Effect of Magnetic Field Strength on Plastic Scintillation Detector Response.

PURPOSE: To characterize the response of plastic scintillation detectors (PSDs) to high-energy photon radiation as a function of magnetic field strength. MATERIALS AND METHODS: PSDs were placed inside a plastic phantom held at the center point between 2 magnets and irradiated using a 6-MV photon beam from a linear accelerator. The magnetic field was varied from 0 T to 1.5 T by 0.3-T increments. The light emission and stem-effect-corrected response as a function of magnetic field strength were obtained for both a commercial PSD (Exradin W1, Standard Imaging) and an in-house hyperspectral PSD. Spectral signatures were obtained for the in-house PSD, and light emission from a bare fiber was also measured. RESULTS: Light emission increased as magnetic field strength increased for all detectors tested. The tested PSDs exhibited an increase in light intensity of 10% to 20%, mostly owing to the increase in Cerenkov light produced within and transmitted along the optical fiber. When corrected for stem effects, the increase in PSD response went down to 2.4% for both detectors. This most likely represents the change in the inherent dose deposition within the phantom. CONCLUSION: PSDs with a suitable stem-effect removal approach were less dependent on magnetic field strength and had better water equivalence than did ion chambers tested in previous studies. PSDs therefore show great promise for use in both quality assurance and in-vivo dosimetry applications in a magnetic field environment.

PET and NIR optical imaging using self-illuminating (64)Cu-doped chelator-free gold nanoclusters.

Self-illuminating fluorescence imaging without autofluorescence background interference has recently aroused more research interests in molecular imaging. Currently, only a few self-illuminating probes were developed, based mainly on toxic quantum dots such as CdSe, CdTe. Herein, we report a novel design of nontoxic self-illuminating gold nanocluster ((64)Cu-doped AuNCs) for dual-modality positron emission tomography (PET) and near-infrared (NIR) fluorescence imaging based on Cerenkov resonance energy transfer (CRET). PET radionuclide (64)Cu was introduced by a chelator-free doping method, which played dual roles as the energy donor and the PET imaging source. Meanwhile, AuNCs acted as the energy acceptor for NIR fluorescence imaging. (64)Cu-doped AuNCs exhibited efficient CRET-NIR and PET imaging both in vitro and in vivo. In a U87MG glioblastoma xenograft model, (64)Cu-doped AuNCs showed high tumor uptake (14.9 %ID/g at 18 h) and produced satisfactory tumor self-illuminating NIR images in the absence of external excitation. This self-illuminating nanocluster with non-toxicity and good biocompatibility can be employed as a novel imaging contrast agent for biomedical applications, especially for molecular imaging.