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1.
Artículo en Inglés | MEDLINE | ID: mdl-32862640

RESUMEN

Because light exhibits excellent spatiotemporal resolution, photodynamic therapy (PDT) is becoming a promising method for cancer treatment. However, in a single photosensitizer (PS), it remains a big challenge to achieve all key properties including effective singlet oxygen (1O2) production under long-wavelength laser and bright near-infrared (NIR) emission without toxicity in the dark. In addition, clinically used traditional PSs encounter quenched fluorescence and decreased 1O2 production because of molecular aggregation in aqueous solution. To solve the aforementioned issues, quinoxalinone CN (QCN) with effective 1O2 generation under long-wavelength (530 nm) laser irradiation and aggregation-induced NIR emission is rationally designed by precise optimization of the quinoxalinone scaffold. After being encapsulated by an amphiphilic polymer (DSPE-PEG), the yielded nanoparticles exhibit highly efficient 1O2 production and stable NIR fluorescence located at 800 nm without obvious toxicity under the dark. Both in vitro and in vivo evaluation identify that QCN would be a promising PS for image-guided PDT of tumors.

2.
Artículo en Inglés | MEDLINE | ID: mdl-32876427

RESUMEN

Cubic N,S codoped carbon coating MnS-FeS2 composites (MnS-FeS2@NSC) with a hollow structure were prepared and used as anode materials for sodium-ion batteries. MnS-FeS2@NSC exhibits excellent cycle performance and high rate capability and delivered a reversible capacity of 501.0 mAh g-1 after 800 cycles at a current density of 0.1 A g-1 with a capacity retention of 81%. More importantly, the MnS-FeS2@NSC anode holds long-term cycle stability; the capacity can remain 134.0 mAh g-1 after 14 500 cycles at 4 A g-1. Kinetic analysis demonstrated that Na+ storage follows a pseudocapacitive dominating process, which is ascribed to the origin of the outstanding rate performance of the MnS-FeS2@NSC material. The enhancement of electrochemical performance is attributed to the hollow structure and the N,S codoped carbon coating structure, which can reduce the diffusion distance for sodium ions and electrons, alleviate volume expansion during sodium-ion insertion/extraction, and retain the structural integrity effectively. Furthermore, a two-step sodiation processes with FeS2 sodiation prior to MnS was demonstrated by X-ray diffraction (XRD), and the electrochemical impedance spectroscopy (EIS) spectra might indicate that the accumulation of the metallic elements in the preconversion reaction can accelerate the transfer of electrons and ions in the further conversion process.

3.
Nano Lett ; 2020 Sep 14.
Artículo en Inglés | MEDLINE | ID: mdl-32881530

RESUMEN

The ability to restrict the shuttle of lithium polysulfide (LiPSn) and improve the utilization efficiency of sulfur represents an important endeavor toward practical application of lithium-sulfur (Li-S) batteries. Herein, we report the crafting of a robust 3D graphene-wrapped, nitrogen-doped, highly mesoporous carbon/sulfur (G-NHMC/S) hierarchical aerogel as an effective polysulfide confinement matrix for a highly stable Li-S battery. Rich polar sites of NHMC firmly anchor LiPSn on the matrix surface. Porous NHMC provides ample space for accommodating sulfur and cushioning its volume expansion. Moreover, graphene wrapped on NHMC/S not only physically hinders the LiPSn shuttle but also interconnects the isolated NHMC/S, thus increasing electron transfer rate. Taken together, triple confinement of G-NHMC/S aerogel synergistically retains the soluble LiPSn and displays a specific capacity of 1322 mAh g-1 and 1000-cycle life. As such, rationally designed 3D carbon/sulfur aerogel affords a unique platform to impart high energy density and stable electrodes for energy storage devices.

4.
J Inorg Biochem ; 212: 111232, 2020 Aug 21.
Artículo en Inglés | MEDLINE | ID: mdl-32889128

RESUMEN

With the rise of two-dimensional nanomaterials in medicine, finding suitable materials has become our top priority. Since the first report of antimonene in 2015, due to its excellent physical and chemical properties, it has gradually attracted widespread attention, including its application prospects in cancer treatment. In this paper, the preparation, stability and infrared degradability of antimonene, as well as its experimental examples in tumor treatment in recent years are reviewed, the latest research results are listed and summarized, the advantages and existing problems are analyzed, and the future of antimonene in tumor therapy is prospected.

5.
Bioorg Chem ; 104: 104252, 2020 Sep 02.
Artículo en Inglés | MEDLINE | ID: mdl-32911187

RESUMEN

Sesquiterpenoids with diverse skeleton types are regarded as potential lead compounds in pharmacological and other applications. Herein, we report the discovery of two new cadinane-type sesquiterpenoids, paecilacadinol A (1) and B (2); two new drimane-type sesquiterpenoids, ustusol D (3) and ustusol E (4); and six known analogs (5-10) from the endophytic fungus Paecilomyces sp. TE-540, enriching the structural diversity of naturally occurring sesquiterpenoids. Their planar structures were determined on the basis of detailed interpretation of 1D and 2D NMR spectroscopy and HRESIMS data, while their stereochemical structures were established by X-ray crystallographic analyses for 1 and 3-8 and theoretical calculations for 2. Notably, compounds 1 and 2 represent novel examples of cadinane-type sesquiterpenoids with ether bonds formed by intramolecular dehydration. Compounds 5 and 6 showed moderate activities against acetylcholinesterase (AChE), with IC50 values of 43.02 ± 6.01 and 35.97 ± 2.12 µM, respectively. Docking analysis predicted that 5 bound well in the catalytic pocket of AChE via hydrophobic interactions with Trp84, Gly117, Ser122, and Tyr121 residues, while 6 was located with Asp72 and Ser122 residues.

6.
Hypertension ; 76(4): 1219-1230, 2020 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-32862709

RESUMEN

Pathological cardiac hypertrophy is one of the major predictors and inducers of heart failure, the end stage of various cardiovascular diseases. However, the molecular mechanisms underlying pathogenesis of pathological cardiac hypertrophy remain largely unknown. Here, we provided the first evidence that STEAP3 (Six-Transmembrane Epithelial Antigen of Prostate 3) is a key negative regulator of this disease. We found that the expression of STEAP3 was reduced in pressure overload-induced hypertrophic hearts and phenylephrine-induced hypertrophic cardiomyocytes. In a transverse aortic constriction-triggered mouse cardiac hypertrophy model, STEAP3 deficiency remarkably deteriorated cardiac hypertrophy and fibrosis, whereas the opposite phenotype was observed in the cardiomyocyte-specific STEAP3 overexpressing mice. Accordingly, STEAP3 significantly mitigated phenylephrine-induced cell enlargement in primary neonatal rat cardiomyocytes. Mechanistically, via RNA-seq and immunoprecipitation-mass screening, we demonstrated that STEAP3 directly bond to Rho family small GTPase 1 and suppressed the activation of downstream mitogen-activated protein kinase-extracellular signal-regulated kinase signaling cascade. Remarkably, the antihypertrophic effect of STEAP3 was largely blocked by overexpression of constitutively active mutant Rac1 (G12V). Our study indicates that STEAP3 serves as a novel negative regulator of pathological cardiac hypertrophy by blocking the activation of the Rac1-dependent signaling cascade and may contribute to exploring effective therapeutic strategies of pathological cardiac hypertrophy treatment.

7.
Nan Fang Yi Ke Da Xue Xue Bao ; 40(7): 942-948, 2020 Jul 30.
Artículo en Chino | MEDLINE | ID: mdl-32895159

RESUMEN

OBJECTIVE: To investigate the effect of periostin on hypoxia-induced oxidative stress and apoptosis in human periodontal ligament fibroblasts and the molecular mechanism involved. METHODS: In vitro cultured human periodontal ligament fibroblasts were placed in an anaerobic gas-producing bag for hypoxia treatment for 48 h followed by treatment with periostin at low (25 ng/mL), moderate (50 ng/mL) or high (100 ng/mL) doses. MTT assay was used to measure the cell viability, and the cell apoptosis rate was determined using flow cytometry. The contents of IL-1ß, IL-6 and TNF-α in the cells were determined with ELISA, and ROS levels were measured using a fluorescent plate reader. The intracellular SOD activity was detected using ELISA. The expressions of HIF-1α, P21, cyclin D1, Bax, cleaved caspase-3, Bcl-2, P38MAPK and p-p38 MAPK proteins in the cells were detected with Western blotting. RESULTS: Hypoxia treatment significantly reduced the cell viability (P < 0.05), increased P21, Bax, and cleaved caspase-3 protein levels (P < 0.05), promoted cell apoptosis (P < 0.05), and decreased cyclin D1 and Bcl-2 protein levels (P < 0.05) in the cells. Compared with the hypoxic group, the cells treated with periostin at different concentrations showed significantly increased cell viability (P < 0.05) with significantly lowered apoptotic rates (P < 0.05) and decreased expression levels of Bax and cleaved caspase-3 (P < 0.05) but significantly increased expression levels of cyclin D1 and Bcl-2 (P < 0.05). Hypoxic exposure of the cells resulted in significantly increased expression levels of HIF-1α and p-p38 MAPK (P < 0.05) and increased levels of IL-1ß, IL-6, TNF-α and ROS (P < 0.05) but decreased SOD activity (P < 0.05). Periostin treatment at different concentrations significantly lowered the expression levels of HIF-1α and p-p38 MAPK (P < 0.05) and the levels of IL-1ß, IL-6, TNF-α and ROS (P < 0.05) and significantly increased SOD activity in the hypoxic cells (P < 0.05). CONCLUSIONS: Periostin promotes the proliferation, inhibits apoptosis, enhances cellular antioxidant capacity, and reduces inflammatory damage in human periodontal ligament fibroblasts exposed to hypoxia possibly by inhibiting the activation of the p38 MAPK signaling pathway.


Asunto(s)
Apoptosis , Ligamento Periodontal , Fibroblastos , Humanos , Hipoxia , Estrés Oxidativo , Transducción de Señal , Proteínas Quinasas p38 Activadas por Mitógenos
8.
Artículo en Inglés | MEDLINE | ID: mdl-32903189

RESUMEN

In this article, the synchronous fault-tolerant near-optimal control strategy design problem is studied for a class of discrete-time nonlinear pursuit-evasion (PE) games. In the studied PE game, the input saturation phenomenon and possible actuator fault are simultaneously taken into consideration. To accelerate the estimation speed, a novel nonlinear fault estimator is designed by introducing a nonlinear function. Then, for the purpose of obtaining the synchronous control strategy for the discrete-time PE games, an approximate Hamilton-Jacobi-Isaacs (HJI) equation is established, which is seldom utilized for the discrete-time approximate dynamic programming in most existing results. It should be noticed that the synchronous control strategy designed based on the approximate HJI equation can be convergent very fast because of its quasi-Newton's iteration form. Furthermore, the sufficient condition is established to guarantee that the studied system is uniformly ultimately bounded. Finally, a numerical simulation of the hypersonic vehicle system is carried out to validate the proposed methodology.

9.
Perfusion ; : 267659120957856, 2020 Sep 10.
Artículo en Inglés | MEDLINE | ID: mdl-32909511

RESUMEN

BACKGROUND: Contrast-induced nephropathy (CIN) has become a common cause of hospital-acquired acute kidney injury in elderly patients. Trimetazidine (TMZ) is a type of anti-ischemic drug developed in recent years, which can reduce the incidence of CIN. This study aimed to evaluate the efficacy of TMZ in the prevention of contrast-induced nephropathy in elderly patients with renal insufficiency undergoing percutaneous coronary intervention (PCI) and to explore the mechanism of action. METHODS: A total of 310 elderly patients with renal insufficiency undergoing elective PCI were enrolled and randomly assigned to a control group (n = 155, hydration only) and a TMZ group (n = 155, 20 mg thrice daily orally 24 hours before and 72 hours after PCI). The primary endpoint of the study was the incidence of CIN, which was defined as an increase of 25% or more, or an absolute increase of 0.5 mg/dL or more in serum creatinine from baseline value, at 48 to 72 hours following the exposure to contrast media (CM). RESULTS: The incidence of CIN was significantly lower in the TMZ group than that in the control group (3.2% vs. 9.7%, p = 0.021). There was no difference regarding the incidence of major adverse events during hospitalization between the TMZ group and control group (1.9% vs. 2.6%, p = 1.000). Binary logistic regression results showed that TMZ was protective factors of CIN (OR = 0.274; 95% CI: 0.089-0.847; p = 0.025). CONCLUSION: Therefore, we came to the conclusion that prophylactic administration of TMZ can prevent the occurrence of CIN in elderly patients with renal insufficiency undergoing PCI and has a certain protective effect on the renal function of patients. According to the experimental results and the mechanism of TMZ on cardiomyocytes, we speculate that TMZ increases kidney glucose metabolism, reduces fatty acid oxidation, and also has a protective effect on kidney free radical damage and ischemia-reperfusion injury.

10.
Res Q Exerc Sport ; : 1-6, 2020 Sep 08.
Artículo en Inglés | MEDLINE | ID: mdl-32897846

RESUMEN

Purpose: The purpose of this study was to examine the relationships linking motivational variables with BMI percentile (BMI%) via segmented physical activity (PA) and sedentary behavior (SB) in adolescents using path analysis. Method: Secondary data analysis was performed using participants from the Family, Life, Activity, Sun, Health, and Eating (FLASHE) study. A non-probability panel balanced to the US population on sex, Census division, household income and size, and race/ethnicity were screened for eligibility. The final sample consisted of 1,643 adolescents (822 girls, 821 boys). Motivational variables consisted of PA enjoyment, self-efficacy, and peer social support. Mediator variables consisted of segmented weekly PA and SB assessed using the Youth Activity Profile (YAP). BMI% was the outcome. A recursive bootstrapped path analysis was conducted to examine the relationships between motivational variables, segmented PA and SB, and BMI% with indirect effects calculated via bootstrapped mediation analyses. Results: The relationships between motivational variables and segmented PA and SB were stronger than relationships between segmented PA and SB and BMI%. Three mediated paths were observed: self-efficacy and BMI% using sedentary YAP as the mediator (IE = -0.38, 95%CI: -0.65, -0.18), enjoyment and BMI% using weekend YAP as the mediator (IE = -0.62, 95%CI: -1.14, -0.12) and social support and BMI% using weekend YAP as the mediator (IE = -0.53, 95%CI: -1.00, -0.07). Conclusion: The relationship between adolescent motivational variables and segmented PA and SB is relatively strong and specific motivational variables' relationships with BMI% is mediated through segmented PA and SB.

11.
Medicine (Baltimore) ; 99(36): e22013, 2020 Sep 04.
Artículo en Inglés | MEDLINE | ID: mdl-32899052

RESUMEN

BACKGROUND: Intensive care unit-acquired weakness (ICU-AW) is an acquired neuromuscular lesion and a common occurrence in patients who are critically ill. We will systematically summarize and incorporate the important risk factors and prevalence from previously published multivariate analyses for ICU-AW. METHODS: We will search the PubMed, Embase, Web of Science, and the Cochrane library to identify the relevant studies about the prevalence and risk factors for ICU-AW. Two reviewers will independently review the studies for eligibility according to the inclusion criteria. Two reviewers will independently assess the quality of studies by using the Newcastle-Ottawa scale for nonrandomized studies. Heterogeneity among studies will be estimated by the I statistic. RESULTS: This systematic review and meta-analysis will provide an evidence of prevalence and risk factors for the ICU-AW. CONCLUSION: We hope that our research will contribute to clinicians and public decision making about the ICU-AW.

12.
Nanoscale ; 2020 Sep 11.
Artículo en Inglés | MEDLINE | ID: mdl-32914812

RESUMEN

Graphene family nanomaterials (GFNs) have shown great potential for biological and environmental applications; however, their future use has been debated due to their reported potential neurotoxicity. Moreover, the effects of surface functionalization on their biological end points are largely unknown. Here, we compared the effects of reduced graphene oxide (RGO), and carboxylated (G-COOH), hydroxylated (G-OH) and aminated (G-NH2) graphene nanosheets on human neuroblastoma cells (SK-N-SH). All GFNs inhibited cellular growth at concentrations of 0.1-10 mg L-1 after 24 h exposure. The toxicity was attenuated over longer exposure times, with the exception of G-NH2. Although the overall acute toxicity followed the order: G-OH ≈ G-COOH > RGO > G-NH2, G-NH2 induced more persistent toxicity and more metabolic disturbance compared to the other GFNs, with lipid and carbohydrate metabolism being the most affected. The potential for physical disruption of the lipid membrane and oxidative damage induced by GFNs varied with different functionalization, which accounts for the observed differences in neurotoxicity. This study provides significant insights into the neurological effects of GFNs, and suggests that G-NH2 is not as safe as reported in many previous studies. The neurological effect of GFNs over longer term exposure should be considered in future studies.

13.
ISA Trans ; 2020 Aug 28.
Artículo en Inglés | MEDLINE | ID: mdl-32893001

RESUMEN

In this paper, the issue of position tracking control of servo system with external disturbance is studied. A novel fractional-order sliding mode control (FOSMC) strategy is proposed. To be specific, firstly, the motor parameter drift, additional unknown disturbance and the uncertainty of load torque are considered as lumped disturbance, and a nonlinear disturbance observer (NDO) is designed to estimate the disturbance. Secondly, fractional-order terminal sliding mode surfaces (FOTSMS) are designed for the current loop and the position-velocity loop, respectively, as well as the FOSMC is presented based on NDO, in which FOSMC of position-velocity loop introduces second-order super-twisting term to reduce the chattering of the system. Furthermore, the stability of the FOSMC is analyzed. Finally, the effectiveness of the proposed algorithm is verified by simulations and experiments.

14.
J Am Soc Mass Spectrom ; 31(1): 47-57, 2020 Jan 02.
Artículo en Inglés | MEDLINE | ID: mdl-32881515

RESUMEN

A series of ultrathin, homogenous gold nanoparticle (AuNP) substrates for surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) were prepared using a simple air/water interface approach. These SALDI substrates enabled soft ionization and provided significant improvements in terms of signal intensities and reduced background levels in comparison to other AuNP morphologies for different analytes such as fatty acids, peptides, amino acids, saccharides, and drugs. Through different microscopic and spectroscopic methods, we determined that the packing homogeneity of the [AuNP]n substrates played a vital role in the efficiency of the SALDI process. We demonstrated that the signal intensities of the investigated analytes were readily optimized by manipulating the thickness of the [AuNP]n substrates. The desorption/ionization efficiency increased as a function of the number of layers and then reached a saturation point. The optimized [AuNP]n substrates not only exhibited high SALDI-MS desorption/ionization efficiencies but also showed excellent reproducibilities of the analyte signals.

15.
Virol J ; 17(1): 134, 2020 Aug 31.
Artículo en Inglés | MEDLINE | ID: mdl-32867792

RESUMEN

An amendment to this paper has been published and can be accessed via the original article.

16.
Inorg Chem ; 2020 Sep 02.
Artículo en Inglés | MEDLINE | ID: mdl-32877172

RESUMEN

Developing an effective strategy to synthesize perfect titanosilicate TS-1 zeolite crystals with desirable morphologies, enriched isolated framework Ti species, and thus enhanced catalytic oxidation properties is a pervasive challenge in zeolite crystal engineering. We here used an amino acid l-carnitine as a crystal growth modifier and ethanol as a cosolvent to regulate the morphologies and the Ti coordination states of TS-1 zeolites. During the hydrothermal crystallization process, the introduced l-carnitine can not only tailor the anisotropic growth rates of zeolite crystals but also induce the formation of uniformly distributed framework Ti species through building a suitable chemical interaction with the Ti precursor species. Condition optimizations could afford the generation of perfect hexagonal plate TS-1 crystals and elongated platelet TS-1 crystals enriched in tetrahedral framework Ti sites (TiO4) or mononuclear octahedrally coordinated Ti species (TiO6). Both samples showed significant improvement in catalytic activity for the H2O2-mediated epoxidation of alkenes. In particular, the elongated platelet TS-1 enriched in "TiO6" species afforded the highest activity in 1-hexene epoxidation, with a turnover frequency (TOF) of up to 131 h-1, which is approximately twice as high as that of the conventional TS-1 zeolite (TOF: 65 h-1) and even higher than those of the literature-reported TiO6-containting TS-1 catalysts derived from the hydrothermal post-treatment of TS-1 zeolites. This work demonstrates that the morphologies and the titanium coordination states of TS-1 zeolites can be effectively tuned by directly introducing suitable crystal growth modifiers, thus providing new opportunities for developing highly efficient titanosilicate zeolite catalysts for important catalytic applications.

17.
J Endourol ; 2020 Sep 02.
Artículo en Inglés | MEDLINE | ID: mdl-32878451

RESUMEN

OBJECTIVE: To share the technique of posteriorly augmented anastomotic ureteroplasty with lingual mucosal onlay grafts for long proximal ureteral strictures as well as our initial experience with the technique. METHODS: From October 2018 to September 2019, ten cases of robotic and laparoscopic posteriorly augmented anastomotic ureteroplasty with lingual mucosal onlay grafts for long proximal ureteral strictures were recruited from our date base of Reconstruction of Urinary Tract: Technology, Epidemiology and Result(RECUTTER). The perioperative and follow-up data were recorded. Complete success was defined as the absence of clinical symptoms, relieved stenosis on imaging and a stable estimated glomerular filtration rate (eGFR) without serious complications. RESULTS: All surgeries were completed successfully without serious complications. There were 8 laparoscopic surgeries and 2 robotic surgeries. The median length of defect after posteriorly augmented anastomosis was 3 cm (range, 3-5). The median length of the lingual mucosa graft was 4 cm (range, 3-5). The median operative time was 237 min (range, 189-310). The median estimated blood loss was 40 ml (range, 10-100). The median postoperative length of stay was 7.5 days (range, 5-22). The DJ stent was removed median 3.5 months (range, 2-7) after the surgery. At median follow-up of 11 months (range, 7-20), all patients achieved the successful criteria of treatment. CONCLUSION: The posteriorly augmented anastomotic ureteroplasty with lingual mucosal onlay grafts for long proximal ureteral strictures is a feasible and safe technique, which may be an option especially for strictures marginally longer than those that can be safely repaired via end-to-end anastomosis.

18.
Bioorg Chem ; 103: 104192, 2020 Aug 26.
Artículo en Inglés | MEDLINE | ID: mdl-32889382

RESUMEN

Structural modification of natural products by biotransformation with fungi is an attractive tool to obtain novel bioactive derivatives. In the present study, cryptotanshinone (1), a quinoid abietane diterpene from traditional Chinese medicine Salvia miltiorrhiza (Danshen), was transformed by two marine-derived fungi. By using Cochliobolus lunatus TA26-46, one new oxygenated and rearranged product (2), containing a 5,6-dihydropyrano[4,3-b]chromene moiety, together with one known metabolite (10), were obtained from the converted broth of cryptotanshinone (1) with the isolated yields of 1.0% and 2.1%, respectively. While, under the action of Aspergillus terreus RA2905, seven new transformation products (3-9) as well as 10 with the fragments of 2-methylpropan-1-ol and oxygenated p-benzoquinone were produced and obtained with the isolated yields of 0.1%-1.3%. The structures of the new compounds were elucidated by comprehensive spectroscopic analysis including High Resolution Electrospray Ionization Mass Spectroscopy (HRESIMS), Nuclear Magnetic Resonance (NMR) and Electronic Circular Dichroism (ECD). The metabolic pathways of cryptotanshinone by these two fungi were presumed to be the opening and rearrangement of furan ring, and/or oxygenation of cyclohexane ring. Cryptotanshinone (1) and its metabolites displayed anti-inflammatory activities against NO production in LPS-stimulated BV-2 cells and antibacterial activities towards methicillin-resistant Staphylococcus aureus. These findings revealed the potential of marine fungi to transform the structures of natural products by biotransformation.

19.
Elife ; 92020 09 11.
Artículo en Inglés | MEDLINE | ID: mdl-32915137

RESUMEN

Post-transcriptional mechanisms regulating cell surface synaptic organizing complexes that control the properties of connections in brain circuits are poorly understood. Alternative splicing regulates the prototypical synaptic organizing complex, neuroligin-neurexin. In contrast to the well-studied neuroligin splice site B, little is known about splice site A. We discovered that inclusion of the positively charged A1 insert in mouse neuroligin-1 increases its binding to heparan sulphate, a modification on neurexin. The A1 insert increases neurexin recruitment, presynaptic differentiation, and synaptic transmission mediated by neuroligin-1. We propose that the A1 insert could be a target for alleviating the consequences of deleterious NLGN1/3 mutations, supported by assays with the autism-linked neuroligin-1-P89L mutant. An enrichment of neuroligin-1 A1 in GABAergic neuron types suggests a role in synchrony of cortical circuits. Altogether, these data reveal an unusual mode by which neuroligin splicing controls synapse development through protein-glycan interaction and identify it as a potential therapeutic target.

20.
Ann Surg Oncol ; 2020 Sep 05.
Artículo en Inglés | MEDLINE | ID: mdl-32892269

RESUMEN

PURPOSE: This study aims to investigate the effect of lymph node examination on overall survival (OS) and lung cancer-specific survival (LCSS) in stage I second primary lung cancer (SPLC) patients who underwent second pulmonary resection. PATIENTS AND METHODS: We conducted a retrospective study with the Surveillance, Epidemiology, and End Results (SEER) database to identify stage I SPLC patients who received surgery from 1998 to 2015. The Kaplan-Meier method with landmark analysis and multivariable Cox regression analysis were performed to evaluate the prognostic value of lymph node examination. RESULTS: A total of 842 patients from the SEER database with stage I SPLC who underwent a second surgical treatment were included. The 5-year survival rate was 54.8% for the whole cohort. Multivariable analysis revealed that the number of lymph nodes examined (LNE) was associated with better OS and LCSS in SPLC patients after 12 months postoperatively. Patients with contralateral SPLC had significantly more nodes removed than those with ipsilateral SPLC. For contralateral SPLC, more than 10 LNE was correlated with improved long-term survival outcomes. Ipsilateral SPLC patients benefited from 4 or more LNE. However, the current analysis did not show a significant survival benefit from lymph node examination within 12 months after surgery. CONCLUSIONS: For stage I SPLC patients who received surgical treatment after initial resection, an adequate number of LNE would improve both OS and LCSS. We recommend more than 10 LNE for contralateral SPLC and at least 4 LNE for ipsilateral SPLC.

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