural magnetic resonance imaging (sMRI) for AD. METHODS: In this study, 22 patients with AD and 26 controls were enrolled. Their amygdala volumes were measured by sMRI and analyzed using an automatic analysis software. RESULTS: The bilateral amygdala volumes of AD patients were significantly lower than those of the controls and were positively correlated with the hippocampal volumes. Receiver operating characteristic curve analyses showed that the sensitivity of the left and right amygdala volumes in diagnosing AD was 80.8% and 88.5%, respectively. Subgroup analyses showed that amygdala atrophy was more serious in AD patients with neuropsychiatric symptoms, which mainly included irritability (22.73%), sleep difficulties (22.73%), apathy (18.18%), and hallucination (13.64%). CONCLUSION: Amygdala volumes measured by sMRI can be used to diagnose AD, and amygdala atrophy is more serious in patients with neuropsychiatric symptoms.

Org Biomol Chem ; 9(2): 363-6, 2011 Jan 21.
Artículo en Inglés | MEDLINE | ID: mdl-21049129


An EtPPh(2)- or PPh(3)-catalyzed tandem three-component reaction of aldehyde, alkyl vinyl ketone, and amide is developed. Its further application in one-pot syntheses of highly functional alkenes starting from aldehydes, alkyl vinyl ketones, and amides is realized. A wide variety of highly functional α,ß-unsaturated ketones can be furnished in 68-99% yields with high stereoselectivity (E/Z up to 98 : 2) within overall 3-29.5 h.

Zhongguo Gu Shang ; 23(10): 769-71, 2010 Oct.
Artículo en Chino | MEDLINE | ID: mdl-21137292


OBJECTIVE: To compare the clinical effects of different fixing methods for intertrochanteric fractures and make theoretical analysis. METHODS: From June 2003 to June 2007, 321 patients with intertrochanteric fractures, male 132 and female 189, ranging in age from 20 to 93 years with an average of 56.8 years, were treated with different fixation including Richard nail (142 cases), proximal femora nail (PFN, 94 cases) and external fixator (85 cases). The clinical data of all the patients were retrospectively analyzed, including the incidence of complications, joint function of hip (according Kudema modified Merli D'Aubigne criteria). RESULTS: All patients were followed up from 10 months to 4 years with an average of 14 months. About the incidence of complications, there was significant difference between the external fixator group and the others two groups (P < 0.05); there was no significant difference between the Richard nail group and the PFN group (P > 0.05). There was significant difference in joint function of hip among three methods. PEN group was best than others two groups. CONCLUSION: There is the best clinical effects and lowest incidence of complications with PFN method, which is the better choice in treating intertrochanteric fractures.

Fémur/lesiones , Fijación Interna de Fracturas/métodos , Fijación Intramedular de Fracturas/métodos , Fracturas de Cadera/cirugía , Adulto , Anciano , Anciano de 80 o más Años , Estudios de Casos y Controles , Femenino , Curación de Fractura/inmunología , Fracturas de Cadera/complicaciones , Fracturas de Cadera/terapia , Humanos , Masculino , Persona de Mediana Edad , Adulto Joven
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue ; 17(12): 756-8, 2005 Dec.
Artículo en Chino | MEDLINE | ID: mdl-16386187


OBJECTIVE: To investigate the changes in myocardial dynamics in early phases of burn shock of dogs and the effects of rapid fluid infusion in delayed resuscitation. METHODS: Twelve mongrel dogs were randomly divided into control (n=6) and burn (n=6) groups. The dogs in burn group were subjected to 35% total body surface area (TBSA) III degree burn and were resuscitated with lactate Ringer's solution 6 hours postburn. The volumes and rates of fluid infusion were controlled basically on the urinary output of 1.0 mlxkg(-1)xh(-1) and cardiac output (CO) of 70%-80% of pre-burn values. The mean arterial pressure (MAP), left ventricular systolic pressure (LVSP), maximum rate of intraventricular pressure rise/down (+/-dp/dt max) and cardiac index (CI) were determined at 0.5, 1,2, 6, 7, 8, 10 and 24 hours postburn. RESULTS: The MAP, LVSP, +/-dp/dt max and CI were significantly lowered from their baseline and those of control group at 0.5 hour postburn, and they kept declining until 6 hours postburn. They showed a tendency of elevation and reached or approached the levels of that in control group within 2 hours of resuscitation, and the differences were not significant between the two groups 4 hours after burn (all P>0.05). The amount of infusion fluid within the first 4 hours of resuscitation was (3.63+/-0.99) ml/kg per 1% TBSA. CONCLUSION: The myocardial dynamics is depressed in the early stage of burn, the effective way to improve it is to infuse a large amount of fluid rapidly when resuscitation is delayed.

Quemaduras/fisiopatología , Fluidoterapia , Corazón/fisiopatología , Animales , Quemaduras/terapia , Gasto Cardíaco/efectos de los fármacos , Modelos Animales de Enfermedad , Perros , Soluciones Isotónicas/uso terapéutico , Contracción Miocárdica/efectos de los fármacos , Distribución Aleatoria , Resucitación , Lactato de Ringer