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BACKGROUND: Treatment of sciatica due to lumbar disc herniation can be surgical or conservative. Conservative management has been described to be effective in 90% of patients; however, in most studies no consistent treatment concept was used. OBJECTIVES: In the present study, we evaluated the effect of a combined nonsurgical management (McKenzie physiotherapy, gabapentin, and periradicular injections) in 40 patients during a 10-day inpatient treatment. METHODS: In addition to the neuro-orthopedic examination, pain severity at rest and after walking were assessed. The Oswestry pain disability scale, the pain severity scale, and the painDETECT scale were examined to assess neuropathic pain components. The duration of incapacity for work and the requirement of a later surgery were recorded. Examinations were performed on the day of admission, on days 3, 6, 10, and 84, 3 months after discharge. RESULTS: During conservative treatment, a continuous reduction of pain and an improvement of the straight leg raise test as well as finger-to-floor distance could be documented. As the three treatment options were introduced with a time delay, it could be demonstrated that all significantly contributed to the improvement. All treatments were tolerated without side-effects and persistent improvement after 12 weeks. On admission, 32% of patients revealed a neuropathic pain component which decreased to 7% at the follow-up. A total of 28 patients showed impaired muscle strength on admission, which decreased to 7 patients on follow-up. Electromyography revealed pathological results in 70% of patients examined. A significant improvement of quality of life (Oswestry Disability Index [ODI]) could be observed and the patients returned to work after 5.8 weeks. Only 3/40 patients required surgical management due to persistent pain. CONCLUSION: The combined nonsurgical operative treatment program is effective and well tolerated.
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Touch is a universal nonverbal action often used by romantic partners to demonstrate affection and care for each other. Attitudes toward touch might be particularly relevant across periods of relational strain-such as the transition to parenthood-when couples face many novel stressors and shifting priorities which can interfere with their sexual and affectionate experiences. New parent couples (N = 203) completed self-report measures online across six time-points (two prenatal). We tested whether couples' attitudes toward touch (touch aversion, touch for affection, touch for emotion regulation) at baseline (20 weeks mid-pregnancy) predicted their frequency of sexual and affectionate behaviors from mid-pregnancy through 12-month postpartum. Both partners' more positive attitudes toward touch (i.e., for affection and emotion regulation) and lower aversive attitudes toward touch, as measured in mid-pregnancy, predicted couples' higher frequency and variety of sexual and affectionate behaviors at 3-month postpartum. Touch attitudes generally did not predict the degree of change in the frequency or variety of sexual or affectionate behaviors, with one exception: non-birthing parents' more positive attitudes toward touch for emotion regulation in mid-pregnancy predicted a slower decline in couples' affectionate behaviors across pregnancy. Findings underscore a link between new parents' attitudes toward touch and their subsequent sexual and affectionate behaviors, particularly in the early postpartum period. New parents need to navigate novel sexual changes and a nonverbal strategy such as touch might be useful to promote intimacy and care.
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Herpes simplex encephalitis (HSVE) is a potentially fatal infectious central nervous system (CNS) disorder. Thus, early detection is critical in determining the case's fate. Clinical history and examination, brain computed tomography, dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and lumbar puncture have been used to establish a diagnosis. This report describes a case of HSVE with hypocellular cerebrospinal fluid (CSF) and an uncommon form of memory impairment. However, MRI results were consistent with HSVE, and CSF PCR tested positive for HSV-1 DNA that responded to treatment. We routinely advise patients to begin antiviral therapy as soon as possible to avoid complications.
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BACKGROUND: Using the sandwich osteotomy technique in the posterior mandible is delicate. This study aimed to assess the safety and the amount of bone gain using a full digital workflow versus the conventional procedure. PATIENTS AND METHODS: This split mouth study included 10 patients with bilateral vertically deficient posterior mandible. One side received conventional sandwich interpositional bone grafting (control group), while the other side received the same protocol using two patient-specific guides. The first guide (cutting guide) was used to place the osteotomies safely and accurately according to the predetermined dimensions and locations, and the second guide was used to fix the mobilized bony segment, leaving the desired gap to be filled with a particulate xenogenic bone graft. RESULTS: Full neurosensory recovery was documented at 2 months postoperative for all patients and bilaterally. After 4 months, there was a statistically significant difference in vertical bone gain between both groups (p = 0.001), measuring an average of 3.76 ± 0.72 mm in the study group and 2.69 ± 0.37 mm in the control group. No statistically significant difference was found between the planned vertical augmentation (3.85 ± 0.58 mm) and the obtained vertical bone gain (3.76 ± 0.72 mm) in the study group (p = 0.765) proving the accuracy of the guided procedure. CONCLUSION: Computer-guided sandwich interpositional grafting is predictable regarding the execution of the osteotomies and the accuracy of fixation of the transport segment.
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Mandíbula , Osteotomía , Humanos , Masculino , Femenino , Mandíbula/cirugía , Adulto , Osteotomía/métodos , Persona de Mediana Edad , Flujo de Trabajo , Trasplante Óseo/métodos , Aumento de la Cresta Alveolar/métodos , Cirugía Asistida por Computador/métodosRESUMEN
Desire discrepancies are a common source of relationship conflict and one reason adults may seek couples counseling. Within romantic relationships, adults individually experience sexual and affectionate desire, but also experience desire relative to their partner. If desire discrepancies exist, partners may attempt to resolve these discrepancies. Thus, we examined adults' strategies for managing sexual and affectionate desire discrepancies. Our sample consisted of 300 adults (45% women; Mage = 29.5; 86.3% LGBTQ+) who were in a romantic relationship and reported a desire discrepancy. Thematic analysis revealed five strategies for managing desire discrepancies: alternative behaviors, communication, doing nothing, engaging in behaviors anyway, and giving control to a specific partner. Adults reported similar strategies for resolving sexual and affectionate desire discrepancies. Perceived effectiveness and strategies varied by whether adults thought that their discrepancies were problematic. Our findings hold implications for clinicians approaching problematic desire discrepancies, and suggest strategies that may promote effective resolutions.
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Relaciones Interpersonales , Conducta Sexual , Parejas Sexuales , Humanos , Femenino , Adulto , Masculino , Parejas Sexuales/psicología , Conducta Sexual/psicología , Adulto Joven , Persona de Mediana Edad , LibidoRESUMEN
INTRODUCTION: Herpes zoster ophthalmicus (HZO) results from the reactivation of varicella zoster virus (VZV) in the ophthalmic branch of the trigeminal nerve. The inflammation caused by VZV involves multiple tissues in the eyes. Our goal is to evaluate pattern electroretinogram (PERG) changes and their relationship with corneal sub-basal nerve changes in patients with HZO. METHODS: Twenty-two patients with herpes zoster keratitis or conjunctivitis and 20 healthy volunteers were recruited for this cross-sectional study. A PERG test was performed on both eyes of HZO patients and one eye of the healthy controls. In vivo confocal microscopy (IVCM) was also performed on both eyes of the HZO patients to detect corneal nerve damage. RESULTS: Our results showed changes in the PERG parameters in both eyes of HZO patients compared to the healthy controls. Affected eyes showed delayed N95 peak time and decreased P50 and N95 amplitude compared to the unaffected eyes (p < 0.05, respectively). Both affected and unaffected eyes in HZO patients showed delayed P50 peak time and decreased N95 amplitude (p < 0.05, respectively) compared to controls. In HZO patients, no significant differences in each PERG parameter were found between eyes with and without corneal lesions or between eyes with and without increased Langham's cells in the corneal epithelial sub-basal layer. The IVCM images showed decreased total nerve length and number at the sub-basal layer of the epithelial cornea in affected eyes compared to unaffected eyes (p < 0.05). No significant correlation was found between total nerve length and PERG changes. CONCLUSIONS: Our results showed that VZV-affected eyes without central cornea involvement displayed reduced N95 amplitude and prolonged P50 peak time in bilateral eyes compared to the healthy controls. Larger studies are needed to further explore the effect of HZO on the electrophysiological response of the eye and the posterior segment.
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Stressful events can disrupt couples' emotional connection, yet prior research is mixed regarding whether stress also disrupts couples' physical intimacy. This study considered whether stress must reach a critical threshold before hindering couples' sexual activity and physical affection (i.e., a curvilinear association). Couples (N = 144 couples plus four additional wives) completed two 14-day daily diary tasks during the early years of marriage. Multilevel modeling revealed a within-person curvilinear association between daily stress and sexual activity. Contrary to expectations, the likelihood of sexual activity declined as stress increased from low to moderate, then leveled off as stress continued to increase. For physical affection, a linear effect emerged. On days of greater stress, women, but not men, reported less affection. Further analyses suggested that women's stress is more influential than men's stress for couple's physical intimacy. Findings highlight the nuanced ways in which stress is linked to a vital component of satisfying relationships.
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Visual stimuli within an immersive virtual environment impact human perception and behavior in notably different ways compared to the real world. Previous studies have presented evidence indicating that individuals in various emotional states exhibit an unconscious attentional bias toward either positive or negative stimuli. However, whether these findings can be replicated within an immersive virtual environment remains uncertain. In this study, we devised an attention-based experiment to explore whether the correlation between participants' emotional states and the valence of visual stimuli influences their attentional bias. Participants (n=28) viewed 360-degree videos with varying valence levels (positive and negative) to evoke emotions. Subsequently, we utilized standard emotional human faces as stimuli to assess how the consistency in video valence and emotional faces affects reaction time (RT) in Go tasks and error rates in No-go tasks. We employed the Ex-Gaussian approach to analyze the RT data. The parameters-mu (µ), sigma (σ), and tau (τ)-were computed to denote response speed and attentional lapses, respectively. Our findings revealed a significant increase in tau (τ) when the valence of the video and emotional faces aligned. This suggests that the Go/No-go paradigm is effective in evaluating the impact of emotion-evoking stimuli within an immersive environment.
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(1) Background: Prosocial behavior aligns with the current societal model, where human values hold greater importance considering cultural, social, and personal variables that may influence the opportunity to benefit others. Hence, the objective of this research was established: to understand how diverse factors influence the values of young people, aiming to promote education and enhance prosocial behavior. (2) Methods: This study is quantitative research employing an empirical-analytical, cross-sectional social research method. A validated instrument was used with a sample of 1702 individuals from the city of Melilla, noteworthy for its multicultural context due to its location in North Africa. (3) Results: Inferential analysis was conducted using multiple linear regression to predict future behaviors, focusing on the factors influencing values. Various models were employed, incorporating twelve variables and four scales: sociability, transcendence, culture, and effects. (4) Conclusions: The results and conclusions suggest the need to enhance affect and sociability, primarily among the most prominent factors.
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Exposure to parental abuse and lack of parental affection during childhood are risk factors for adulthood psychopathology. Tendency to engage in positive reappraisal may be a plausible mechanism underlying this relationship. The current study examined if positive reappraisal coping mediated the relationship between maternal/paternal abuse/affection and adulthood generalized anxiety disorder (GAD) symptoms. Participant data (N = 3294) from the Midlife Development in the United States study was collected in three waves, spaced nine years apart. Longitudinal structural equation mediation modeling examined whether positive reappraisal coping at Time 2 mediated the relationship between maternal/paternal abuse/affection at Time 1 and GAD symptoms at Time 3, controlling for GAD symptoms at Time 1. Positive reappraisal coping mediated maternal/paternal childhood abuse - GAD symptom severity and maternal/paternal childhood affection - GAD severity relations. Maternal and paternal abuse was associated with lower positive reappraisal tendencies, predicting increased GAD symptom severity. Conversely, higher maternal/paternal affection was associated with increased positive reappraisal, predicting lower GAD severity. Incremental prediction revealed that childhood abuse to GAD severity via positive reappraisal path was significant for maternal but not paternal abuse, whereas affection from both parents remained significant. Positive reappraisal coping may be a possible mechanism linking childhood experiences to adulthood GAD severity.
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Ansiedad , Padres , Niño , Humanos , Familia , Trastornos de Ansiedad/diagnóstico , Habilidades de AfrontamientoRESUMEN
ABSTRACT High Intensity Interval Training (HIIT) promotes similar adaptations and in some cases, superior to continuous aerobic training of moderate intensity, even when performed at all-out intensities. In this condition, it tends to have the greatest physiological disturbance and accumulation of metabolites compared to submaximal intensities, being one of the main factors associated with the negative response of pleasure in training. Objective: To verify the relationship between physiological and psychophysiological responses in order to repeat the training of two HIIT protocols of mesm volume load and different periods of work in trained adults of both sexes. Methods: In a randomized experiment, the sample consisted of 9 individuals aged 28±5 years, body mass 69.6±14.2 kg, height 169±0.1cm, BMI 24.1±2.3 kg/m2 and body fat percentage 20.2±7.9% practitioners of structured aerobic physical exercises for at least six months. Two different HIIT protocols were performed on an exercise bike, being (I) protocol 1:0.5, with prescribed intensity (80-90% of MAX HR), (II) protocol 1:2 with prescribed intensity (all-out) with total duration of effort of 20 minutes and interval of at least 48 hours between each session. Heart rate (HR), systemic blood pressure (SBP), subjective perception of exertion (SPE), visual analog scale (VAS), affective response (AR), fun (PACES) and intention to repeat the session were analyzed. The statistical analysis used was ANOVA with Tukey's post-hoc (p<0.05). Results: The analyses of HR, SBP, VAS, PACES and SPE showed no significant difference between the training protocols. The affective response (AR and intention to repeat) showed a decline in the protocol 1:0.5, but without significance (p>0.05). Conclusion: The data allow us to conclude that the 1:2 protocol caused greater physiological disturbances during exertion and presented greater positive affective response and intention to repeat the exercise session, variables that may contribute to adherence to regular physical exercise. Level of Evidence I; Therapeutic studies - Investigation of treatment results.
RESUMEN El entrenamiento de intervalos de alta intensidad (HIIT) promueve adaptaciones similares y, en algunos casos, superiores al entrenamiento aeróbico continuo de intensidad moderada. En esta condición, tiende a tener una mayor alteración fisiológica y acumulación de metabolitos en comparación con las intensidades submáximas, siendo uno de los principales factores asociados con la respuesta negativa del placer en el entrenamiento. Objetivo: Verificar la relación entre las respuestas fisiológicas y psicofisiológicas para repetir el entrenamiento de dos protocolos HIIT de carga del mismo volumen y diferentes períodos de trabajo en adultos entrenados de ambos sexos. Métodos: En un experimento aleatorizado, la muestra estuvo constituida por 9 individuos de 28±5 años, masa corporal 69,6±14,2 kg, altura 169±0,1cm, IMC 24,1±2,3 kg/m2 y porcentaje de grasa corporal 20,2±7,9% practicantes de ejercicios físicos aeróbicos estructurados durante al menos seis meses. Se realizaron dos protocolos HIIT diferentes en bicicleta estática, siendo protocolo 1: 0,5, con intensidad prescrita (80-90% de la FC MÁXIMA), protocolo 1: 2 con intensidad prescrita (total) con duración total del esfuerzo de 20 minutos e intervalo de al menos 48 horas entre cada sesión. Se analizaron la frecuencia cardíaca (FC), presión arterial sistémica (PAS), percepción subjetiva de esfuerzo (PSE), escala analógica visual (EVA), respuesta afectiva (FS), diversión (PACES) e intención de repetir la sesión. El análisis estadístico utilizado fue ANOVA con post-hoc de Tukey (p<0,05). Resultados: Los análisis de HR, PAS, EVA, PACES y PSE no mostraron diferencias significativas entre los protocolos de entrenamiento. La respuesta afectiva (FS e intención de repetir) mostró una disminución en el protocolo 1:0,5, pero sin significancia (p>0,05). Conclusión: Los datos permiten concluir que el protocolo 1:2 causó mayores alteraciones fisiológicas durante el esfuerzo y presentó mayor respuesta afectiva positiva e intención de repetir la sesión de ejercicio, variables que pueden contribuir para la adhesión al ejercicio físico. Nivel de Evidencia I; Estudios Terapéuticos - Investigación de los Resultados del Tratamiento.
RESUMO O Treinamento Intervalado de Alta Intensidade (HIIT) promove adaptações semelhantes e em alguns casos, superiores ao treinamento aeróbico contínuo de intensidade moderada, mesmo quando executado em intensidades all out. Nesta condição, tende a maior perturbação fisiológica e acúmulo de metabólitos comparado a intensidades submáximas, sendo um dos principais fatores associados a resposta negativa de prazer no treinamento. Objetivo: Verificar qual relação entre respostas fisiológicas e psicofisiológicas na intenção de repetir o treinamento de dois protocolos HIIT de mesmo volume load e distintos períodos de trabalho, em adultos treinados de ambos os sexos. Métodos: Em experimento randomizado, a amostra foi composta por 9 indivíduos com idade entre 28±5 anos, massa corporal 69,6±14,2 kg, estatura 169±0,1cm, IMC 24,1±2,3 kg/m2 e percentual de gordura corporal 20,2±7,9% praticantes de exercícios físicos aeróbicos estruturados por pelo menos seis meses. Realizaram dois diferentes protocolos de HIIT em bicicleta ergométrica, sendo (I) protocolo 1:0,5, com intensidade prescrita (80-90% da FCmáx), (II) protocolo 1:2 com intensidade prescrita (all-out) com duração total de esforço de 20 minutos e intervalo de pelo menos 48 horas entre cada sessão. Foram analisados frequência cardíaca (FC), pressão arterial sistêmica (PAS), percepção subjetiva de esforço (PSE), escala visual analógica (EVA), resposta afetiva (FS), divertimento (PACES) e intenção de repetir a sessão. A análise estatística usada foi ANOVA com post-hoc de Tukey (p<0,05). Resultados: As análises da FC, PAS, EVA, PACES e PSE não apresentaram diferença significativa entre os protocolos de treinamento. As respostas afetivas (FS e intenção de repetir) apresentaram maior declínio no protocolo 1:0,5, porém sem significância (p>0,05). Conclusão: Os dados permitem concluir que o protocolo 1:2 provocou maiores perturbações fisiológicas durante esforço e apresentou maior resposta afetiva positiva e intenção de repetir a sessão de exercício, variáveis que podem vir a contribuir na aderência à prática regular de exercícios físicos. Nível de Evidência I; Estudos terapêuticos - Investigação dos resultados do tratamento.
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La relación con los progenitores es un aspecto clave en el desa-rrollo adolescente, pues el sentimiento de aceptación o rechazo por parte de estos se ha visto relacionado con el ajuste psicológico de la descenden-cia. A su vez, la resiliencia, habitualmente conceptualizada como capacidad para gestionar o adaptarse a los retos y la adversidad, resultaría fundamental para el ajuste en dicho periodo, caracterizado por numerosos cambios y re-tos simultáneos en distintos aspectos vitales. Por ello, el objetivo de este trabajo es analizar la capacidad predictiva de las dimensiones de socializa-ción parental afecto-comunicacióny crítica-rechazosobre la resiliencia adolescen-te. Método:Participan 899 adolescentes (50.4% mujeres) de entre 12 y 19 años (M= 14.68; DT= 1.73). Mediante regresiones lineales se analiza la capacidad predictiva de las dimensiones de socialización parental sobre la resiliencia filial. Resultados:Se comprueba que las dimensiones paternas, es-pecialmente la crítica-rechazo, resultan más significativas a la hora de predecir las puntuaciones en resiliencia. Discusión: Los resultados apuntan a la rele-vancia de la crítica-rechazo sentida por los y las adolescentes, especialmente en el caso de proceder del padre. Se discute la posible interpretación dife-rencial de los y las adolescentes de las dimensiones en función del sexo de los progenitores.(AU)
Parent-child relations are a key aspect in adolescent develop-ment, since feelings of parental acceptance or rejection have been found to be associated with teenagers psychological adjustment. Resilience, usually conceptualised as the ability to manage or adapt to challenges and adversi-ty, is a fundamental factor in adjustment during adolescence, a period characterised by numerous simultaneous changes and challenges in differ-ent aspects of life. The aim of the present study is therefore to analyse the predictive capacity of different dimensions of parental socialisation (affec-tion-communication and criticism-rejection) on adolescent resilience. Meth-od:Participants were 899 adolescents (50.4% female), aged 12 to19 years (M= 14.68; SD= 1.73). Linear regressions were performed to analyse the predictive capacity of the different dimensions of parental socialisation on adolescent resilience. Results:Paternal dimensions, especially paternal criti-cism-rejection, were revealed as relevant factors for predicting resilience scores. Discussion:The results point to the important impact of the criti-cism-rejection felt by adolescents, especially if perceived from the father. Different possible interpretations of these dimensions are discussed, in ac-cordance with whether they are perceived from the mother or the fathe.(AU)
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Humanos , Masculino , Femenino , Adolescente , Resiliencia Psicológica , Psicología del Adolescente , Responsabilidad Parental , Relaciones Madre-Hijo , Relaciones Padre-Hijo , Rechazo en Psicología , Afecto , Comunicación , Psicología Social , Psicología Clínica , Conducta del AdolescenteRESUMEN
BACKGROUND: Previous studies have reported conflicting results about the association of vitamin D (VD) level with coronary artery disease (CAD). We aimed to study the association of VD with atherosclerotic CAD in Egyptian individuals. RESULTS: We prospectively enrolled 188 consecutive CAD patients with a median age of 55(50-62) years; 151(80.3%) were male. All patients were diagnosed by cardiac catheterization and were compared with 131 healthy controls. VD levels were measured in serum samples of all participants. Compared to controls, CAD patients had a significantly lower median VD level, 14.65 (9.25-21.45) versus 42.0 (32.0-53.0) ng/mL, p < 0.001. VD was correlated with the number of diseased coronary arteries and lipid profile (total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides, p < 0.001 for each). By multivariate analyses, VD was an independent predictor of CAD [OR 1.22 (95% CI 1.07-1.4), p = 0.003, optimal cut-off value 30 ng/mL (AUC 0.92, sensitivity 81% and specificity 81.4%), p < 0.001], and the number of diseased coronary arteries, p < 0.001, especially three-vessel disease [OR 0.83 (95% CI 0.72-0.95), p = 0.008]. CONCLUSIONS: We have shown that low VD should be considered a non-traditional risk factor for CAD in Egyptian individuals. Low VD was correlated with coronary atherosclerosis, especially in patients with multivessel effects.
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Individuals who perceive greater support or approval for their relationships from friends and family also report greater relationship stability and commitment and better mental and physical health (known as the "social network effect"). These associations have been explained, in part, through three cognitive-affective processes: uncertainty reduction, cognitive balance, and dyadic identity formation. However, we know less about cognitive-behavioral mechanisms that might help explain the social network effect. In this study, we propose and test a model in which physical affection-sharing acts as one such behavioral mechanism. In a sample of 1848 individuals in same-sex (n = 696), mixed-sex (n = 1045), and gender-diverse (n = 107) relationships, we found support for our overall model. Our findings suggest that perceived support for one's relationships is a significant predictor of perceived support for physical affection-sharing, which in turn predicts the frequency of affection-sharing in private and public contexts and, ultimately, relationship well-being. However, we also found that relationship type moderates these associations, highlighting how the experience of sharing affection with one's partner changes for many in marginalized relationships, especially in public. We conclude by discussing how our findings contribute to theories of social support for relationships, underscoring the importance of considering affective, cognitive, and behavioral factors relevant to the process. We also emphasize the understudied role of context in shaping affection-sharing experiences across all relationship types.
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INTRODUCTION: Collodion baby "CB" is an extremely rare dermatological condition. Approximately 1 in 100,000 births are identified as infants with CB syndrome, including stillbirths (Dyer et al., 2013). A cornified substance replaces the newborn's skin, giving the body a varnished or parchment-like appearance. CASE PRESENTATION: Patient aged 30 years, third gesture, third pare, admitted for premature delivery of 8 months. After labor management, she gave birth 2 h after admission to the maternity ward of a living newborn female weighing 2400 g. The initial physical examination revealed large, thick scales all over the body. Examination of the head and neck revealed an abnormal parchment-like membrane covering the head and sparse hairs. Excessive scaling around the mouth gives a typical fish-like appearance. No other obvious abnormalities were observed. CLINICAL DISCUSSION: CB is an extremely rare dermatological condition. This is a disorder secondary to cornification. These children are generally born prematurely, and are not diagnosed until after birth. Due to the presence of a tight membrane, these babies develop numerous complications such as eclabium, ectropion, limited movement of the extremities and fingers. Treatment consists mainly of support, such as the use of intravenous fluids, incubators, tube feeding and emollients. CONCLUSION: The collodion baby is a newborn characterized by an altered skin barrier, exposing him or her to numerous complications. Fortunately, the mortality rate has fallen thanks to improved neonatal care.
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Background: Activation of the NLRC4 inflammasome appears to start many signalling processes inside the host, including caspase-1, the principal protease responsible for converting proIL-1ß and IL-18 to active, secreted IL-1ß and IL-18, resulting in pyroptosis. Aims: To evaluate NLRC4 level in patient's blood serum to highlight its role in the pathogenesis of leprosy. Materials and Methods: This prospective study was conducted on 40 patients with leprosy and 30 healthy individuals of matched ages and sexes. All patients were subjected to complete history taking, general and dermatological examination, laboratory investigations, slit skin smear with bacillary index, and clinical classification of the studied leprosy group patients regarding disability according to disability grading. And finally, measurement of serum NLRC4 level by ELISA. Results: In the paucibacillary (PB) group, NLRC4 serum level ranged from 0.9 to 1.8 ng/ml with 1.43 ± 0.28 ng/ml, while in the multibacillary (MB) group, it ranged from 1.2 to 5.7 ng/ml with 2.83 ± 1.11 ng/ml. NLRC4 serum level had increased significantly in MB patients compared to PB patients (P < 0.05). There was a significant difference among the three studied groups, regarding the serum level of NLRC4 (P < 0.05). In leprosy patients, significant positive correlations were found between serum levels of NLRC4 and bacillary index and duration of leprosy. Conclusions: Leprosy patients had considerably greater serum levels of NLRC4 than controls. It was much greater in MB patients than in PB patients.
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Parenting stress and child psychopathology are closely linked in parent-child dyads, but how the bidirectional association varies across childhood and adolescence, and shifts depending on maternal affection are not well understood. Guided by the transactional model of development, this longitudinal, prospective study examined the bidirectional relations between parenting stress and child internalizing and externalizing problems and investigated the moderating role of maternal affection from childhood to adolescence. Participants were from the Future of Families and Child Wellbeing Study, a diverse, nationally representative sample of 2,143 caregiving mothers who completed assessments at children ages 5, 9, and 15. Using cross-lagged panel modeling, we found bidirectional effects between parenting stress and child internalizing and externalizing problems. However, additional multigroup analyses showed that bidirectional associations depend on the levels of maternal affection. In the high maternal affection group, parenting stress at age 5 predicted higher internalizing and externalizing problems at age 9, and reverse child-to-parent paths were found from age 9 to age 15. In contrast, only one cross-lagged path was found in the low maternal affection group. Findings suggest that maternal affection can heighten the transactional associations between parenting stress and child psychopathology.
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BACKGROUND: Adult distal humeral fractures (DHF) comprise 2%-5% of all fractures and 30% of all elbow fractures. Treatment of DHF may be technically demanding due to fracture complexity and proximity of neurovascular structures. Open reduction and internal fixation (ORIF) are often the treatment of choice, but arthroplasty is considered in case of severe comminution or in elderly patients with poor bone quality. Ulnar nerve affection following surgical treatment of distal humerus fractures is a well-recognized complication. AIM: To report the risk of ulnar nerve affection after surgery for acute DHFs. METHODS: We retrospectively identified 239 consecutive adult patients with acute DHFs who underwent surgery with ORIF, elbow hemiarthroplasty (EHA) or total elbow arthroplasty (TEA) between January 2011 and December 2019. In all cases, the ulnar nerve was released in situ without anterior transposition. We used our institutional database to review patients' medical records for demographics, fracture morphology, type of surgery and ulnar nerve affection immediately; records were reviewed after surgery and at 2 wk and 12 wk of routine clinical outpatient follow-up. Twenty-nine percent patients were excluded due to pre- or postoperative conditions. Final follow-up examination was a telephone interview in which ulnar nerve affection was reported according to the McGowen Classification Score. A total of 210 patients were eligible for interview, but 13 patients declined participation and 17 patients failed to respond. Thus, 180 patients were included. RESULTS: Mean age at surgery was 64 years (range 18-88 years); 121 (67.3%) patients were women; 59 (32.7%) were men. According to the AO/OTA classification system, we recorded 47 patients with type A3, 55 patients with type B and 78 patients with type C fractures. According to the McGowen Classification Score, mild ulnar nerve affection was reported in nine patients; severe affection, in two. A total of 69 patients were treated with ORIF of whom three had mild temporary ulnar nerve affection and one had severe ulnar nerve affection. In all, 111 patients were treated with arthroplasty (67 EHA, 44 TEA) of whom seven had mild ulnar nerve affection and one had severe persistent ulnar nerve affection. No further treatment was provided. CONCLUSION: The risk of ulnar nerve affection after surgical treatment for acute DHF is low when the ulnar nerve is released in situ without nerve transposition, independently of the treatment provided.
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PURPOSE: This study aimed to determine the factors associated with new onset father-to-infant (paternal) bonding failure from 1 to 6 months postpartum. METHODS: This was a prospective birth-cohort study. Paternal bonding failure was evaluated using the Japanese version of the Mother-to-Infant Bonding Scale (MIBS-J) at 1 and 6 months postpartum. For cut-off scores, overall bonding failure, MIBS-J total scores ≥ 5; subscale for lack of affection, MIBS-J_LA scores ≥ 3; and subscale for anger/rejection, MIBS-J_AR scores ≥ 3 were used in this study. Multivariate regression analysis was performed to analyze relative variables. RESULTS: We analyzed 872 fathers. The frequency of new-onset overall bonding failure, lack of affection, and anger/rejection was 5.6%, 4.9%, and 6.3%, respectively. For new-onset overall bonding failure, significant associated factors were paternal childcare leave (adjusted odds ratio [AOR] 3.192; 95% confidence interval [CI] 1.203-8.469), paternal new-onset depression symptoms (AOR 3.181; 95% Cl 1.311-7.716), and maternal new-onset overall bonding failure (AOR 4.595; 95% Cl 1.119-18.866). For new-onset lack of affection, significant associated factors were preterm birth (AOR 4.189; 95% Cl 1.473-11.913) and paternal new-onset depression symptoms (AOR 3.290; 95% Cl 1.294-8.362). For new-onset anger and rejection, significant associated factors were paternal childcare leave (AOR 3.142; 95% Cl 1.138-8.676), paternal new-onset depression symptoms (AOR 2.829; 95% Cl 1.133-7.068), and maternal new-onset anger/rejection (AOR 7.064; 95% Cl 2.300-21.700). CONCLUSIONS: The factors associated with new-onset paternal bonding failure from 1 to 6 months postpartum were paternal childcare leave, preterm birth, paternal postpartum depression symptoms, and maternal bonding failure.
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Depresión Posparto , Nacimiento Prematuro , Masculino , Femenino , Humanos , Lactante , Recién Nacido , Niño , Relaciones Madre-Hijo , Estudios de Cohortes , Japón/epidemiología , Estudios Prospectivos , Encuestas y Cuestionarios , Periodo Posparto , Madres , PadreRESUMEN
White matter disconnection is the primary cause of cognition and affection abnormality in mild cognitive impairment (MCI). Adequate understanding of behavioral disturbances, such as cognition and affection abnormality in MCI, can help to intervene and slow down the progression of Alzheimer's disease (AD) promptly. Diffusion MRI is a non-invasive and effective technique for studying white matter microstructure. This review searched the relevant papers published from 2010 to 2022. Sixty-nine studies using diffusion MRI for white matter disconnections associated with behavioral disturbances in MCI were screened. Fibers connected to the hippocampus and temporal lobe were associated with cognition decline in MCI. Fibers connected to the thalamus were associated with both cognition and affection abnormality. This review summarized the correspondence between white matter disconnections and behavioral disturbances such as cognition and affection, which provides a theoretical basis for the future diagnosis and treatment of AD.