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1.
Chin J Integr Med ; 2021 Apr 21.
Artículo en Inglés | MEDLINE | ID: mdl-33881717

RESUMEN

OBJECTIVE: To compare the analgesic effect of Jin Ling Zi Powder (, JLZ) and its two single herbs. METHODS: The hot plate method was used to induce pain. Totally 36 mice were randomly divided into 6 groups by a complete random design, including control, model, aspirin (ASP, 0.14 g/kg body weight), JLZ (14 g/kg body weight), Corydalis yanhusuo (YHS, 14 g/kg body weight), and Toosendan Fructus (TF, 14 g/kg body weight) groups, 6 mice in each group. The mice in the control and model groups were given the same volume of saline, daily for 2 consecutive weeks. At 30, 60, 90, and 120 min after the last administration, the pain threshold of mice in each group was measured, and the improvement rate of pain threshold was calculated. Serum endogenous metabolites were analyzed by gas chromatography-mass spectrometry (GC-MS). RESULTS: There was no statistical difference in pain threshold among groups before administration (P>0.05). After 2 weeks of administration, compared with the model group, the pain threshold in JLZ, YHS, TF and ASP groups were increased to varying degrees (P<0.05). JLZ had the best analgesic effect and was superior to YHS and TF groups. A total of 14 potential biomarkers were screened in serum data analysis and potential biomarkers levels were all reversed to different degrees after the treatment with JLZ and its single herbs. These potential biomarkers were mainly related to glyoxylate and dicarboxylate metabolism, glycine, serine and threonine metabolism, valine, leucine and isoleucine biosynthesis, aminoacyl-tRNA biosynthesis and inositol phosphate metabolism. CONCLUSIONS: The analgesic mechanism of JLZ and YHS was mainly due to the combination of glycine and its receptor, producing post-synaptic potential, reducing the excitability of neurons, and weakening the afferent effect of painful information.

2.
Chemistry ; 2021 Apr 19.
Artículo en Inglés | MEDLINE | ID: mdl-33871899

RESUMEN

Photoresponsive materials are a key part of the smart age, which have broad applied potential. Coordination Networks (CNs) are widely used due to their designability and stability. In this work, three novel alkaline earth metal coordination networks (AEM-CNs): [Mg(CMNDI)(H 2 O) 2 ], [Ca(CMNDI)(H 2 O) 2 ]·H 2 O, and [Sr(CMNDI)(H 2 O)(DMF)] with fsl , cds , and scn topology nets were synthetized by N,N'-bis(carboxymethyl)-1,4,5,8-naphthalenediimide (H 2 CMNDI), and the scn net is not found in the Reticular Chemistry Structure Resource and ToposPro. The reusable and sensitive photochromic properties of three CNs enable them to be used as secret inks or ultraviolet detectors. In addition, the CNs also exhibited reusable photoluminescence turn-off toward drug molecules, balsalazide disodium (Bal.) and colchicine (Col.), with a nice limit of detection of 0.16 and 0.70 µM. To our best knowledge, fluorescence sensor towards Bal. is the first time to be studied. Therefore, the AEM-CNs provided a design idea of integrated photoresponsive materials. We believe that related study would be further improved in near future.

3.
Artículo en Inglés | MEDLINE | ID: mdl-33827068

RESUMEN

We propose a theoretical model for studying the effective velocities of polaron spin states in monolayer transition metal dichalcogenides (TMDS) on the substrate. It is found that the effective velocity of polaron shows the splitting with different magnitudes due to the Rashba spin-orbit coupling, which results in the reversed distribution of the effective velocities of polaron spin states. Moreover, the reversed points depend on the truncated wave-vector of optical phonon and can be modulated by the polarity of substrate and the internal distance between monolayer TMDS and substrate. These theoretical results enlighten some simple ways to distinguish and modulate the polaron spin states in two-dimensional heterostructures.

4.
Biochem Biophys Res Commun ; 557: 26-32, 2021 Apr 13.
Artículo en Inglés | MEDLINE | ID: mdl-33862456

RESUMEN

Development of novel targeted therapies remains the priority in hepatocellular carcinoma (HCC) treatments. Early reports have demonstrated that androgen receptor (AR) plays a suppressive role in HCC progression. However, the underlying mechanisms by which AR attenuates HCC development are still elusive, especially under hypoxic conditions. Herein, we demonstrated that AR/circ-LNPEP/miR-532-3p/RAB9A signaling axis was tightly involved in hypoxia-induced cell invasion of HCC cells. AR worked as a transcription factor to reduce circ-LNPEP expression level, which released its sponge potential of miR-532-3p, leading to the downregulation of RAB9A and inhibiting cell invasion of HCC cells. In vitro and in vivo animal model also confirmed that overexpression of circ-LNPEP could reverse the suppressive effect of AR on HCC cell invasion or tumor metastasis. Overall, our study supplements a critical mechanism by which AR suppresses HCC invasion/metastasis under hypoxic conditions, providing compelling rationale to develop novel therapy for better treatments of HCC.

5.
Plants (Basel) ; 10(3)2021 Mar 17.
Artículo en Inglés | MEDLINE | ID: mdl-33802900

RESUMEN

The FHY3/FAR1 transcription factor family, derived from transposases, plays important roles in light signal transduction, and in the growth and development of plants. However, the homologous genes in tea plants have not been studied. In this study, 25 CsFHY3/FAR1 genes were identified in the tea plant genome through a genome-wide study, and were classified into five subgroups based on their phylogenic relationships. Their potential regulatory roles in light signal transduction and photomorphogenesis, plant growth and development, and hormone responses were verified by the existence of the corresponding cis-acting elements. The transcriptome data showed that these genes could respond to salt stress and shading treatment. An expression analysis revealed that, in different tissues, especially in leaves, CsFHY3/FAR1s were strongly expressed, and most of these genes were positively expressed under salt stress (NaCl), and negatively expressed under low temperature (4 °C) stress. In addition, a potential interaction network demonstrated that PHYA, PHYC, PHYE, LHY, FHL, HY5, and other FRSs were directly or indirectly associated with CsFHY3/FAR1 members. These results will provide the foundation for functional studies of the CsFHY3/FAR1 family, and will contribute to the breeding of tea varieties with high light efficiency and strong stress resistance.

6.
Biol Reprod ; 2021 Apr 23.
Artículo en Inglés | MEDLINE | ID: mdl-33899086

RESUMEN

The WNT signaling system plays an important but paradoxical role in regulation of pluripotency. In the cow, IWR-1, which inhibits canonical WNT activation and has WNT-independent actions, promotes derivation of primed pluripotent embryonic stem cells (ESC) from the blastocyst. Here we describe a series of experiments to determine whether derivation of ESC could be generated by replacing IWR-1 with other inhibitors of WNT signaling. Results confirm the importance of inhibition of canonical WNT signaling for establishment of pluripotent ESC in cattle and indicate that actions of IWR-1 can be mimicked by the WNT secretion inhibitor IWP2 but not by the tankyrase inhibitor XAV939 or WNT inhibitory protein dickopf 1. The role of janus kinase (JAK)-mediated signaling pathways for maintenance of pluripotency of ESC was also evaluated. Maintenance of pluripotency of ESC lines was blocked by a broad inhibitor of JAK even though cells did not express phosphorylated signal transducer and activator of transcription 3 (STAT3). Further studies with blastocysts indicated IWR-1 blocks activation of STAT3 phosphorylation. A likely explanation is that IWR-1 blocks differentiation of ESC into a pSTAT3+ lineage. In conclusion, results presented here indicated the importance of inhibition of WNT signaling for derivation of pluripotent bovine ESC (bESC), the role of JAK signaling for maintenance of pluripotency and the participation of IWR-1 in inhibition of activation of STAT3.

7.
Microb Cell Fact ; 20(1): 80, 2021 Apr 07.
Artículo en Inglés | MEDLINE | ID: mdl-33827572

RESUMEN

BACKGROUND: Daqu is the most important fermentation starter for Chinese liquor, with large number of microbes and enzymes being openly enriched in the Daqu system over thousands of years. However, only a few enzymes have been analyzed with crude protein for total liquefying power and saccharifying power of Daqu. Therefore, the complex enzymatic system present in Daqu has not been completely characterized. Moreover, their pivotal and complicated functions in Daqu are completely unknown. RESULTS: In this study, a novel α-amylase NFAmy13B, from GH13_5 subfamily (according to the Carbohydrate-Active enZYmes Database, CAZy) was successfully heterologous expressed by Escherichia coli from Chinese Nong-flavor (NF) Daqu. It exhibited high stability ranging from pH 5.5 to 12.5, and higher specific activity, compared to other GH13_5 fungal α-amylases. Moreover, NFAmy13B did not show activity loss and retained 96% residual activity after pre-incubation at pH 11 for 21 h and pH 12 for 10 h, respectively. Additionally, 1.25 mM Ca2+ significantly improved its thermostability. NFAmy13B showed a synergistic effect on degrading wheat starch with NFAmy13A (GH13_1), another α-amylase from Daqu. Both enzymes could cleave maltotetraose and maltopentaose in same degradation pattern, and only NFAmy13A could efficiently degrade maltotriose. Moreover, NFAmy13B showed higher catalytic efficiency on long-chain starch, while NFAmy13A had higher catalytic efficiency on short-chain maltooligosaccharides. Their different catalytic efficiencies on starch and maltooligosaccharides may be caused by their discrepant substrate-binding region. CONCLUSIONS: This study mined a novel GH13_5 fungal α-amylase (NFAmy13B) with outstanding alkali resistance from Nong-flavor (NF) Daqu. Furthermore, its synergistic effect with NFAmy13A (GH13_1) on hydrolyzing wheat starch was confirmed, and their possible contribution in NF Daqu was also speculated. Thus, we not only provide a candidate α-amylase for industry, but also a useful strategy for further studying the interactions in the complex enzyme system of Daqu.

8.
Nanotechnology ; 2021 Apr 27.
Artículo en Inglés | MEDLINE | ID: mdl-33906187

RESUMEN

As a new large-scale energy storage candidate owing to their low cost and high theoretical capacity, rechargeable aqueous zinc-ion batteries (AZIBs) have garnered widespread attention. However, the unique divalent state of Zn2+ and the existence of a strong electrostatic repulsion phenomenon has prompted increased research on high-performance cathode materials is currently attracting considerable attention. In this study, we synthesized aluminum vanadate (AlV3O9) as a cathode material for AZIBs using a solvothermal method. Al3+ acts as a pillar in the result of the proposition and plays a role in stabilizing the structure. Furthermore, this large interlayer spacing also enhanced the ion diffusion coefficient and accelerated the ion transport process. Because of these advantages, the AlV3O9 (AVO) cathode exhibited excellent electrochemical performance, including a high capacity of 421.0 mA h g-1 at 0.1 A g-1, and a stable rate capability of 348.2 mA h g-1 at 1 A g-1. Moreover, it exhibited a specific capacity of 202 mA h g-1even at a high current density of 3 A g-1 (the capacity retention rate reached 84.38% after 1600 cycles). Moreover, the prepared ZIBs present a high power density of 286.0 W kg-1 at an energy density of 366.6 W h kg-1. These extraordinary results indicate the great application potential of AVO as a cathode material for AZIBs.

10.
Anal Bioanal Chem ; 413(11): 2879-2891, 2021 May.
Artículo en Inglés | MEDLINE | ID: mdl-33822260

RESUMEN

Medicinal plants are complex chemical systems containing thousands of secondary metabolites. The rapid classification and characterization of the components in medicinal plants using mass spectrometry (MS) remains an immense challenge. Herein, a novel strategy is presented for MS through the combination of solid-phase extraction (SPE), multiple mass defect filtering (MMDF) and molecular networking (MN). This strategy enables efficient classification and annotation of natural products. When combined with SPE and MMDF, the improved analytical method of MN can perform the rapid annotation of diverse natural products in Citrus aurantium according to the tandem mass spectrometry (MS/MS) fragments. In MN, MS2LDA can be initially applied to recognize substructures of natural products, according to the common fragmentation patterns and neutral losses in multiple MS/MS spectra. MolNetEnhancer was adopted here to obtain chemical classifications provided by ClassyFire. The results suggest that the integrated SPE-MMDF-MN method was capable of rapidly annotating a greater number of natural products from Citrus aurantium than the classical MN strategy alone. Moreover, SPE and MMDF enhanced the effectiveness of MN for annotating, classifying and distinguishing different types of natural products. Our workflow provides the foundation for the automated, high-throughput structural classification and annotation of secondary metabolites with various chemical structures. The developed approach can be widely applied in the analysis of constituents in natural products.

11.
J Chromatogr A ; 1642: 462021, 2021 Apr 12.
Artículo en Inglés | MEDLINE | ID: mdl-33714771

RESUMEN

Although ultraviolet detector or mass spectrometer could be coupled with two-dimensional liquid chromatography (2DLC) to analyze complex constituents, full detection and identification of the compounds are difficult. Suffering from biased UV detection and insufficient MS data interpretation, a number of minor compounds are neglected though they are separated. In this study, we report a global chemical profiling strategy using comprehensive 2DLC coupled with dual-MS platforms, including Orbitrap-MS and QqQ-MS. It was exemplified by an 11-herb Chinese medicine formula Xiaoer-Feire-Kechuan (XFK). Firstly, constituents in XFK were separated on a CSH C18 × Phenyl-Hexyl 2DLC system with a practical peak capacity of 990.5 and an orthogonality of 90.3%. Secondly, untargeted mass spectral data was collected using dd-MS2 scan on an Orbitrap-MS. In total 542 peaks were detected, which was 4 times of that detected by 2DLC/UV (131 peaks). A total of 108 compounds were tentatively identified. Thirdly, targeted mass spectral data was collected for 8 characteristic substructures using neutral loss and precursor ion (NL/PRE) scan on a QqQ-MS. Extracted ion chromatogram was used to recognize minor constituents. An additional of 151 compounds were detected. Our study indicated that comprehensive 2DLC coupled with dd-MS2 and NL/PRE-MS is a powerful technique for the global profiling of multi-component systems.


Asunto(s)
Medicamentos Herbarios Chinos/análisis , Espectrometría de Masas , Cromatografía Liquida , Medicamentos Herbarios Chinos/química , Glicósidos/análisis , Glicósidos/química , Fenoles/análisis , Fenoles/química , Estándares de Referencia
12.
ChemSusChem ; 2021 Mar 09.
Artículo en Inglés | MEDLINE | ID: mdl-33751834

RESUMEN

Rechargeable magnesium batteries (RMBs) have attracted significant attention owing to the high energy density and economic viability. However, the lack of suitable cathode materials, owing to the high polarizability of divalent Mg-ion and slow Mg-ion diffusion, hinders the development of RMBs. V2 O5 is a promising RMBs cathode material, but its limited interlayer spacing is unfavorable for the rapid diffusion of Mg2+ , demonstrating unsatisfactory electrochemical performance. In this study, the superlattices of V2 O5 and polyaniline (PANI) with expanded interlayer spacing are assembled as the cathode material for RMBs. The intercalation of PANI in the interlayer region of V2 O5 significantly improves the reversible capacities, Mg2+ diffusion kinetics, and cycling performance of the PVO cathode. Furthermore, RMBs with PVO as the cathode and Mg metal as the anode deliver high specific capacities. The introduced polyaniline layer not only expands the interlayer spacing of V2 O5 , but also increases the electrical conductivity. Moreover, ex situ XRD characterization indicates that PVO does not undergo obvious phase transformation with the continuous insertion of Mg2+ , which may be ascribed to the π-conjugated chains of PANI that give flexibility to the structure to improve cycling stability. This study demonstrates that designing organic-inorganic superlattices is an efficient strategy for developing high-performance cathode materials for RMBs.

13.
Sci Total Environ ; 779: 146443, 2021 Mar 14.
Artículo en Inglés | MEDLINE | ID: mdl-33752017

RESUMEN

The real part of the refractive index (RRI) of ambient aerosol, which is widely used in remote sensing and atmospheric models, is one of the key factors determining its particles' optical properties. The characteristics of ambient aerosol RRI in China have not yet been well studied owing to a lack of observations. For the first time, the properties of aerosol RRI were studied based on field measurements in China at four sites with different atmospheres. The results revealed that the measured ambient aerosol RRI varied significantly between 1.36 and 1.78, increasing with the mass ratio of organic components. The scattering coefficient and direct radiative effects of the aerosols were estimated to increase by factors of 2 and 3, respectively, when RRI increased from 1.36 to 1.78. Our results indicate that variation in ambient aerosol RRI should be considered in aerosol and climate models to achieve an accurate estimation of aerosol's radiative impacts.

14.
ACS Infect Dis ; 7(4): 800-810, 2021 04 09.
Artículo en Inglés | MEDLINE | ID: mdl-33705114

RESUMEN

The modulation of the interaction between macrophages and Mycobacterium tuberculosis (M.tb) through microRNA during M.tb infection is increasingly capturing the attention of researchers. However, the potential role of microRNA-18b-5p (miR-18b) is not elucidated yet. In this study, miR-18b was found to be downregulated in M.tb-infected macrophage cell lines (THP-1 and RAW264.7) in time- and dose-dependent manners. Furthermore, when the miR-18b mimic and inhibitor and small interfering RNA hypoxia-inducible factor 1α (si-HIF-1α) were transfected into the macrophages separately or in combination, it was found that miR-18b targeted hypoxia-inducible factor 1α (HIF-1α). During M.tb infection, the decrease in the expression of miR-18b facilitated HIF-1α expression, which led to the increased production of pro-inflammatory cytokines, such as IL-6, resulting in decreased bacterial survival in the host cells. Moreover, the phosphorylation of p38 MAPK and NF-κB p65 was activated by the miR-18b inhibitor. Our findings expand the current understanding of the M.tb-cell interaction mechanism and provide a potential target to control M.tb infection.

15.
J Environ Sci (China) ; 103: 93-107, 2021 May.
Artículo en Inglés | MEDLINE | ID: mdl-33743922

RESUMEN

In order to enhance the removal performance of graphitic carbon nitride (g-C3N4) on organic pollutant, a simultaneous process of adsorption and photocatalysis was achieved via the compounding of biochar and g-C3N4. In this study, g-C3N4 was obtained by a condensation reaction of melamine at 550°C. Then the g-C3N4/biochar composites were synthesized by ball milling biochar and g-C3N4 together, which was considered as a simple, economical, and green strategy. The characterization of resulting g-C3N4/biochar suggested that biochar and g-C3N4 achieved effective linkage. The adsorption and photocatalytic performance of the composites were evaluated with enrofloxacin (EFA) as a model pollutant. The result showed that all the g-C3N4/biochar composites displayed higher adsorption and photocatalytic performance to EFA than that of pure g-C3N4. The 50% g-C3N4/biochar performed best and removed 45.2% and 81.1% of EFA (10 mg/L) under darkness and light with a dosage of 1 mg/mL, while g-C3N4 were 19.0% and 27.3%, respectively. Besides, 50% g-C3N4/biochar showed the highest total organic carbon (TOC) removal efficiency (65.9%). Radical trapping experiments suggested that superoxide radical (•O2-) and hole (h+) were the main active species in the photocatalytic process. After 4 cycles, the composite still exhibited activity for catalytic removal of EFA.


Asunto(s)
Luz , Adsorción , Carbón Orgánico , Enrofloxacina , Grafito , Compuestos de Nitrógeno
16.
J Biomed Nanotechnol ; 17(1): 1-17, 2021 Jan 01.
Artículo en Inglés | MEDLINE | ID: mdl-33653493

RESUMEN

Soft Tissue augmentation is a way to restore lost tissue and also a way to reshape confidence for patients who suffer from soft tissue loss. Materials that can realize such a function are called soft tissue fillers. Among the large number of fillers, injectable fillers have attracted widespread attention in facial cosmetic fields due to their convenience and competitive performance. Meanwhile, there is a huge demand for better injectable soft tissue fillers in medical cosmetology market. This review introduces several fillers which were once used in clinical or are now still in use. Furthermore, we update recent improvements and progress on injectable filling materials hoping to contribute to its further developments.


Asunto(s)
Técnicas Cosméticas , Envejecimiento de la Piel , Materiales Biocompatibles , Humanos , Ácido Hialurónico
17.
Zhong Nan Da Xue Xue Bao Yi Xue Ban ; 46(2): 176-182, 2021 Feb 28.
Artículo en Inglés, Chino | MEDLINE | ID: mdl-33678655

RESUMEN

Decision-making aid for cancer patients is of great significance in the diagnosis and treatment for diseases. Breast cancer is one of the most common malignant tumors in women all over the world, and breast cancer patients have become the main target population for decision-aided research. Application of decision-making assistance for patients in Western countries has developed to a certain extent, while relevant research in China is still at the early stage. There are kinds of intervention forms for patients' decision aids, including traditional brochures and videos, decision aids systems, decision coaching, multidisciplinary breast cancer teams, etc. The tools for decision-making quality evaluation include the patients' awareness for decision-making, participation, decision-making conflict, decision-making satisfaction, decision-making regret, which can provide important guidance for the application of decision-making aid treatment in breast cancer patients in the future.


Asunto(s)
Neoplasias de la Mama , Neoplasias de la Mama/terapia , China , Toma de Decisiones , Emociones , Femenino , Humanos , Satisfacción Personal
18.
Zhongguo Zhong Yao Za Zhi ; 46(4): 1000-1009, 2021 Feb.
Artículo en Chino | MEDLINE | ID: mdl-33645106

RESUMEN

To systematically evaluate the clinical efficacy and safety of Lianhua Qingwen in the treatment of adult pneumonia. The randomized controlled trial of Lianhua Qingwen combined with conventional Western medicine in the treatment of pneumonia were retrieved from PubMed, EMbase, Wanfang database, VIP database, and CNKI from the establishment of database to March 2020. Two researchers independently conducted literature screening and data extraction, and the third researcher was in charge of arbitration in case of any disagreement. Outcome indicators included total clinical effective rate, symptom improvement time, and incidence of adverse events. R 3.6.1 was used for Meta-analysis, and RevMan 5.3 was used for quality evaluation. Twenty-two studies were included, with a total of 2 007 patients, including 1 017 patients in the experimental group and 990 patients in the control group. The results showed that the total clinical effective rate of the experimental group was higher than that of the control group(RR=1.11, 95%CI[1.08, 1.15], P<0.001), and the antifebrile time(MD=-1.81, 95%CI[-2.42,-1.21], P<0.001), cough duration(MD=-2.32, 95%CI[-2.89,-1.76], P<0.001), rale duration(MD=-2.19, 95%CI[-2.74,-1.63], P<0.001), imaging recovery time(MD=-2.17, 95%CI[-2.76,-1.58], P<0.001) and post-treatment CRP(MD=-4.07, 95%CI[-6.39,-1.75], P<0.001] were all significantly lower than those of the control group. However, it did not proved that the experimental group was safer than the control group(RR=0.84, 95%CI[0.57, 1.24], P=0.382). The results confirmed that Lianhua Qingwen combined with conventional Western medicine in the treatment of pneumonia could improve the clinical treatment efficiency, shorten the time of fever, cough, rale disappearance and imaging recovery, improve CRP index and accelerate the recovery of pneumonia patients. However, the literatures included in this study had a low quality, and the conclusions still need to be further confirmed by more high-quality, multi-center, rigorously designed randomized controlled trial.


Asunto(s)
Medicamentos Herbarios Chinos , Neumonía , Adulto , Tos , Medicamentos Herbarios Chinos/efectos adversos , Humanos , Neumonía/tratamiento farmacológico , Resultado del Tratamiento
19.
BMC Gastroenterol ; 21(1): 49, 2021 Feb 02.
Artículo en Inglés | MEDLINE | ID: mdl-33530944

RESUMEN

BACKGROUND: Aortoenteric fistula (AEF) is a rare cause of gastrointestinal bleeding and is often misdiagnosed in clinical practice. Herein, a case series of AEFs are presented and the clinical characteristics, diagnosis, and management strategies are summarized. METHODS: A retrospective analysis was performed on consecutive hospitalized patients with a final diagnosis of AEF at Beijing Friendship Hospital, Capital Medical University, between January 1, 2007 and March 31, 2020. The clinical data including diagnostic and management procedures as well as outcomes were collected and summarized. RESULTS: A total of nine patients were included in this study, five with primary AEF and four with secondary AEF. Eight of the patients were male, and the median age was 63 years. The fistulas were located in both the small intestine and the colon. All patients presented with gastrointestinal bleeding and pain, followed by weight loss, anorexia, and fever. A typical abdominal triad was found in only two cases. Seven patients experienced complications with preoperative abdominal infections and sepsis, and multiple organ failure occurred in four of these patients. All patients were assessed by computed tomography and five underwent abdominal and/or iliac aorta angiography. Two of these patients showed contrast agent leakage from the abdominal aorta into the intestine. Two cases were diagnosed with AEF by endoscopy before the operation. Eight patients received surgery and six patients survived. CONCLUSIONS: AEF is a rare cause of gastrointestinal bleeding that is associated with high mortality. Gastrointestinal bleeding and pain are the most common presentations. Timely diagnosis and multidisciplinary management are crucial to achieve a positive outcome.

20.
Nanoscale Res Lett ; 16(1): 36, 2021 Feb 16.
Artículo en Inglés | MEDLINE | ID: mdl-33591425

RESUMEN

In this study, amino hyperbranched polymers (HBP)-grafted polyacrylonitrile (PAN) fiber was prepared through an amidation reaction in an autoclave. The prepared PAN-G-HBP fiber can complex Ag+ through amino groups of amino HBP, and in a hot steaming condition, Ag+ can be converted to Ag0 through the reducibility of HBP. PAN-G-HBP and Ag nanoparticles (NPs)-coated fibers were then characterized through FTIR, UV-VIS DRS, FE-SEM, EDS, XPS and antibacterial measurement. FTIR results confirmed HBP was grafted on the surface of PAN fiber. FE-SEM showed that after grafting with HBP, the average diameter of PAN fibers was amplified. EDS, XPS, and UV-VIS DRS method indicated that under hot steaming condition and with the reducibility of HBP, Ag NPs uniform coating on the PAN-G-HBP. Ag NPs-coated fibers exhibits excellent antibacterial property against Escherichia coli and Staphylococcus aureus. Even under 20 times home washing conditions, the antibacterial reduction of Ag NPs-coated PAN fiber can achieved more than 98.94%.

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