Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 1.487
Filtrar
1.
J Environ Manage ; 291: 112598, 2021 May 06.
Artículo en Inglés | MEDLINE | ID: mdl-33965709

RESUMEN

Extensive urbanization leads to the degradation of vegetation, which aggravates the deterioration of many ecological environments. However, the research on the impact of urbanization on vegetation change mainly focuses on cities. But the research on urban agglomeration is relatively scarce. The impact of urbanization on vegetation is explored by quantifying the changes in construction land and normalized difference vegetation index (NDVI) in China's urban agglomerations from 2000 to 2018. Results showed that in China, 72.73% of the regional NDVI presented a significant increasing trend, and 2.05% of the regional NDVI presented a significant downward trend. Vegetation degradation occurred in urban areas, but there was an improvement in vegetation in the urban centers of 2000. In urban agglomerations, the shift of the center of gravity of construction land can affect the direction of the transfer of NDVI cold spots or hot spots. Urbanization intensity in most urban agglomerations was negatively correlated with vegetation cover and showed a downward trend along the intensity gradient. However, NDVI in areas covered by complete vegetation showed an upward trend. Based on these findings, we suggest that vegetation protection and restoration should be strengthened, and effective urban landscape planning should be carried out to promote vegetation greening.

2.
Environ Sci Technol ; 2021 May 11.
Artículo en Inglés | MEDLINE | ID: mdl-33974404

RESUMEN

Advanced materials and processes are required to separate halides and fission products from complex salt waste streams associated with the chemical reprocessing of used nuclear fuels and molten salt reactor technologies for immobilization into chemically durable waste forms. In this work, we explore an innovative concept using metal halide perovskites as advanced host phases to incorporate Cs and Cl with very high waste loadings. Wet chemistry-synthesized Cs2SnCl6 powders from CsCl salt solutions are successfully encapsulated into a silica matrix to form a composite using low-temperature spark plasma sintering with tunable Cs and Cl loadings up to 31 and 26 wt %, respectively. Chemical durability testing of the composite waste forms by semi-dynamic leaching experiments demonstrates that an incongruent leaching mechanism dominates the release of Cs and Cl. The metal halide perovskite-silica composite waste forms display exceptional chemical durability with the long-term release rates of Cs and Cl comparable to or outperforming the state-of-the-art waste form materials but with significantly higher waste loadings. The scalable synthesis of the metal halide perovskite from wet chemistry processes opens up new opportunities in designing advanced waste forms for salt wastes with very high waste loadings and exceptional chemical durability for the sustainable development of advanced fuel cycles and next-generation reactor technologies.

3.
Artículo en Inglés | MEDLINE | ID: mdl-33945482

RESUMEN

Molecular communication, as an emerging research direction, has emerged in the field of communication, which usually combined with nanotechnology and bio-related knowledge. In the direction of communication channel research, the most widespread model for a molecular communication channel is the diffusion-based channel, where the information-carrying molecules propagate randomly in the medium based on Brownian motion. Multi-input multi-output (MIMO) technology is often used to improve communication quality in the traditional communication field. Compared with the SISO model, which only has inter-symbol interference (ISI) as the interference source, the interference in MIMO communication model includes ISI as well as inter-link interference (ILI), which emerges when receiver receive other transmitters' molecules. In this paper, MIMO communication models are built, based on diffusion channel, CSK, probabilistic theory, considered with ISI and ILI, to establish the calculation formula of related bit error rate, And the influence of relevant parameters in the model on bit error rate is studied. Then, SISO and SIMO models will be built to compare with MIMO models. Last, self-adaptive dual threshold algorithm is proposed to reduce BER of the 2×2 MIMO system. Simulation results show that the proposed algorithm has better performance on reducing BER than other approaches.

4.
BMJ Open ; 11(5): e043039, 2021 May 04.
Artículo en Inglés | MEDLINE | ID: mdl-33947730

RESUMEN

INTRODUCTION: In recent years, the transcarotid artery revascularisation (TCAR) with flow reversal technique has been developed to treat carotid artery stenosis. The superiority of TCAR over transfemoral carotid artery stenting has been demonstrated. However, the safety and efficacy of TCAR and carotid endarterectomy remain unclear. This study aims to introduce a protocol for a systematic review and meta-analysis to compare the morbidity and mortality rates between TCAR and carotid endarterectomy in the treatment of atherosclerotic carotid artery stenosis. METHODS AND ANALYSIS: This protocol was drafted using the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols statement. Herein, major databases will be searched, including Medline, Web of Science, Embase and the Cochrane Library, and randomised controlled trials and high-quality observational studies will be included. We will screen all studies published from January 2000 to March 2021. Bias risk will be evaluated using the Cochrane Collaboration criteria or Methodological Index for Non-randomised Studies criteria, depending on the study type. Two reviewers will select eligible studies and extract the data independently. The primary outcome will include stroke or death during the perioperative period and follow-up. Subgroup and sensitivity analyses will be performed to explore any potential sources of heterogeneity. Specific results will be described in a narrative form when available eligible studies are insufficient for meta-analysis. Publication bias will be assessed using a funnel plot. ETHICS AND DISSEMINATION: This study will summarise and analyse the existing literature; hence, ethics approval will not be required. The final results may be published at a relevant academic conference or in a journal. PROSPERO REGISTRATION NUMBER: CRD42020178691.

5.
Mol Plant ; 2021 May 06.
Artículo en Inglés | MEDLINE | ID: mdl-33965632

RESUMEN

Phytophthora pathogens are a persistent threat to the world's commercially important agricultural crops, including potato and soybean. Current strategies aimed at reducing crop losses rely mostly on disease resistance breeding and chemical pesticides, which can be frequently overcome by the rapid adaptive evolution of pathogens. Transgenic crops with intrinsic disease resistance offer a promising alternative and continue to be developed. Here, we used Phytophthora-derived PI3P (phosphatidylinositol 3-phosphate) as a novel control target, using proteins that bind this lipid to direct secreted antimicrobial peptides and proteins (AMPs) to the surface of the pathogen. In transgenic Nicotiana benthamiana, soybean, and potato plants, significantly enhanced resistance to different pathogen isolates was achieved by expression of two AMPs (GAFP1 or GAFP3 from the Chinese medicinal herb Gastrodia elata) fused with a PI3P-specific binding domain (FYVE). Using the soybean pathogen P. sojae as an example, we demonstrated that the FYVE domain could boost the activities of the GAFPs in multiple independent assays, including in vitro, in vivo, and in planta. Mutational analysis of the PI3K1 and PI3K2 genes of this pathogen confirmed that the enhanced activities of the targeted GAFPs were correlated with PI3P levels in the pathogen. The strategy could be used against Phytophthora pathogens of many plants, and for other kinds of plant pathogens with unique targets.

6.
Artículo en Inglés | MEDLINE | ID: mdl-33957291

RESUMEN

Covalent binding of DNA to proteins produces DNA-protein cross-links (DPCs). DPCs are formed as intermediates of enzymatic processes, generated from the reactions of protein nucleophiles with DNA electrophiles, and produced by endogenous and exogenous cross-linking agents. DPCs are heterogeneous due to the variations of DNA conjugation sites, flanking DNA structures, protein sizes, and cross-link bonds. Unrepaired DPCs are toxic because their bulky sizes physically block DNA replication and transcription, resulting in impaired genomic integrity. Compared to other types of DNA lesions, DPC repair is less understood. Emerging evidence suggests a general repair model that DPCs are proteolyzed by the proteasome and/or DPC proteases, followed by the peptide removal through canonical repair pathways. Herein, we first describe the recently discovered DPCs. We then review the mechanisms of DPC proteolysis with the focus on recently identified DPC proteases. Finally, distinct pathways that bypass or remove the cross-linked peptides following proteolysis are discussed.

7.
BMC Surg ; 21(1): 216, 2021 Apr 26.
Artículo en Inglés | MEDLINE | ID: mdl-33902530

RESUMEN

BACKGROUND: A complete dissection of infrapyloric lymph nodes is the key to a curative gastrectomy, which can be sometimes technically challenging in laparoscopic surgery. METHODS: One hundred and eighteen patients with gastric cancer undergoing laparoscopic gastrectomy with D2 lymphadenectomy in which the infrapyloric lymph nodes were dissected through the right bursa omentalis approach were included. The clinicopathologic characteristics and surgical outcomes were analyzed retrospectively. RESULTS: The laparoscopic gastrectomy with D2 lymphadenectomy was successful in all 118 patients with no open conversion. The mean operation time was 246.6 ± 45.7 min. The mean estimated blood loss was 87.0 ± 35.9 mL. Postoperative complications occurred in 17.8% of the patients, which were treated successfully with conservative therapy or aspiration in all. There were no No.6 lymphadenectomy-associated complications, such as injury of transverse colon, vessels of mesocolon, pancreas or duodenum, no pancreatitis, pancreatic leakage or postoperative hemorrhage. The mean postoperative hospital stay was 9.6 ± 3.7 days. On average, the total lymph nodes harvested were 36.8 ± 12.9, in which the ones from the infrapyloric area were 5.1 ± 3.1. CONCLUSION: Laparoscopic dissection of infrapyloric lymph nodes through the right bursa omentalis approach seems to be feasible and safe, facilitating a more complete No.6 lymphadenectomy for gastric cancer.

8.
Langenbecks Arch Surg ; 406(3): 641-650, 2021 May.
Artículo en Inglés | MEDLINE | ID: mdl-33825045

RESUMEN

BACKGROUND: Data about whether laparoscopic gastrectomy (LG) is applicable in serosa-positive (pT4a) gastric cancer patients remain rare. The purpose of this study is to compare the perioperative and long-term outcomes between the laparoscopic and open gastrectomy (OG) in pT4a gastric cancer patients who underwent curative resection. METHODS: A total of 1086 consecutive pT4a patients (101 patients with LG and 985 with OG) who underwent curative gastrectomy in a high-volume center between 2006 and 2016 were evaluated. Demographics, surgical, and oncologic outcomes were analyzed. Propensity score matching (PSM) analysis was performed to balance baseline confounders, and COX regression analysis was performed to identify independent prognostic factors. RESULTS: After PSM adjustment, a well-balanced cohort comprising 101 patients who underwent LG and 201 who underwent OG was analyzed. Operative time (288.7 vs. 234.2 min; P < 0.001) was significantly longer, while estimated blood loss (172.8 vs. 220.7 ml; P < 0.001) was significantly less in the LG group compared with the OG group. There were no significant differences between groups in total number of harvested lymph nodes, postoperative stays, readmission rate, and postoperative complication rate. The 3-year overall survival (OS) rate was not significant different in the LG and OG groups (66.7% vs. 62.8%, P = 0.668), and the subsequent multivariate analysis revealed that the surgical approach was not an independent prognostic factor for OS (HR = 1.123; 95%CI: 0.803-1.570; P = 0.499). In sensitivity analysis including 78 pairs well-matched patients operated by an experienced surgeon, the results were similar to these for the matched entire cohort. CONCLUSION: LG can be a safe and feasible approach for pT4a gastric cancer treatment. However, well-designed high-quality RCTs are expected to draw a definitive conclusion on this topic.

9.
Medicine (Baltimore) ; 100(17): e25685, 2021 Apr 30.
Artículo en Inglés | MEDLINE | ID: mdl-33907141

RESUMEN

BACKGROUND: Despite the developments in diagnosis and treatment of HER2-positive metastatic breast cancer, there is a high likelihood in the development of resistance to trastuzumab. In general, HER2-positive patients with deteriorated health face negative clinical outcomes. The present study is conducted to systematically explore the medicinal properties of trastuzumab in HER2-positive breast cancer patients. METHODS: Randomized controlled trials investigating the clinical properties of including trastuzumab to treat HER2-positive breast cancer cases will be sourced by exploring these online-based databases: MEDLINE, BIOSIS, China National Knowledge Infrastructure (CNKI), Cochrane Library, EMBASE, Central Register of Controlled Trials, and WanFang. Two independent authors will screen the literature, gather data, and assess the quality of selected studies. The significance of the relationship between the medical properties of trastuzumab when incorporated to treat HER2-positive breast cancer cases will be evaluated according to the relative risk, mean differences or standardized mean differences, and 95% confidence interval. RESULTS: The outcomes from this review shall be issued in a journal that will be reviewed by peers. CONCLUSION: The conclusions presented in this review will serve as a reference for clinical practitioners and scholars to determine whether trastuzumab is an effective and safety intervention for treating HER2-positive breast cancer patients. ETHICS AND DISSEMINATION: Since this study is a systematic review of published studies, an ethical approval is not needed. SYSTEMATIC REVIEW REGISTRATION NUMBER: March 31, 2021.osf.io/wvqkf (https://osf.io/wvqkf/).


Asunto(s)
Antineoplásicos Inmunológicos/uso terapéutico , Neoplasias de la Mama/tratamiento farmacológico , Neoplasias de la Mama/metabolismo , Receptor ErbB-2/metabolismo , Trastuzumab/uso terapéutico , Neoplasias de la Mama/mortalidad , Supervivencia sin Enfermedad , Método Doble Ciego , Femenino , Humanos , Metaanálisis como Asunto , Ensayos Clínicos Controlados Aleatorios como Asunto , Receptor ErbB-2/efectos de los fármacos , Proyectos de Investigación , Revisiones Sistemáticas como Asunto , Resultado del Tratamiento
10.
BMC Plant Biol ; 21(1): 173, 2021 Apr 10.
Artículo en Inglés | MEDLINE | ID: mdl-33838661

RESUMEN

BACKGROUND: The shedding of premature sweet cherry (Prunus avium L) fruitlet has significantly impacted production, which in turn has a consequential effect on economic benefits. RESULT: To better understand the molecular mechanism of sweet cherry fruitlet abscission, pollen viability and structure had been observed from the pollination trees. Subsequently, the morphological characters of the shedding fruitlet, the plant hormone titers of dropping carpopodium, the transcriptome of the abscising carpopodium, as well as the HD-ZIP gene family were investigated. These findings showed that the pollens giving rise to heavy fruitlet abscission were malformed in structure, and their viability was lower than the average level. The abscising fruitlet and carpopodium were characterized in red color, and embryos of abscising fruitlet were aborted, which was highly ascribed to the low pollen viability and malformation. Transcriptome analysis showed 6462 were significantly differentially expressed, of which 2456 genes were up-regulated and 4006 down-regulated in the abscising carpopodium. Among these genes, the auxin biosynthesis and signal transduction genes (α-Trp, AUX1), were down-regulated, while the 1-aminocyclopropane-1-carboxylate oxidase gene (ACO) affected in ethylene biosynthesis, was up-regulated in abscising carpopodium. About genes related to cell wall remodeling (CEL, PAL, PG EXP, XTH), were up-regulated in carpopodium abscission, which reflecting the key roles in regulating the abscission process. The results of transcriptome analysis considerably conformed with those of proteome analysis as documented previously. In comparison with those of the retention fruitlet, the auxin contents in abscising carpopodium were significantly low, which presumably increased the ethylene sensitivity of the abscission zone, conversely, the abscisic acid (ABA) accumulation was considerably higher in abscising carpopodium. Furthermore, the ratio of (TZ + IAA + GA3) / ABA also obviously lower in abscising carpopodium. Besides, the HD-ZIP gene family analysis showed that PavHB16 and PavHB18 were up-regulated in abscising organs. CONCLUSION: Our findings combine morphology, cytology and transcriptional regulation to reveal the molecular mechanism of sweet cherry fruitlet abscission. It provides a new perspective for further study of plant organ shedding.


Asunto(s)
Frutas/crecimiento & desarrollo , Genes de Plantas , Proteínas de Homeodominio/genética , Reguladores del Crecimiento de las Plantas/metabolismo , Proteínas de Plantas/genética , Prunus avium/genética , Transcriptoma , Proteínas de Homeodominio/metabolismo , Familia de Multigenes , Proteínas de Plantas/metabolismo , Prunus avium/crecimiento & desarrollo
11.
Panminerva Med ; 2021 Apr 28.
Artículo en Inglés | MEDLINE | ID: mdl-33908728

RESUMEN

BACKGROUND: To explore the role of Atorvastatin in rescuing pulmonary artery hypertension (PAH) via inhibiting the AKT/ERK-dependent PDGF-BB/HIF-1α axis. METHODS: PAH model in rats was established by MCT induction, followed by Atorvastatin intervention. Pulmonary hemodynamic measurement and pulmonary morphological evaluation in rats were conducted. Human pulmonary artery smooth muscle cells (hPASMCs) were subjected to hypoxic exposure or PDGF-BB treatment, followed by Atorvastatin induction. Relative levels of HIF-1α, p-ERK and p-Akt were detected. Viability and apoptosis were respectively determined by cell counting kit-8 (CCK-8) assay and flow cytometry. RESULTS: Atorvastatin protected PAH-induced increases in RVSP and Fulton's index in rats. Meanwhile, it inhibited vascular remodeling following PAH by downregulating HIF-1α and PDGF-BB. Hypoxia or PDGF-BB treatment in hPASMCs resulted in upregulation of p-ERK and p-Akt, and viability increase, which were partially abolished by Atorvastatin intervention. In addition, Atorvastatin triggered apoptosis in hypoxia or PDGF-BB-induced hPASMCs. CONCLUSIONS: Atorvastatin inhibits the activation of HIF-1α and proliferative ability, and triggers apoptosis in hPASMCs exposed to hypoxia or PDGF-BB treatment through inactivating the AKT/ERK pathway.

12.
PLoS One ; 16(4): e0245956, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33830996

RESUMEN

Based on the separation voltage type of cascaded H bridge-modular multilevel converters (CHB-MMC) and current predictive model control (CPMC) technology, a novel flexible fault-current limiter (NFFCL) is firstly proposed for restraining the negative impact of the distribution network's disturbance in this paper. When a disturbance occurs, the inner-loop CPMC of the multilevel converters establish the value function to offer the specific current, thus increasing the voltage deviation at both ends of the series capacitor or generating reverse harmonic compensation voltage. In that case, three single-phase MNFFCLs can be regarded as variable voltage sources to eliminate the negative effects of faults or harmonics. Owing to the multi-capacitance series structure, the maximum voltage drops of the single capacitance can be predetermined by the number of capacitors. And with the low voltage drop of single capacitance, the output current of the CHB-MMC can also be controlled within an acceptable range. Through the simulation results, the disturbance's negative impact on the non-fault area can be eliminated almost 100%.

13.
Sci Total Environ ; 782: 146824, 2021 Mar 29.
Artículo en Inglés | MEDLINE | ID: mdl-33839651

RESUMEN

Biochar application into the soils has been reported to have huge carbon sequestration potential, although it remains unclear that how the biochar aging in the soil affects its mechanical properties and soil CO2 and N2O emissions. This work assessed the impact of soil biochar aging on its physicochemical properties, microbiota community in the biochar, and soil CO2 and N2O emissions. Various characterizations (e.g., SEM-EDS, XRD, and FTIR) of fresh and aged biochar indicated that soil minerals accumulated on the biochar during the field aging process, forming organo-mineral complexes and blocking the cracks and channels on the biochar. The measured hardness and compressive strength of aged biochar were significantly higher than those of fresh biochar, consistent with the presence of soil minerals on the aged biochar. The soil CO2 and N2O emissions were significantly decreased after the addition of aged biochar particles, as compared to fresh biochar particles. This was probably because that the improved mechanical properties could inhibit the fragmentation of biochar particles, reducing the release of labile fractions from the biochar and the subsequent CO2 and N2O emissions. Moreover, the presence of CO2-fixing bacteria (e.g., Chloroflexi) and inhibited nitrification and ammonia oxidation in aged biochar particles might also reduce CO2 and N2O emissions. These findings suggest aged biochar particles with improved physical stability to the soil could enhance soil carbon sequestration and greenhouse gas emission reduction.

14.
J Food Sci ; 2021 Apr 15.
Artículo en Inglés | MEDLINE | ID: mdl-33856047

RESUMEN

This study investigated the influence of sarcoplasmic proteins (SPs) treated by the oxidation system (0.1 mmol/L FeCl3 , 0.1 mmol/L ascorbic acid, and 0, 1, 5, 10 mmol/L H2 O2 ) on the properties of pork myofibrillar proteins (MPs) gel. After oxidation treatment, the SPs showed an increased in carbonyl content and a decreased in total sulfhydryl content, coupled with the cross-linking of protein components by disulfide bonds and covalent bonds. The MPs gel with SPs oxidized at 1 mmol/L H2 O2 exhibited the maximal strength while the minimal water holding capacity (WHC). The WHC of MPs gel was significantly decreased with increasing SPs oxidation, leading to the increase of free water and the decrease of immobilized water in the gel system. The microstructures of MPs gels with moderately (1 mmol/L H2 O2 ) oxidized SPs showed a more compact and smaller pore gel network than MPs alone, suggesting adding oxidized SPs can expel water trapped in the gel. Furthermore, the environmental polarity of aliphatic C-H groups increased with SPs oxidation.

15.
Artículo en Inglés | MEDLINE | ID: mdl-33826285

RESUMEN

Capacity fading of Li-rich cathodes in the cycling process is mainly caused by the irreversible side reactions at the interface of electrode and electrolyte by reason of the lack of a corrosion resistant surface. In this work, isocyanate-related functional groups (-N═C═O groups and polyamide-like groups) were tightly bonded on the surface of Li-rich oxides through a urea decomposition gas heat-treatment. The surface isocyanate functionalization inhibits the side reaction of PF5 hydrolysis to give LixPFyOz and HF species at the surface of Li-rich materials in the cycle process. As compared to the untreated Li-rich sample U0, the samples with the spinel-like layer and isocyanate functionalized surface exhibited an enhanced cycle stability. The capacity retention of the treated sample U3 reached as high as 92.6% after 100 cycles at the current density of 100 mA/g, larger than 66.8% for the untreated sample. Even at a higher current density of 1000 mA/g, sample U3 gives a capacity retention of 81.7% after 300 cycles. The findings of this work reveal the importance of surface isocyanate functionalization in restraining the surface side reactions and also suggest an effective method to design Li-rich cathode materials with better electrochemistry performance.

16.
Sci Total Environ ; 781: 146646, 2021 Mar 21.
Artículo en Inglés | MEDLINE | ID: mdl-33794451

RESUMEN

Humic acids (HAs) are frequently subjected to pyrolysis and carbonization by wildfires, which could significantly change the sorption of organic contaminants and their environmental risks in natural system. In previous studies, sorption of organic compounds was investigated for HAs pyrolyzed at temperature below 330 °C, but not for HAs pyrolyzed at higher temperature. Therefore, in this study, sorption of 22 typical organic compounds by HAs pyrolyzed at a series of temperatures from 300 to 700 °C was investigated. Sorption of organic compounds was dominated by nonlinear partition for HAs pyrolyzed at low temperature (e.g., 300 and 400 °C) due to the aliphatic and nonporous structures of pyrolyzed humic acids (PyHAs), while it was dominated by pore-filling adsorption for HAs pyrolyzed at high temperature (e.g., 700 °C) due to the aromatic and porous structures of PyHAs. For HAs pyrolyzed at moderate temperature (e.g., 450, 500 and 600 °C), both nonlinear partition and pore-filling adsorption were responsible for the sorption of organic compounds. Meanwhile, the contribution of pore-filling adsorption to overall sorption increased but the contribution of nonlinear partition decreased with the increasing pyrolytic temperature of PyHAs, attributed to the structure change of PyHAs from aliphatic and nonporous to the aromatic and porous. Moreover, with the increasing pyrolytic temperature of PyHAs, sorption affinity of organic compounds increased, while the change of sorption capacity could be explained by the decrease of nonlinear partition and the increase of pore-filling adsorption. The obtained results could help to evaluate the transport, bioavailability and health risks of organic contaminants in the environment.

17.
Medicine (Baltimore) ; 100(17): e25733, 2021 Apr 30.
Artículo en Inglés | MEDLINE | ID: mdl-33907167

RESUMEN

ABSTRACT: The relationship between serum uric acid (UA) and bone mineral density (BMD) has been proposed by several researchers. However, there has been no consensus regarding the relationships among serum UA, diabetes, and BMD. The aim of this study is to investigate the association between UA, BMD, and at least osteopenia in type 2 diabetes patients.This research was a longitudinal study performed at Xiao-Tang-Shan Hospital in Beijing. Type 2 diabetes diagnosis was consistent with the WHO standard classification. Participants with osteopenia or osteoporosis documented by dual-energy X-ray absorptiometry were defined as having "at least osteopenia." A generalized additive model and multivariable logistic regressions were performed to explore the relationship between serum UA and at least osteopenia. Receiver operating characteristic analysis was conducted. Propensity score matching was used to verify the correctness of the cutoff point.In total, 3476 type 2 diabetes patients free of any osteopenia-related diseases were recruited in 2012 and followed up to 2018. The general proportions of patients with at least osteopenia in 2018 was 16.46% (572/3476). Serum UA was negatively associated with BMD stratified by sex, age group, and BMI level. Setting the first quartile as the reference, the risk of at least osteopenia in the fourth quartile was significant among all patients (odds ratio [OR]: 0.75; 95% confidence interval [CI]: 0.57, 0.98) and specifically in females (OR: 0.79; 95% CI: 0.43, 0.97), patients aged over 50 years (OR: 0.79; 95% CI: 0.60, 0.97) and patients with a BMI greater than 25 (OR: 0.74; 95% CI: 0.47, 0.97). The optimal cutoff point for the serum UA level to distinguish at least osteopenia in diabetic patients was 395 µmol/L.Serum UA concentration is negatively associated with the occurrence of at least osteopenia in Chinese patients with type 2 diabetes.


Asunto(s)
Densidad Ósea , Enfermedades Óseas Metabólicas , Diabetes Mellitus Tipo 2 , Osteoporosis , Ácido Úrico/sangre , Absorciometría de Fotón/métodos , Absorciometría de Fotón/estadística & datos numéricos , Enfermedades Óseas Metabólicas/diagnóstico , Enfermedades Óseas Metabólicas/epidemiología , China/epidemiología , Estudios Transversales , Diabetes Mellitus Tipo 2/sangre , Diabetes Mellitus Tipo 2/epidemiología , Diabetes Mellitus Tipo 2/fisiopatología , Femenino , Humanos , Estudios Longitudinales , Vértebras Lumbares/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Osteoporosis/diagnóstico , Osteoporosis/epidemiología , Medición de Riesgo/métodos , Factores de Riesgo
18.
Drug Des Devel Ther ; 15: 1479-1484, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33854300

RESUMEN

Objective: The present study was designed to compare the changes in ovarian and uterine parameters in girls with idiopathic central precocious puberty (ICPP) before and after gonadotropin-releasing hormone analogues (GnRHa) treatment to determine which sensitive indexes effectively reflect the therapeutic effect. Methods: Sixty girls diagnosed with ICPP were enrolled in the present study. Relevant data were recorded before treatment. Leuprorelin acetate microspheres were injected at a dose of 30-180 µg/(kg four weeks). Relevant parameters were measured and recorded every three months. Changes in each parameter were analyzed to evaluate the clinical effect of leuprorelin in the treatment of girls with ICPP. Results: 1) The height grew at a constant rate. 2) The breasts retracted. 3) Changes in pelvic parameters: the volume of the ovary and uterus and major axes of the ovary, uterus, and cervix were reduced; there were no significant changes in vaginal thickness or the uterine fundal-cervical ratio (FCR). 4) Body mass index (BMI) increased. Conclusion: Pelvic ultrasound is helpful in evaluating the efficacy of GnRHA treatment. The changes of ovarian volume and the major axes of the ovary, uterus, cervix can be used as sensitive observation indexes.

19.
Dis Markers ; 2021: 8870562, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33854651

RESUMEN

Background: Several studies have been conducted to investigate the association between the presence of perineural invasion (PNI) and overall survival (OS) of gastric cancer (GC) patients who underwent curative resection, but no consensus has been reached. This study is aimed at determining the prognostic significance of PNI in gastric cancer. Study Design. The data of 2969 patients with gastric cancer and who had undergone curative gastrectomy from 2006 to 2010 in two high-volume hospitals of China and Korea were retrospectively analyzed. PNI positivity was identified when carcinoma cells were found to infiltrate into the perineurium or neural fascicles. The relationships between PNI and other clinicopathological factors were evaluated, and survival analyses were performed. Results: The presence of PNI was detected in 1055 of the 2969 patients (35.5%). Nationality, age, tumor location, size of tumor, differentiation of the tumor, pT stage, pN stage, lymphatic invasion, and vascular invasion had been associated with PNI positivity. The mean survival time of patients with and without PNI was 62.5 months and 87.3 months, respectively (P < 0.001). However, the presence of PNI was not an independent prognostic factor for gastric cancer, except for patients in stage III (P = 0.037, hazard ratio: 1.21, 95% confidence interval: 1.01-1.44). Conclusion: PNI occurs frequently in patients with gastric cancer, and the incidence of PNI increases with the staging of the tumor. The presence of PNI can provide additional information in predicting the survival outcome for those with stage III tumors.

20.
Infect Dis Poverty ; 10(1): 47, 2021 Apr 07.
Artículo en Inglés | MEDLINE | ID: mdl-33827710

RESUMEN

BACKGROUND: Schistosomiasis japonica is a chronic parasitic disease that seriously harms people's health. Oncomelania hupensis is the only intermediate host of Schistosoma japonicum. The micro-environmental factors surrounding the snail have a great impact on the survival, growth and reproduction of O. hupensis, but there are few relevant systematic analyses until the present. This scoping review aims to identify and summarize the micro-environmental factors that greatly affect O. hupensis, and to find gaps in research thus to provide directions for future in-depth studies. MAIN BODY: This scoping review searched databases with search terms of the combinations of "Micro(-)environment", "Oncomelania" and their expanded aspects. A total of 133 original articles were recruited. Predefined data fields were extracted including research methods, influencing factors, and their effects on O. hupensis. Most studies focused on vegetation factors (54.1%), and other factors noted were soil composition (27.8%), water environmental factors (24.1%), and predator (3.0%), respectively. The factors with positive impacts included water level, pH value, soil temperature, soil humidity, the coverage and height of vegetation at suitable levels. This could provide more detailed information for O. hupensis habitat identification and prediction. The factors with negative impacts included plant extracts, snail control and disease prevention forests, and microorganisms with molluscicidal activities. It revealed a potential application as ecological molluscicides in the future. Factors such as physico-chemical properties of water, soil chemistry showed a gap in scientific studies, thus required further extensive research. CONCLUSIONS: Micro-environmental factors including water quality, soil composition as well as the technology and application of biomolluscicides (plant extracts and microorganisms) deserve more attention. Relative study findings on micro-environment have good potentials in snail control applications. Further studies should be implemented to investigate the impact of micro-environmental factors on snails and close the research gaps.

SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA
...