RESUMEN
La toma de decisiones en pacientes con metástasis vertebral es de gran complejidad. En ella intervienen distintos factores del paciente, de su enfermedad oncológica y de las opciones de tratamiento. Los esquemas y estrategias de tratamiento se han ido modificando con la propia evolución del conocimiento y tratamiento de la enfermedad oncológica diseminada. En este trabajo se analiza la bibliografía que se ha empleado para la toma de decisiones en las tres últimas décadas, así como la evolución a los esquemas que podríamos considerar contemporáneos.(AU)
Decision-making in patients with vertebral metastases is highly complex. Different factors of the patient, their cancer disease and treatment options are involved in it. Treatment schemes and strategies have been modified with the evolution of knowledge and treatment of disseminated oncological disease. This paper analyzes the bibliography that has been used for decision-making in the last three decades, as well as the evolution to the schemes that we could consider contemporary.(AU)
Asunto(s)
Humanos , Masculino , Femenino , Toma de Decisiones , Metástasis de la Neoplasia/terapia , Compresión de la Médula Espinal , Columna Vertebral , Traumatología , Procedimientos OrtopédicosRESUMEN
La toma de decisiones en pacientes con metástasis vertebral es de gran complejidad. En ella intervienen distintos factores del paciente, de su enfermedad oncológica y de las opciones de tratamiento. Los esquemas y estrategias de tratamiento se han ido modificando con la propia evolución del conocimiento y tratamiento de la enfermedad oncológica diseminada. En este trabajo se analiza la bibliografía que se ha empleado para la toma de decisiones en las tres últimas décadas, así como la evolución a los esquemas que podríamos considerar contemporáneos.(AU)
Decision-making in patients with vertebral metastases is highly complex. Different factors of the patient, their cancer disease and treatment options are involved in it. Treatment schemes and strategies have been modified with the evolution of knowledge and treatment of disseminated oncological disease. This paper analyzes the bibliography that has been used for decision-making in the last three decades, as well as the evolution to the schemes that we could consider contemporary.(AU)
Asunto(s)
Humanos , Masculino , Femenino , Toma de Decisiones , Metástasis de la Neoplasia/terapia , Compresión de la Médula Espinal , Columna Vertebral , Traumatología , Procedimientos OrtopédicosRESUMEN
El cáncer es en España la segunda causa de muerte en mujeres (22%) y la primera en varones (31%). En este capítulo describimos los tipos más frecuentes de metástasis raquídeas, sus localizaciones más habituales dentro de la columna vertebral, así como su comportamiento clínico. Analizamos también los cuadros neurológicos más comúnmente asociados a las metástasis de columna: compresión radicular, compresión medular, cauda equina y afectación medular.(AU)
Cancer is in Spain the second cause of death in women (22%) and the first in men (31%). In this chapter we describe the most frequent types of spinal metastases, their most frequent locations within the spine, as well as their clinical behavior. We also analyze the neurological conditions most frequently associated with spinal metastases: root compression, spinal cord compression, cauda equina, and spinal cord involvement.(AU)
Asunto(s)
Humanos , Masculino , Femenino , Columna Vertebral , Neoplasias de la Columna Vertebral/tratamiento farmacológico , Metástasis de la Neoplasia , Compresión de la Médula Espinal , Osteoprotegerina , España/epidemiología , Traumatología , Procedimientos Ortopédicos , OrtopediaRESUMEN
El cáncer es en España la segunda causa de muerte en mujeres (22%) y la primera en varones (31%). En este capítulo describimos los tipos más frecuentes de metástasis raquídeas, sus localizaciones más habituales dentro de la columna vertebral, así como su comportamiento clínico. Analizamos también los cuadros neurológicos más comúnmente asociados a las metástasis de columna: compresión radicular, compresión medular, cauda equina y afectación medular.(AU)
Cancer is in Spain the second cause of death in women (22%) and the first in men (31%). In this chapter we describe the most frequent types of spinal metastases, their most frequent locations within the spine, as well as their clinical behavior. We also analyze the neurological conditions most frequently associated with spinal metastases: root compression, spinal cord compression, cauda equina, and spinal cord involvement.(AU)
Asunto(s)
Humanos , Masculino , Femenino , Columna Vertebral , Neoplasias de la Columna Vertebral/tratamiento farmacológico , Metástasis de la Neoplasia , Compresión de la Médula Espinal , Osteoprotegerina , España/epidemiología , Traumatología , Procedimientos Ortopédicos , OrtopediaRESUMEN
Las metástasis vertebrales son una causa común de dolor en el paciente oncológico, lo cual puede generar limitación funcional, además de complicaciones derivadas de una posible compresión medular, radicular y fracturas. Se requiere de un abordaje complejo de estas metástasis por el riesgo de secuelas permanentes. Con el aumento de las supervivencia gracias a los nuevos tratamientos emergentes, las posibilidades de presentar metástasis vertebrales son cada vez mayores, por ende, el manejo de estas lesiones debe ir encaminado al alivio del dolor y el mantenimiento de la deambulación. La radioterapia juega un papel fundamental en el manejo de estas lesiones, y disponemos de avances tecnológicos en los últimos años que han permitido mejorar la calidad e intencionalidad de los tratamientos, pasando de ser meramente paliativos a proponer tratamientos que mejoren el control local. En este articulo hacemos una descripción de como la técnica de SBRT (stereotactic body radiotherapy), en pacientes seleccionados puede mejorar el control local de forma más duradera, y el valor que tiene en paciente oligometastásico y tras cirugía.(AU)
Spine metastases are a common cause of pain in the oncologic patient which can generate functional limitation, in addition to complications derived from spinal cord compression, radicular compression and fractures. A complex approach to these metastases is required due to the risk of permanent sequelae. With the increase in survival rates due to new emerging treatments, the possibilities of presenting vertebral metastases are increasing, therefore, the management of these lesions should be aimed at pain relief and maintenance of ambulation. Radiotherapy has a fundamental role in the management of these lesions, and technological advances in recent years have made it possible to improve the quality and intentionality of the treatments, going from having a palliative intent to proposing treatments that improve local control. In this article we describe how the stereotactic body radiotherapy (SBRT) technique, in selected patients, can improve local control and its value in oligometastatic patients and after surgery.(AU)
Asunto(s)
Humanos , Masculino , Femenino , Neoplasias Óseas/terapia , Neoplasias de la Columna Vertebral/terapia , Radioterapia/tendencias , Compresión de la Médula Espinal , Dolor en Cáncer , Terapéutica/tendencias , Traumatología , Procedimientos Ortopédicos , Ortopedia , Supervivencia , Columna VertebralRESUMEN
Las metástasis vertebrales son una causa común de dolor en el paciente oncológico, lo cual puede generar limitación funcional, además de complicaciones derivadas de una posible compresión medular, radicular y fracturas. Se requiere de un abordaje complejo de estas metástasis por el riesgo de secuelas permanentes. Con el aumento de las supervivencia gracias a los nuevos tratamientos emergentes, las posibilidades de presentar metástasis vertebrales son cada vez mayores, por ende, el manejo de estas lesiones debe ir encaminado al alivio del dolor y el mantenimiento de la deambulación. La radioterapia juega un papel fundamental en el manejo de estas lesiones, y disponemos de avances tecnológicos en los últimos años que han permitido mejorar la calidad e intencionalidad de los tratamientos, pasando de ser meramente paliativos a proponer tratamientos que mejoren el control local. En este articulo hacemos una descripción de como la técnica de SBRT (stereotactic body radiotherapy), en pacientes seleccionados puede mejorar el control local de forma más duradera, y el valor que tiene en paciente oligometastásico y tras cirugía.(AU)
Spine metastases are a common cause of pain in the oncologic patient which can generate functional limitation, in addition to complications derived from spinal cord compression, radicular compression and fractures. A complex approach to these metastases is required due to the risk of permanent sequelae. With the increase in survival rates due to new emerging treatments, the possibilities of presenting vertebral metastases are increasing, therefore, the management of these lesions should be aimed at pain relief and maintenance of ambulation. Radiotherapy has a fundamental role in the management of these lesions, and technological advances in recent years have made it possible to improve the quality and intentionality of the treatments, going from having a palliative intent to proposing treatments that improve local control. In this article we describe how the stereotactic body radiotherapy (SBRT) technique, in selected patients, can improve local control and its value in oligometastatic patients and after surgery.(AU)
Asunto(s)
Humanos , Masculino , Femenino , Neoplasias Óseas/terapia , Neoplasias de la Columna Vertebral/terapia , Radioterapia/tendencias , Compresión de la Médula Espinal , Dolor en Cáncer , Terapéutica/tendencias , Traumatología , Procedimientos Ortopédicos , Ortopedia , Supervivencia , Columna VertebralRESUMEN
Decision-making in patients with vertebral metastases is highly complex. Different factors of the patient, their cancer disease and treatment options are involved in it. Treatment schemes and strategies have been modified with the evolution of knowledge and treatment of disseminated oncological disease. This paper analyzes the bibliography that has been used for decision-making in the last three decades, as well as the evolution to the schemes that we could consider contemporary.
RESUMEN
Spine metastases are a common cause of pain in the oncologic patient which can generate functional limitation, in addition to complications derived from spinal cord compression, radicular compression and fractures. A complex approach to these metastases is required due to the risk of permanent sequelae. With the increase in survival rates due to new emerging treatments, the possibilities of presenting vertebral metastases are increasing, therefore, the management of these lesions should be aimed at pain relief and maintenance of ambulation. Radiotherapy has a fundamental role in the management of these lesions, and technological advances in recent years have made it possible to improve the quality and intentionality of the treatments, going from having a palliative intent to proposing treatments that improve local control. In this article, we describe how the stereotactic body radiotherapy (SBRT) technique, in selected patients, can improve local control and its value in oligometastatic patients and after surgery.
RESUMEN
Cancer is in Spain the second cause of death in women (22%) and the first in men (31%). In this chapter, we describe the most frequent types of spinal metastases, their most frequent locations within the spine, as well as their clinical behaviour. We also analyse the neurological conditions most frequently associated with spinal metastases: root compression, spinal cord compression, cauda equina, and spinal cord involvement.
RESUMEN
Spine metastases are a common cause of pain in the oncologic patient which can generate functional limitation, in addition to complications derived from spinal cord compression, radicular compression and fractures. A complex approach to these metastases is required due to the risk of permanent sequelae. With the increase in survival rates due to new emerging treatments, the possibilities of presenting vertebral metastases are increasing, therefore, the management of these lesions should be aimed at pain relief and maintenance of ambulation. Radiotherapy has a fundamental role in the management of these lesions, and technological advances in recent years have made it possible to improve the quality and intentionality of the treatments, going from having a palliative intent to proposing treatments that improve local control. In this article we describe how the stereotactic body radiotherapy (SBRT) technique, in selected patients, can improve local control and its value in oligometastatic patients and after surgery.
RESUMEN
Cancer is in Spain the second cause of death in women (22%) and the first in men (31%). In this chapter we describe the most frequent types of spinal metastases, their most frequent locations within the spine, as well as their clinical behavior. We also analyze the neurological conditions most frequently associated with spinal metastases: root compression, spinal cord compression, cauda equina, and spinal cord involvement.
RESUMEN
Decision-making in patients with vertebral metastases is highly complex. Different factors of the patient, their cancer disease and treatment options are involved in it. Treatment schemes and strategies have been modified with the evolution of knowledge and treatment of disseminated oncological disease. This paper analyzes the bibliography that has been used for decision-making in the last three decades, as well as the evolution to the schemes that we could consider contemporary.
RESUMEN
El quiste hidatídico en Uruguay continúa siendo un problema de salud pública. A pesar de los esfuerzos realizados en prevención primaria y secundaria, es una patología con alta incidencia. La hidatidosis de partes blandas es infrecuente. Su incidencia se estima en 0,5% a 5,3%. El objetivo de esta publicación es presentar un caso clínico de un paciente portador de una compresión medular, producto de una hidatidosis muscular lumbar complicada, hecho extremadamente infrecuente. Los sitios más frecuentes de infestación por equinococosis hidatídica son hígado (75%), pulmones (15%) cerebro (2-4%) tracto genitourinario (2%-3%). La afectación espinal ocurre en menos del 1%. Los síntomas de compresión no son habituales, pero es una de las posibles complicaciones, hecho que motiva la publicación del caso clínico.
Summary: Hydatid cyst continues to be a public health problem in Uruguay despite efforts made in primary and secondary prevention, and in fact, its incidence is high. Hydatid cyst of the soft tissues is rather unusual. Estimated incidence ranges between 0.5 and 5.3%. The study aims to present the clinical case of a patient carrier of bone marrow compression caused by a complicated lumbar hydatid cyst, something significantly rare. Liver (75%), lungs (15%), brain (2-4%), genitourinary tract (2-3%) are the most frequent sites where hydatid cyst is found. Spinal cord compromise occurs in less than 1%. Compression symptoms are not frequent, although it is one of the potential complications, what resulted in the clinical case being published.
O cisto hidático continua sendo um problema em nível de saúde pública no Uruguai, mesmo com os esforços realizados na prevenção primária e secundária, sendo uma patologia com alta incidência. A hidatidose dos tecidos moles é rara; sua incidência é estimada em 0,5% a 5,3%. O objetivo desta publicação é apresentar o caso clínico de um paciente com compressão medular, produto de uma complicada doença hidática muscular lombar, evento extremamente raro. Os locais mais frequentes de infestação por equinococose hidática são fígado (75%), pulmões (15%), cérebro (2-4%) e trato geniturinário (2-3%). O envolvimento da coluna ocorre em menos de 1% dos casos. Os sintomas de compressão não são comuns, mas é uma das possíveis complicações e motivo da publicação deste caso clínico.
Asunto(s)
Compresión de la Médula Espinal , EquinococosisRESUMEN
Ganglioneuromas are slow growing tumours arising from tissues of the neural crest, mainly in autonomic nervous system. They are frequently localized in the posterior mediastinum being the intraspinal involvement very uncommon. We present the case of a female patient with bilateral cervical ganglioneuroma, together with a review of the cases published to date, emphasizing in the main characteristics of these tumours and including them as part of neurofibromatosis type 1 spectrum.
Los ganglioneuromas son tumores de lento crecimiento que se originan en tejidos derivados de la cresta neural, principalmente en el sistema nervioso autónomo. Se localizan sobre todo en el mediastino posterior, siendo la afectación intraespinal muy poco frecuente. Presentamos el caso de una mujer intervenida de ganglioneuromas localizados en la columna cervical y agrupamos los casos descritos previamente en la literatura inglesa revisando las características principales de estas neoplasias e incluyéndolas en el espectro de manifestaciones de la neurofibromatosis tipo 1.
Asunto(s)
Ganglioneuroma , Neurofibromatosis 1 , Vértebras Cervicales/diagnóstico por imagen , Femenino , Ganglioneuroma/complicaciones , Ganglioneuroma/diagnóstico por imagen , Ganglioneuroma/cirugía , Humanos , Cuello , Neurofibromatosis 1/complicacionesRESUMEN
Mucopolisacaridosis es una rara enfermedad que afecta al metabolismo de los mucopolisacaridos debida a la ausencia o deficiencia de las enzimas encargadas de su síntesis lo que produce depósitos de aminoglucósidos en casi todos los tejidos del organismo. De acuerdo a la enzima faltante se clasifican los distintos tipos de la enfermedad, siendo más frecuente el Tipo I con sus tres variantes: Hurler, Hurler-Sheie y Sheie de distinta gravedad y tratamiento. Al nacimiento el niño no presenta síntomas, éstos van apareciendo a partir del año de vida: retardo físico y mental, múltiples deformidades esqueléticas, hepatoesplenomegalia, sordera, opacidades corneanas, entre otras. La intervención neuroquirúrgica en esta entidad es en dos patologías: la hidrocefalia, que al no presentar los signos clásicos de hipertensión endocraneana puede ser confundida con atrofia y la compresión medular cervical por los depósitos de mucopolisacáridos en vértebras, ligamentos y leptomeninges.
Mucopolysaccharidosis is a rare illness that involves the metabolism of mucopolysaccharides, that due to the absence or deficiency of corresponding enzymes, accumulate in almost all the tissues of the body. According to which enzyme is missing, different types of the disease have been identified; the most frequent being Type I with its three variants: Hurler, Hurler-Sheie, and Sheie. Symptoms of this disorder progress and range from mental and physical retardation, multiple skeletal deformities, hepatosplenomegaly, deafness, and corneal opacities among others. Children affected usually appear normal at birth and the slowness in their development may be the first evidence of the disorder whose progression is downhill. Neurosurgical intervention occurs in two pathologies: hydrocephalus that does not show signs of intracranial hypertension and can be confused with atrophy, and cervical cord compression due to storage of mucopolysaccharides in vertebrae, ligaments, and leptomeninges.
Asunto(s)
Mucopolisacaridosis , Atrofia , Hipertensión Intracraneal , Médula Cervical , Glicosaminoglicanos , HidrocefaliaRESUMEN
Spinal arachnoid cysts are rare entities, most of which have a congenital or spontaneous etiology. Secondary cases are infrequent and can constitute a cause of neurological deterioration several months or years after spinal trauma. We present the case of a male patient with traumatic spinal arachnoid cyst, together with a review of the cases published to date. Finally, we explain the different surgical options for this pathology relating them to the physiopathological theories that try to explain the origin of these lesions.
Asunto(s)
Quistes Aracnoideos , Compresión de la Médula Espinal , Enfermedades de la Médula Espinal , Quistes Aracnoideos/complicaciones , Quistes Aracnoideos/diagnóstico por imagen , Quistes Aracnoideos/cirugía , Humanos , Imagen por Resonancia Magnética , Masculino , Compresión de la Médula Espinal/diagnóstico por imagen , Compresión de la Médula Espinal/etiología , Compresión de la Médula Espinal/cirugíaRESUMEN
BACKGROUND: Metastatic spinal cord compression (MSCC) is a severe complication in patients with cancer, and its incidence rate is difficult to accurately estimate. The aim of this study is to report the incidence and epidemiological and prognostic characteristics of MSCC in patients with cancer. MATERIAL AND METHODS: We analysed a cohort of 1736 patients diagnosed with cancer of any origin who were hospitalised in a palliative care unit. We collected epidemiological data, signs and symptoms, mean time to diagnosis, treatment regimen, response to treatment and mortality for the patients diagnosed with MSCC. RESULTS: In the 1736 patients, we identified 28 (1.6%) cases of MSCC. The average age was 67.2 (SD, 12.7) years, and lung cancer was the most common primary tumour (42.8%). The thoracic spine was the most affected location (12 cases, 42.8%), and pain was the predominant symptom (13 cases, 46.4%). The median survival after the MSCC diagnosis was 84.5 days. CONCLUSIONS: We observed an incidence rate of 1.6% (N=28) for MSCC in a cohort of 1736 patients with cancer. MSCC is a marker of poor prognosis, with a mean survival of less than 3 months from diagnosis and a hospital mortality of 32.4%.
RESUMEN
Resumen Una complicación importante que ocurre entre 5 y 10% de los pacientes con cáncer es el síndrome de compresión medular que representa una urgencia oncológica. Existe relación entre el cáncer pulmonar y el síndrome de compresión medular, porque puede ocurrir infiltración del cáncer a la columna vertebral. Sin embargo, no es frecuente que ocurra como manifestación inicial. Se comunica el caso de un paciente de 40 años de edad diagnosticado con adenocarcinoma pulmonar que tuvo como manifestación inicial una paraplejía.
Abstract An important complication that occurs between 5 and 10% of patients with cancer is spinal cord compression syndrome that represents an oncological emergency. There is a relationship between lung cancer and spinal cord compression syndrome, because cancer can infiltrate the spine. However, it is not common to occur as an initial manifestation. We report the case of a 40-year-old patient diagnosed with pulmonary adenocarcinoma who had paraplegia as an initial manifestation.
RESUMEN
Objetivo: Describir los resultados quirúrgicos y evolución de pacientes con metástasis espinales toraco-lumbares operadas con técnica mínimamente invasiva (MISS) utilizando para la decisión terapéutica la evaluación: Neurológica, Oncológica, Mecánica y Sistémica (NOMS). Material y Métodos: Se incluyeron en forma prospectiva pacientes con metástasis espinales toraco-lumbares operados con técnica MISS por el Servicio de Neurocirugía del Hospital Italiano de Buenos Aires, entre junio de 2014 y junio de 2017. Se utilizó en todos los casos el algoritmo de evaluación NOMS para la decisión terapéutica. Se analizaron los resultados quirúrgicos postoperatorios como el Karnofsky Performance Status (KPS), dolor (VAS: Visual Analogue Scale), Frankel, pérdida sanguínea, necesidad de transfusiones, complicaciones, uso de opioides y días de internación. Se consideró como estadísticamente significativo una p<0,05. Resultados: Durante el período de estudio 26 pacientes cumplieron los criterios de inclusión, de los cuales 13 fueron mujeres. La edad promedio fue 57 (27-83) años. El origen más frecuente de las lesiones fue cáncer de mama (27%). El síntoma más constante fue el dolor (96%), aunque 12 pacientes manifestaron inicialmente mielopatía (46%). Se observaron grados avanzados de invasión del canal con requerimiento de descompresión en el 65% de los casos. Acorde al Spinal Instability Neoplastic Score (SINS), 23 pacientes (89%) presentaron lesiones potencialmente inestables o inestables, requiriendo estabilización. Se evidenció una mejoría estadísticamente significativa del VAS en el 77% y del Frankel en el 67% de los casos tras la cirugía. No hubo necesidad de transfusiones. Se registró sólo una complicación quirúrgica leve (4%). La media de internación fue de 5,5 días. Conclusión: En nuestra serie y utilizando como algoritmo terapéutico el NOMS, la cirugía MISS resultó efectiva tanto para la descompresión para la estabilización espinal, con baja tasa de complicaciones y rápida recuperación postoperatoria.
Objective: To describe the surgical results and evolution of patients who undergo minimally-invasive spinal surgery (MISS) to treat thoracolumbar metastases, using the NOMS (Neurological, Oncological, Mechanical, Systemic) assessment tool to aid therapeutic decisions. Methods: Patients who underwent MISS to treat thoracolumbar metastases were prospectively enrolled at the Hospital Italiano de Buenos Aires, from June 2014 to June 2017. In all cases, the NOMS assessment tool was employed for therapeutic decision-making. Surgical results were analyzed, in terms of improvements in Karnofsky Performance Status (KPS), pain severity (VAS), and the Frankel neurological scale; also measured were blood loss and the need for transfusions, complications, use of opioids, and the length of hospitalization. P values <0.05 were considered statistically significant. Results: Twenty-six patients were enrolled (13 women) of mean age 57 years old (27-83). Breast cancer was the most frequent primary tumor (27%). The main presenting symptom was pain (96%), although 12 patients presented with myelopathy (46%). High-grade epidural spinal cord compression requiring decompression was observed in 17 patients (65%). According to the SINS (Spinal Instability Neoplastic Score), most lesions were either potentially unstable or unstable (89%), requiring stabilization. After surgery, pain severity and neurological status improved significantly in 77% and 67% of patients, respectively, with low intraoperative blood loss and no need for transfusions. Only one minor surgical complication occurred (4%). The average hospital stay was 5.5 days. Conclusion: In our series, using the NOMS instrument as the therapeutic algorithm, MISS was effective for spinal decompression and stabilization, with a low rate of complications and rapid postoperative recovery.
Asunto(s)
Humanos , Columna Vertebral , Compresión de la Médula Espinal , Enfermedades de la Médula Espinal , Terapéutica , Metástasis de la NeoplasiaRESUMEN
Cervical Traumatic SSH are very rare in literature. They are usually caused by cardiopulmonary diseases that increase vascular pressure causing spinal vessels rupture. In thoracolumbar spine, the spinal puncture is the most common cause. The ventrolateral position is even more unusual. In traumatic brain injury (TBI), an abrupt extension-flexion movement could have caused the rupture of subarachnoid vessels. This, accompanied by the slowed blood "wash out" (probably due to the previous osteoarthrosis and spinal canal stenosis), led to the formation of an organized clot, which caused an acute spinal cord compression syndrome. Cervical subarachnoid spinal hematoma can present as Brown-Séquard syndrome. The treatment is prompt surgical removal and decompression. The posterior approach (partial hemilaminectomy with or without laminoplasty) with microsurgical technique is feasible, fast and simple to evacuate the hematoma with good results. Surgical nuances in posterior approach are: small spinal canal, difficulty in mobilizing the cervical cord, these haematomas are wrapped and attached to the spinal cord or nerve roots by multiple arachnoid bands, requiring techniques of Microdissection for its evacuation unlike the epidural and subdural haematomas that are easily aspirated. Here, we report a unique case of a ventrolateral SSH due to TBI.