Greater celandine (Chelidonium majus L.) for COVID-19: A twenty-case series.

In December 2019, an outbreak of coronavirus disease 2019 (COVID-19) occurred in Wuhan, China, with a rapid increase in cases worldwide. Until now, among several drugs tested, none demonstrated sufficient efficacy for its etiological treatment. Greater celandine (Chelidonium majus L.) is a well-known medicinal plant, traditionally indicated for digestive disorders and topically to remove warts. This study, performed at private offices in São Paulo and Aracaju (Brazil), describes 20 consecutive COVID-19 outpatients treated with greater celandine and their clinical evolution. The patients, aged 14-71 years (median of 41 years), were treated with Chelidonium majus 10% mother tincture, 20-30 drops three times a day for 3-12 days (median of 5 days). Clinical features were assessed during the treatment and at least until 1 week after its end. These cases were considered mild, as most COVID-19 cases. The symptoms were mainly fever, fatigue, cough, sore throat, coryza, anosmia, ageusia, and headache. Ten patients had comorbidities, such as hypertension, diabetes, and overweight. Complete or almost complete clinical improvement occurred within 1-9 days of treatment (median of 3 days). There were no adverse events. This casuistry, although small, may inspire other researchers to continue investigating Chelidonium majus as a healing treatment for COVID-19.

Efeito do Chelidonium majus D3 sobre a hipercolesterolemia experimentalmente induzida em coelhos / Effect of Chelidonium majus D3 on the experimentally induced hypercholesterolemia in rabbits

Introdução: A dislipidemia é um dos maiores fatores de risco para doenças cardiovasculares. Chelidonium majus é uma planta que tem possíveis efeitos sobre a colerese. Objetivo: Verificar a ação do Chelidonium majus D3 sobre a hipercolesterolemia induzida em coelhos. Metodologia: Utilizaram-se 13 coelhos Nova Zelândia brancos em ambiente controlado, recebendo ração hipercolesterolemiante, divididos em dois grupos: tratado e placebo. O grupo tratado recebeu dose via oral de Chelidonium majus D3 diluído em solução hidroalcoólica 30%, duas vezes por dia durante 30 dias, verificando-se os níveis de colesterol total, HDL-colesterol, triglicerídios e relação colesterol total / HDL-colesterol em ambos os grupos. O grupo-placebo recebeu apenas solução hidroalcoólica 30%. Foi utilizado o teste Mann-Whitney para análise dos dados. Resultados: Relacionandose os resultados das diferenças das medianas da coleta intermediária com a basal entre os grupos, obtiveram-se os seguintes resultados: colesterol total: 0,073; HDL-colesterol: 0,628; relação colesterol total / HDL-colesterol: 0,181; triglicerídios: 0,445. Entre a coleta final e a basal, verificaram-se entre os grupos os seguintes resultados: colesterol total: 0,628; HDL-colesterol: 0,366; relação colesterol total / HDL-colesterol: 0,035 (p < 0,05); triglicerídios: 0,035 (p < 0,05). Conclusão: Na amostra estudada não se verificou ação do Chelidonium majus como redutor do colesterol total ou estímulo à elevação do HDLcolesterol. Observou-se, no entanto, ação significativa sobre a redução dos triglicerídios e na redução da relação entre colesterol total e HDL-colesterol (AU)

Introduction: Dyslipidemia is one of the biggest risk factors for cardiovascular disease. Chelidonium majus is a plant that has possible action on choleresis. Objective: Verify the action of Chelidonium majus D3 on the induced hypercholesterolemia in rabbits. Methodology: Were used 13 white rabbits New Zeland in controlled environment, receiving hypercholesterolemic feeding, divided in two groups: treated and placebo. The treated group received oral dose of Chelidonium majus D3 diluted in hydro alcoholic solution 30%, twice a day during 30 days, verifying the total cholesterol, HDL-cholesterol and triglycerides levels and relation total cholesterol / HDL-cholesterol in both groups. The placebo group receveid just hydro alcoholic solution 30%. The Mann-Whitney Test was used for analysis of the data. Results: Becoming related the results of the differences of medians from the intermediate collection with the basal one between groups, we got the following results: Total Cholesterol: 0,073; HDL-cholesterol: 0,628; Relation Total Cholesterol / HDL-cholesterol: 0,181; Triglycerides: 0,445. Between the final collection and the basal one, was verified the following results between groups: Total Cholesterol: 0,628; HDL-cholesterol: 0,366; Relation Total Cholesterol / HDL-cholesterol: 0,035 (p<0,05); Triglycerides: 0,035(p<0,05). Conclusion: In this sample, the action of Chelidonium majus D3 in reducing the total cholesterol or stimulating the rising of HDL-cholesterol was not verified. It was observed, however, significant action on the reduction of the triglycerides and in the reduction of the relation between Total Cholesterol and HDL-cholesterol (AU)