Characterization and Bile Acid Binding Capacity of Dietary Fiber Obtained from Three Different Amaranth Products.

Amaranth is a dicotyledonous plant, now considered a health-promoting food. It has been rediscovered by the worldwide food industry, which is increasingly becoming aware of the many uses and benefits provided by amaranth in various food preparations. Amaranth dietary fibers, soluble and insoluble fractions, obtained from flour, protein isolate, and beverage were physicochemically characterized and their potential bile acid binding capacity was evaluated. Primary bile acids binding to fiber might contribute to a hypocholesterolemic effect, while the binding of secondary bile acids could minimize the cytotoxic effect that these metabolites exert on the colon. Amaranth fiber fractions were capable of sequestering cholate, taurocholate, deoxycholate, and bovine bile, with a percentage depending not only on the origin and the type of amaranth fiber evaluated but also on the bile acid studied. Flour fiber and the protein isolate insoluble fractions were the most efficient for binding bile and bile acids with uptake values between 29 and 100% relative to cholestyramine. Moreover, deoxycholate, a hydrophobic secondary bile acid, was the most captured by all the fractions, reaching 100% uptake with total and insoluble fibers of the three amaranth products. These results would suggest that the main effect through which amaranth fiber binds bile acids corresponds to an adsorptive effect mediated by hydrophobic interactions.

Micro problems with macro consequences: accumulation of persistent organic pollutants and microplastics in human breast milk and in human milk substitutes.

Industrial activities provide a modern human lifestyle with advances and comforts in every field. However, such scenario has brought several negative issues. Persistent organic pollutants (POPs) and a growing plastic usage together with the degradation byproducts, namely microplastics (MPs), are current environmental problems present in every ecosystem, disturbing all forms of life. POPs and MPs are also found in human consumption products including animal and vegetal derivatives, human milk substitutes, and in human breast milk. To date, it is currently unknown what are the effects of MPs and POPs when ingested during the first and most important stage for health programming of the offspring, the first 1000 days of life. Here, we add epidemiological and clinical evidence supporting major sources of POPs and MPs in the ecosystem; and we will precisely describe the effect of POP and MP accumulation in animal- or plant-based infant formulas and human breast milk, modulating health outcomes in the newborn. This review provides a rational to incentive the POP and MP identification in human breast milk and human milk substitutes for avoiding susceptibility to negative health outcomes for the newborn.

Health risk assessments of exposure carbon dioxide among communities and children around Tonasa cement plant, Pangkep Regency, Indonesia. Monte Carlo Simulation (MCS) application / Avaliações de risco à saúde na exposição ao dióxido de carbono entre comunidades e crianças ao redor da fábrica de cimento Tonasa, Pangkep Regency, Indonésia. Aplicação da Simulação de Monte Carlo (MCS)

Abstract Chronic exposure to carbon dioxide (CO2) can have a negative influence on one's health and be hazardous to the environment. It could be both directly and indirectly to those communities who are living near the CO2 point sources. This study aimed to investigate the magnitude of CO2 level in ambient air and its spatial distribution which then continued to assess the potential health risks posed by communities living surround the site as well as applied the Monte Carlo Simulation (MCS) approach to predict the risks magnitude among adult and children due to CO2 air pollution from the cement industry activities in Pangkep. This observational analytic study applied health risk assessment due to the CO2 exposure both to adult and children population. To estimate the non carcinogenic risk, study used the Monte Carlo Simulation model with 10,000 iterations to estimate the risk through the inhalation pathway suffered by communities, as well as analyzing the sensitivity level every single health risk parameter. The highest risks for the adults was in station 7 with 7,641 whereas the lowest risks was in station 3 with 1,194, respectively. Furthermore, the highest risks for child was in station 4 with 498 whereas the lowest one was in station 15 with 32, respectively. Those non carcinogenic HQ were exceed the standard for adult but not at risks for children. The results of the Monte Carlo Simulation that assessed the non risks cancer probability with the 5th and 95th percentiles demonstrated that adult population were at value of 0.83 and 1.53 0.83 and 1.53 respectively, that still indicated at low risk for developing adverse health effects among those communities temporarily. However, at the same percentiles children indicated at value of 199 and 388 that indicated at risk for developing adverse health effects among those children. In addition, level of sensitivity analysis result indicated that exposure frequency with (20,9%) for adult and the exposure duration with (25,6%) for children were the most contributing factors to health risks among, respectively. Simulation determines the critical factors with major effects in reducing health risks. The CO2 magnitude not poses risks to adults, by contrast, children are at risk. Thus, limiting exposure frequency and inhalation of CO2 levels in the school for children area are highly demanded.

Resumo A exposição crônica ao dióxido de carbono (CO2) pode ter uma influência negativa sobre a saúde e ser perigosa para o meio ambiente. Pode ser direta ou indiretamente para as comunidades que vivem perto das fontes pontuais de CO2. Este estudo teve como objetivo investigar a magnitude do nível de CO2 no ar ambiente e sua distribuição espacial, que então continuou a avaliar os riscos potenciais à saúde apresentados pelas comunidades que vivem no entorno do local, bem como aplicou a abordagem da Simulação de Monte Carlo (MCS) para prever a magnitude dos riscos entre adultos e crianças devido à poluição do ar por CO2 das atividades da indústria de cimento em Pangkep. Este estudo analítico observacional aplicou a avaliação de risco à saúde devido à exposição ao CO2 tanto na população adulta quanto na infantil. Para estimar o risco não cancerígeno, o estudo utilizou o modelo da Simulação de Monte Carlo com 10.000 iterações para estimar o risco pela via inalatória sofrida pelas comunidades, bem como analisar o nível de sensibilidade de cada parâmetro de risco à saúde. O maior risco para os adultos foi na estação 7 com 7.641 enquanto o menor risco foi na estação 3 com 1.194, respectivamente. Além disso, o maior risco para crianças estava na estação 4 com 498 enquanto o menor estava na estação 15 com 32, respectivamente. Aqueles HQ não cancerígenos excederam o padrão para adultos, mas não representam riscos para crianças. Os resultados da Simulação de Monte Carlo que avaliaram a probabilidade de câncer sem riscos com os percentis 5 e 95 demonstraram que a população adulta estava no valor de 0,83 e 1,53 respectivamente, que ainda indicava baixo risco para desenvolver efeitos adversos à saúde entre essas comunidades temporariamente. No entanto, nos mesmos percentis, as crianças indicaram valores de 199 e 388, que mostraram risco de desenvolver efeitos adversos à saúde entre essas crianças. Além disso, o resultado da análise de nível de sensibilidade indicou que a frequência de exposição com 20,9% para adultos e a duração da exposição com 25,6% para crianças foram os fatores que mais contribuíram para riscos à saúde, respectivamente. A simulação determina os fatores críticos com efeitos importantes na redução dos riscos à saúde. A magnitude do CO2 não oferece riscos aos adultos, ao contrário, as crianças correm risco. Assim, a limitação da frequência de exposição e inalação de níveis de CO2 na área escolar para crianças é altamente exigida.

Evaluation of blood Bisphenol A contents: a case study / Evaluación de las concentraciones de Bisfenol A en la sangre: estudio de caso

OBJECTIVE: It has been recently reported that Bisphenol A (BPA) may leach out into food, beverages and water samples from the plastic ware in which it is stored. Serious health hazards have been reported from BPA. The purpose of this study is to assess the BPA contents in blood and to assess the risk of cancer. METHOD: A total of 100 individuals were selected for study according to the following five age groups: 5-10, 11-20, 21-30, 31-40 and 41-50 years. They were then further divided into normal and diseased. Age, gender, education, source of drinking water, type of food, smoking habit, any exposure to chemicals and history of cancer were elicited during interview. Blood samples were collected and processed for analysis using reversed phase-high performance liquid chromatography (rp-HPLC) in isocratic mode. The mobile phase consisted of acetonitrile and water (1:1) at a flow-rate of 1 ml min-1. RESULTS: Bisphenol A contents found in blood samples of all age groups ranged from 1.53-3.98 (mean = 2.94, SD = 0.9). P-values, for the exposed people and those having a history of cancer, were < 0.05 showing a significant relationship between BPA and cancer. The United States Environmental Protection Agency (US EPA) has established a reference dose of 50 µg/L. Odd ratios and relative risk for smoking habit were < 1 while for all others they were > 1. CONCLUSION: It was concluded from the study that people using bottled water, packaged food, having a history ofcancer and who had been exposed to any type ofchemicals are at higher risk ofdisease.

OBJETIVO: Se ha reportado recientemente que el bisfenol A (BPA) puede filtrarse a alimentos, bebidas y agua, a partir de los recipientes plásticos en que aquellos se almacenan. En tal sentido, se han reportado serios casos de riesgo para la salud a causa del BPA. El propósito de este estudio es evaluar la concentración de BPA en sangre, y el consiguiente riesgo de enfermedades cancerosas. MÉTODO: Un total de 100 individuos fueron seleccionados para el estudio, de acuerdo con los siguientes cinco grupos etarios: 5-10, 11-20, 21-30, 31-40 y 41-50 años. Dichos grupos fueron divididos entonces sobre la base de sujetos normales frente a enfermos. En la entrevista se tomó nota de la edad, el género, la educación, la fuente de agua potable, el tipo de comida, el hábito de fumar, cualquier exposición a productos químicos, así como la historia de cáncer. Las muestras de sangre fueron recogidas y procesadas para realizar análisis, utilizando cromatografía líquida de alta eficacia de fase reversa (rp-HPLC) en modo isocrático. La fase móvil consistió en acetonitrilo y agua (1:1) con una tasa de flujo de 1 ml min-1. RESULTADOS: Las concentraciones de bisfenol-A halladas en las muestras de sangre de todos los grupos etarios, oscilaron de 1.53 - 3.98 (M = 2.94, SD = 0.9). Los valores P para las personas expuestas y con una historia de cáncer, fueron < 0.05, indicando una relación directa entre el BPA y el cáncer. La Agencia de Protección Ambiental de los Estados Unidos (US EPA) ha establecido una dosis de referencia de 50 µg/L. El cociente de probabilidades (odd ratios) y el riesgo relativo con respecto al hábito de fumar fueron < 1 mientras que para todos los otros casos otros fueron >1. CONCLUSIÓN: A partir del estudio se concluye que las personas que usan agua embotellada, alimentos empaquetados, así como las personas que poseen una historia de cáncer, y los individuos que habían estado expuestos a cualquier tipo de productos químicos, presentan un mayor riesgo de enfermedad.