Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 22
Filtrar
1.
Nutr Clin Pract ; 35(6): 1021-1028, 2020 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-32141138

RESUMEN

BACKGROUND: Malnutrition is a consistent finding in hemodialysis (HD) patients and is associated with high mortality. The aim was to compare nutrition status indicators using dual-energy x-ray absorptiometry (DXA) as reference in HD patients. METHODS: Observational cross-sectional study with 42 patients, 55.8 years (±14.6) old, 60% male, HD 2-3 times per week for ≥3 months. HD ranged from 3 months to 28 years (median, 17.3; interquartile range, 8.73-39.0). We used body mass index (BMI) and fat mass (FM) by skinfold thickness (SFT), bioelectrical impedance analysis (BIA), and DXA. Statistical analyses used Bland-Altman plots, Lin's concordance correlation coefficient, the paired t-test, and Pearson or Spearman correlation. P < .05 was significant. RESULTS: SFT and DXA presented the lowest prevalence of malnutrition (2.4%) and BMI the highest (28.6%). BMI, BIA FM, and SFT FM presented strong positive correlations with DXA FM (r = 0.915; r = 0.976; r = 0.910, P < .001, respectively). BIA FM and fat-free mass (FFM) demonstrated substantial agreement with DXA values (ρ = 0.974 and 0.960, P < .001). Thus, the measurement procedures used, SFT and BIA, underestimated %FM (-4.65% and -2.13%) and overestimated FFM (3.12 kg and 1.0 kg) according to DXA. No differences were found between mean values of BIA FM and DXA (P = .178). CONCLUSIONS: Compared with DXA, BIA was the most appropriate nutrition indicator for measuring body composition.

2.
Nutr Res ; 64: 56-63, 2019 04.
Artículo en Inglés | MEDLINE | ID: mdl-30802723

RESUMEN

Oxidative stress (OS) is associated with increased morbidity and mortality in hemodialysis (HD) patients, and the consumption of fruits seems to improve OS due to their antioxidant properties. Therefore, we hypothesized that Fuji apple intake improves OS markers in HD patients due to its polyphenolic compounds without increasing serum potassium levels. This trial was a 1-group, pre- and posttest comparison between 16 patients who had been on hemodialysis for at least 3 months without any acute illness or hyperkalemia. Each volunteer consumed 2 Fuji apples (~360 g) per day for 1 week. Blood samples were collected at the baseline period and after 8 days for the measurement of total antioxidant status, ascorbic acid, catalase, glutathione peroxidase, superoxide dismutase, reduced glutathione, total oxidant status, oxidative stress index, potassium, phosphorus, uric acid, glucose, and fructosamine. For tolerance evaluation, participants were asked about their bowel habits. Apple intake increased glutathione peroxidase (P = .006) and superoxide dismutase activities (P = .006) and ascorbic acid levels (P = .002). No significant changes were observed in uric acid, potassium, phosphorus, glucose, and fructosamine levels. Additionally, there was a decrease in the catalase activity (P = .021) and in the total antioxidant status values (P = .004). However, increased total oxidant status (P = .003) and oxidative stress index (P = .033) levels were observed after apple intake. In conclusion, the intake of 2 Fuji apples per day for 1 week was well tolerated and improved antioxidant parameters in HD patients without affecting serum potassium levels.


Asunto(s)
Antioxidantes/farmacología , Dieta , Malus/química , Estrés Oxidativo/efectos de los fármacos , Polifenoles/farmacología , Potasio/sangre , Diálisis Renal/efectos adversos , Adulto , Anciano , Antioxidantes/metabolismo , Ácido Ascórbico/sangre , Glucemia/metabolismo , Catalasa/sangre , Conducta Alimentaria , Femenino , Fructosamina/sangre , Frutas/química , Glutatión/sangre , Glutatión Peroxidasa/sangre , Humanos , Masculino , Persona de Mediana Edad , Fósforo/sangre , Superóxido Dismutasa/sangre , Ácido Úrico/sangre
3.
Clin Nutr ESPEN ; 28: 12-20, 2018 12.
Artículo en Inglés | MEDLINE | ID: mdl-30390867

RESUMEN

BACKGROUND AND AIMS: Fluid retention is a risk factor for mortality in several medical conditions. However, the accurate and fast assessment of hydration status remains a challenge in the clinical practice. Bioelectrical impedance analysis (BIA) could be an alternative to assess volume status. This systematic review aimed to evaluate the use of BIA to identify hydration status in patients with different medical conditions and to verify the association of hyperhydration, assessed by BIA, with mortality. METHODS: This systematic review and meta-analyses included 29 studies conducted from 2002 to 2017 among different medical conditions in adults. Eligible studies were randomized and non-randomized clinical trials, prospective and retrospective observational studies. For quality assessment of studies, Effective Public Health Practice Project (EPHPP) was used. RESULTS: Twelve studies provided data eligible for meta-analyses. A direct association between hyperhydration and mortality was observed (Odds Ratio [OR] 4.38; Confidence interval 95% [95% CI] 2.76-6.94), even when stratified for medical condition (OR 4.37; 95% CI 1.15-6.92) and BIA device (OR 4.37; 95% CI 2.75-6.92). CONCLUSION: Hyperhydration, evaluated by BIA, was positive associated with mortality. Therefore, the prognostic impact of hyperhydration may be properly assessed by a bedside tool such as BIA.


Asunto(s)
Enfermedad Crítica/mortalidad , Impedancia Eléctrica , Fluidoterapia , Equilibrio Hidroelectrolítico , Enfermedad Crítica/terapia , Humanos
4.
Nutr Clin Pract ; 33(6): 831-842, 2018 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-29786896

RESUMEN

BACKGROUND: In the absence of a gold standard technique for assessing nutrition status in patients receiving hemodialysis (HD), we aimed to determine the diagnostic accuracy of single-frequency (50 kHz) bioelectrical impedance analysis parameters, resistance/height (R/H), reactance/height (Xc/H), and impedance/height (Z/H), and their cutoff points for malnutrition. METHODS: The reference standards, Subjective Global Assessment (SGA), Malnutrition Inflammation Score, and Nutritional Risk Screening 2002, were performed at baseline and then once a year for 2 years. At least 2 assessments for each reference standard were performed during the monitoring period, and those patients who were assessed as malnourished on at least 2 consecutive occasions were classified as malnourished. RESULTS: A total 101 patients receiving HD were evaluated. R/H and Z/H demonstrated low to moderate accuracy to diagnose malnutrition in men and low accuracy in women, whereas the accuracy of Xc/H was uncertain. The cutoff points of bioelectrical impedance vector analysis (BIVA) parameters, determined based on the SGA to maximize sensitivity and specificity simultaneously, were: R/H ≥330.05 and ≥420.92 ohms/m for men and women, respectively; Z/H ≥332.71 and ≥423.19 ohms/m for men and women, respectively. In men, sensitivity based on the cutoff points of R/H and Z/H together ranged from 73% to 89% and specificity ranged from 49% to 50%. In women, sensitivity ranged from 58% to 80% and specificity from 48% to 55%. CONCLUSION: BIVA parameters demonstrated low to moderate accuracy in men and low accuracy in women for the diagnosis of malnutrition.


Asunto(s)
Impedancia Eléctrica , Fallo Renal Crónico/complicaciones , Desnutrición/diagnóstico , Evaluación Nutricional , Estado Nutricional , Diálisis Renal , Adulto , Anciano , Composición Corporal , Femenino , Humanos , Masculino , Desnutrición/etiología , Tamizaje Masivo , Persona de Mediana Edad , Valores de Referencia , Sensibilidad y Especificidad , Factores Sexuales
5.
Geriatr Gerontol Int ; 17(11): 2074-2082, 2017 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-28488316

RESUMEN

AIM: To assess the influence of sociodemographic, behavioral and health status variables on longitudinal changes in height, weight, and waist circumference in older adults. METHODS: This is a population-based cohort study in Southern Brazil (EpiFloripa Study) investigating 1702 individuals aged 70.6 ± 8.0 years (62.5% women). Height, weight and waist circumference were measured in 2009/10 and 2013/14 (n = 1197). Linear mixed regression models were used to estimate age-related changes in anthropometric measurements according to the explanatory variables. RESULTS: Unmarried individuals, with higher education level or household income, with excessive alcohol consumption, former smokers and positives for some chronic disease were heavier than their counterparts. Similar associations were observed for waist circumference in terms of marital status, smoking and the presence of chronic diseases. Height was higher among the wealthiest, in former smokers and those physically active. Only in men were a lower education level and being unmarried associated with higher weight loss after the age of 75 years, but not with waist circumference reduction. CONCLUSIONS: Despite their association with current height, weight and waist circumference, neither behavioral variables nor the presence of chronic diseases influenced the anthropometric changes. Less educated and unmarried men lose weight at a higher rate, showing a higher risk of sarcopenia. Geriatr Gerontol Int 2017; 17: 2074-2082.


Asunto(s)
Antropometría , Conductas Relacionadas con la Salud , Estado de Salud , Anciano , Estatura , Peso Corporal , Brasil , Estudios de Cohortes , Femenino , Humanos , Masculino , Persona de Mediana Edad , Factores Socioeconómicos , Circunferencia de la Cintura
6.
Int Psychogeriatr ; 29(8): 1307-1316, 2017 08.
Artículo en Inglés | MEDLINE | ID: mdl-28162115

RESUMEN

BACKGROUND: The relation between body weight status and depressive symptoms in the elderly differs according to age and country of origin. The goal of this study was to analyze the cross-sectional and longitudinal relationship between body mass index (BMI), waist circumference (WC) and depressive symptoms in the elderly. METHODS: A population-based cohort study of 1,702 elderly individuals (70.6+8.0 years) in Southern Brazil evaluated in 2009/10 and 2013/14 was accessed. The body weight status was assessed using measured data of BMI and WC. The Geriatric Depression Scale (GDS-15) was used to determine depressive symptoms. Logistic regression analysis adjusted for sociodemographic and behavioral variables was performed. RESULTS: The prevalence of depressive symptoms in 2009/10 was 23.3% (95% CI 20.3-26.6) and the cumulative incidence in the 4-years period was 10.9% (95% CI 8.7-13.6). Elderly people with obesity class II-III and WC in the highest quartile had higher prevalence odds ratio of being depressed than individuals with normal weight or WC in the lower quartile (OR 2.34; 95% CI 1.42-3.87 and OR 1.73; 95% CI 1.13-2.65, respectively). Meanwhile, intermediary values of BMI and WC were associated with a lower prevalence. When evaluating the incidence of depressive symptoms, overweight individuals and those in the second quartile of WC had a lower risk (58% and 57%, respectively), but severely obese individuals had the same risk compared to those with normal BMI/WC. CONCLUSIONS: Severely obese individuals presented a similar incidence of depressive symptoms compared to those with normal BMI/WC, but higher prevalence. Intermediary values of body weight status decrease the risk of depressive symptoms.


Asunto(s)
Depresión/epidemiología , Obesidad Mórbida/epidemiología , Obesidad Mórbida/psicología , Anciano , Índice de Masa Corporal , Brasil/epidemiología , Estudios Transversales , Femenino , Humanos , Incidencia , Modelos Logísticos , Estudios Longitudinales , Masculino , Persona de Mediana Edad , Prevalencia , Factores de Riesgo , Circunferencia de la Cintura
7.
Braspen J ; 31(3): 187-191, jul.-set. 2016.
Artículo en Portugués | LILACS | ID: biblio-827454

RESUMEN

Introdução: O conhecimento e caracterização do estado nutricional de pacientes com doença renal crônica (DRC) em hemodiálise (HD) são fundamentais para a prevenção da desnutrição e para propiciar a intervenção nos pacientes em risco nutricional ou desnutridos. Objetivo: Verificar a associação entre o Malnutrition-Inflammation Score (MIS) e os indicadores: albumina sérica, índice de massa corporal, circunferência muscular do braço, força do aperto da mão, Avaliação Subjetiva Global (ASG) e Nutritional Risk Screening 2002 (NRS 2002). Método: Estudo transversal analítico, realizado na Unidade de Terapia Dialítica do Hospital Universitário da Universidade Federal de Santa Catarina, de junho a agosto de 2013. Realizada avaliação nutricional após sessão de hemodiálise. Foram utilizados os testes qui quadrado, t de Student ou Mann Whitney. Resultados: A amostra foi constituída de 25 pacientes e a prevalência de desnutrição variou de 21,7 a 96%, conforme o indicador nutricional utilizado. Conclusões: O MIS foi o indicador nutricional composto que identificou maior prevalência de desnutrição e foi associado com a ASG e o NRS 2002.(AU)


Introduction: The knowledge and characterization of the nutritional status of patients with chronic kidney disease (CKD) on hemodialysis (HD) are essential for the prevention of malnutrition and to provide intervention in patients at nutritional risk or malnourished. Objective: To investigate the association between Malnutrition-Inflammation Score (MIS) and indicators: serum albumin, body mass index, arm muscle circumference, hand grip strength, Subjective Global Assessment (SGA) and Nutritional Risk Screening 2002 (NRS 2002). Methods: A cross-sectional study conducted in Dialytic Care Unit of the University Hospital of the Federal University of Santa Catarina, from June to August 2013. Nutritional assessment was held after hemodialysis session. Chi-square test, Student's t test or Mann-Whitney test were used. Results: The sample consisted of 25 patients and the prevalence of malnutrition varied from 21.7 to 96% as the nutritional indicator used. Conclusions: The MIS was the nutritional indicator compound identified higher prevalence of malnutrition and was associated with SGA and NRS 2002.(AU)


Asunto(s)
Humanos , Estado Nutricional , Diálisis Renal , Desnutrición/prevención & control , Insuficiencia Renal Crónica , Albúmina Sérica/análisis , Evaluación Nutricional , Antropometría/instrumentación , Estudios Transversales/instrumentación , Análisis Estadístico , Fuerza de la Mano
8.
Rev. Nutr. (Online) ; 29(3): 317-327, mai.-jun. 2016. tab, graf
Artículo en Inglés | LILACS | ID: lil-782906

RESUMEN

ABSTRACT Objective To verify the ability of nutritional indicators to predict risk of hospitalization in hemodialysis patients. Methods This prospective cohort study was conducted in two hemodialysis units in Southern Brazil. The following nutritional indicators were evaluated: subjective global assessment, malnutrition-inflammation score, nutritional risk screening 2002, percentage of body fat, mid-upper arm muscle circumference, hand grip strength, phase angle, and serum albumin. The association between nutritional indicators and risk of hospitalization over a period of two years was analyzed. Results One hundred thirty-eight patients (55.4±15.2 years, 61.6% men) were evaluated. The cumulative incidence of hospitalization during the study was 48.0% (95%CI=37.9-58.0). Patients hospitalized during the study period had higher body mass index and lower serum albumin than those who were not hospitalized. Based on the other indicators, malnourished patients did not have a significant risk of hospitalization (p>0.05). Serum albumin was the only predictor of hospitalization. Patients with levels <3.8 g/dL had a density ratio for incidence of hospitalization 2.47 times greater than those with higher levels (p=0.003). Gender was a modifier of the effect (p interaction=0.042), with an effect in women of 7.31 (95%CI=2.34-22.9; p=0.001) and in men of 1.37 (95%CI=0.60-3.12; p=0.448). Conclusion Serum albumin was able to predict the risk of hospitalization over a period of two years in female patients undergoing hemodialysis.


RESUMO Objetivo Verificar a capacidade preditiva de indicadores nutricionais em relação ao risco de hospitalização em pacientes em hemodiálise. Métodos Estudo de coorte prospectivo em duas unidades de hemodiálise no Sul do Brasil. Os indicadores nutricionais avaliados foram: avaliação subjetiva global, escore de desnutrição-inflamação, rastreamento de risco nutricional 2002, percentual de gordura corporal, circunferência muscular do braço, força do aperto da mão, ângulo de fase e albumina sérica. Foi analisada a associação entre indicadores nutricionais e risco de hospitalização no período de dois anos. Resultados Foram avaliados 138 pacientes (55.4±15.2 anos), sendo 61.6% homens. A incidência cumulativa de hospitalização foi 48.0% (IC95%=37,9-58,0). Os pacientes hospitalizados durante o período do estudo apresentaram maior índice de massa corporal e menores valores de albumina sérica em comparação aos não hospitalizados. Com base nos outros indicadores, pacientes desnutridos não apresentaram risco significativo de hospitalização (p>0,05). Albumina sérica foi o único preditor de hospitalização; pacientes com níveis <3,8 g/dL apresentaram taxa de densidade de incidência de hospitalização 2,47 vezes maior do que aqueles com níveis mais elevados (p=0,003). Sexo foi um modificador do efeito (p interação=0,042), com efeito em mulheres de 7,31 (IC95%=2,34-22,9; p=0,001) e em homens de 1,37 (IC95%=0,60-3,12; p=0,448). Conclusão A albumina sérica foi capaz de prever o risco de hospitalização no período de dois anos, em pacientes do sexo feminino em hemodiálise.


Asunto(s)
Humanos , Masculino , Femenino , Persona de Mediana Edad , Evaluación Nutricional , Diálisis Renal/estadística & datos numéricos , Albúminas/análisis , Hospitalización/estadística & datos numéricos , Desnutrición
9.
Nutr Clin Pract ; 31(3): 378-86, 2016 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-26920645

RESUMEN

BACKGROUND: (1) To compare nutrition and hydration status between a group of children/adolescents with cystic fibrosis (CFG; n = 46; median age, 8.5 years) and a control group without cystic fibrosis (CG). (2) To examine the association of nutrition and hydration status with lung function in the CFG. MATERIAL AND METHODS: A cross-sectional study. Nutrition screening, anthropometric parameters, and bioelectrical impedance analysis (BIA) were assessed. The z scores for body mass index for age, height for age, mid upper arm circumference, triceps and subscapular skinfold thickness, mid upper arm muscle area, resistance/height, and reactance/height were calculated. Bioelectrical impedance vector analysis was conducted. Forced expiratory volume in 1 second <80% was considered lung function impairment. An adjusted logistic regression was applied (P < .05). RESULTS: In the CFG, lung function impairment was observed in 51.1%. All anthropometric parameters were lower, and the mean z-resistance/height and z-reactance/height were higher in the CFG (P < .05) compared with the CG. In the CFG, 43% were severely/mildly dehydrated, while none were in the CG (P = .007). In the CFG, there was an association between high nutrition risk-via nutrition screening (odds ratio [OR], 22.28; P < .05), lower values of anthropometric parameters, higher z-resistance/height (OR, 2.23; P < .05) and z-reactance/height (OR, 1.81; P < .05), and dehydration (OR, 4.94; P < .05)-and lung function impairment. CONCLUSIONS: The CFG exhibited a compromised nutrition status assessed by anthropometric and BIA parameters. Nutrition screening, anthropometric and BIA parameters, and hydration status were associated with lung function.


Asunto(s)
Composición Corporal/fisiología , Agua Corporal/fisiología , Fibrosis Quística/fisiopatología , Impedancia Eléctrica , Pulmón/fisiopatología , Estado Nutricional/fisiología , Adolescente , Niño , Estudios Transversales , Femenino , Humanos , Masculino
10.
Clin Nutr ESPEN ; 10(1): e21-e25, 2015 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-28531443

RESUMEN

BACKGROUND & AIMS: Several parameters might indicate protein-energy wasting in patients undergoing haemodialysis (HD), and such depletion has been associated with the survival of these patients. Our aim was to identify the parameters that are associated with an increased risk of death among HD patients. METHODS: This was a prospective study with at least 13 months follow-up three times per week of 138 HD patients; 61.6% of the patients were men, 28.9% had diabetes mellitus, and 81.9% had hypertension. The associations of the survival rates based on by Kaplan-Meier analysis with the following nutritional parameters were verified: albumin, lymphocytes, % fat mass (% FM), mid-arm muscle circumference (MAMC), subjective global assessment (SGA), malnutrition-inflammation score (MIS), and nutritional risk screening 2002 (NRS 2002). Cox proportional hazard analysis was used to identify the patients' risk of death (hazard proportional ratio - HR). RESULTS: The nutritional parameters of lymphocytes and % FM were not associated with the risk of patient death. The patients who were classified as malnourished based on MAMC had a greater risk of death than did those considered nourished, but this difference was not statistically significant. The parameters of serum albumin, SGA, MIS, and NRS 2002 were associated with the risk of patient death (HR = 2.77 P = 0.042, HR = 1.88 P = 0.202, HR = 4.47 P = 0.011, HR = 3.13 P = 0.022, respectively), and the latter two parameters were significantly associated with a high risk among malnourished. CONCLUSIONS: The scores for the MIS and NRS 2002 composite methods of nutritional assessment were associated with the highest mortality risk values; thus, in conditions similar to those of our study, we suggest that the use of these parameters should be preferred.

11.
Rev. nutr ; 26(1): 49-57, Jan.-Feb. 2013. tab
Artículo en Inglés | LILACS | ID: lil-668223

RESUMEN

OBJECTIVE: This study verified the association between hand grip strength and body mass index, subjective global assessment and nutritional risk screening 2002. METHODS: This cross-sectional study calculated the body mass index, measured hand grip strength and administered the subjective global assessment and nutritional risk screening 2002 to 118 patients hospitalized at the University Hospital of the Universidade Federal de Santa Catarina, Florianópolis, Brazil. Hand grip strength was compared with the reference values for the Brazilian population according to gender and age. The statistical analyses included the Student's t-test or Mann-Whitney test and multiple linear regression. The results were considered significant when p<0.05. RESULTS: The prevalences of nutritional risk or malnutrition according to body mass index, global subjective assessment, nutritional risk screening 2002 and hand grip strength were 3.5%, 50.9%, 33.9% and 35.6%, respectively. Malnourished individuals according to body mass index had, on average, 11.0kg less hand grip strength than the nourished individuals (p=0.008). There was no association between hand grip strength and the subjective global assessment (malnourished individuals had -2.8kg; p=0.078) and nutritional risk screening 2002 (malnourished individuals had -1.5kg; p=0.352). CONCLUSION: Hand grip strength was associated with body mass index but not with the subjective global assessment or nutritional risk screening 2002.


OBJETIVO: Verificar a associação da força do aperto da mão com o índice de massa corporal, a avaliação subjetiva global e o rastreamento de risco nutricional 2002. MÉTODOS: Estudo transversal com 118 pacientes internados no Hospital Universitário da Universidade Federal de Santa Catarina, Florianópolis, Brasil. Foi calculado o índice de massa corporal e foram aplicados a avaliação subjetiva global, o rastreamento de risco nutricional 2002 e a força do aperto da mão. Esta última foi comparada aos valores de referência da população brasileira, segundo sexo e idade. Para análise estatística, foi utilizado o teste t Student ou Mann-Whitney e regressão linear múltipla, considerando uma significância estatística de p<0,05. RESULTADOS: A prevalência de risco nutricional ou desnutrição pelo índice de massa corporal, avaliação subjetiva global, rastreamento de risco nutricional 2002 e força do aperto da mão foi de 3,5%, 50,9%, 33,9% e 35,6%, respectivamente. Os indivíduos, identificados como desnutridos pelo índice de massa corporal, tiveram, em média, 11,0kg a menos na força do aperto da mão do que os nutridos (p=0,008). Não houve associação da força do aperto da mão com a avaliação subjetiva global (desnutridos tiveram -2,8kg; p=0,078) e com o rastreamento de risco nutricional 2002 (desnutridos tiveram -1,5kg; p=0,352). CONCLUSÃO: A força do aperto da mão foi associada com o índice de massa corporal, mas não com avaliação subjetiva global ou com o rastreamento de risco nutricional 2002.


Asunto(s)
Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Anciano de 80 o más Años , Índice de Masa Corporal , Fuerza de la Mano , Hospitalización , Evaluación Nutricional , Estado Nutricional
12.
Nutr Res ; 32(9): 684-93, 2012 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-23084641

RESUMEN

The aim of this study was to evaluate the effects of green tea extract (GTE) administration on vascular reactivity and atherosclerosis progression in low-density lipoprotein receptor knockout mice. We hypothesized that GTE intake may ameliorate atherosclerosis by improving endothelial dysfunction. Animals (n = 12 per group) were fed a hypercholesterolemic diet and received either water or GTE at a dose of 50, 100, or 300 mg/kg once a day by gavage (100 µL/10 g weight). After 4 weeks, atherosclerosis extension and vascular reactivity were evaluated in the aorta, and the levels of lipids, monocyte chemotactic protein-1 (MCP-1), and tumor necrosis factor α were measured in the plasma. Administration of GTE at a dose of 50 mg/kg significantly decreased the area of atherosclerotic lesions by 35%, improved the vascular reactivity in the isolated thoracic aorta, and lowered the plasma levels of both MCP-1 and triglycerides. Delivery of 100 mg/kg of GTE only promoted vasocontraction and vasorelaxation (P < .05), whereas a dose of 300 mg/kg was ineffective. Maximum contraction and relaxation negatively correlated with the lesion area (r = -0.755 and -0.767, respectively), whereas the plasma levels of MCP-1 and triglycerides positively correlated with plaque size (r = 0.549 and 0.421, respectively). In summary, our results supported the hypothesis that administration of GTE at low doses may contribute to a decrease in atherosclerosis progression by reversing endothelial dysfunction.


Asunto(s)
Antioxidantes/farmacología , Aterosclerosis/tratamiento farmacológico , Catequina/análogos & derivados , Endotelio Vascular/efectos de los fármacos , Extractos Vegetales/farmacología , Té/química , Alanina Transaminasa/metabolismo , Animales , Aorta/efectos de los fármacos , Aorta/metabolismo , Aterosclerosis/patología , Biomarcadores/sangre , Catequina/farmacología , Quimiocina CCL2/sangre , Modelos Animales de Enfermedad , Endotelio Vascular/fisiopatología , Femenino , Inflamación/tratamiento farmacológico , Inflamación/patología , Lipoproteínas LDL/sangre , Masculino , Ratones , Ratones Endogámicos C57BL , Ratones Noqueados , Receptores de LDL/genética , Triglicéridos/sangre , Factor de Necrosis Tumoral alfa/sangre
13.
J Acad Nutr Diet ; 112(10): 1543-9, 2012 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-23017565

RESUMEN

BACKGROUND: Nutritional risk and malnutrition are highly prevalent among hospitalized patients. As a result, several methods have been developed to produce an adequate nutritional diagnosis. OBJECTIVE: We aimed to assess the relationship between nutritional risk tools and parameters derived from bioelectrical impedance analysis with a Subjective Global Assessment (SGA). DESIGN: A cross-sectional study was conducted from April to September 2010. PARTICIPANTS/SETTING: The study included 124 patients admitted to the Surgical Clinic I, University Hospital, Federal University of Santa Catarina, Florianópolis, Brazil, to undergo elective surgery. MAIN OUTCOME MEASURES: We utilized SGA and Nutritional Risk Screening 2002 (NRS 2002), Nutritional Risk Index (NRI), Fat-Free Mass Index (FFMI), Fat Mass Index (FMI), body cell mass as a percentage of the total weight (%BCM), and standardized phase angle (SPA). STATISTICAL ANALYSIS PERFORMED: The agreement was tested by κ coefficient, while bivariate associations were tested by Mann-Whitney U test. RESULTS: Prevalence of nutritional risk by NRS 2002 and NRI or malnutrition by SGA, FFMI, FMI, %BCM, and SPA was 19.3%, 69.5%, 35.5%, 12.9%, 8.1%, 46.8%, and 4.8%, respectively. The best agreement was between SGA and NRS 2002 (κ=.490), possibly because they constitute similar instruments. Patients identified as malnourished by SGA (B+C) showed considerably lower values of FFMI, FMI, BCM, and SPA. CONCLUSIONS: The results suggest that the NRS 2002 and parameters derived from bioelectrical impedance analysis identify patients with impaired nutritional status.


Asunto(s)
Composición Corporal/fisiología , Impedancia Eléctrica , Desnutrición/diagnóstico , Evaluación Nutricional , Adulto , Anciano , Anciano de 80 o más Años , Índice de Masa Corporal , Estudios Transversales , Femenino , Hospitalización , Humanos , Masculino , Desnutrición/epidemiología , Persona de Mediana Edad , Estado Nutricional , Prevalencia , Medición de Riesgo , Factores de Riesgo , Estadísticas no Paramétricas , Adulto Joven
14.
Nutrition ; 28(6): 657-64, 2012 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-22578980

RESUMEN

OBJECTIVE: To evaluate the effect of long-term ingestion of mate tea, with or without dietary intervention, on the markers of oxidative stress in dyslipidemic individuals. METHODS: Seventy-four dyslipidemic volunteers participated in this randomized clinical trial. Subjects were divided into three treatment groups: mate tea (MT), dietary intervention (DI), and mate tea with dietary intervention (MD). Biochemical and dietary variables were assessed at the beginning of the study (baseline) and after 20, 40, 60, and 90 d of treatment. Participants in the MT and MD groups consumed 1 L/d of mate tea. Those in the DI and MD groups were instructed to increase their intake of fruit, legumes and vegetables and decrease their consumption of foods rich in cholesterol and saturated and trans-fatty acids. Biomarkers of oxidative stress such as antioxidant capacity of serum (ferric reducing antioxidant potential assay), uric acid, reduced glutathione, paraoxonase-1 enzyme, lipid hydroperoxide (LOOH), and protein carbonyl were analyzed. RESULTS: Participants in the DI group showed a significant decrease in total fat and saturated fatty acid intakes. Those in the DI and MD groups presented a significant increase in vitamin C consumption. For all groups, there was a significant increase in ferric reducing antioxidant potential and reduced glutathione concentrations but no significant changes in LOOH, protein carbonyl, and paraoxonase-1 values. The reduced glutathione concentration was positively correlated with the consumption of monounsaturated fatty acids, fiber, and vitamin C, whereas levels of LOOH were inversely correlated with intakes of vitamin C and fiber. In addition, LOOH correlated positively with low-density lipoprotein cholesterol and inversely with high-density lipoprotein cholesterol, which had a positive association with paraoxonase-1. CONCLUSION: The ingestion of mate tea independently of the dietary intervention increased plasma and blood antioxidant protection in patients with dyslipidemia.


Asunto(s)
Ácido Ascórbico/administración & dosificación , Dieta , Dislipidemias/terapia , Ácidos Grasos/administración & dosificación , Ilex paraguariensis , Estrés Oxidativo/efectos de los fármacos , Fitoterapia , Adulto , Antioxidantes/metabolismo , Antioxidantes/farmacología , Antioxidantes/uso terapéutico , Arildialquilfosfatasa/sangre , Ácido Ascórbico/farmacología , Ácido Ascórbico/uso terapéutico , Biomarcadores/sangre , HDL-Colesterol/sangre , LDL-Colesterol/sangre , Grasas de la Dieta/administración & dosificación , Fibras de la Dieta/farmacología , Fibras de la Dieta/uso terapéutico , Dislipidemias/sangre , Ingestión de Energía , Ácidos Grasos Monoinsaturados/farmacología , Ácidos Grasos Monoinsaturados/uso terapéutico , Femenino , Glutatión/sangre , Humanos , Peróxidos Lipídicos/sangre , Masculino , Persona de Mediana Edad , Preparaciones de Plantas/farmacología , Preparaciones de Plantas/uso terapéutico , Carbonilación Proteica/efectos de los fármacos
15.
J Am Coll Nutr ; 30(5): 320-32, 2011 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-22081618

RESUMEN

OBJECTIVES: Yerba mate (Ilex paraguariensis) infusions have been shown to reduce plasma glucose in animals and serum lipids in humans. The aim of this study was to evaluate the effects of roasted mate tea consumption, with or without dietary counseling, on the glycemic and lipid profiles of individuals with type 2 diabetes mellitus (T2DM) or pre-diabetes. METHODS: Twenty-nine T2DM and 29 pre-diabetes subjects were divided into 3 groups: mate tea, dietary intervention, and mate tea and dietary intervention. Individuals drank 330 mL of roasted mate tea 3 times a day and/or received nutritional counseling over 60 days. Blood samples were collected and food intake was assessed at baseline and after 20, 40, and 60 days of treatments. RESULTS: Mate tea consumption decreased significantly the levels of fasting glucose (25.0 mg/dL), glycated hemoglobin A(1c) (HbA(1c)) (0.85%), and low-density lipoprotein cholesterol (LDL-c) (13.5 mg/dL) of T2DM subjects (p < 0.05); however, it did not change the intake of total energy, protein, carbohydrate, cholesterol, and fiber. In pre-diabetes individuals, mate tea consumption combined with nutritional counseling diminished significantly the levels of LDL-c (11 mg/dL), non-high-density lipoprotein cholesterol (HDL-c) (21.5 mg/dL), and triglycerides (53.0 mg/dL) (p < 0.05). Individuals of this group decreased significantly their consumption of total fat (14%), cholesterol (28%), and saturated (23.8%) and monounsaturated (28.0%) fatty acids, and increased their fiber intake by 35% (p < 0.05). CONCLUSIONS: Mate tea consumption improved the glycemic control and lipid profile of T2DM subjects, and mate tea consumption combined with nutritional intervention was highly effective in decreasing serum lipid parameters of pre-diabetes individuals, which may reduce their risk of developing coronary disease.


Asunto(s)
Diabetes Mellitus Tipo 2/tratamiento farmacológico , Hipoglucemiantes/uso terapéutico , Ilex paraguariensis/química , Lípidos/sangre , Extractos Vegetales/uso terapéutico , Estado Prediabético/tratamiento farmacológico , Anciano , Glucemia/análisis , Glucemia/efectos de los fármacos , Diabetes Mellitus Tipo 2/sangre , Grasas de la Dieta/administración & dosificación , Femenino , Productos Finales de Glicación Avanzada/sangre , Índice Glucémico , Humanos , Masculino , Persona de Mediana Edad , Proyectos Piloto , Estado Prediabético/sangre , Método Simple Ciego , Triglicéridos/sangre
16.
J Med Food ; 14(1-2): 156-60, 2011.
Artículo en Inglés | MEDLINE | ID: mdl-21138347

RESUMEN

Bran cereals are known to contain substantial concentrations of important nutrients, bioactive compounds, fiber, minerals, proteins, lipids, and vitamins. The vitamins present in rice bran include those of the B complex (B(1) and B(3)), which affect the central nervous system (natural antidepressant and tranquilizer effects) acting in schizophrenia, neuralgia, and fatigue. The elevated plus maze (EPM) test is a model widely used for the study of anxiety in animals. The forced swimming (FS) test is the model used most often for evaluating the antidepressant activity in animal models in pharmacology. This study examined the behavior of 32 male Wistar rats, 21 days old, in the FS and EPM tests after treatment with strawberry- or chocolate-flavored rice bran drink for 28 days. The concentration of adrenocorticotropic hormone in the plasma of the animals was determined at the beginning and end of treatment. The values found (<1.0 mg/dL) showed no significant difference between the test and control groups in the periods analyzed. In the EPM, ingesting the chocolate-flavored drink showed an anxiogenic trend in the rats, and the strawberry-flavored rice bran drink led to an anxiolytic profile, although the difference was not statistically significant (P > .05). In the FS test, the duration of immobility of rats in groups consuming rice bran drinks was higher than in the control group, but without a statistically significant difference (P > .05). However, this result may indicate a tendency toward an effect on the central nervous system of the animals after the ingestion of the rice bran beverage.


Asunto(s)
Ansiedad/dietoterapia , Ansiedad/psicología , Bebidas/análisis , Oryza/química , Preparaciones de Plantas/administración & dosificación , Natación , Animales , Ansiedad/fisiopatología , Bebidas/estadística & datos numéricos , Modelos Animales de Enfermedad , Ingestión de Alimentos , Humanos , Masculino , Aprendizaje por Laberinto/efectos de los fármacos , Ratas , Ratas Wistar
17.
Nutr Res ; 30(9): 594-600, 2010 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-20934600

RESUMEN

There is currently no criterion standard to assess nutritional status, and different methods have been used in hospitalized patients. The aim of this study was to investigate the agreement and the association between bioelectrical impedance analysis derived by standardized phase angle (SPA) and other methods used for the nutritional assessment of body composition, metabolic status, and functional status in surgical patients. The hypothesis was that the SPA is effective for evaluating nutritional status in surgical patients; therefore, it could be used when the application of other assessment methods is not possible. The sample consisted of 125 patients (20-94 years of age) before elective gastrointestinal or hernia repair. The participants were from the Surgical Clinic 1 at the University Hospital of the Federal University of Santa Catarina, Florianópolis, SC, Brazil. Nutritional status was evaluated during the preoperative period based on the triceps skinfold thickness, mid-arm circumference, body mass index, percent weight loss, nutritional risk screening 2002 (NRS 2002), subjective global assessment (SGA), and SPA. The agreement between the SPA and the other methods was assessed with the k coefficient. The agreement between the SPA and the methods of nutritional assessment that were investigated for diagnosing malnutrition was moderate for NRS 2002 and SGA, weak for percent weight loss, and poor for triceps skinfold thickness, mid-arm circumference, and body mass index. There was a significant association between SPA and both NRS 2002 and SGA (P < .001). Our results suggest that SPA is able to indicate the risk of nutritional deficiency in the patients assessed. However, good agreement between SPA and the methods investigated was not observed.


Asunto(s)
Impedancia Eléctrica , Desnutrición/diagnóstico , Evaluación Nutricional , Estado Nutricional , Periodo Preoperatorio , Adulto , Anciano , Anciano de 80 o más Años , Brazo/anatomía & histología , Índice de Masa Corporal , Pesos y Medidas Corporales , Brasil , Estudios Transversales , Femenino , Cirugía General , Hospitalización , Humanos , Masculino , Persona de Mediana Edad , Grosor de los Pliegues Cutáneos , Pérdida de Peso , Adulto Joven
18.
J Agric Food Chem ; 57(18): 8316-24, 2009 Sep 23.
Artículo en Inglés | MEDLINE | ID: mdl-19694438

RESUMEN

The objective of this study was to verify the effect of yerba mate (Ilex paraguariensis) consumption on lipid and lipoprotein levels in humans. One hundred and two individuals participated of this single-blind controlled trial. Normolipidemic (n = 15), dyslipidemic (n = 57), and hypercholesterolemic subjects on long-term statin therapy (n = 30) ingested 330 mL, 3 times/day, of green or roasted yerba mate infusions for 40 days. In normolipidemic subjects, yerba mate consumption reduced LDL-cholesterol by 8.7% (p < 0.05). Compared with the baseline period, yerba mate intake by dyslipidemic individuals for 20 and 40 days lowered LDL-cholesterol by 8.1 and 8.6% (p < 0.001) and non-HDL cholesterol by 5.4 and 6.5% (p < 0.01). After 20 days of yerba mate intake, apolipoprotein B was reduced by 6.0% (p < 0.05) and HDL-cholesterol was increased by 4.4% (p < 0.01). In all participants triglyceride levels remained unchanged. The consumption of yerba mate by hypercholesterolemic individuals on statin therapy promoted additional 10.0 and 13.1% reductions in LDL-C after 20 and 40 days, respectively (p < 0.001) and increased HDL-cholesterol by 6.2% after 40 days (p < 0.05). It was thus concluded that intake of yerba mate infusion improved the lipid parameters in normolipidemic and dyslipidemic subjects and provided an additional LDL-cholesterol reduction in hypercholesterolemic subjects on statin treatment, which may reduce the risk for cardiovascular diseases.


Asunto(s)
LDL-Colesterol/sangre , Inhibidores de Hidroximetilglutaril-CoA Reductasas/uso terapéutico , Hipercolesterolemia/terapia , Ilex paraguariensis , Lípidos/sangre , Fitoterapia , Adulto , Bebidas , Femenino , Flavonoides/análisis , Calor , Humanos , Hipercolesterolemia/sangre , Ilex paraguariensis/química , Masculino , Persona de Mediana Edad , Fenoles/análisis , Hojas de la Planta/química , Polifenoles , Saponinas/análisis , Xantinas/análisis
19.
Rev. nutr ; 21(6): 659-669, nov.-dez. 2008. graf, tab
Artículo en Portugués | LILACS | ID: lil-509600

RESUMEN

OBJETIVO: Investigar os efeitos da suplementação com ácidos graxos ômega-3, nas doses de 0,5 e 1,0g/kg/dia, nos lipídeos sangüíneos de ratos submetidos ou não ao protocolo do nado. MÉTODOS: Ratos Wistar foram divididos em grupos: controle, controle+nado, ácidos graxos ômega-3 e ácidos graxos ômega-3+nado. Os ácidos graxos ômega-3 e ácidos graxos ômega-3+nado receberam suplementação; os demais receberam água por gavagem. Os controle+nado e ácidos graxos ômega-3+nado foram submetidos ao exercício. Foram avaliadas as concentrações plasmáticas de colesterol total, triglicérides e lipoproteína de alta densidade, antes e após os procedimentos experimentais. RESULTADOS: No protocolo de 0,5g/kg/dia, em relação às concentrações de colesterol total, foi observada redução significativa proporcionalmente maior no grupo ácidos graxos ômega-3+nado, apesar de o grupo controle+nado e o ácidos graxos ômega-3 também terem apresentado diminuição. No ensaio de 1,0g/kg/dia todos os grupos apresentaram uma diminuição que foi maior, respectivamente, no ácidos graxos ômega-3+nado e, a seguir, no ácidos graxos ômega-3. Quanto aos triglicérides, foram encontradas reduções em todos os grupos experimentais, que foi maior no grupo ácidos graxos ômega-3+nado, do protocolo de 0,5g/kg/dia, enquanto que no de 1,0g/kg/dia a diminuição foi significativa apenas nos grupos ácidos graxos ômega-3 e ácidos graxos ômega-3+nado. Quanto ao HDL, no protocolo de 0,5g/kg/dia foi encontrado aumento nos animais que não foram suplementados, enquanto que em todos os grupos de 1,0g/kg/dia houve uma diminuição do HDL. CONCLUSÃO: A suplementação com ácidos graxos ômega-3 nas doses 0,5 ou 1,0g/kg/dia, associada ao nado, reduzem as concentrações plasmáticas de colesterol total e triglcérides, mas estudos adicionais, também com outras doses, são necessários para a compreensão da relação entre a ingestão de óleo de peixe e as concentrações de lipídeos sangüíneos.


OBJECTIVE: To investigate the effects of omega-3 fatty acid supplementation at doses of 0.5 and 1.0g/kg/day on the blood lipids of rats submitted or not to swimming exercise. METHODS: Wistar rats were divided into the following groups: control, control+swimming, omega-3 fatty acids and omega-3 fatty acids+swimming. The omega-3 fatty acids and omega-3 fatty acids+swimming groups received supplements by gavage, while the remaining animals received water by the same method. The control+swimming and omega-3 fatty acids +swimming groups were submitted to exercise. Plasma concentrations of total cholesterol, triglycerides and HDL were determined before and after the experimental procedures. RESULTS: The concentrations of total cholesterol in the 0.5g/kg/day groups reduced proportionally more in the omega-3 fatty acids+swimming group, even though total cholesterol of the control+swimming and omega-3 fatty acids groups also decreased. Total cholesterol decreased in both groups receiving 1.0g/kg/day supplementation, but the decrease was higher in the omega-3 fatty acids+swimming group than in the omega-3 fatty acids group. Triglycerides also decreased in all experimental groups. The greatest decrease was seen in the omega-3 fatty acids+swimming group receiving 0.5g/kg/day supplementation. In the 1.0g/kg/day protocol, the decrease was significant in both groups: the omega-3 fatty acids and omega-3 fatty acids+swimming groups. HDL increased among the non-supplemented animals and decreased among the animals receiving a supplementation of 1.0g/kg/day. CONCLUSION: Omega-3 fatty acid supplementation at doses of 0.5 or 1.0g/kg/day associated with swimming exercise reduced plasma concentrations of total cholesterol and triglycerides, yet additional studies, including varying doses, are necessary to better understand the relationship between ingestion of fish oil and blood lipid concentrations.


Asunto(s)
Animales , Masculino , Ratas , Lípidos/sangre , Natación/fisiología , Ratas Wistar/sangre
20.
Nutrition ; 24(5): 433-42, 2008 May.
Artículo en Inglés | MEDLINE | ID: mdl-18337059

RESUMEN

OBJECTIVE: This study investigated the effects of the consumption of green tea (GT) for 7 d on biomarkers of oxidative stress in young men undergoing resistance exercise. METHODS: Fourteen subjects performed a bench press exercise (four sets, 10 to 4 repetitions) after undergoing a period without (control group) or with the intake of GT (GT group; 2 g of leaves in 200 mL of water, three times per day). Blood samples were obtained before and after exercise and analyzed for total antioxidant capacity (ferric reducing ability of plasma [FRAP]), total polyphenols, reduced glutathione (GSH), lipid hydroperoxide (LH) and thiobarbituric acid-reactive substances, creatine kinase (CK), aspartate aminotransferase (AST), xanthine oxidase (XO), hypoxanthine, and uric acid (UA). RESULTS: In the control group, exercise did not affect the values of LH, thiobarbituric acid-reactive substances, and FRAP, although it did reduce the levels of GSH (P < 0.05). In addition, exercise increased CK, AST, and XO activities, although it did not change the values for hypoxanthine or UA. Green tea reduced the postexercise concentration of LH and increased the values of total polyphenols, GSH, and FRAP. GT also inhibited a significant rise in CK and XO activities induced by exercise. Furthermore, GT decreased the AST activity and hypoxanthine and UA concentrations before and after exercise. The assessment of food consumption revealed that the participants had an unbalanced diet, particularly in relation to vitamin E and carotenoids. CONCLUSION: Consumption of GT, a beverage rich in polyphenols, may offer protection against the oxidative damage caused by exercise, and dietary guidance for sports participants should be emphasized.


Asunto(s)
Antioxidantes/farmacología , Flavonoides/farmacología , Peroxidación de Lípido/efectos de los fármacos , Fenoles/farmacología , , Levantamiento de Peso/fisiología , Adulto , Antioxidantes/análisis , Aspartato Aminotransferasas/metabolismo , Bebidas , Biomarcadores/análisis , Biomarcadores/metabolismo , Creatina Quinasa/metabolismo , Estudios Cruzados , Ejercicio Físico/fisiología , Flavonoides/análisis , Glutatión/metabolismo , Humanos , Hipoxantina/metabolismo , L-Lactato Deshidrogenasa/metabolismo , Masculino , Oxidación-Reducción , Estrés Oxidativo , Consumo de Oxígeno , Fenoles/análisis , Polifenoles , Té/química , Sustancias Reactivas al Ácido Tiobarbitúrico/metabolismo , Ácido Úrico/metabolismo , Xantina Oxidasa/metabolismo
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA
...