Depressive symptoms among older adults with diabetes mellitus: a cross-sectional study

ABSTRACT BACKGROUND: Diabetes mellitus is a chronic disease with long-term consequences that is often associated with depressive symptoms. This relationship predicts increased morbidity and mortality rates, leading to serious health consequences. OBJECTIVE: To identify the prevalence and health factors associated with depressive symptoms among older adults with diabetes mellitus. DESIGN AND SETTING: An observational cross-sectional study was conducted among 236 older adults in the Basic Healthcare Units of Jequié, Brazil. METHODS: A survey containing sociodemographic, behavioral, and health conditions was used as a data collection instrument, in addition to the Geriatric Depression Scale. The main inclusion criterion was older adults diagnosed with diabetes mellitus. To identify the risk factors associated with depressive symptoms among older adults with diabetes mellitus, logistic regression analysis was conducted for calculating the odds ratio (OR), and a 95% confidence interval (CI) was considered statistically significant. RESULTS: The prevalence of depressive symptoms was 24.2% among older adults with diabetes, corroborating the Brazilian average of 30%. The final multivariate analysis model for the risk of depressive symptoms showed a significant association with diabetes complications [OR = 2.50, 95% CI 1.318-4.74)] and osteoporosis [OR = 2.75, 95% CI 1.285-5.891)]. CONCLUSION: A high prevalence of depressive symptoms was observed among older adults with diabetes. Critically examining older adults with diabetes mellitus is necessary, and screening for depressive symptoms is highly recommended, especially for those with complications resulting from diabetes mellitus and musculoskeletal comorbidities, such as osteoporosis, as it seems to be associated with depressive symptoms.

The Geriatric Depression Scale (GDS-15): Validation in Mexico and Disorder in the State of Knowledge.

The objective of this study was to evaluate the reliability and validity of the Geriatric Depression Scale in its 15-item version (GDS-15) in Mexican older adults. Participants included 1178 older adults between the ages of 60 and 94 (M = 69.16, SD = 7.69); 53.9% were women and 55.8% were married or with a partner. They completed the GDS-15, a subjective well-being scale, and a quality-of-life questionnaire. A Kuder-Richardson coefficient of .80 was obtained, which indicates an acceptable internal consistency of the GDS-15, as well as evidence of divergent validity with significant correlations of -.783 with subjective well-being and -.569 with quality of life, in addition to concurrent validity when discriminating between participants with low scores from those with high scores of depressive symptoms. The need for a simple screening tool such as the GDS-15 that helps in the identification of depressive symptoms in Mexican older adults is underlined.

Internal Consistency of Yesavage Geriatric Depression Scale (GDS 15-Item Version) in Ecuadorian Older Adults.

The present study aimed to assess the validity of a Spanish version of the Geriatric Depression-15 Scale (GDS-15) in Ecuadorian adults. Cross-sectional study to validate GDS-15 in its short version (GDS-15). Internal consistency and factor structure were assessed through Kuder Richardson 20 and Confirmatory Factor Analysis. A total of 211 subjects 65 years of age and older participated in the validation process. Internal consistency was adequate, the Kuder Richardson 20 coefficient for the total scale was 0.73. Three factor structure was found for the scale. This study highlights the importance of having a validated scale for screening depression in the elderly. This study provides an evidence for the use of GDS-15 in Ecuadorian elderly population to screen for depression.

Geriatric depression: concepts and risk factors: a literature review

The population increase of the elderly in Chile, as well as worldwide, has caused the appea-rance of phenomena specific to older adulthood, including Geriatric Depression. The aim of this review is to describe the main concepts and risk factors of Geriatric Depression. This review is structured in three main sections: "Older adulthood", "Geriatric Depression", and "Factors associated with Geriatric Depression", the latter is subdivided into "Psychosocial Components" and "Physical Components". Finally, in the discussion it is highlighted that for future investigations, as well as for professionals, it is key to include an approach to older adulthood as a complex evolutionary cycle that is in a constant relationship with its social context.

Relationship between childhood maltreatment and geriatric depression: the mediator effect of personality traits.

BACKGROUND: Childhood maltreatment is an important factor associated with adverse mental health outcomes including geriatric depression and the "big five" personality characteristics. The objective of this study was to evaluate a model where personality characteristics mediate the relationship between childhood maltreatment and geriatric depression. METHOD: In this cross-sectional study, elderly subjects from socioeconomically disadvantaged neighborhoods of Porto Alegre, Brazil (n = 260) completed the Childhood Trauma Questionnaire (CTQ), NEO-Five Factor Inventory (NEO-FFI), and Mini International Neuropsychiatric Interview 5.0 (MINI plus). We used structural equation modeling (SEM) to evaluate the mediation hypothesis. RESULTS: The five personality factors (neuroticism, extraversion, agreeableness, openness, and conscientiousness) were related to childhood maltreatment and depression. Mediation analysis revealed that neuroticism and extraversion are complete mediators, agreeableness and conscientiousness are partial mediators, and openness is not a mediator. CONCLUSIONS: These findings support the hypothesis in which childhood maltreatment is associated with geriatric depression and mediated by personality factors. These results suggest that reducing the maladaptive personality trait in elderly people who suffered childhood maltreatment could prevent geriatric depression.

Influence of childhood abuse and neglect subtypes on late-life suicide risk beyond depression.

The association of childhood maltreatment and suicide has been extensively examined within the population. Depression figures as a main cause for the elevated suicide rate in advanced ages and is often related to childhood maltreatment. The purpose of the present study was to examine the relationship between childhood maltreatment subtypes and suicide risk, testing geriatric depression as a moderator. This is a cross-sectional study looking at a sample of 449 individuals 60 year s old or older from the Multidimensional Study of the Elderly of Porto Alegre Family Health Strategy, Brazil (EMI-SUS/POA). Childhood maltreatment (Childhood Trauma Questionnaire), geriatric depressive symptoms (Geriatric Depression Scale), and suicide risk (Mini International Neuropsychiatric Interview) were assessed. The subtypes of childhood abuse and neglect were significantly associated with suicide risk. In the multivariate analysis, controlling for age, gender, income, marital status, ethnicity, smoking, and geriatric depression symptoms, all trauma subtypes remained associated with suicide risk with the exception of physical neglect (EA = 3.65; PA = 3.16; SA = 5.1; EN = 2.43; PN = 1.76). The present study showed that childhood maltreatment subtypes predicted suicide risk, and geriatric depression does not directly mediate this relation.

Relationship between depressive symptomatology and cognitive performance in older people.

OBJECTIVE: To analyze the relationship of depressive symptoms with differentiated components of cognitive function in older adults using the Neuronorma.Co protocol. METHODOLOGY: We analyzed the cognitive performance of 144 adults, 58.3% women, with an average age of 68.1 ± 11.2 years. A factor analysis of main components was performed to identify independent factors of cognitive function. Multiple linear regression analysis was used to estimate the type and strength of association between depressive symptoms and neurocognitive performance components. RESULTS: Seven differentiated components of cognitive performance were identified. In the multivariate analysis, interference control and language were affected by the total score on the Yesavage Geriatric Depression Scale. CONCLUSIONS: The presence and intensity of depressive symptoms is associated with a lower performance in tasks dependent on executive control.

OBJETIVO: Analizar la relación de los síntomas depresivos con componentes diferenciados de la función cognitiva de adultos mayores usando el protocolo Neuronorma.Co. METODOLOGÍA: Se analizó el rendimiento cognitivo de 144 adultos, 58, 3% mujeres, con una edad media de 68, 1 ± 11, 2 años. Se realizó un análisis factorial de componentes principales, para identificar factores independientes de la función cognitiva. Se usó el análisis de regresión lineal múltiple para estimar el tipo y la fuerza de asociación entre síntomas depresivos y los componentes del desempeño neurocognitivo. RESULTADOS: Se identificaron siete componentes diferenciados del rendimiento cognitivo. En el análisis multivariado el control de la interferencia y el lenguaje resultaron afectados por la puntuación total en la Escala de Depresión Geriátrica de Yesavage.

Cognitive performance of community-dwelling oldest-old individuals with major depression: the Pietà study.

BACKGROUND: Individuals with late-life depression (LLD) may present cognitive symptoms. We sought to determine whether a brief cognitive battery (BCB) could identify cognitive and functional deficits in oldest-old individuals with LLD and a low level of education. METHODS: We evaluated 639 community-dwelling individuals aged 75+ years in Caeté (MG), Brazil. We used the MINI and GDS-15 to diagnose major depression and evaluate its severity, respectively. The cognitive evaluation comprised the Mini-Mental State Examination (MMSE), BCB, clock-drawing test, category fluency test (animals) and Pfeffer's Functional Activities Questionnaire (FAQ). RESULTS: Fifty-four (11.6%) of the included individuals were diagnosed with LLD; on average, these participants were aged 81.0 ± 4.8 years and had 3.9 ± 3.4 years of schooling, and 77.8% of the subjects with LLD were female. Depressed individuals scored lower than subjects without dementia/depression on the MMSE overall (p < 0.001) and on several of the MMSE subscales, namely, time (p < 0.001) and spatial orientation (p = 0.021), attention/calculation (p = 0.019), and language (p = 0.004). Individuals with LLD performed worse on the incidental and (p = 0.011) immediate memory (p = 0.046) and learning tasks (p = 0.039) of the BCB. Individuals with LLD also performed worse on the category fluency test (p = 0.006), clock-drawing test (p = 0.011) and FAQ (p < 0.001). Depression severity was negatively correlated with incidental memory (ρ = -0.412; p = 0.003) and positively correlated with FAQ score (ρ = 0.308; p = 0.035). In the multiple regression analysis, only temporal orientation and FAQ score remained independently associated with LLD. CONCLUSION: Individuals with depression and a low level of education presented several cognitive and functional deficits. Depression severity was negatively correlated with incidental memory and functionality. Our findings serve as a description of the presence of cognitive dysfunction in individuals with LLD and suggest that these deficits may be identified based on the results of a BCB.

Reducing anxiety, geriatric depression and worry in a sample of older adults through a mindfulness training program / Reducción de la ansiedad, la depresión geriátrica y la preocupación en una muestra de adultos mayores a través de un programa de entrenamiento en mindfulness

This study aimed to analyze the effects of a mindfulness training program on anxiety, worry, and geriatric depression in a sample of older adults. A randomized controlled trial with pretest-posttest measurements was used on an experimental group (n = 42) and a control group (waiting list; n = 45). Participants in the experimental group completed the Short Cognitive Examination, the Penn State Worry Questionnaire (PSWQ), and the Geriatric Depression Scale. Analyses showed significantly stronger reductions in geriatric depression, anxiety and worry in the experimental group than in the control group, confirming the effectiveness of mindfulness techniques in reducing these conditions and, especially, for the trait-worry variable, followed by important changes in anxiety, depression and meta-worry. This is one of the few studies examining the effects of mindfulness training in the elderly. Results are especially noteworthy because traits are quite resistant to change. Implications for future research and intervention are underlined.

Se analizan los efectos de un programa de entrenamiento en mindfulness en la ansiedad, la preocupación y la depresión en una muestra de adultos mayores en este estudio controlado y aleatorizado con medidas pretrest-posttest con un grupo experimental (n = 42) y control (lista de espera; n = 42). El grupo experimental completó el Mini-Examen cognitivo, el Inventario de Preocupación de Pensilvania, y la Escala de Depresión Geriátrica. Se obtuvieron mayores reducciones significativas en este grupo comparado con el grupo control, confirmándose la efectividad de las técnicas de mindfulness en la reducción de estos transtornos y, especialmente, en la variable preocupación de rasgo, seguida de importantes cambios en ansiedad, depresión y metapreocupación. Este es uno de los pocos estudios que examinan los efectos del entrenamiento en mindfulness en la tercera edad. Los resultados son especialmente importantes porque los rasgos son resistentes al cambio. Se destacan implicaciones para la investigación futura e intervención.

ST-elevation myocardial infarction risk in the very elderly.

BACKGROUND: Despite the high incidence and mortality of ST-segment elevation myocardial infarction (STEMI) among the very elderly, risk markers for this condition remain poorly defined. This study was designed to identify independent markers of STEMI among individuals carefully selected for being healthy or manifesting STEMI in < 24 h. METHODS: We enrolled participants aged 80 years or older of whom 50 were STEMI patients and 207 had never manifested cardiovascular diseases. Blood tests, medical and psychological evaluations were obtained at study admission. Odds Ratio (OR) and attributed risk (AR) were obtained by multivariate regression models using STEMI as dependent variable. RESULTS: Low glomerular filtration rate (GFR) [OR:4.41 (1.78-10.95); p = 0.001], reduced levels of HDL-C [OR:10.70 (3.88-29.46); p = 0.001], male gender [OR:12.08 (5.82-25.08); p = 0.001], moderate to severe depressive symptoms [OR:10.00 (2.82-35.50); p = 0.001], prior smoking [OR:2.00 (1.05-3.80); p = 0.034] and current smoking [OR:6.58 (1.99-21.70); p = 0.002] were significantly associated with STEMI. No association was found between STEMI and age, diabetes, hypertension, mild depressive symptoms, triglyceride or LDL-C. CONCLUSIONS: This is the first case-control study carried out with very elderlies to assess STEMI risk. Our findings indicate that reduced HDL-C, GFR, male gender, smoking habits and moderate to severe depressive symptoms are markers of STEMI in this age group. GENERAL SIGNIFICANCE: In Individuals aged 80 or more years, a greater attention must be paid to low HDL-C and GFR at the expense of conventional STEMI risk factors for younger adults such as diabetes mellitus, hypertension and high LDL-C or triglyceride.

Shared Biologic Pathways Between Alzheimer Disease and Major Depression: A Systematic Review of MicroRNA Expression Studies.

OBJECTIVE: The clinical-epidemiological relationship between major depressive disorder (MDD) and Alzheimer disease (AD) suggests that they may share common neurobiologic abnormalities. METHODS: The authors conducted a systematic review and identified microRNAs abnormally expressed in both AD and MDD. The pattern of microRNA regulation in each disorder and the genes regulated by each microRNA and the biologic processes and pathways regulated by these genes were identified. RESULTS: Seventy-four microRNAs were abnormally expressed in AD and 30 in MDD; 7 were common for both disorders (hsa-let-7f-5p, hsa-miR-664a-3p, hsa-miR-361-5p, hsa-let-7g-5p, hsa-let-7d-5p, hsa-miR-191-5p, hsa-miR-26b-5p). These microRNAs interact with 45 validated genes, and the main biologic pathways and processes regulated by them were proteostasis control, maintenance of genomic integrity, regulation of transcriptional activity, immune-inflammatory control, and neurotrophic support. CONCLUSION: The current results suggest that the maintenance of genomic integrity, proteostasis control, immune-inflammatory regulation, and neurotrophic support are key neurobiologic links between these conditions. A comprehensive hypothetical model for the interaction between MDD, aging, and the development of AD is provided.

Los modelos de mezcla de la Teoría de respuesta al ítem

Se presentan los modelos de mezcla de la Teoría de respuesta al ítem y cómo estos pueden ser utilizados para identificar subagrupaciones no observadas de examinados denominadas como clases latentes. Asimismo se ejemplifica la utilidad del modelo de mezcla de la Teoría de respuesta al ítem de dos parámetros, mediante el cual se logra detectar la presencia de ítems en una escala de depresión que miden de manera distinta a los examinados en comparación con el resto de ítems que componen dicho instrumento. Finalmente, se presentan algunas recomendaciones generales en cuanto a la complementariedad que debe existir entre la teoría sustantiva que subyace al desarrollo de una escala y la aplicación de los modelos de mezcla de la Teoría de respuesta al ítem.

The Item Response Theory mixture models and how these can be used to identify unobserved sub-groups of examinees, known as latent classes, are presented. The usefulness of the two-parameter mixture model parameters is exemplified by detecting the presence of items in a depression scale that measure the examinees differently in comparison with the rest of items. Finally, some general recommendations regarding the complementarity that should exist between the substantive theory underlying the development of a scale and the use of these models are given.

Late-life depressive symptoms: prediction models of change.

BACKGROUND: Depression is a well-recognised problem in the elderly. The aim of this study was to determine the factors associated with predictors of change in depressive symptoms, both in subjects with and without baseline significant depressive symptoms. METHODS: Longitudinal study of community-dwelling elderly people (>60 years or older), baseline evaluations, and two additional evaluations were reported. Depressive symptoms were measured using a 30-item geriatric depression scale, and a score of 11 was used as cut-off point for significant depressive symptoms in order to stratify the analyses in two groups: with significant depressive symptoms and without significant depressive symptoms. Sociodemographic data, social support, anxiety, cognition, positive affect, control locus, activities of daily living, recent traumatic life events, physical activity, comorbidities, and quality of life were evaluated. Multi-level generalised estimating equation model was used to assess the impact on the trajectory of depressive symptoms. RESULTS: A number of 7882 subjects were assessed, with 29.42% attrition. At baseline assessment, mean age was 70.96 years, 61.15% were women. Trajectories of depressive symptoms had a decreasing trend. Stronger associations in those with significant depressive symptoms, were social support (OR.971, p<.001), chronic pain (OR 2.277, p<.001) and higher locus of control (OR.581, p<.001). In contrast for those without baseline significant depressive symptoms anxiety and a higher locus of control were the strongest associations. CONCLUSIONS: New insights into late-life depression are provided, with special emphasis in differentiated factors influencing the trajectory when stratifying regarding basal status of significant depressive symptoms. LIMITATIONS: The study has not included clinical evaluations and nutritional assessments.

Reflexões Sobre o Uso da Escala de Depressão Geriátrica (GDS-15) em Idosos Hospitalizados / Reflections about using the Geriatric Depression Scale (GDS-15) in Hospitalized Aged People

A desordem mental mais comum na terceira idade é a depressão. Os sintomas depressivos nem sempre se apresentam de maneira típica. Nos idosos as queixas somáticas são frequentes e podem ser reforçadas pela hospitalização, tornando os idosos mais suscetíveis ainda a sintomas depressivos. Isso se avigora numa ala geriátrica, onde os pacientes lá internados são muitas vezes mais frágeis, poliqueixosos, e com múltiplas comorbidades. Fundamentado a partir deste contexto, o presente trabalho teve como objetivo buscar reflexões críticas sobre o uso da Escala de Depressão Geriátrica (na versão reduzida - GDS-15), amplamente utilizada, como método para avaliar o quadro depressivo em idosos internados numa enfermaria de geriatria. Este estudo é, sobretudo, qualitativo, cuja coleta de informações envolveu a aplicação da escala proposta. Os resultados incitaram discussões acerca da necessidade de reavaliação da confiabilidade da Escala, podendo ser esta pouco suficiente/adequada para medir os sintomas depressivos destes pacientes específicos.(AU)

The most common mental disorder in the elderly is depression. Depressive symptoms are not always presented in a typical way. In depressed aged people multiple somatic complaints are frequently and can be reinforced by hospitalization, making the elderly more susceptible to depressive symptoms. This happens quite frequently in a geriatric ward, where patients admitted there are often more fragile, sensitive to pain and soreness, and with multiple comorbidities. Based on this context, this study aimed to look for critical reflections about the use of the Geriatric Depression Scale (reduced version - GDS-15), widely used as an evaluation method for assessing depression in elderly patients in a geriatric ward. This study is especially qualitative, in which the information gathered has involved application of the required scale. The results have prompted discussions about the need to reassess the reliability of the scale, making it not sufficient or appropriated to measure the depressive symptoms of these specific patients.(AU)

Déficits na memória de trabalho em idosos com depressão maior: uma revisão sistemática / Impairment of working memory during a depression of the elderly: a systematic review

A depressão em idosos é associada com prejuízos cognitivos, entretanto a extensão destes à Memória de Trabalho (MT) ainda não é consensual. Portanto, o objetivo deste estudo é revisar sistematicamente as associações encontradas entre MT e depressão em idosos. Para tanto conduzimos uma revisão sistemática dos artigos publicados entre 2000 e 2011 nas principais bases de dados internacionais. Posteriormente a aplicação dos critérios de exclusão, 17 artigos foram revisados integralmente. Os resultados apresentam evidências da associação entre depressão geriátrica e prejuízos da MT, que em alguns trabalhos ainda foram mantidos mesmo após a remissão da sintomatologia de humor.

Geriatric depression is related with cognitive impairments, but how this is connected to specific Working Memory deficits is still unknown. Hence, the aim of this study is to systematically review the literature about the associations between Working Memory impairments and major depression in the elderly. Thus we performed a systematic review, considering published articles in major international databases between 2000 and 2011. After exclusion criteria, 17 articles were fully reviewed. There is evidence that there is indeed an association between depression in elderly and Working Memory impairments. In addition, some articles found that such deficits are sustained even after mood symptoms remission.

Reflexões sobre o uso da escala de depressão geriátrica (GDS-15) em idosos hospitalizados / Reflections about using the geriatric depression scale (GDS-15) in hospitalized aged people

A desordem mental mais comum na terceira idade é a depressão. Os sintomas depressivos nem sempre se apresentam de maneira típica. Nos idosos as queixas somáticas são frequentes e podem ser reforçadas pela hospitalização, tornando os idosos mais suscetíveis ainda a sintomas depressivos. Isso se avigora numa ala geriátrica, onde os pacientes lá internados são muitas vezes mais frágeis, poliqueixosos, e com múltiplas comorbidades. Fundamentado a partir deste contexto, o presente trabalho teve como objetivo buscar reflexões críticas sobre o uso da Escala de Depressão Geriátrica (na versão reduzida - GDS-15), amplamente utilizada, como método para avaliar o quadro depressivo em idosos internados numa enfermaria de geriatria. Este estudo é, sobretudo, qualitativo, cuja coleta de informações envolveu a aplicação da escala proposta. Os resultados incitaram discussões acerca da necessidade de reavaliação da confiabilidade da Escala, podendo ser esta pouco suficiente/adequada para medir os sintomas depressivos destes pacientes específicos.

The most common mental disorder in the elderly is depression. Depressive symptoms are not always presented in a typical way. In depressed aged people multiple somatic complaints are frequently and can be reinforced by hospitalization, making the elderly more susceptible to depressive symptoms. This happens quite frequently in a geriatric ward, where patients admitted there are often more fragile, sensitive to pain and soreness, and with multiple comorbidities. Based on this context, this study aimed to look for critical reflections about the use of the Geriatric Depression Scale (reduced version - GDS-15), widely used as an evaluation method for assessing depression in elderly patients in a geriatric ward. This study is especially qualitative, in which the information gathered has involved application of the required scale. The results have prompted discussions about the need to reassess the reliability of the scale, making it not sufficient or appropriated to measure the depressive symptoms of these specific patients.

Déficits na memória de trabalho em idosos com depressão maior: uma revisão sistemática / Impairment of working memory during a depression of the elderly: a systematic review

A depressão em idosos é associada com prejuízos cognitivos, entretanto a extensão destes à Memória de Trabalho (MT) ainda não é consensual. Portanto, o objetivo deste estudo é revisar sistematicamente as associações encontradas entre MT e depressão em idosos. Para tanto conduzimos uma revisão sistemática dos artigos publicados entre 2000 e 2011 nas principais bases de dados internacionais. Posteriormente a aplicação dos critérios de exclusão, 17 artigos foram revisados integralmente. Os resultados apresentam evidências da associação entre depressão geriátrica e prejuízos da MT, que em alguns trabalhos ainda foram mantidos mesmo após a remissão da sintomatologia de humor.(AU)

Geriatric depression is related with cognitive impairments, but how this is connected to specific Working Memory deficits is still unknown. Hence, the aim of this study is to systematically review the literature about the associations between Working Memory impairments and major depression in the elderly. Thus we performed a systematic review, considering published articles in major international databases between 2000 and 2011. After exclusion criteria, 17 articles were fully reviewed. There is evidence that there is indeed an association between depression in elderly and Working Memory impairments. In addition, some articles found that such deficits are sustained even after mood symptoms remission.(AU)

Effects of physical exercise on plasma levels of brain-derived neurotrophic factor and depressive symptoms in elderly women--a randomized clinical trial.

OBJECTIVES: To investigate the effect of 2 standardized exercise programs, muscle strength exercises (SE) and aerobic exercises (AE), on the plasma levels of brain-derived neurotrophic factor (BDNF) and depressive symptoms in 451 elderly women. DESIGN: A randomized controlled trial. SETTING: Belo Horizonte/MG-Brazil. PARTICIPANTS: Community-dwelling older women (N=451; age, 65-89y). INTERVENTION: The participants were divided into 2 groups: SE and AE. Both protocols lasted 10 weeks, and 30 sessions (1-h sessions) in total were performed 3 times a week under the direct supervision of physical therapists. MAIN OUTCOME MEASURES: Plasma levels of BDNF (enzyme-linked immunosorbent assay) and depressive symptoms (Geriatric Depression Scale). RESULTS: There was a significant difference for BDNF plasma levels between the SE and AE groups (P=.009). Post hoc analysis revealed a pre-post intervention difference in BDNF levels only for the SE group (P=.008). A statistically significant difference was found for the pre- and postintervention Geriatric Depression Scale scores in both groups (P=.001), showing that the effects of both exercise protocols were comparable regarding depressive symptoms (P=.185). CONCLUSIONS: The present findings have demonstrated the positive effect of muscle strengthening and aerobic intervention on depressive symptoms in community-dwelling elderly women. Interestingly, only SE significantly increased the plasma levels of BDNF in our sample. The positive effects of physical exercise on depressive symptoms in the elderly were not mediated by BDNF.

Depresión en adultos mayores de cuatro hogares geriátricos de Barranquilla (Colombia): prevalencia y factores de riesgo / Depression older adults in four nursing homes of Barranquilla (Colombia): prevalence and risk factors

Resumen Objetivo: Establecer la prevalencia y factores de riesgo para depresión en adultos de 65 - 95 años de centros de cuidado geriátrico de Barranquilla. Materiales y métodos: Estudio descriptivo transversal, con análisis de casos y controles. Participaron 66 adultos mayores. Se aplicó encuesta de factores de riesgo, Minimental Test y la Escala de Depresión Geriátrica de Yesavage. Se estudiaron las variables independientes: edad, sexo, nivel educativo, ingresos económicos, fuentes de ingresos, coomorbilidad y tipo, polifarmacia, y tipo de institución. Se realizó análisis bivariado de depresión y las variables independientes. Se efectuó el análisis mediante porcentaje, tendencia central y media y desviación estándar y asociación (Or e IC 95 % y Chi-cuadrado y p). Resultados: La prevalencia de depresión fue de 36.4 %, y predominó la leve (24.2 %). Fueron factores de riesgo: nivel educativo: primaria incompleta (OR: 1,9, IC 95 %:0,02 - 5,43, p: 0,0090) y presentar trastornos neurológicos y psiquiátricos (OR: 6,6, IC 95 %: 1,21 - 35,9, p: 0,0215). Presentaron fuerza de asociación significativa: el sexo masculino y ser soltero. Mostraron fuerza en la asociación no significante, la fuente de ingresos, los ingresos económicos menores de 1 salario mínimo legal vigente (SMLV), la polifarmacia y el tipo de hogar. Conclusiones: La depresión está en un tercio de la población institucionalizada, en este estudio afectó a los adultos con primaria incompleta y algún trastorno neurológico o psiquiátrico. Asimismo, los hombres, los solteros, los que tienen ingresos muy bajos, que provienen de las familias con ingresos menores a 1 salario mínimo, que tienen hipotensión arterial y viven en hogares geriátricos públicos.

Abstract Objective: To determine the prevalence and risk factors for depression in adults of 65 - 95 years of geriatric care centers in Barranquilla. Materials and methods: Cross-sectional study, with case-control analysis. 66 seniors participated. Survey was risk factors and Minimental Test and Yesavage Geriatric Depression Scale. Independent variables were studied: age, sex, educational level, income, income sources, associated diseases and type, polypharmacy, and type of institution. It was performed Bivariate analysis was done according depression and the independent variables. Analysis was performed by: percent, average and standard deviation and association (Or and CI 95 % and Chi-square and p). Results: The prevalence of depression was 36.4 % predominantly mild depression (24.2 %). Were established risk factors to have an incomplete primary education level (OR: 1.9, IC 95% 0.02 - 5.43, p: 0, 0090) and present neurological and psychiatric disorders (OR: 6, 6, IC 95 %: 1.21-35.9, p: 0, 0215). Showed significant association strength: male sex and single marital status. Strength showed no significant association, the source of income, income less than 1 SMLV, polypharmacy and the type of home. Conclusions: Depression was found in one third of the institutionalized population, being more affected, adults with incomplete primary education and some neurological or psychiatric disorder. Likewise, men, singles, those with low incomes, which come from families who have low blood pressure and living in public nursing homes.

Long-term prognosis of geriatric major depression in relation to cognition and white matter integrity: follow up of two cases / Prognóstico de longo prazo da depressão geriátrica em relação à cognição e à integridade da substância branca: acompanhamento de dois casos

INTRODUCTION: The geriatric depression (GD) represents one of the most frequent psychiatric disorders in outpatient services specialized in old-age treatment. OBJECTIVE: The course of two illustrative cases of GD is discussed, highlighting its clinical picture after antidepressant treatment and underlining variables related to disease prognosis, treatment effectiveness and conversion to major cognitive disorders such as vascular dementia (VD). METHODS: The cognitive performance, depressive symptoms, autonomy and brain structural measurements as white matter hyperintensities (WMH) and hippocampal size, and microstructural integrity of WM with diffusion tensor imaging were followed during four years. RESULTS: Case 1, with a severe degree of WMH, was associated with worsening cognition and increasing functional disability. Case 2, with mild WMH, an improvement of cognitive functioning could be seen. CONCLUSIONS: The existence of different subtypes of GD, as presented in this report, points a pathophysiological heterogeneity of GD, and suggests a possible continuum vascular depression (VaDp) and vascular cognitive impairment (VCI).

INTRODUÇÃO: A depressão geriátrica (DG) representa um dos mais frequentes transtornos psiquiátricos em ambulatórios especializados em idosos. OBJETIVO: Discutir a evolução da DG por meio de dois casos ilustrativos, destacando-se as variáveis relacionadas ao prognóstico da doença e à conversão para quadros cognitivos mais graves como demência vascular (DV). MÉTODOS: Os casos foram acompanhados por quatro anos com medidas do desempenho cognitivo, funcional, sintomas depressivos, juntamente com as alterações de estruturas cerebrais, como hiperintensidades da substância branca (HSB), dimensões hipocampais, e a integridade microestrutural da SB, por meio de imagens com tensor de difusão. RESULTADOS: Caso 1, com grave intensidade de HSB, evoluiu com piora cognitiva e funcional. Caso 2, com leve intensidade de HSB, evoluiu com melhora cognitiva após o tratamento da depressão. CONCLUSÕES: A existência de diferentes subtipos de DG, como apresentado neste relato, aponta para a heterogeneidade da fisiopatologia da DG, sugerindo um possível continuum entre depressão vascular (DpVa) e comprometimento cognitivo vascular (CCV).