Treatment of knee osteoarthritis with intra-articular injection of allogeneic adipose-derived stem cells (ADSCs) ELIXCYTE®: a phase I/II, randomized, active-control, single-blind, multiple-center clinical trial.

OBJECTIVE: To evaluate the safety and efficacy of intra-articular (IA) injection of allogeneic adipose-derived stem cells (ADSCs) ELIXCYTE® for knee osteoarthritis. METHODS: This was a patient-blind, randomized, active-control trial consisted of 4 arms including hyaluronic acid (HA) control and 3 ELIXCYTE® doses. A total of 64 subjects were screened, and 57 subjects were randomized. The primary endpoints included the changes from baseline to post-treatment visit of Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain score at Week 24 and the incidence of adverse events (AEs) and serious adverse events (SAEs). RESULTS: No ELIXCYTE®-related serious adverse events were reported during 96 weeks of follow-up and no suspected unexpected serious adverse reaction (SUSAR) or death was reported. The changes of the primary endpoint, WOMAC pain score at Week 24, showed significant differences in all ELIXCYTE® groups, as well as in HA groups between post-treatment visit and baseline. The ELIXCYTE® groups revealed significant decreases at Week 4 compared to HA group in WOMAC total scores, stiffness scores, functional limitation scores suggested the potential of ELIXCYTE® in earlier onset compared to those from HA. The significant differences of visual analog scale (VAS) pain score and Knee Society Clinical Rating System (KSCRS) functional activities score at Week 48 after ELIXCYTE® administration suggested the potential of ELIXCYTE® in the longer duration of the effectiveness compared to HA group. CONCLUSIONS: ELIXCYTE® for knee osteoarthritis treatment was effective, safe, and well-tolerated. The efficacy results were showed that ELIXCYTE® conferred the earlier onset of reductions in pain scores and improvements in functional scores than HA group. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02784964. Registered 16 May, 2016-Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02784964.

2012 Survey of KSCRS and KOS Member: Current Trends in Cataract Surgery in Korea

PURPOSE: This study investigated the current trends and changes in the field of cataract surgery in Korea. METHODS: The members of the Korean Society of Cataract and Refractive Surgery (KSCRS) and the members of the Korean Ophthalmological Society (KOS) participated in a survey on cataract surgery in 2012, the 16th survey, consisting of 108 multiple-choice questions, mailed in July 2013 to 301 KSCRS and KOS members. Sixty two (20.6%) members answered the questions. Current data were compared with previous surveys performed in 2006 and 2009. RESULTS: Most of the respondents (46%) were in the fourth decade, 43% in the fifth decade and 10% in the sixth decade of life. The duration of hospital stay had decreased annually and the use of topical anesthesia (69%) was the most preferred. Self-sealing wound construction was the main wound closure technique in phacoemulsification (72%). The most preferred intraocular lens (IOL) for cataract surgery was hydrophobic acrylic (76%) which showed an increasing trend. The implantation of phakic IOL was performed by 41% of the respondents and interest in the value added IOLs such as presbyopia IOL and toric IOL had increased annually. In addition, to minimize astigmatism following cataract surgery, several methods were performed according to the degree of astigmatism. However, there was little interest in new cataract surgery techniques such as femtosecond laser and many respondents were skeptical whether to adopt the femtosecond laser cataract surgery system. CONCLUSIONS: This survey summarized current trends and changes in the field of cataract surgery in Korea.

Cataract and refractive surgery in ; a survey of KSCRS members from 1995~2006.

PURPOSE: This purpose of this report was to study trends in cataract and refractive surgeries conducted during the past twelve years and to compare results to previous reports from the ASCRS and New Zealand (NZ) in order to forecast future medical services. METHODS: We surveyed members of the Korean Society of Cataract and Refractive Surgery (KSCRS) every year from 1995 to 2006, and studied changes in cataract and refractive surgeries (RS). RESULTS: The duration of hospitalization has been gradually decreasing to the point that a one day hospitalization following surgery has become common. The rate of topical anesthesia use has significantly increased since 1998. Sutureless incision methods are now commonly practiced. The use of acryl IOL as an optic material has been gradually increasing for cataract surgeries. KSCRS members showed an interest in the special intraocular lenses as multifocal IOL. While Excimer laser PRK was the most popular refractive surgery during the first stage, KSCRS members increasingly prefer LASIK to the Excimer laser PRK. Regression of the corrected visual acuity, dry eye, night halo, and flashes were the most common complications following refractive surgeries. Medical disputes related to PRK and LASIK have been gradually increasing throughout the study period. CONCLUSIONS: We confirm that the KSCRS practice styles for cataract and RS are similar to those of the ASCRS and NZ. We infer a world-wide trend from the comparison of these three societies.

2007 Survey for KSCRS Members: Current Trends in Cataract Surgery in Korea

PURPOSE: This study investigated the current situation and future trends in the field of cataract surgery in Korea. METHODS: Since 1995, the members of the Korean Society of Cataract and Refractive Surgery (KSCRS) have conducted annual surveys regarding cataract and refractive surgery. The 2007 annual survey, consisting of 85 multiple-choice questions, was mailed in February 2008 to 301 KSCRS members. Sixty-two (20.6%) members answered the questions. Current data were compared with data from previous annual surveys and with surveys in the United States and Europe. RESULTS: Fifty-four percent of the respondents were over 50 years of age. The duration of hospital stay has decreased annually and the use of topical anesthesia (57%) has slightly increased. Self-sealing wound construction was the main wound closure technique in phacoemulsification (60%). The implantation of phakic intraocular lenses (IOL) was performed in 56% of the respondents and the most preferred IOL for small incision cataract surgery were acrylic (88%). Interest in the additional value of IOL has increased annually. CONCLUSIONS: This survey summarized current trends and changes in cataract surgery in Korea.

2006 Survey for KSCRS Members: Current Trends in Refractive Surgery in Korea

PURPOSE: To investigate the current situation and future trends in the field of refractive surgery in Korea. METHODS: Since 1995, the members of the Korean Society of Cataract and Refractive Surgery (KSCRS) have been annually surveyed on cataract and refractive surgery. The 2006 annual survey, consisting of 63 multiple-choice questions, was mailed in July 2007 to 298 KSCRS members. Forty-eight (16.1%) of the members responded to the survey. The current data were compared with those of previous annual surveys and with those of the USA. RESULTS: The society members in their forties accounted for the highest percentage (39%) of the respondents, and LASIK was the most common (50%) of the refractive surgeries. Among the possible complications that arise after refractive surgeries, the regression of corrected vision after PRK, and dry eye syndrome after LASIK accounted for the highest proportion. LASIK was preferred for patients with myopia less than -12 diopter, and phakic IOL was preferred for patients with myopia more than -12 diopter. Almost all of the respondents answered that the most promising refractive surgery is LASIK or phakic IOL. CONCLUSIONS: This survey summarized current trends and changes in cataract and refractive surgery in Korea.

2007 Survey for KSCRS Members: Current Trends in Refractive Surgery in Korea

PURPOSE: To investigate the current situation and future trends in the field of refractive surgery in Korea. METHODS: Since 1995, the members of the Korean Society of Cataract and Refractive Surgery (KSCRS) have been annually surveyed on cataract and refractive surgery. The 2007 annual survey, consisting of 66 multiple-choice questions, was mailed in August 2008 to 336 KSCRS members. Fifty (14.9%) members answered. Current data were compared with those of previous annual survey and with those of the USA. RESULTS: The respondents in their forties accounted for the highest percentage (38%) of the subjects, and VISX S4 was the most popularly used (32%). The use of IntraLase femtosecond laser (AMO, USA) had increased. LASIK still accounted for the highest percentage (48%) of refractive surgeries. LASIK was preferred for myopia less than -8D, and phakic IOL was preferred for myopia more than -8D. Almost all the respondents answered that most promising refractive surgery is phakic IOL and the respondents who preferred LASIK decreased. CONCLUSIONS: This survey summarized current trends and changes in cataract and refractive surgery in Korea.

Cataract and Refractive Surgery in ; a Survey of KSCRS Members From 1995~2006

PURPOSE: This purpose of this report was to study trends in cataract and refractive surgeries conducted during the past twelve years and to compare results to previous reports from the ASCRS and New Zealand (NZ) in order to forecast future medical services. METHODS: We surveyed members of the Korean Society of Cataract and Refractive Surgery (KSCRS) every year from 1995 to 2006, and studied changes in cataract and refractive surgeries (RS). RESULTS: The duration of hospitalization has been gradually decreasing to the point that a one day hospitalization following surgery has become common. The rate of topical anesthesia use has significantly increased since 1998. Sutureless incision methods are now commonly practiced. The use of acryl IOL as an optic material has been gradually increasing for cataract surgeries. KSCRS members showed an interest in the special intraocular lenses as multifocal IOL. While Excimer laser PRK was the most popular refractive surgery during the first stage, KSCRS members increasingly prefer LASIK to the Excimer laser PRK. Regression of the corrected visual acuity, dry eye, night halo, and flashes were the most common complications following refractive surgeries. Medical disputes related to PRK and LASIK have been gradually increasing throughout the study period. CONCLUSIONS: We confirm that the KSCRS practice styles for cataract and RS are similar to those of the ASCRS and NZ. We infer a world-wide trend from the comparison of these three societies.

2006 Survey for KSCRS Members: Current Trends in Cataract Surgery in Korea

PURPOSE: To investigate the current situation and future trends in the field of cataract surgery in Korea. METHODS: Since 1995, the members of the Korean Society of Cataract and Refractive Surgery (KSCRS) have conducted annual surveys on cataract and refractive surgery. The 2006 annual survey, consisting of 89 multiple-choice questions, was mailed in February 2007 to 289 KSCRS members. Sixty (20.7%) members answered the questions. Current data were compared with data of previous annual surveys and with data of surveys in the United States and Europe. RESULTS: Fifty-one percent of the respondents were in their fifties. The duration of hospital stays has decreased annually, and the use of topical anesthesia (53%) has not changed. Self-sealing wound construction was the main wound closure technique in phacoemulsification (52%). The implantation of phakic intraocular lenses (IOL) was performed on 50% of the respondents, and the preferred IOLs for small incision cataract surgery were acrylic (87%). Interest in the added value of IOL has increased annually. CONCLUSIONS: This survey summarized current trends and changes in cataract surgery in Korea.

Refractive Surgery 2005 in Korea

PURPOSE: This study investigates the current situation and future trends in the field of refractive surgery in Korea. METHODS: Since 1995, members of the Korean Society of Cataract and Refractive Surgery (KSCRS) have been surveyed annually on cataract and refractive surgery. The 2005 annual survey, consisting of 63 multiple-choice questions, was mailed in June 2005 to 300 KSCRS members. Fifty-four (18.0%) members responded. Current data were compared with those of previous annual surveys and with data from the USA. RESULTS: The highest percentage of patients were in their forties (37%), and LASIK accounted for the highest percentage of refractive surgeries (81%). Of complications arising after refractive surgery, the degeneration of corrected vision after PRK and dry eye syndrome after LASIK accounted for the high proportions. LASIK was preferred for myopia less than -12 diopter, and phakic IOL was preferred for myopia greater than -12 diopter. Almost all respondents answered that the most promising refractive surgery is LASIK or phakic IOL. CONCLUSIONS: This survey summarized the current trends and changes in cataract and refractive surgery in Korea.

2005 Survey for KSCRS Members: Current Trends in Cataract Surgery in Korea

PURPOSE: This study investigates the current state of and future trends in the field of cataract surgery in Korea. METHODS: Since 1995, the members of the Korean Society of Cataract and Refractive Surgery (KSCRS) have made annual surveys on cataract and refractive surgery. The 2005 annual survey, consisting of 76 multiple-choice questions, was mailed in February 2005 to 300 KSCRS members. Sixty-six (22.0%) members answered the questions. Current data were compared with those of previous annual surveys and with those of surveys in the United States. RESULTS: Forty-six percent of the respondents were in the fifth decade. The duration of hospital stay has decreased annually and the use of topical anesthesia (44%) did not change. Self sealing wound construction was the main wound closure technique in phacoemulsification (63%). The implantation of phakic IOL was performed by 38% of the respondents and the most preferred intraocular lenses for small incision cataract surgery were acrylic (79%). Interest in the value added IOL has increased annually. CONCLUSIONS: This survey summarized current trends and changes in cataract surgery in Korea.

Refractive Surgery 2004 in Korea

PURPOSE: This study investigates both the current situation and future trends in the field of refractive surgery in Korea. METHODS: Members of the Korean Society of Cataract and Refractive Surgery (KSCRS) have been annually surveyed regarding cataract and refractive surgery since 1995. The 2004 annual survey, which consisted of 58 multiple-choice questions, was mailed in May 2004 to 322 KSCRS members; fifty-four (16.8%) members responded. Data from the 2004 survey was compared with that of previous annual surveys and similar studies from the USA. RESULTS: The respondents indicated that patients in their forties accounted for the highest percentage (57%) of subjects, and LASIK accounted for the highest percentage (82%) of refractive surgeries. Degeneration of corrected vision, night halo, and glare accounted for a high proportion of the complications arising after refractive surgery. LASIK was the preferred method for treating myopia less than -12 diopters, while phakic IOL was preferred for myopia more than -12 diopters. Lastly, more respondents indicated that they had experienced legal problems associated with PRK or LASIK than the previous year. CONCLUSIONS: LASIK remains the refractive surgery procedure of choice, although wavefront-guided ablation is gaining in popularity. Approximately half of the respondents indicated they used MMC in their refractive surgeries.

2004 Survey for KSCRS Members: Current Trends in Cataract Surgery in Korea

PURPOSE: This study investigates the current situation and future trends in the field of cataract and refractive surgery in Korea. METHODS: Since 1995, the members of the Korean Society of Cataract and Refractive Surgery (KSCRS) have been surveyed annually on cataract and refractive surgery. The 2005 annual survey, consisting of 74 multiple-choice questions, was mailed in February 2005 to 364 KSCRS members. Seventy-six (20.8%) members answered. Current data were compared with those of previous annual surveys and with those of annual surveys of ASCRS (American Society of Cataract and Refractive Surgery) members. RESULTS: The duration of hospitalization has decreased annually and the use of topical anesthesia (49%) has hemained stationary. Self sealing wound construction was the main wound closure technique in phacoemulsification (66%). Acrylic intraocular lenses are the most preferred (75%) for small incisioncataract surgery. The implantation of phakic IOL was performed by 30% of respondents and interests in the value added by IOL has increased annually. CONCLUSIONS: This survey summarized current trends and changes in cataract and refractive surgery in Korea.

2003 Survey for KSCRS Members: Current Trends in Cataract and Refractive Surgery in Korea

PURPOSE: This study investigates the current situation and future trends in the field of cataract and refractive surgery in Korea. METHODS: Since 1995, the members of the Korean Society of Cataract and Refractive Surgery (KSCRS) have been annually surveyed on cataract and refractive surgery. The 2004 annual survey, consisting of 128 multiple-choice questions, was mailed in February 2004 to 396 KSCRS members. Eighty-eight(22.2%) members answered. Current data were compared with those of previous annual survey and with those of the USA. RESULTS: The duration of hospitalization has decreased annually and the use of topical anesthesia (41%) was stationary. Self sealing wound construction was the main wound closure technique in phacoemulsification (51%). The most preferred intraocular lenses for small incision cataract surgery are acrylic (60%). Excimer laser keratomileusis was performed for refractive surgery by 63% of the repondents. Most respondents preferred LASIK regardless of diopter range. More respondents had experienced legal problems associated with PRK or LASIK than in the last year survey. The implantation of phakic IOL was performed by 29% of the respondents and 96% of the respondents were interested in it. CONCLUSIONS: This survey summarized current trends and changes in cataract and refractive surgery in Korea.

2001 Survey for KSCRS Members Current Trends in Cataract and Refractive Surgery in Korea

PURPOSE: We purposed to understand the current trends in the field of cataract and refractive surgery in Korea. METHODS: Since 1995, The members of the Korean Society of Cataract and Refractive Surgery (KSCRS) has annually surveyed on cataract and refractive surgery. 2002 annual survey forms which consists of 106 multiple-choice questions mailed to 358 members of the KSCRS. Approximately 35% of the members answered. Current data were compared with previous annual survey data and with those of Japan and USA. RESULTS: Duration of hospitalization has decreased annually and the use of topical anesthesia(35%) slightly decreased steadily. Self sealing wound construction was the main wound closure technique in phacoemulsification (35%). Acrylic intraocular lens in small incision cataract surgery was most preferred (48%). Seventy percent of the respondents performed excimer laser keratectomy. The most common complication of excimer laser was the regression of visual acuity (40%). Most respondents preferred LASIK regardless of diopter range. More respondents experienced legal problems associated with PRK or LASIK than those in last year survey. CONCLUSIONS: This survey summarized current trends and changes in cataract and refractive surgery in Korea are similar to those of Japan and USA.

A Factual Survey on PRK and LASIK in Korea

The surgeons performing photorefractive keratectomy[PRK]and laser in situ keratomileusis[LASIK]and patients got these relatively convenient and effective procedures for correcting myopia are increasing now. Korean Society of cataract and refractive surgery[KSCRS]performed a survey on PRK and LASIK with the members of this society. Seventy-six members replied to questionnaire and fifty answered that they were doing PRK or LASIK. The number of surgeons who had performed more than three hundred cases of PRK or LASIK were twenty-four and seventeen, respectively. The number of surgeons who having done these procedures less than three years were twenty-five and this suggested these operations were much increased recently. Maximum attempted corrections were -5.9 to -6.5 diopter in PRK and -14.4 to -14.9 diopter in LASIK. The surgeons thought reduction of best corrected visual acuity as the complication of LASIK procedure was occurred the incidence of 3.97%[0.1~30%]. Eighty percent of members replied they explained the predictable result and possible complication of operation to their patients by themselves and seventy seven percent of members agreed to the plan that surgeons should do PRK and LASIK with qualification from Korean Ophthalmological Society. We suggest this survey could help performing better procedure by establishing common therapeutic criteria with communication of information and opinion between ophthal-mologist.