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1.
Rev Sci Instrum ; 93(6): 063103, 2022 Jun 01.
Artículo en Inglés | MEDLINE | ID: mdl-35777994

RESUMEN

A new type of compact high-resolution high-sensitivity gamma-ray spectrometer for short-pulse intense gamma-rays (250 keV to 50 MeV) has been developed by combining the principles of scintillators and attenuation spectrometers. The first prototype of this scintillator attenuation spectrometer (SAS) was tested successfully in Trident laser experiments at LANL. Later versions have been used extensively in the Texas Petawatt laser experiments in Austin, TX, and more recently in OMEGA-EP laser experiments at LLE, Rochester, NY. The SAS is particularly useful for high-repetition-rate laser applications. Here, we give a concise description of the design principles, capabilities, and sample preliminary results of the SAS.

2.
Artículo en Chino | MEDLINE | ID: mdl-35610680

RESUMEN

Objective: To explore the feasibility and short-term effect of tensor tympani muscle Tenotomy in the treatment of Meniere's disease under otoscope. The possible pathogenesis was discussed and our views were put forward. Methods: The clinical data of 9 cases of Meniere's disease treated by otoscopic Tenotomy were analyzed retrospectively, including 2 males, 7 females, 5 right ones, 2 left ones and 2 bilateral ones. The average age was (56.33± 10.56) years, ranging from 38 to 75 years. We evaluated intraoperative findings and short-term postoperative efficacy, respectively evaluated postoperative aural fullness, tinnitus and hearing recovery, and evaluated postoperative vertigo attack in a short time. Results: Nine patients were completed the operation under general anaesthesia and otoscopy, and no serious complications occurred. We found new pathological changes in tympanic cavity in some cases during operation. There were rupture of round window membrane in 1 case, severe fibrous hyperplasia near the round window membrane and vestibular window and adhesion with ossicular chain in 1 case, fibrous cord and membranous hyperplasia near vestibular window and round window membrane in 1 case, fibrous hyperplasia and adhesion near the round window membrane in 2 cases, membranous hyperplasia and adhesion around vestibular window in 1 case. No fibrous hyperplasia was found in 3 cases in the tympanic cavity. The round window membrane can be exposed in 4 cases and failed in 5 cases. After 3 months of follow-up, we found that we found that 5/5 cases of aural fullness disappeared, 2/2 cases of earache disappeared, 3/8 cases of tinnitus improved, 5/8 cases presented with improvement and no aggravation, 3/3 cases of hearing allergy improved, 4/9 cases of hearing improved, and 5/9 cases showed no improvement or decrease. 9 patients were followed up for 3 months, of whom 8 patients had no vertigo, one patient suffered from vertigo twice within 3 months after operation, and the patient suffered from rupture of round window membrane. Conclusions: Endoscopic Tenotomy for Meniere's disease has obvious curative effect and quick recovery after operation. During the operation, we find that most of Meniere's patients have fibrous cord hyperplasia near the inner ear window membrane, which may be the pathological manifestation after repeated rupture and repair of the inner ear window membrane. The vertigo of Meniere's disease may be related to the destruction and repair of inner ear membrane structure caused by improper contraction or spasm of tympanic tensor muscle.


Asunto(s)
Enfermedad de Meniere , Acúfeno , Anciano , Femenino , Humanos , Hiperplasia/patología , Masculino , Enfermedad de Meniere/complicaciones , Enfermedad de Meniere/cirugía , Persona de Mediana Edad , Otoscopios/efectos adversos , Estudios Retrospectivos , Tenotomía/efectos adversos , Tensor del Tímpano/patología , Tensor del Tímpano/cirugía , Acúfeno/complicaciones , Vértigo/etiología
3.
Zhonghua Yan Ke Za Zhi ; 58(4): 279-288, 2022 Apr 11.
Artículo en Chino | MEDLINE | ID: mdl-35391515

RESUMEN

Objective: To evaluate the preliminary efficacy and safety of ab interno canaloplasty (ABiC) combined with micro-incision cataract surgery for treating primary open angle glaucoma (POAG) combined with cataract. Methods: Prospective case series study. Patients diagnosed with POAG and concurrent cataract were enrolled to receive ABiC combined with micro-incision phacoemulsification and intraocular lens implantation in the Eye Center of the Second Affiliated Hospital of Zhejiang University School of Medicine from June 2018 to October 2019. Intraocular pressure (IOP), use of hypotensive medications, visual acuity, visual field, and optic nerve at baseline as well as at 1 day, 1 week, 1 month, 3 months, 6 months, and 12 months postoperatively were assessed. Subgroup analyses were further performed to evaluate these data between controlled and uncontrolled POAG, as well as among mild, moderate, and advanced POAG. Success rate and complications were analyzed. Results: A total of 68 eyes in 42 patients completed a follow-up of 12 months. Compared to the baseline IOP under medical control [(18.25±2.65) mmHg (1 mmHg=0.133 kPa)], the mean postoperative IOP at 1 month [(14.31±3.25) mmHg], 3 months [(14.00±3.09) mmHg], 6 months[ (14.58±2.93) mmHg], and 12 months[ (14.84±2.73) mmHg] was all significantly reduced (P<0.05). The median (upper quadrant, lower quadrant) of the hypotensive medication number was 2.5 (2, 3) at baseline, which was significantly reduced to 0 (0, 1) at 1 month, and 0 (0, 0) at 3, 6, and 12 months (P<0.05). The complete success rate and qualified success rate at 12 months were 80.88%(55/68) and 89.71%(61/68), respectively. No deterioration in the visual field or optical coherence tomography scan of the optic nerve was observed at 12 months compared to the baseline status. Hyphema (26 eyes, 38.24%) and transient IOP spike (23 eyes, 33.82%) were the most common complications, but no severe case was present. Conclusion: ABiC combined with micro-incision cataract surgery is considerably effective and safe in the treatment of POAG combined with cataract in the Chinese population.


Asunto(s)
Extracción de Catarata , Catarata , Glaucoma de Ángulo Abierto , Facoemulsificación , Herida Quirúrgica , Trabeculectomía , Antihipertensivos , Catarata/complicaciones , Catarata/terapia , Glaucoma de Ángulo Abierto/complicaciones , Glaucoma de Ángulo Abierto/cirugía , Humanos , Presión Intraocular , Facoemulsificación/métodos , Herida Quirúrgica/complicaciones , Herida Quirúrgica/cirugía , Trabeculectomía/métodos , Resultado del Tratamiento
4.
Chemosphere ; 300: 134609, 2022 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-35430197

RESUMEN

Artisanal and small-scale gold mining (ASGM), energy production and other industrial inputs are a major source of anthropogenic mercury (Hg) to the aquatic environment globally, and these inputs have led to environmental contamination and human exposure. While studies have documented the effects of Hg inputs to rivers and marine waters of the West African region, estuarine waters of Cote d'Ivoire have been understudied, besides the waters surrounding Abidjan. To fill this gap, and to examine the potential for human exposure to methylmercury (MeHg), we measured the concentrations of total Hg, MeHg, and ancillary parameters in water (dissolved and particulate phases), sediment and fish to determine the extent of environmental impact and the potential for MeHg exposure for people consuming these fish. Levels of Hg and MeHg in sediment were elevated in the vicinity of the urban environment (up to 0.3 ng/g dry weight (dw) MeHg and 623 ng/g dw total Hg) and lowest in the more remote estuarine environments. Measurements of Hg in tuna and other larger pelagic coastal species indicated that levels were elevated but comparable to other North Atlantic regions. However, levels of Hg in fish, even smaller estuarine species, were such that the rural and urban populations are potentially being exposed to unsafe levels of MeHg, primarily as a result of the relatively high fish consumption in Cote d'Ivoire compared to other countries. Overall, both local point sources and the transport of Hg used in interior ASGM activities are the sources for Hg contamination to these coastal waters.


Asunto(s)
Mercurio , Compuestos de Metilmercurio , Contaminantes Químicos del Agua , Animales , Costa de Marfil , Monitoreo del Ambiente , Peces , Oro , Humanos , Mercurio/análisis , Ríos , Contaminantes Químicos del Agua/análisis
5.
Zhonghua Er Ke Za Zhi ; 60(3): 209-214, 2022 Mar 02.
Artículo en Chino | MEDLINE | ID: mdl-35240740

RESUMEN

Objective: To summarize the clinical features of Streptococcus pneumoniae-associated hemophagocytic syndrome (SP-HLH), and the serotypes and drug-resistant characteristics of the isolated strains. Methods: There were 15 children with SP-HLH admitted to the Pediatric Intensive Care Unit (PICU) of Beijing Children's Hospital, Capital Medical University from January 2013 to December 2020 were included in this study. Clinical data including children's general characteristics, clinical features, laboratory examinations, treatments, prognosis and the outcomes of follow-up by May 2021 were analyzed retrospectively. The serotypes and drug resistance of the isolated strains were identified. All children were divided into the clinical improvement group and the death group. Mann-Whitney U test, Fisher's exact test were used to compare the data of the two groups. Results: Among the 15 children with SP-HLH, 8 were males and 7 were females. The age of these children was 1.0 (1.0, 2.5) years. Regarding the primary infection, there were 9 cases of severe pneumonia, 3 cases of meningitis and 3 cases of blood stream infection. None of these children had received pneumoniae conjugate vaccine (PCV) and all of them were admitted to the PICU. Respiratory failure was observed in 10 patients, acute renal injury in 5, and hemolytic uremic syndrome in 3 patients. All children received glucocorticoids and high-dose intravenous immunogloblin (IVIG) in addition to anti-infective treatment. Eight of the children were cured while the other 7 died. The neutrophil count in the death group was lower than that in the clinical improvement group ((5.0 (1.7, 9.3) × 109 vs. 5.2 (3.4, 10.5) ×109/L, Z =-2.43, P<0.015), and the length of hospital stay and days of PICU stay in the death group were both shorter than those in the improvement group statistically (3 (1, 11) vs. 39 (34, 48) d, 2 (1, 4) vs. 19 (12, 31) d, Z=-3.25, -3.24, both P=0.001). Ten serotypes of Streptococcus pneumoniae were identified, including 4 strains of 19F, 3 of 19A, 1 of 23F, 1 of 15A and 1 of 14, among which 9 strains (9/10) were covered by PCV13. All strains were resistant to erythromycin yet sensitive to vancomycin and linezolid. Conclusions: SP-HLH is more common in children under the age of 3, with a high mortality rate. The death cases have lower neutrophil count and rapid disease progression. The comprehensive treatment is anti-infective combined with glucocorticoids and high-dose IVIG. The predominant serotypes are 19F and 19A and all isolated strains were susceptible to vancomycin and linezolid.


Asunto(s)
Linfohistiocitosis Hemofagocítica , Infecciones Neumocócicas , Antibacterianos/uso terapéutico , Niño , Femenino , Humanos , Lactante , Linfohistiocitosis Hemofagocítica/tratamiento farmacológico , Masculino , Pruebas de Sensibilidad Microbiana , Infecciones Neumocócicas/complicaciones , Infecciones Neumocócicas/tratamiento farmacológico , Estudios Retrospectivos , Serogrupo , Streptococcus pneumoniae
6.
Zhonghua Bing Li Xue Za Zhi ; 51(1): 33-38, 2022 Jan 08.
Artículo en Chino | MEDLINE | ID: mdl-34979751

RESUMEN

Objective: To investigate the clinicopathological characteristics and differential diagnosis of pediatric SMARCB1/INI1-deficient poorly differentiated chordoma (PDC) of the skull base. Methods: Five cases of SMARCB1/INI1-deficient PDC were identified in 139 cases of chordoma diagnosed in Sanbo Brain Institute, Capital Medical University, Beijing, China from March 2017 to March 2021. The clinical and imaging data of the 5 PDCs were collected. H&E and immunohistochemical staining, and DNA methylation array were used, and the relevant literatures were reviewed. Results: All 5 PDCs were located at the clivus. The average age of the patients was 6.4 years, ranging from 3 to 16 years. Three patients were female and two were male. Morphologically, in contrast with classical chordomas, they presented as epithelioid or spindle tumor cells organized in sheets or nests, with necrosis, active mitoses, and infiltration into surrounding tissue. All cases showed positivity of CKpan, EMA, vimentin and brachyury (nuclear stain), and loss of nuclear SMARCB1/INI1 expression. S-100 protein expression was not frequent (2/5). Ki-67 proliferative index was high (20%-50%). All cases had over-expressed p53. It was necessary to differentiate SMARCB1/INI1-dificient PDC from SMARCB1/INI1-dificient tumors occurring at skull base of children or the tumors with epithelial and spindle cell morphological features. The 3 PDCs with DNA methylation testing showed the methylation profiles different from the pediatric atypical teratoid/rhabdoid tumors. They formed an independent methylation profile cluster. The clinical prognosis of the 5 patients was poor, and the overall survival time was 2-17 months. Conclusions: PDC is a special subtype of chordoma, which often affects children and occurs in the clivus. The PDC shares epithelioid or spindle cell morphologic features which are different from the classic chordoma. Besides the typical immunohistochemical profile of chordoma, PDC also has loss of nuclear SMARCB1/INI1 expression and distinct epigenetic characteristics.


Asunto(s)
Cordoma , Tumor Rabdoide , Biomarcadores de Tumor/genética , Niño , Cordoma/diagnóstico , Cordoma/genética , Diagnóstico Diferencial , Femenino , Humanos , Masculino , Pronóstico , Tumor Rabdoide/diagnóstico , Proteína SMARCB1/genética , Base del Cráneo
7.
Nat Commun ; 12(1): 5741, 2021 Sep 30.
Artículo en Inglés | MEDLINE | ID: mdl-34593793

RESUMEN

Twisted two-dimensional van der Waals (vdW) heterostructures have unlocked a new means for manipulating the properties of quantum materials. The resulting mesoscopic moiré superlattices are accessible to a wide variety of scanning probes. To date, spatially-resolved techniques have prioritized electronic structure visualization, with lattice response experiments only in their infancy. Here, we therefore investigate lattice dynamics in twisted layers of hexagonal boron nitride (hBN), formed by a minute twist angle between two hBN monolayers assembled on a graphite substrate. Nano-infrared (nano-IR) spectroscopy reveals systematic variations of the in-plane optical phonon frequencies amongst the triangular domains and domain walls in the hBN moiré superlattices. Our first-principles calculations unveil a local and stacking-dependent interaction with the underlying graphite, prompting symmetry-breaking between the otherwise identical neighboring moiré domains of twisted hBN.

8.
Zhonghua Xin Xue Guan Bing Za Zhi ; 49(9): 880-885, 2021 Sep 24.
Artículo en Chino | MEDLINE | ID: mdl-34530595

RESUMEN

Objective: To evaluate the safety and effectiveness of left atrial appendage occlusion (LAAO) in patients with atrial fibrillation and end-stage renal disease undergoing long-term hemodialysis. Methods: Six patients with AF and end-stage renal disease(ESRD)on long term hemodialysis who underwent LAAO from March 2017 to March 2021 in Beijing Anzhen Hospital were enrolled. Baseline characteristics such as age, sex, types of arrhythmia, stroke and bleeding score, and continuous dialysis time were collected. Four patients underwent LAAO, two patients underwent the combined procedure of catheter ablation and LAAO. Perioperative treatment and serious complications were recorded. Transesophageal echocardiography was repeated at 45 days and 60 days after the procedure. Telephone follow-up was conducted at 3, 6 and 12 months after the procedure, and every 6 months thereafter. Thromboembolism and major bleeding events and survival were evaluated. Results: The average age was (66.7±17.0) years old, and 5 were male (5/6). There were 4 patients with paroxysmal AF (4/6), and 2 patients with persistent AF (2/6). The mean CHA2DS2-VASc score was (4.8±1.5), and the HAS-BLED score was (3.5±1.4). The duration of hemodialysis was 2.6 (1.1, 8.3) years. Successfully Watchman implantation was achieved in all patients. There were no severe perioperative complications, and no device related thrombosis or leaks were observed by transesophageal echocardiography. During a mean of 22.0 (12.0, 32.0) months follow-up, there was no thromboembolism or major bleeding events. A total of 2 patients died, one from sudden cardiac death, and another one from heart failure. Conclusions: LAAO may be a safe and effective therapeutic option for prevention of thromboembolism in patients with atrial fibrillation and end-stage renal disease undergoing long-term hemodialysis, further studies with larger patient cohort are needed to confirm our results.


Asunto(s)
Apéndice Atrial , Fibrilación Atrial , Fallo Renal Crónico , Accidente Cerebrovascular , Tromboembolia , Anciano , Anciano de 80 o más Años , Apéndice Atrial/diagnóstico por imagen , Apéndice Atrial/cirugía , Fibrilación Atrial/complicaciones , Fibrilación Atrial/cirugía , Ecocardiografía Transesofágica , Humanos , Fallo Renal Crónico/complicaciones , Fallo Renal Crónico/terapia , Masculino , Persona de Mediana Edad , Diálisis Renal , Resultado del Tratamiento
9.
Zhonghua Yan Ke Za Zhi ; 57(7): 481-486, 2021 Jul 11.
Artículo en Chino | MEDLINE | ID: mdl-34256466

RESUMEN

Cataract is the main cause of treatable visual impairment in children. Children face more risks during the perioperative period of cataract surgery than adults because of their anatomical, physiological, behavioral, and developmental characteristics; therefore, special attention and management are required. This article comprehensively discusses the perioperative management of children's cataract surgery on the base of relevant literatures and the authors' clinical experience, including the indications and timing of surgery, preoperative examination, prevention and treatment of surgical complications, and postoperative visual function reconstruction. (Chin J Ophthalmol, 2021, 57: 481-486).


Asunto(s)
Extracción de Catarata , Catarata , Oftalmología , Baja Visión , Catarata/terapia , Niño , Humanos , Complicaciones Posoperatorias , Periodo Posoperatorio
11.
Bull Soc Pathol Exot ; 113(1): 52-59, 2020.
Artículo en Francés | MEDLINE | ID: mdl-32881445

RESUMEN

During dry season of 2014, some ticks were collected on cattle (Bos taurus and Bos indicus) and grasscutters (Thryonomys swinderianus) in sugar complex areas of Savanna District of Côte-d'Ivoire. Two localities were concerned; SUCAF 1 in Ferkessédougou and SUCAF 2 in Komborodougou. The main objective was to inventory tick species that parasite cattle and grasscutters in this region, then, to identify the shared species between these two groups of animals. To this end, ticks were collected from 70 cattle (35 females and 35 males) and 50 grasscutters (30 females and 20 males). Four tick species were found on cattle: Amblyomma variegatum, Hyalomma truncatum, Rhipicephalus annulatus and Rhipicephalus microplus. On grasscutters, three species of ticks were found: A. variegatum, Ixodes aulacodi and Rhipicephalus simpsoni. The species A. variegatum dominated cattle infestation and was the only tick present in the two groups of animals. But, only immature forms were found on grasscutters. This later specie was mainly infested by adults R. simpsoni.


Pendant la saison sèche de l'année 2014, des tiques ont été collectées sur des bovins (Bos taurus et Bos indicus) et sur des aulacodes (Thryonomys swinderianus), respectivement à Ferkessédougou et Komborodougou au niveau des complexes sucriers SUCAF 1 et 2, dans le district des Savanes de Côte-d'Ivoire. L'objectif principal recherché était d'inventorier les espèces de tiques parasitant les bovins et les aulacodes sauvages dans cette région puis de déterminer les espèces communes à ces deux groupes d'animaux. Au total, les prélèvements de tiques ont été effectués sur 70 bovins et 50 aulacodes. Après identification morphologique, quatre espèces ont été trouvées chez les bovins : Amblyomma variegatum, Hyalomma truncatum, Rhipicephalus annulatus et Rhipicephalus microplus, et trois espèces chez les aulacodes : A. variegatum, Ixodes aulacodi et Rhipicephalus simpsoni. La tique A. variegatum, la seule espèce commune aux deux types d'animaux, était majoritaire chez les bovins. Chez les aulacodes par contre, seules les formes immatures d'A. variegatum ont été trouvées, et les adultes de l'espèce R. simpsoni ont été trouvés en majorité.


Asunto(s)
Enfermedades de los Bovinos/parasitología , Roedores/parasitología , Infestaciones por Garrapatas/veterinaria , Garrapatas/clasificación , Animales , Bovinos , Costa de Marfil , Femenino , Pradera , Masculino , Infestaciones por Garrapatas/epidemiología
12.
Zhonghua Yan Ke Za Zhi ; 56(6): 409-413, 2020 Jun 11.
Artículo en Chino | MEDLINE | ID: mdl-32842325

RESUMEN

Dry eye is a common ocular surface disease that can occur in more than half of cataract patients before surgery. The perioperative damage to ocular surface can lead to tear film insufficiency and a series of dry eye symptoms, which reduce the visual outcome and life quality of the patients. Therefore, clinicians should standardize the management of dry eye disease during the perioperative period of cataract surgery to further improve patients' satisfaction with surgery, in terms of the evaluation and optimization of preoperative ocular surface, the protection of ocular surface during surgery, and the diagnosis and treatment of postoperative dry eye disease. ( Chin J Ophthalmol, 2020, 56: 409-413).


Asunto(s)
Catarata/terapia , Síndromes de Ojo Seco/prevención & control , Facoemulsificación , Humanos , Periodo Perioperatorio , Estudios Prospectivos
13.
Obes Surg ; 30(10): 3803-3812, 2020 10.
Artículo en Inglés | MEDLINE | ID: mdl-32529354

RESUMEN

BACKGROUND: Emerging evidence has revealed that obstructive sleep apnea (OSA) is associated with non-alcoholic fatty liver disease (NAFLD). However, the impact of OSA on NAFLD among obese patients undergoing metabolic and bariatric surgery (MBS), especially during follow-up period, remains unclear. OBJECTIVE: To analyze the correlation based on preoperative characteristics and postoperative conditions among bariatric patients with comorbid OSA and NAFLD. METHODS: Clinical data of patients who underwent MBS in our institution between January 2016 and June 2019 were reviewed retrospectively. Correlation analysis and linear regressions were used to identify how OSA links with NAFLD before and after treatment of MBS. RESULTS: Of 308 patients, 181 were diagnosed with OSA and enrolled in the present study, and 127 completed follow-up visits at 6 months. The proportion of NAFLD in the mild-moderate OSA and severe OSA groups was 75.0% and 96.0%, respectively. MBS was effective at improving sleep apnea and nocturnal hypoxia, as well as liver steatosis and fibrosis (P < 0.05). And we also found that there were significant correlations not only between OSA- and NAFLD-related characteristics at baseline but also between their improvements after surgery, eventually leading to similar prognosis of NAFLD for both groups (P < 0.05), no matter what presurgical differences existed. In addition, the results of the univariate and multivariate linear regression analyses supported preoperative liver/spleen Hounsfield units ratio (LSR) by computerized tomography (CT) as an independent predictor of the effect of MBS on liver steatosis. CONCLUSION: In conclusion, MBS plays a pivotal role in the control of medical conditions in obese patients with OSA and NAFLD. Given the correlation between OSA and NAFLD in the present study, in the case of both the severity at baseline as well as the improvement after surgery, OSA may pose an impact on the prognosis of NAFLD in bariatric patients.


Asunto(s)
Cirugía Bariátrica , Enfermedad del Hígado Graso no Alcohólico , Obesidad Mórbida , Apnea Obstructiva del Sueño , Humanos , Enfermedad del Hígado Graso no Alcohólico/complicaciones , Obesidad Mórbida/cirugía , Estudios Retrospectivos , Apnea Obstructiva del Sueño/complicaciones
14.
Zhonghua Yan Ke Za Zhi ; 56(5): 321-324, 2020 May 11.
Artículo en Chino | MEDLINE | ID: mdl-32450663

RESUMEN

Since the founding of the People's Republic of China, with the unremitting efforts of several generations of ophthalmologists, the level of cataract diagnosis and treatment in our country has made great progress, which has made a significant contribution to the cause of preventing and treating blindness. On the occasion of the 70th anniversary of Chinese Journal of Ophthalmology, this article reviews the development of cataract surgery and intraocular lenses, aiming to help better understand the key points and breakthroughs in cataract diagnosis and treatment in our country at various historical periods, and to encourage the new generation of ophthalmologists to work hard to further promote the progress of ophthalmology in China. (Chin J Ophthalmol, 2020, 56: 321-324).


Asunto(s)
Extracción de Catarata , Catarata , Lentes Intraoculares , Oftalmología , Catarata/diagnóstico , China , Humanos
15.
Zhonghua Er Ke Za Zhi ; 58(3): 259-261, 2020 Mar 02.
Artículo en Chino | MEDLINE | ID: mdl-32135606
16.
Zhonghua Liu Xing Bing Xue Za Zhi ; 41(2): 167-172, 2020 Feb 10.
Artículo en Chino | MEDLINE | ID: mdl-32164124

RESUMEN

Post-traumatic tetanus is the main type of non-neonatal tetanus. To reduce the incidence and mortality rateof tetanus and guide the primary medical institutions to prevent and control tetanus after trauma, the National Immunization Planning Technical Working Group of the Chinese Center for Disease Control and Prevention has compiled this document in the reference with Position Paper by World Health Organization, and the latest research progress both at home and abroad. The guidelines focus on the basic procedures for the prevention and treatment of post-traumatic tetanus, the application of tetanus vaccines and immune preparation, and pre-exposure immunization in high-risk populations of trauma.


Asunto(s)
Inmunización Pasiva , Toxoide Tetánico/administración & dosificación , Tétanos/prevención & control , China , Humanos , Tétanos/inmunología
17.
Zhonghua Yan Ke Za Zhi ; 56(9): 653-656, 2020 Sep 11.
Artículo en Chino | MEDLINE | ID: mdl-32171189

RESUMEN

This article was published ahead of print on the official website of Chinese Journal of Ophthalmology on March 14, 2020. Novel coronavirus pneumonia broke out and spread to the whole nation since December 2019. The fight against the virus is now at a critical stage. Previous epidemiological investigations and animal experiments suggested aerosol could perform as a virus transmitter. Based on the clinical observation, the possibility of aerosol transmission of 2019 novel coronavirus has aroused much attention. This article focuses on the feature of aerosol transmission and the pathogens involved in. We analyze the possibility of aerosol transmission of the novel coronavirus. Relevant strategies for preventing novel coronavirus pneumonia are established for the medical personnel and general public during their work or daily life. (Chin J Ophthalmol, 2020, 56:653-656).


Asunto(s)
Aerosoles , Infecciones por Coronavirus/transmisión , Neumonía Viral/transmisión , Betacoronavirus , COVID-19 , Humanos , Pandemias , SARS-CoV-2
18.
Zhonghua Yi Shi Za Zhi ; 50(6): 355-359, 2020 Nov 28.
Artículo en Chino | MEDLINE | ID: mdl-33596612

RESUMEN

Many studies in modern times claim that the name " 100-day cough" is from traditional Chinese medicine, and even think that there is a description of pertussis as early as the Sui Dynasty classics. By reviewing the original texts of the classics, we found that these interpretations are not exactly. The description of the pertussis and the chronological distribution of the literature in traditional Chinese books are similar to those of Western medicine. They started about 500 years ago, and then become more detailed and specific. The domestic medical community has a variety of nomenclature for this disease, and there is no sign or evidence to uniformly use "100-day cough" as the disease name. The literature records suggest that "100-day cough" first became a more recognized disease name in Japan, and through the direct input of medical education, entered the modern medical textbooks of western medicine in China.


Asunto(s)
Tos , Medicina Tradicional China , Libros , China , Historia del Siglo XV , Humanos , Japón
19.
JNCI Cancer Spectr ; 4(6): pkaa094, 2020 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-33409458

RESUMEN

BACKGROUND: Few studies have examined gene-specific associations with contralateral and/or second breast cancer (SBC). METHODS: The frequency of pathogenic and likely pathogenic (P/LP) variants in clinically actionable genes (BRCA1, BRCA2, PTEN, TP53, CHEK2, CDH1, ATM, PALB2, NBN, and NF1) was compared between women with a primary breast cancer (PBC) and SBC who underwent multigene panel testing at a single diagnostic testing laboratory. Race- and ethnicity-specific logistic regression burden tests adjusted for age at diagnosis of first breast cancer, histology, presence of first- or second-degree relatives with breast cancer, and prior testing for BRCA1/2 genes were used to test for associations with SBC. All statistical tests were 2-sided. RESULTS: The study was comprised of 75 550 women with PBC and 7728 with SBC. Median time between breast cancers for SBC was 11 (interquartile range = 6-17) years. Restricting to women tested for all actionable genes (n = 60 310), there were 4231 (7.8%) carriers of P/LP variants in actionable genes among the controls (PBC) compared with 652 (11.1%) women with SBC (P< .001). Among Caucasians, exclusive of Ashkenazi Jewish women, those carrying a P/LP variant in a clinically actionable gene were 1.44 (95% confidence interval [CI] = 1.30 to 1.60) times as likely to have SBC than noncarriers, after accounting for potential confounders. Among African American and Hispanic women, a P/LP variant in a clinically actionable gene was 1.88 (95% CI = 1.36 to 2.56) and 1.66 (9% CI = 1.02 to 2.58) times as likely to be associated with SBC, respectively (P < .001 and P = .03). CONCLUSION: Women with P/LP variants in breast cancer predisposition genes are more likely to have SBC than noncarriers. Prospective studies are needed confirm these findings.

20.
Zhonghua Yu Fang Yi Xue Za Zhi ; 53(12): 1212-1217, 2019 Dec 06.
Artículo en Chino | MEDLINE | ID: mdl-31795577

RESUMEN

Post-traumatic tetanus is the main type of non-neonatal tetanus. To reduce the incidence and mortality rate of tetanus and guide the primary medical institutions to prevent and control tetanus after trauma, National Immunization Planning Technical Working Group of the Chinese Center for Disease Control and Prevention has compiled this document in the reference with Position Paper by World Health Organization, the latest research progress from home and abroad. The guidelines focus on the basic procedures for the prevention and disposition of post-traumatic tetanus, the application of tetanus vaccines and immune preparation, and the pre-exposure immunization in high-risk populations of trauma.


Asunto(s)
Guías de Práctica Clínica como Asunto , Toxoide Tetánico/administración & dosificación , Tétanos/prevención & control , Humanos , Inmunización , Programas de Inmunización , Tétanos/inmunología , Vacunación
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