Detection and interpretation of clonal hematopoiesis variants during routine solid tumor next-generation sequencing: a single institution experience.

Clonal hematopoiesis (CH) and Clonal Cytopenia of Undetermined Significance (CCUS) are recently recognized diagnostic entities that serve as an independent risk factor for cardiovascular disease and myeloid malignancy. CH is an incidental finding and evaluation of the incidence of CH/CCUS associated mutations in solid tumor Next Generation Sequencing (NGS) samples was undertaken to better understand the prevalence of mutations in this population. A retrospective review of clinical sequencing data for solid tumor malignancies diagnosed February 2022-April 2023 on NGS data was performed. Cases were reviewed for variants in genes associated with CH/CCUS. Variant allele frequencies and other factors of the sequencing data were assessed for determining risk of CH/CCUS. 2,479 cases were evaluated during the study period. Of these, 29 cases demonstrated potential CH/CCUS associated mutations with a total of 33 variants identified. These were identified in a variety of tumor types, with gliomas being the most common. Significant cardiac histories were found in over half of cases identified and few cases had abnormal blood counts. Detailed criteria for flagging variants as suspicious for CH and recommend these criteria as future guidelines for reporting are described. These variants are incidental findings which require more extensive follow up or change in therapy management utilizing a single institutional cohort.

Chemical-Assisted CO2 Water-Alternating-Gas Injection for Enhanced Sweep Efficiency in CO2-EOR.

CO2-enhanced oil recovery (CO2-EOR) is a crucial method for CO2 utilization and sequestration, representing an important zero-carbon or even negative-carbon emission reduction technology. However, the low viscosity of CO2 and reservoir heterogeneity often result in early gas breakthrough, significantly reducing CO2 utilization and sequestration efficiency. A water-alternating-gas (WAG) injection is a technique for mitigating gas breakthrough and viscous fingering in CO2-EOR. However, it encounters challenges related to insufficient mobility control in highly heterogeneous and fractured reservoirs, resulting in gas channeling and low sweep efficiency. Despite the extensive application and research of a WAG injection in oil and gas reservoirs, the most recent comprehensive review dates back to 2018, which focuses on the mechanisms of EOR using conventional WAG. Herein, we give an updated and comprehensive review to incorporate the latest advancements in CO2-WAG flooding techniques for enhanced sweep efficiency, which includes the theory, applications, fluid displacement mechanisms, and control strategies of a CO2-WAG injection. It addresses common challenges, operational issues, and remedial measures in WAG projects by covering studies from experiments, simulations, and pore-scale modeling. This review aims to provide guidance and serve as a reference for the application and research advancement of CO2-EOR techniques in heterogeneous and fractured reservoirs.

An investment decision framework for offshore CCUS project under interval-valued fermatean fuzzy environment.

Carbon Capture, Utilization and Storage (CCUS) is an indispensable technology for achieving a net-zero emission society. The offshore CCUS project is still in its infancy. To promote its sustainable development, developing a comprehensive framework for investment decision-making is very crucial. First, a comprehensive evaluation criteria system is established. Second, in order to characterize the ambiguity and uncertainty of information in the process of making decisions, the interval-valued fermatean fuzzy set (IVFFS) is introduced, and the extended variance method of IVFFS is proposed to systematically calculate the weights of experts. Then, the power weighted average (PWA) operator based similarity measure of IVFFSs is developed to aggregate different expert information. Meanwhile, the fuzzy-weighted zero-inconsistency (FWZIC) method and the method based on the removal effects of criteria (MEREC) are used to determine the criteria weights. In addition, considering the interactions between the criteria, we introduce the Hamacher operator into the measurement of alternatives and ranking according to the compromise solution (MARCOS) method to select the optimal alternative in the interval-valued fermatean fuzzy (IVFF) environment. The suggested framework is then used to analyse a case study. After that, sensitivity and comparative analyses are conducted to confirm its robustness and viability. This study creates a practical investment framework for offshore CCUS projects, identifies a number of investment-sensitive criteria and provides management insights. The proposed framework expands the methods and applications in the field of decision-making and provides a scientific approach for investment decision-making in offshore CCUS projects, which can be a useful reference for managers.

Potential assessment of CO2 source/sink and its matching research during CCS process of deep unworkable seam.

It is of great significance for the engineering popularization of CO2-ECBM technology to evaluate the potential of CCUS source and sink and study the matching of pipeline network of deep unworkable seam. In this study, the deep unworkable seam was taken as the research object. Firstly, the evaluation method of CO2 storage potential in deep unworkable seam was discussed. Secondly, the CO2 storage potential was analyzed. Then, the matching research of CO2 source and sink was carried out, and the pipe network design was optimized. Finally, suggestions for the design of pipe network are put forward from the perspective of time and space scale. The results show that the average annual CO2 emissions of coal-fired power plants vary greatly, and the total emissions are 58.76 million tons. The CO2 storage potential in deep unworkable seam is huge with a total amount of 762 million tons, which can store CO2 for 12.97 years. During the 10-year period, the deep unworkable seam can store 587.6 million tons of CO2, and the cumulative length of pipeline is 251.61 km with requiring a cumulative capital of $ 4.26 × 1010. In the process of CO2 source-sink matching, the cumulative saving mileage of carbon sink is 98.75 km, and the cumulative saving cost is $ 25.669 billion with accounting for 39.25% and 60.26% of the total mileage and cost, respectively. Based on the three-step approach, the whole line of CO2 source and sink in Huainan coalfield can be completed by stages and regions, and all CO2 transportation and storage can be realized. CO2 pipelines include gas collection and distribution branch lines, intra-regional trunk lines, and interregional trunk lines. Based on the reasonable layout of CO2 pipelines, a variety of CCS applications can be simultaneously carried out, intra-regional and inter-regional CO2 transport network demonstrations can be built, and integrated business models of CO2 transport and storage can be simultaneously built on land and sea. The research results can provide reference for the evaluation of CO2 sequestration potential of China's coal bases, and lay a foundation for the deployment of CCUS clusters.

The role of water bridge on gas adsorption and transportation mechanisms in organic shale.

This work introduces and discusses the impacts of the water bridge on gas adsorption and diffusion behaviors in a shale gas-bearing formation. The density distribution of the water bridge has been analyzed in micropores and meso-slit by molecular dynamics. Na+ and Cl- have been introduced into the system to mimic a practical encroachment environment and compared with pure water to probe the deviation in water bridge distribution. Additionally, practical subsurface scenarios, including pressure and temperature, are examined to reveal the effects on gas adsorption and diffusion properties, determining the shale gas transportation in realistic shale formation. The outcomes suggest carbon dioxide (CO2) usually has higher adsorption than methane (CH4) with a water bridge. Increasing temperature hinders gas adsorption, density distribution decreases in all directions. Increasing pressure facilitates gas adsorption, particularly as a bulk phase in the meso-slit, whereas it restricts gas diffusion by enhancing the interaction strength between gas and shale. Furthermore, ions make the water bridge distributes more unity and shifts to the slit center, impeding gas adsorption onto shale while encouraging gas diffusion. This study provides updated guidelines for gas adsorption and transportation characteristics and supports the fundamental understanding of industrial shale gas exploration and transportation.

Carbon utilization and storage through rehabilitation of groundwater wells.

According to the Intergovernmental Panel on Climate Change (IPCC) of the United Nations (UN), rise in atmospheric concentration of carbon dioxide (CO 2 ) due to anthropogenic factors is considered as the primary driver for global climate change. With almost every major corporation around the world working towards their "net-zero goals", it is becoming increasingly important to have more technologies that can help reduce carbon footprint. Achieving sequestration of CO 2 in the subsurface through Carbon Capture Utilization and Storage (CCUS) technologies like CO 2 -Enhanced Oil Recovery, CO 2 -Enhanced Geothermal Systems, CO 2 -Enhanced Coal Bed Methane, etc. is well accepted. We introduce yet another attractive CCUS opportunity through well rehabilitation. Aqua Freed® and Aqua Gard® are well-known well rehabilitation and preventive well maintenance technologies that utilize (inject underground) liquid CO 2 for the purpose. The goal of this study was to quantify the storage capacity of Aqua Freed® and Aqua Gard®, and establish their CCUS credentials. Depending on the well being serviced, these technologies can inject up to 40 US tons of CO 2 per well. Based on field data collection and statistical modeling, we estimated that 82-96% (median 90%) of the injected CO 2 remains in the subsurface post injection. Overall, our results and analysis of the US market suggest that using CO 2 for well rehabilitation and maintenance has a storage potential of several megatonnes of CO 2 annually in the US alone.

On the Maximum Obtainable Purity and Resultant Maximum Useful Membrane Selectivity of a Membrane Separator.

Design considerations concerning the maximum purity of a membrane separator, and the resultant maximum effective selectivity of the membranes were explored by modeling a binary gas membrane separator (pressure-driven permeance) using a dimensionless form. Although the maximum purity has an analytical solution at the limit of zero recovery or stage cut, this solution over-predicts the obtained purity as the recovery is increased. Furthermore, at combinations of high recovery, low feed mole fraction, and low pressure ratio, the maximum purity becomes independent of selectivity above some critical selectivity. As a consequence of this purity limitation, a maximum selectivity is defined at which further increases in selectivity will result in less than a 1% change in the final purity. An equation is obtained that specifies the region in which a limiting purity is less than unity (indicating the existence of a limiting selectivity); operating at less than the limiting pressure ratio results in a purity limitation less than unity. This regime becomes larger and more significant as the inlet mole fraction decreases (e.g., inlet feed mole fraction of 10% and pressure ratio of 100 results in a maximum useful membrane selectivity of only 130 at 95% recovery). These results suggest that membrane research should focus on increasing permeance rather than selectivity for low-concentration separations. The results found herein can be used to set benchmarks for membrane development in various gas separation applications.

The integrated approach of carbon capture, utilization, and storage via CO2 mineralization for the removal of fly ash, bottom ash, and exhaust gas-A case study of circulating fluidized bed combustion.

Despite efforts to reduce dependence on coal-fired power generation due to climate concerns, continued usage for energy stability is anticipated. This study was conducted to address environmental issues associated with coal-fired power generation and promote its persistent utilization. we aimed to establish both eco-friendly and economically sustainable practices by mitigating waste such as fly ash (FA) and bottom ash (BA) emissions while recycling them in circulating fluidized bed combustion (CFBC). Initially, we conducted a literature review to analyze the global and domestic trends in coal-fired power generation. Subsequently, we performed experimental research on CO2 crystallization as a multifaceted approach for treating exhaust gases and waste materials such as FA and BA simultaneously. Throughout this research, we implemented a simple process to ensure scalability. In the context of carbon capture, utilization, and storage (CCUS) technology, we conducted experimental research on mineralizing CO2 targeting FA and BA by applying ambient temperature, atmospheric pressure, and simulated exhaust gas. The empirical findings demonstrated that 12.28 kg CO2/ton and 58.14 kg CO2/ton of CO2 were immobilized for BA and FA, respectively. The economic evaluation was measured based on the experimental results obtained from the techno-economic analysis (TEA). The B/C ratio stands at 1.07, with the cost of composite carbonate estimated at USD 159.6 per ton. With an internal rate of return (IRR) of 7.78 % and a net present value (NPV) of USD 7294.59, the economic viability demonstrates considerable promise. Ultimately, this study aims to mitigate the impact of coal-fired power plants on climate change and enhance environmental sustainability through CO2 removal and waste recycling.

Research on carbon dioxide capture materials used for carbon dioxide capture, utilization, and storage technology: a review.

In recent years, climate change has increasingly become one of the major challenges facing mankind today, seriously threatening the survival and sustainable development of mankind. Dramatically increasing carbon dioxide concentrations are thought to cause a severe greenhouse effect, leading to severe and sustained global warming, associated climate instability and unwelcome natural disasters, melting glaciers and extreme weather patterns. The treatment of flue gas from thermal power plants uses carbon capture, utilization, and storage (CCUS) technology, one of the most promising current methods to accomplish significant CO2 emission reduction. In order to implement the technological and financial system of CO2 capture, which is the key technology of CCUS technology and accounts for 70-80% of the overall cost of CCUS technology, it is crucial to create more effective adsorbents. Nowadays, with the development and application of various carbon dioxide capture materials, it is necessary to review and summarize carbon dioxide capture materials in time. In this paper, the main technologies of CO2 capture are reviewed, with emphasis on the latest research status of CO2 capture materials, such as amines, zeolites, alkali metals, as well as emerging MOFs and carbon nanomaterials. More and more research on CO2 capture materials has used a variety of improved methods, which have achieved high CO2 capture performance. For example, doping of layered double hydroxides (LDH) with metal atoms significantly increases the active site on the surface of the material, which has a significant impact on improving the CO2 capture capacity and performance stability of LDH. Although many carbon capture materials have been developed, high cost and low technology scale remain major obstacles to CO2 capture. Future research should focus on designing low-cost, high-availability carbon capture materials.

CO2 utilization for concrete production: Commercial deployment and pathways to net-zero emissions.

Approximately 10 % of global anthropogenic CO2 emissions arise from the cement and concrete industry driven by urban expansion and a constant need for infrastructure renewal. Reusing waste CO2 to make new construction materials produces circular carbon flows and constitutes a key step toward a carbon-negative economy. To establish a holistic view of the field, this paper examines upscaled technologies with industrial deployments for utilizing CO2 in manufacturing cement-based materials and analyzes their interplay for attaining net-zero emissions (NZE) in the concrete sector. By scrutinizing the status quo, it suggests that NZE agendas should be diversified catering to the wide-ranging built products. Small-sized precast elements and lightweight components lead the way in carbon-neutral manufacturing, while the market-dominating ready-mix concrete is by far difficult to decarbonize and relies on the incorporation of pre­carbonated ingredients, preferably sourced from alkaline wastes, to leverage large-scale CO2 utilization. To expedite the race to NZE, it is necessary to combine the development of CO2 utilization and low-CO2 cement to create decarbonization strategies tailoring for individual products. In this regard, the paper reveals credible pathways and research needs to facilitate their implementation in sustainable construction.

Addressing Health Equity in the Context of Carbon Capture, Utilization, and Sequestration Technologies.

PURPOSE OF REVIEW: To describe the role of health equity in the context of carbon capture, utilization, and sequestration (CCUS) technologies. RECENT FINDINGS: CCUS technologies have the potential to both improve and worsen health equity. They could help reduce greenhouse gas emissions, a major contributor to climate change, but they could also have negative health impacts like air and noise pollution. More research is needed to fully understand the health equity implications of CCUS technologies. CCUS technologies have both health equity risks and benefits. Implementing misguided CCUS projects in vulnerable communities could exacerbate environmental injustice and health disparities and have the potential to increase carbon emissions. However, well-conceived projects could benefit communities through economic development. Governments, industry, and society should prioritize and expedite the reduction of CO2 emissions before considering carbon reductions via CCUS. Furthermore, CCUS projects must be thoroughly evaluated and should only proceed if they have demonstrated a net reduction in CO2 emissions and provide more benefits than risks to local communities. This underscores the importance of prioritizing health equity in the planning of CCUS projects.

Cancer patients with clonal hematopoiesis die from primary malignancy or comorbidities despite higher rates of transformation to myeloid neoplasms.

BACKGROUND: The occurrence of somatic mutations in patients with no evidence of hematological disorders is called clonal hematopoiesis (CH). CH, whose subtypes include CH of indeterminate potential and clonal cytopenia of undetermined significance, has been associated with both hematologic cancers and systemic comorbidities. However, CH's effect on patients, especially those with concomitant malignancies, is not fully understood. METHODS: We performed a retrospective evaluation of all patients with CH at a tertiary cancer center. Patient characteristics, mutational data, and outcomes were collected and analyzed. RESULTS: Of 78 individuals included, 59 (76%) had a history of cancer and 60 (77%) had moderate to severe comorbidity burdens. DNMT3A, TET2, TP53, and ASXL1 were the most common mutations. For the entire cohort, the 2-year overall survival rate was 79% (95% CI: 70, 90), while the median survival was not reached. Of 20 observed deaths, most were related to primary malignancies (n = 7, 35%), comorbidities (n = 4, 20%), or myeloid neoplasms (n = 4, 20%). Twelve patients (15%) experienced transformation to a myeloid neoplasm. According to the clonal hematopoiesis risk score, the 3-year transformation rate was 0% in low-risk, 15% in intermediate-risk (p = 0.098), and 28% in high-risk (p = 0.05) patients. By multivariate analysis, transformation was associated with variant allele frequency ≥0.2 and hemoglobin <10 g/dL. CONCLUSIONS: In a population including mostly cancer patients, CH was associated with comorbidities and myeloid transformation in patients with higher mutational burdens and anemia. Nevertheless, such patients were less likely to die of their myeloid neoplasm than of primary malignancy or comorbidities.

Towards the prospect of carbon-neutral power system 2060: A Power-Meteorology-Society systematic view.

With the target of achieving carbon peaking and neutrality in the power sector in China, both State Grid and China Southern Power Grid have made plans of a rapid increase of renewables in future years towards 2060. However, considering the interactions between the power system and meteorological, society factors, whether those plans would lead to CO2 emission peak in 2030 and carbon neutrality in 2060 is still questionable and needs further analysis. Therefore, a Power-Meteorology-Society System is formulated and interactions between these factors will impact the CO2 emission of the power system is studied. Case study shows that these environmental, social factors as well as their interactions will have significant negative impact to the CO2 emission reduction in China's power grid; With current trend of generation and transmission development and higher-than-expected CO2 emission, while the grid could still reach its target of carbon peak in 2030, there will be some challenge for the grid to reach carbon neutrality in the year 2060. Based on that, the authors analyze some potential solutions such as transmission construction, energy storage and the Carbon Capture, Utilization and Storage (CCUS), and try to find a relatively cost-benefit path to reach carbon-neutrality for the grid in 2060.

Bipolar membrane electrodialysis integrated with in-situ CO2 absorption for simulated seawater concentrate utilization, carbon storage and production of sodium carbonate.

In the context of carbon capture, utilization, and storage, the high-value utilization of carbon storage presents a significant challenge. To address this challenge, this study employed the bipolar membrane electrodialysis integrated with carbon utilization technology to prepare Na2CO3 products using simulated seawater concentrate, achieving simultaneous saline wastewater utilization, carbon storage and high-value production of Na2CO3. The effects of various factors, including concentration of simulated seawater concentrate, current density, CO2 aeration rate, and circulating flow rate of alkali chamber, on the quality of Na2CO3 product, carbon sequestration rate, and energy consumption were investigated. Under the optimal condition, the CO32- concentration in the alkaline chamber reached a maximum of 0.817 mol/L with 98 mol% purity. The resulting carbon fixation rate was 70.50%, with energy consumption for carbon sequestration and product production of 5.7 kWhr/m3 CO2 and 1237.8 kWhr/ton Na2CO3, respectively. This coupling design provides a triple-win outcome promoting waste reduction and efficient utilization of resources.

Carbon capture, utilization and storage opportunities to mitigate greenhouse gases.

Carbon capture, utilization and storage (CCUS) technologies are utmost need of the modern era. CCUS technologies adoption is compulsory to keep global warming below 1.5 °C. Mineral carbonation (MC) is considered one of the safest and most viable methods to sequester anthropogenic carbon dioxide (CO2). MC is an exothermic reaction and occur naturally in the subsurface because of fluid-rock interactions with serpentinite. In serpentine carbonation, CO2 reacts with magnesium to produce carbonates. This article covers CO2 mitigation technologies especially mineral carbonation, mineral carbonation by natural and industrial materials, mineral carbonation feedstock availability in Pakistan, detailed characterization of serpentine from Skardu serpentinite belt, geo sequestration, oceanic sequestration, CO2 to urea and CO2 to methanol and other chemicals. Advantages, disadvantages, and suitability of these technologies is discussed. These technologies are utmost necessary for Pakistan as recent climate change induced flooding devastated one third of Pakistan affecting millions of families. Hence, Pakistan must store CO2 through various CCUS technologies.

Effect of micro-fractures on gas flow behavior in coal for enhanced coal bed methane recovery and CO2 storage.

This study investigates the impact of micro-fractures on gas flow behavior in coal formations, specifically within the context of CO2-based Enhanced Coal Bed Methane Recovery (ECBMR). Employing comparative analysis, various gas flow models, including Unipore Diffusion Model (UDM), Bidispersed Diffusion Model (BDM), Fractal Fractional Diffusion Model (FFDM), Time-Dependent Diffusivity Model (TDDM), Anomalous Sub-Diffusion Model (ASM), and Free Gas Density Gradient Model (FGDGM), are evaluated for their efficacy in capturing the complexities. The study aims to provide insights into the accuracy and applicability of these models, considering the heterogeneity of coal seams and the influence of micro-fractures on gas flow dynamics. The major findings include the categorization of different gas flow models based on their applicability to CO2-based ECBMR. For instance, the study suggests utilizing BDM and FFDM models while considering the heterogeneity of coal seams. Similarly using the TDDM model for time dynamics of ECBMR will give higher accuracy. The article contributes to a deeper understanding of gas migration processes in coal, particularly in the context of ECBMR, with implications for optimizing recovery strategies and addressing challenges associated with micro-fracture-induced variations in gas flow behavior.

Atmospheric CO2 Sequestration in Seawater Enhanced by Molluscan Shell Powders.

Carbon capture, utilization, and storage (CCUS) are widely recognized as a promising technology for mitigating climate change. CO2 mineralization using Ca-rich fluids and high-concentration CO2 gas has been studied extensively. However, few studies have reported CO2 mineralization with atmospheric CO2, owing to the difficulty associated with its low concentration. In seawater, the biomineralization process promotes Ca accumulation and CaCO3 precipitation, assisted by specific organic matter. In this study, we examined the conversion of atmospheric CO2 into CaCO3 in seawater using shell powders (Pinctada fucata, Haliotis discus, Crassostrea gigas, Mizuhopecten yessoensis, Turbo sazae, and Saxidomus purpurata). Among the six species, the shell powder of S. purpurata showed the highest rate of CaCO3 formation and recovery of CaCO3. NaClO treatment test revealed that the organic matter in the shells enhanced the CO2 mineralization. All materials used in this study, including atmospheric CO2, seawater, and shells, are economically feasible for large-scale applications. Using shell powder for CO2 mineralization in seawater embodies an innovative technological advancement to address climate change.

Development and Applications of CO2-Responsive Gels in CO2 Flooding and Geological Storage.

Gel systems are widely used as plugging materials in the oil and gas industry. Gas channeling can be mitigated by reducing the heterogeneity of the formation and the mobility ratio of CO2 to crude oil. Cracks and other CO2 leaking pathways can be plugged during the geological storage of CO2 to increase the storage stability. By adding CO2-responsive groups to the classic polymer gel's molecular chain, CO2 responsive gel is able to seal and recognize CO2 in the formation while maintaining the superior performance of traditional polymer gel. The application of CO2 responsive gels in oil and gas production is still in the stage of laboratory testing on the whole. To actually achieve the commercial application of CO2 responsive gels in the oil and gas industry, it is imperative to thoroughly understand the CO2 responsive mechanisms of the various types of CO2 responsive gels, as well as the advantages and drawbacks of the gels and the direction of future development prospects. This work provides an overview of the research progress and response mechanisms of various types of CO2 responsive groups and CO2 responsive gels. Studies of the CO2 responsive gel development, injectivity, and plugging performance are comprehensively reviewed and summarized. The shortcomings of the existing CO2 responsive gels system are discussed and the paths for future CO2 responsive gel development are suggested.